Role of protein crystallization in type 2 immunity and asthma

Información del proyecto

ASTHMACRYSTALCLEAR

Identificador del acuerdo de subvención: 789384

DOI

10.3030/789384

Proyecto cerrado

Fecha de la firma de la CE 13 Julio 2018

Fecha de inicio 1 Agosto 2018

Fecha de finalización 31 Julio 2023

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 499 846,00

Aportación de la UE

€ 2 499 846,00

Coordinado por

VIB VZW
Belgium

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (25)

A bispecific antibody strategy to target multiple type 2 cytokines in asthma

Autores: Marie Godar, Kim Deswarte, Karl Vergote, Michael Saunders, Hans de Haard, Hamida Hammad, Christophe Blanchetot, Bart N. Lambrecht
Publicado en: Journal of Allergy and Clinical Immunology, Edición 142/4, 2018, Página(s) 1185-1193.e4, ISSN 0091-6749
Editor: Mosby Inc.
DOI: 10.1016/j.jaci.2018.06.002

Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux

Autores: Jeanne-Marie Perotin, James P.R. Schofield, Susan J. Wilson, Jonathan Ward, Joost Brandsma, Fabio Strazzeri, Aruna Bansal, Xian Yang, Anthony Rowe, Julie Corfield, Rene Lutter, Dominick E. Shaw, Per S. Bakke, Massimo Caruso, Barbro Dahlén, Stephen J. Fowler, Ildikó Horváth, Peter Howarth, Norbert Krug, Paolo Montuschi, Marek Sanak, Thomas Sandström, Kai Sun, Ioannis Pandis, Charles Auffray, Be
Publicado en: European Respiratory Journal, Edición 53/6, 2019, Página(s) 1900453, ISSN 0903-1936
Editor: European Respiratory Society
DOI: 10.1183/13993003.00453-2019

Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection

Autores: Cedric Bosteels, Katrijn Neyt, Manon Vanheerswynghels, Mary J. van Helden, Dorine Sichien, Nincy Debeuf, Sofie De Prijck, Victor Bosteels, Niels Vandamme, Liesbet Martens, Yvan Saeys, Els Louagie, Manon Lesage, David L. Williams, Shiau-Choot Tang, Johannes U. Mayer, Franca Ronchese, Charlotte L. Scott, Hamida Hammad, Martin Guilliams, Bart N. Lambrecht
Publicado en: Immunity, Edición 52/6, 2020, Página(s) 1039-1056.e9, ISSN 1074-7613
Editor: Cell Press
DOI: 10.1016/j.immuni.2020.04.005

Local immune response to food antigens drives meal-induced abdominal pain

Autores: Javier Aguilera-Lizarraga, Morgane V. Florens, Maria Francesca Viola, Piyush Jain, Lisse Decraecker, Iris Appeltans, Maria Cuende-Estevez, Naomi Fabre, Kim Van Beek, Eluisa Perna, Dafne Balemans, Nathalie Stakenborg, Stavroula Theofanous, Goele Bosmans, Stéphanie U. Mondelaers, Gianluca Matteoli, Sales Ibiza Martínez, Cintya Lopez-Lopez, Josue Jaramillo-Polanco, Karel Talavera, Yeranddy A. Alpiz
Publicado en: Nature, Edición 590/7844, 2021, Página(s) 151-156, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-020-03118-2

CCR2- and Flt3-Dependent Inflammatory Conventional Type 2 Dendritic Cells Are Necessary for the Induction of Adaptive Immunity by the Human Vaccine Adjuvant System AS01

Autores: Cedric Bosteels, Kaat Fierens, Sofie De Prijck, Justine Van Moorleghem, Manon Vanheerswynghels, Caroline De Wolf, Aurélie Chalon, Catherine Collignon, Hamida Hammad, Arnaud M. Didierlaurent, Bart N. Lambrecht
Publicado en: Frontiers in Immunology, Edición 11, 2021, ISSN 1664-3224
Editor: Front. Immunol
DOI: 10.3389/fimmu.2020.606805

Professional and ‘Amateur’ Antigen-Presenting Cells In Type 2 Immunity

Autores: Martijn J. Schuijs, Hamida Hammad, Bart N. Lambrecht
Publicado en: Trends in Immunology, Edición 40/1, 2019, Página(s) 22-34, ISSN 1471-4906
Editor: Elsevier BV
DOI: 10.1016/j.it.2018.11.001

The ORMDL3 asthma susceptibility gene regulates systemic ceramide levels without altering key asthma features in mice

Autores: Nincy Debeuf, Assem Zhakupova, Regula Steiner, Sofie Van Gassen, Kim Deswarte, Farzaneh Fayazpour, Justine Van Moorleghem, Karl Vergote, Benjamin Pavie, Kelly Lemeire, Hamida Hammad, Thorsten Hornemann, Sophie Janssens, Bart N. Lambrecht
Publicado en: Journal of Allergy and Clinical Immunology, Edición 144/6, 2019, Página(s) 1648-1659.e9, ISSN 0091-6749
Editor: Mosby Inc.
DOI: 10.1016/j.jaci.2019.06.041

