Role of mTOR signaling dysregulation in the tumor suppressor networks in hepatocellular carcinoma

Project Information

mTORmorS

Grant agreement ID: 797491

DOI

10.3030/797491

Project terminated on 4 June 2020

EC signature date 17 April 2018

Start date 15 April 2019

End date 14 April 2021

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 187 419,60

EU contribution

€ 187 419,60

Coordinated by

UNIVERSITAT BASEL
Switzerland

Periodic Reporting for period 1 - mTORmorS (Role of mTOR signaling dysregulation in the tumor suppressor networks in hepatocellular carcinoma)

Reporting period: 2019-04-15 to 2021-04-14

Summary of the context and overall objectives of the project

Mammalian target of rapamycin (mTOR) signaling is a central controller of cell growth and is commonly deregulated in cancer. Because the regulation of mTOR signaling is still not well defined, here we substantially profiled the interactors of mTOR signaling components using proteomics approach. Our data not only reconstructed the known mTOR signaling connections, but also identified putative novel binding partners. Together, our study provides a good resource to pursue the mTOR regulation mechanisms and suggests putative novel regulation nodes related to mTOR. This study could contribute to potential targeted therapy against conditions with dysregulated mTOR signaling.

Work performed from the beginning of the project to the end of the period covered by the report and main results achieved so far

1) The interacome profiling method were optimized in this study.
2) The interactome profillling reconstitutes the carnonical mTOR complexes.
3) Putative novel binding proteins of mTOR signaling componets were validated.
4) Putative mTOR substrates were identified.
Exploitation and dissemination of these results still remain further study.

Progress beyond the state of the art and expected potential impact (including the socio-economic impact and the wider societal implications of the project so far)

This study has identified many potential unexpected regulations linked to mTOR. These data were not fully examined in this projects, but future study based on these may unveil some novel nodes with therapeutic potential.

The interactome profilling reconstitutes the carnonical mTOR complexes.