Role of protein crystallization in type 2 immunity and asthma

Publikacje

A bispecific antibody strategy to target multiple type 2 cytokines in asthma

Autorzy: Marie Godar, Kim Deswarte, Karl Vergote, Michael Saunders, Hans de Haard, Hamida Hammad, Christophe Blanchetot, Bart N. Lambrecht
Opublikowane w: Journal of Allergy and Clinical Immunology, Numer 142/4, 2018, Strona(/y) 1185-1193.e4, ISSN 0091-6749
Wydawca: Mosby Inc.
DOI: 10.1016/j.jaci.2018.06.002

Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux

Autorzy: Jeanne-Marie Perotin, James P.R. Schofield, Susan J. Wilson, Jonathan Ward, Joost Brandsma, Fabio Strazzeri, Aruna Bansal, Xian Yang, Anthony Rowe, Julie Corfield, Rene Lutter, Dominick E. Shaw, Per S. Bakke, Massimo Caruso, Barbro Dahlén, Stephen J. Fowler, Ildikó Horváth, Peter Howarth, Norbert Krug, Paolo Montuschi, Marek Sanak, Thomas Sandström, Kai Sun, Ioannis Pandis, Charles Auffray, Be
Opublikowane w: European Respiratory Journal, Numer 53/6, 2019, Strona(/y) 1900453, ISSN 0903-1936
Wydawca: European Respiratory Society
DOI: 10.1183/13993003.00453-2019

Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection

Autorzy: Cedric Bosteels, Katrijn Neyt, Manon Vanheerswynghels, Mary J. van Helden, Dorine Sichien, Nincy Debeuf, Sofie De Prijck, Victor Bosteels, Niels Vandamme, Liesbet Martens, Yvan Saeys, Els Louagie, Manon Lesage, David L. Williams, Shiau-Choot Tang, Johannes U. Mayer, Franca Ronchese, Charlotte L. Scott, Hamida Hammad, Martin Guilliams, Bart N. Lambrecht
Opublikowane w: Immunity, Numer 52/6, 2020, Strona(/y) 1039-1056.e9, ISSN 1074-7613
Wydawca: Cell Press
DOI: 10.1016/j.immuni.2020.04.005

Local immune response to food antigens drives meal-induced abdominal pain

Autorzy: Javier Aguilera-Lizarraga, Morgane V. Florens, Maria Francesca Viola, Piyush Jain, Lisse Decraecker, Iris Appeltans, Maria Cuende-Estevez, Naomi Fabre, Kim Van Beek, Eluisa Perna, Dafne Balemans, Nathalie Stakenborg, Stavroula Theofanous, Goele Bosmans, Stéphanie U. Mondelaers, Gianluca Matteoli, Sales Ibiza Martínez, Cintya Lopez-Lopez, Josue Jaramillo-Polanco, Karel Talavera, Yeranddy A. Alpiz
Opublikowane w: Nature, Numer 590/7844, 2021, Strona(/y) 151-156, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/s41586-020-03118-2

CCR2- and Flt3-Dependent Inflammatory Conventional Type 2 Dendritic Cells Are Necessary for the Induction of Adaptive Immunity by the Human Vaccine Adjuvant System AS01

Autorzy: Cedric Bosteels, Kaat Fierens, Sofie De Prijck, Justine Van Moorleghem, Manon Vanheerswynghels, Caroline De Wolf, Aurélie Chalon, Catherine Collignon, Hamida Hammad, Arnaud M. Didierlaurent, Bart N. Lambrecht
Opublikowane w: Frontiers in Immunology, Numer 11, 2021, ISSN 1664-3224
Wydawca: Front. Immunol
DOI: 10.3389/fimmu.2020.606805

Professional and ‘Amateur’ Antigen-Presenting Cells In Type 2 Immunity

Autorzy: Martijn J. Schuijs, Hamida Hammad, Bart N. Lambrecht
Opublikowane w: Trends in Immunology, Numer 40/1, 2019, Strona(/y) 22-34, ISSN 1471-4906
Wydawca: Elsevier BV
DOI: 10.1016/j.it.2018.11.001

The ORMDL3 asthma susceptibility gene regulates systemic ceramide levels without altering key asthma features in mice

Autorzy: Nincy Debeuf, Assem Zhakupova, Regula Steiner, Sofie Van Gassen, Kim Deswarte, Farzaneh Fayazpour, Justine Van Moorleghem, Karl Vergote, Benjamin Pavie, Kelly Lemeire, Hamida Hammad, Thorsten Hornemann, Sophie Janssens, Bart N. Lambrecht
Opublikowane w: Journal of Allergy and Clinical Immunology, Numer 144/6, 2019, Strona(/y) 1648-1659.e9, ISSN 0091-6749
Wydawca: Mosby Inc.
DOI: 10.1016/j.jaci.2019.06.041

Co-Activation of Glucocorticoid Receptor and Peroxisome Proliferator–Activated Receptor-γ in Murine Skin Prevents Worsening of Atopic March