Co-Activation of Glucocorticoid Receptor and Peroxisome Proliferator–Activated Receptor-γ in Murine Skin Prevents Worsening of Atopic March

Autores: Julie Deckers, Nadia Bougarne, Viacheslav Mylka, Sofie Desmet, Astrid Luypaert, Michael Devos, Giel Tanghe, Justine Van Moorleghem, Manon Vanheerswynghels, Lode De Cauwer, Jonathan Thommis, Marnik Vuylsteke, Jan Tavernier, Bart N. Lambrecht, Hamida Hammad, Karolien De Bosscher
Publicado en: Journal of Investigative Dermatology, Edición 138/6, 2018, Página(s) 1360-1370, ISSN 0022-202X
Editor: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2017.12.023

IL-33trap is a novel IL-33–neutralizing biologic that inhibits allergic airway inflammation

Autores: Aurora Holgado, Harald Braun, Elien Van Nuffel, Sammy Detry, Martijn J. Schuijs, Kim Deswarte, Karl Vergote, Mira Haegman, Griet Baudelet, Jurgen Haustraete, Hamida Hammad, Bart N. Lambrecht, Savvas N. Savvides, Inna S. Afonina, Rudi Beyaert
Publicado en: Journal of Allergy and Clinical Immunology, Edición 144/1, 2019, Página(s) 204-215, ISSN 0091-6749
Editor: Mosby Inc.
DOI: 10.1016/j.jaci.2019.02.028

Wnt and Hippo pathways in regulatory T cells: a NOTCH above in asthma

Autores: Hamida Hammad, Bart N. Lambrecht
Publicado en: Nature Immunology, Edición 21/11, 2020, Página(s) 1313-1314, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41590-020-0797-z

Isolated Schistosoma mansoni eggs prevent allergic airway inflammation

Autores: Katja Obieglo, Martijn J. Schuijs, Arifa Ozir-Fazalalikhan, Frank Otto, Yolanda van Wijck, Louis Boon, Bart N. Lambrecht, Christian Taube, Hermelijn H. Smits
Publicado en: Parasite Immunology, Edición 40/10, 2018, Página(s) e12579, ISSN 0141-9838
Editor: Blackwell Publishing Inc.
DOI: 10.1111/pim.12579

How a farming environment protects from atopy

Autores: Julie Deckers, Bart N Lambrecht, Hamida Hammad
Publicado en: Current Opinion in Immunology, Edición 60, 2019, Página(s) 163-169, ISSN 0952-7915
Editor: Elsevier BV
DOI: 10.1016/j.coi.2019.08.001

A pathophysiological role of PDE3 in allergic airway inflammation

Autores: Jan Beute, Melanie Lukkes, Ewout P. Koekoek, Hedwika Nastiti, Keerthana Ganesh, Marjolein J.W. de Bruijn, Steve Hockman, Menno van Nimwegen, Gert-Jan Braunstahl, Louis Boon, Bart N. Lambrecht, Vince C. Manganiello, Rudi W. Hendriks, Alex KleinJan
Publicado en: JCI Insight, Edición 3/2, 2018, ISSN 2379-3708
Editor: ASCI
DOI: 10.1172/jci.insight.94888

The hygiene hypothesis: immunological mechanisms of airway tolerance

Autores: Eline Haspeslagh, Ines Heyndrickx, Hamida Hammad, Bart N Lambrecht
Publicado en: Current Opinion in Immunology, Edición 54, 2018, Página(s) 102-108, ISSN 0952-7915
Editor: Elsevier BV
DOI: 10.1016/j.coi.2018.06.007

Personalized medicine with biologics for severe type 2 asthma: current status and future prospects

Autores: Marie Godar, Christophe Blanchetot, Hans de Haard, Bart N. Lambrecht, Guy Brusselle
Publicado en: mAbs, Edición 10/1, 2018, Página(s) 34-45, ISSN 1942-0870
Editor: Landes Bioscience
DOI: 10.1080/19420862.2017.1392425

Prophylactic allergen immunotherapy with Der p 2 prevents murine asthma by regulating lung GM-CSF

Autores: Eline Haspeslagh, Manon Vanheerswynghels, Kim Deswarte, Justine Van Moorleghem, Alain Jacquet, Bart N. Lambrecht, Hamida Hammad
Publicado en: Journal of Allergy and Clinical Immunology, Edición 143/6, 2019, Página(s) 2307-2311.e5, ISSN 0091-6749
Editor: Mosby Inc.
DOI: 10.1016/j.jaci.2019.02.007

Charcot-Leyden crystals promote neutrophilic inflammation in patients with nasal polyposis

