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Role of mTOR signaling dysregulation in the tumor suppressor networks in hepatocellular carcinoma

Periodic Reporting for period 1 - mTORmorS (Role of mTOR signaling dysregulation in the tumor suppressor networks in hepatocellular carcinoma)

Reporting period: 2019-04-15 to 2021-04-14

Mammalian target of rapamycin (mTOR) signaling is a central controller of cell growth and is commonly deregulated in cancer. Because the regulation of mTOR signaling is still not well defined, here we substantially profiled the interactors of mTOR signaling components using proteomics approach. Our data not only reconstructed the known mTOR signaling connections, but also identified putative novel binding partners. Together, our study provides a good resource to pursue the mTOR regulation mechanisms and suggests putative novel regulation nodes related to mTOR. This study could contribute to potential targeted therapy against conditions with dysregulated mTOR signaling.
1) The interacome profiling method were optimized in this study.
2) The interactome profillling reconstitutes the carnonical mTOR complexes.
3) Putative novel binding proteins of mTOR signaling componets were validated.
4) Putative mTOR substrates were identified.
Exploitation and dissemination of these results still remain further study.
This study has identified many potential unexpected regulations linked to mTOR. These data were not fully examined in this projects, but future study based on these may unveil some novel nodes with therapeutic potential.