Autorzy: Julie Deckers, Nadia Bougarne, Viacheslav Mylka, Sofie Desmet, Astrid Luypaert, Michael Devos, Giel Tanghe, Justine Van Moorleghem, Manon Vanheerswynghels, Lode De Cauwer, Jonathan Thommis, Marnik Vuylsteke, Jan Tavernier, Bart N. Lambrecht, Hamida Hammad, Karolien De Bosscher
Opublikowane w: Journal of Investigative Dermatology, Numer 138/6, 2018, Strona(/y) 1360-1370, ISSN 0022-202X
Wydawca: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2017.12.023

IL-33trap is a novel IL-33–neutralizing biologic that inhibits allergic airway inflammation

Autorzy: Aurora Holgado, Harald Braun, Elien Van Nuffel, Sammy Detry, Martijn J. Schuijs, Kim Deswarte, Karl Vergote, Mira Haegman, Griet Baudelet, Jurgen Haustraete, Hamida Hammad, Bart N. Lambrecht, Savvas N. Savvides, Inna S. Afonina, Rudi Beyaert
Opublikowane w: Journal of Allergy and Clinical Immunology, Numer 144/1, 2019, Strona(/y) 204-215, ISSN 0091-6749
Wydawca: Mosby Inc.
DOI: 10.1016/j.jaci.2019.02.028

Wnt and Hippo pathways in regulatory T cells: a NOTCH above in asthma

Autorzy: Hamida Hammad, Bart N. Lambrecht
Opublikowane w: Nature Immunology, Numer 21/11, 2020, Strona(/y) 1313-1314, ISSN 1529-2908
Wydawca: Nature Publishing Group
DOI: 10.1038/s41590-020-0797-z

Isolated Schistosoma mansoni eggs prevent allergic airway inflammation

Autorzy: Katja Obieglo, Martijn J. Schuijs, Arifa Ozir-Fazalalikhan, Frank Otto, Yolanda van Wijck, Louis Boon, Bart N. Lambrecht, Christian Taube, Hermelijn H. Smits
Opublikowane w: Parasite Immunology, Numer 40/10, 2018, Strona(/y) e12579, ISSN 0141-9838
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/pim.12579

How a farming environment protects from atopy

Autorzy: Julie Deckers, Bart N Lambrecht, Hamida Hammad
Opublikowane w: Current Opinion in Immunology, Numer 60, 2019, Strona(/y) 163-169, ISSN 0952-7915
Wydawca: Elsevier BV
DOI: 10.1016/j.coi.2019.08.001

A pathophysiological role of PDE3 in allergic airway inflammation

Autorzy: Jan Beute, Melanie Lukkes, Ewout P. Koekoek, Hedwika Nastiti, Keerthana Ganesh, Marjolein J.W. de Bruijn, Steve Hockman, Menno van Nimwegen, Gert-Jan Braunstahl, Louis Boon, Bart N. Lambrecht, Vince C. Manganiello, Rudi W. Hendriks, Alex KleinJan
Opublikowane w: JCI Insight, Numer 3/2, 2018, ISSN 2379-3708
Wydawca: ASCI
DOI: 10.1172/jci.insight.94888

The hygiene hypothesis: immunological mechanisms of airway tolerance

Autorzy: Eline Haspeslagh, Ines Heyndrickx, Hamida Hammad, Bart N Lambrecht
Opublikowane w: Current Opinion in Immunology, Numer 54, 2018, Strona(/y) 102-108, ISSN 0952-7915
Wydawca: Elsevier BV
DOI: 10.1016/j.coi.2018.06.007

Personalized medicine with biologics for severe type 2 asthma: current status and future prospects

Autorzy: Marie Godar, Christophe Blanchetot, Hans de Haard, Bart N. Lambrecht, Guy Brusselle
Opublikowane w: mAbs, Numer 10/1, 2018, Strona(/y) 34-45, ISSN 1942-0870
Wydawca: Landes Bioscience
DOI: 10.1080/19420862.2017.1392425

Prophylactic allergen immunotherapy with Der p 2 prevents murine asthma by regulating lung GM-CSF

Autorzy: Eline Haspeslagh, Manon Vanheerswynghels, Kim Deswarte, Justine Van Moorleghem, Alain Jacquet, Bart N. Lambrecht, Hamida Hammad
Opublikowane w: Journal of Allergy and Clinical Immunology, Numer 143/6, 2019, Strona(/y) 2307-2311.e5, ISSN 0091-6749
Wydawca: Mosby Inc.
DOI: 10.1016/j.jaci.2019.02.007

Charcot-Leyden crystals promote neutrophilic inflammation in patients with nasal polyposis

Autorzy: Elien Gevaert, Tim Delemarre, Joyceline De Volder, Nan Zhang, Gabriele Holtappels, Natalie De Ruyck, Emma Persson, Ines Heyndrickx, Kenneth Verstraete, Helena Aegerter, Hans Nauwynck, Savvas N. Savvides, Bart N. Lambrecht, Claus Bachert
Opublikowane w: Journal of Allergy and Clinical Immunology, Numer 145/1, 2020, Strona(/y) 427-430.e4, ISSN 0091-6749
Wydawca: Mosby Inc.
DOI: 10.1016/j.jaci.2019.08.027