Autores: Elien Gevaert, Tim Delemarre, Joyceline De Volder, Nan Zhang, Gabriele Holtappels, Natalie De Ruyck, Emma Persson, Ines Heyndrickx, Kenneth Verstraete, Helena Aegerter, Hans Nauwynck, Savvas N. Savvides, Bart N. Lambrecht, Claus Bachert
Publicado en: Journal of Allergy and Clinical Immunology, Edición 145/1, 2020, Página(s) 427-430.e4, ISSN 0091-6749
Editor: Mosby Inc.
DOI: 10.1016/j.jaci.2019.08.027

Protein crystallization promotes type 2 immunity and is reversible by antibody treatment

Autores: Emma K. Persson, Kenneth Verstraete, Ines Heyndrickx, Elien Gevaert, Helena Aegerter, Jean-Michel Percier, Kim Deswarte, Koen H. G. Verschueren, Ann Dansercoer, Delphine Gras, Pascal Chanez, Claus Bachert, Amanda Gonçalves, Hanne Van Gorp, Hans De Haard, Christophe Blanchetot, Michael Saunders, Hamida Hammad, Savvas N. Savvides, Bart N. Lambrecht
Publicado en: Science, Edición 364/6442, 2019, Página(s) eaaw4295, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.aaw4295

Tnfaip3 expression in pulmonary conventional type 1 Langerin‐expressing dendritic cells regulates T helper 2‐mediated airway inflammation in mice

Autores: Heleen Vroman, Denise Uden, Ingrid M. Bergen, Jennifer A. C. Hulst, Melanie Lukkes, Geert Loo, Björn E. Clausen, Louis Boon, Bart N. Lambrecht, Hamida Hammad, Rudi W. Hendriks, Mirjam Kool
Publicado en: Allergy, Edición 75/10, 2020, Página(s) 2587-2598, ISSN 0105-4538
Editor: Blackwell Publishing Inc.
DOI: 10.1111/all.14334

Characterization of a lung epithelium specific E-cadherin knock-out model: Implications for obstructive lung pathology

Autores: S. Post, I. H. Heijink, L. Hesse, H. K. Koo, F. Shaheen, M. Fouadi, V. N. S. Kuchibhotla, B. N. Lambrecht, A. J. M. Van Oosterhout, T. L. Hackett, M. C. Nawijn
Publicado en: Scientific Reports, Edición 8/1, 2018, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-31500-8

Eicosanoid Control Over Antigen Presenting Cells in Asthma

Autores: Nincy Debeuf, Bart N. Lambrecht
Publicado en: Frontiers in Immunology, Edición 9, 2018, ISSN 1664-3224
Editor: IUIS
DOI: 10.3389/fimmu.2018.02006

An anti‐siglec‐8 antibody depletes sputum eosinophils from asthmatic subjects and inhibits lung mast cells

Autores: Sheena C. Kerr, Jeanmarie R. Gonzalez, Julia Schanin, Michael C. Peters, Bart N. Lambrecht, Emily C. Brock, Annabelle Charbit, K. M. Ansel, Bradford A. Youngblood, John V. Fahy
Publicado en: Clinical & Experimental Allergy, Edición 50/8, 2020, Página(s) 904-914, ISSN 0954-7894
Editor: Blackwell Publishing Inc.
DOI: 10.1111/cea.13681

Osteopontin Promotes Protective Antigenic Tolerance against Experimental Allergic Airway Disease

Autores: Themis Alissafi, Evangelia Kourepini, Davina C. M. Simoes, Nikolaos Paschalidis, Maria Aggelakopoulou, Tim Sparwasser, Louis Boon, Hamida Hammad, Bart N. Lambrecht, Vily Panoutsakopoulou
Publicado en: The Journal of Immunology, Edición 200/4, 2018, Página(s) 1270-1282, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.1701345

Human Lung Conventional Dendritic Cells Orchestrate Lymphoid Neogenesis during Chronic Obstructive Pulmonary Disease

Autores: Thomas Naessens, Yannick Morias, Eva Hamrud, Ulf Gehrmann, Ramachandramouli Budida, Johan Mattsson, Tina Baker, Gabriel Skogberg, Elisabeth Israelsson, Kristofer Thörn, Martijn J. Schuijs, Bastian Angermann, Faye Melville, Karl J. Staples, Danen M. Cunoosamy, Bart N. Lambrecht
Publicado en: American Journal of Respiratory and Critical Care Medicine, Edición 202/4, 2020, Página(s) 535-548, ISSN 1073-449X
Editor: American Thoracic Society
DOI: 10.1164/rccm.201906-1123oc

TAO-kinase 3 governs the terminal differentiation of NOTCH2-dependent splenic conventional dendritic cells

Autores: Matthias Vanderkerken, Bastiaan Maes, Lana Vandersarren, Wendy Toussaint, Kim Deswarte, Manon Vanheerswynghels, Philippe Pouliot, Liesbet Martens, Sofie Van Gassen, Connie M. Arthur, Margaret E. Kirkling, Boris Reizis, Daniel Conrad, Sean Stowell, Hamida Hammad, Bart N. Lambrecht
Publicado en: Proceedings of the National Academy of Sciences, Edición 117/49, 2020, Página(s) 31331-31342, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2009847117