As planned, I worked 9 months (1 April 2018-31 December 2018) in Novo Nordisk Foundation Center for Basic Metabolic Research, Human Genomics and Metagenomics in Metabolism
Faculty of Health and Medical Sciences, University of Copenhagen under the supervision of associate professor Tuomas Kilpeläinen. After that I worked for three months (1 January 2019-31 March 2019) in Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland under the supervision of professor Olli Raitakari.
During the 9 months in Copenhagen, I analysed the data and wrote the manuscript of the first two articles called "Genetic predisposition to higher body fat yet lower cardiometabolic risk in children and adolescents" (Figure 1) and "Abdominal adiposity and cardiometabolic risk in children and adolescents; a Mendelian randomization analysis" (Figure 2). I also started to work on the third article called "Increase in adiposity from childhood to adulthood predicts a metabolically obese phenotype in normal-weight adults" that I finished during the secondmend in Turku. During the secondment, I also made revisions of the first two articles to International Journal of Obesity and American Journal of Clinical Nutrition. The first article has been accepted by International Journal of Obesity. The second article is under review for the second round in American Journal of Clinical Nutrition. The third atricle has been submitted to International Jounal of Obesity.
The main result of the first article was that genetic predisposition to higher body fat yet lower cardiometabolic risk exerts its influence before puberty (Figure 3).
The main results of the second article was that abdominal adiposity may have a causal, unfavorable effect on plasma triglycerides and potentially other cardiometabolic risk factors starting in childhood (Figure 4).
The main result of the third article was that an increase in adiposity from childhood to adulthood is detrimental to cardiometabolic health, even among individuals remaining normal weight.
The results of this project will be published in high-impact international journals. The Marie Sklodowska-Curie actions have been mentioned in the articles. During the project, I took part in several group and section meetings, several workshops, thesis presentations, and conferences. I also gave oral and poster presentations in some of these gatherings addressed for both academic and/or non- (such as "science and social meeting "at the University of CPH, section meetings, "End of the year event" at University of CPH). I have also planned to present the resuts in conferences and meetings after the end of the project. Once the artciles are published, it has been planned that the resuls will be presented in the homepage of the Novo Nordisk Foundation Centre for Basic Metabolic Research and press releases sent. We have been interviewed about this project to CORDIS EU*Magazine by writer Thomas Bauwens and the arcile will be published soon.