Protein crystallization promotes type 2 immunity and is reversible by antibody treatment

Autorzy: Emma K. Persson, Kenneth Verstraete, Ines Heyndrickx, Elien Gevaert, Helena Aegerter, Jean-Michel Percier, Kim Deswarte, Koen H. G. Verschueren, Ann Dansercoer, Delphine Gras, Pascal Chanez, Claus Bachert, Amanda Gonçalves, Hanne Van Gorp, Hans De Haard, Christophe Blanchetot, Michael Saunders, Hamida Hammad, Savvas N. Savvides, Bart N. Lambrecht
Opublikowane w: Science, Numer 364/6442, 2019, Strona(/y) eaaw4295, ISSN 0036-8075
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/science.aaw4295

Tnfaip3 expression in pulmonary conventional type 1 Langerin‐expressing dendritic cells regulates T helper 2‐mediated airway inflammation in mice

Autorzy: Heleen Vroman, Denise Uden, Ingrid M. Bergen, Jennifer A. C. Hulst, Melanie Lukkes, Geert Loo, Björn E. Clausen, Louis Boon, Bart N. Lambrecht, Hamida Hammad, Rudi W. Hendriks, Mirjam Kool
Opublikowane w: Allergy, Numer 75/10, 2020, Strona(/y) 2587-2598, ISSN 0105-4538
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/all.14334

Characterization of a lung epithelium specific E-cadherin knock-out model: Implications for obstructive lung pathology

Autorzy: S. Post, I. H. Heijink, L. Hesse, H. K. Koo, F. Shaheen, M. Fouadi, V. N. S. Kuchibhotla, B. N. Lambrecht, A. J. M. Van Oosterhout, T. L. Hackett, M. C. Nawijn
Opublikowane w: Scientific Reports, Numer 8/1, 2018, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-018-31500-8

Eicosanoid Control Over Antigen Presenting Cells in Asthma

Autorzy: Nincy Debeuf, Bart N. Lambrecht
Opublikowane w: Frontiers in Immunology, Numer 9, 2018, ISSN 1664-3224
Wydawca: IUIS
DOI: 10.3389/fimmu.2018.02006

An anti‐siglec‐8 antibody depletes sputum eosinophils from asthmatic subjects and inhibits lung mast cells

Autorzy: Sheena C. Kerr, Jeanmarie R. Gonzalez, Julia Schanin, Michael C. Peters, Bart N. Lambrecht, Emily C. Brock, Annabelle Charbit, K. M. Ansel, Bradford A. Youngblood, John V. Fahy
Opublikowane w: Clinical & Experimental Allergy, Numer 50/8, 2020, Strona(/y) 904-914, ISSN 0954-7894
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/cea.13681

Osteopontin Promotes Protective Antigenic Tolerance against Experimental Allergic Airway Disease

Autorzy: Themis Alissafi, Evangelia Kourepini, Davina C. M. Simoes, Nikolaos Paschalidis, Maria Aggelakopoulou, Tim Sparwasser, Louis Boon, Hamida Hammad, Bart N. Lambrecht, Vily Panoutsakopoulou
Opublikowane w: The Journal of Immunology, Numer 200/4, 2018, Strona(/y) 1270-1282, ISSN 0022-1767
Wydawca: American Association of Immunologists
DOI: 10.4049/jimmunol.1701345

Human Lung Conventional Dendritic Cells Orchestrate Lymphoid Neogenesis during Chronic Obstructive Pulmonary Disease

Autorzy: Thomas Naessens, Yannick Morias, Eva Hamrud, Ulf Gehrmann, Ramachandramouli Budida, Johan Mattsson, Tina Baker, Gabriel Skogberg, Elisabeth Israelsson, Kristofer Thörn, Martijn J. Schuijs, Bastian Angermann, Faye Melville, Karl J. Staples, Danen M. Cunoosamy, Bart N. Lambrecht
Opublikowane w: American Journal of Respiratory and Critical Care Medicine, Numer 202/4, 2020, Strona(/y) 535-548, ISSN 1073-449X
Wydawca: American Thoracic Society
DOI: 10.1164/rccm.201906-1123oc

TAO-kinase 3 governs the terminal differentiation of NOTCH2-dependent splenic conventional dendritic cells

Autorzy: Matthias Vanderkerken, Bastiaan Maes, Lana Vandersarren, Wendy Toussaint, Kim Deswarte, Manon Vanheerswynghels, Philippe Pouliot, Liesbet Martens, Sofie Van Gassen, Connie M. Arthur, Margaret E. Kirkling, Boris Reizis, Daniel Conrad, Sean Stowell, Hamida Hammad, Bart N. Lambrecht
Opublikowane w: Proceedings of the National Academy of Sciences, Numer 117/49, 2020, Strona(/y) 31331-31342, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.2009847117

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