Role of mTOR signaling dysregulation in the tumor suppressor networks in hepatocellular carcinoma

Informazioni relative al progetto

mTORmorS

ID dell’accordo di sovvenzione: 797491

DOI

10.3030/797491

Progetto concluso il 4 Giugno 2020

Data della firma CE 17 Aprile 2018

Data di avvio 15 Aprile 2019

Data di completamento 14 Aprile 2021

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 187 419,60

Contributo UE

€ 187 419,60

Coordinato da

UNIVERSITAT BASEL
Switzerland

Periodic Reporting for period 1 - mTORmorS (Role of mTOR signaling dysregulation in the tumor suppressor networks in hepatocellular carcinoma)

Periodo di rendicontazione: 2019-04-15 al 2021-04-14

Sintesi del contesto e degli obiettivi generali del progetto

Mammalian target of rapamycin (mTOR) signaling is a central controller of cell growth and is commonly deregulated in cancer. Because the regulation of mTOR signaling is still not well defined, here we substantially profiled the interactors of mTOR signaling components using proteomics approach. Our data not only reconstructed the known mTOR signaling connections, but also identified putative novel binding partners. Together, our study provides a good resource to pursue the mTOR regulation mechanisms and suggests putative novel regulation nodes related to mTOR. This study could contribute to potential targeted therapy against conditions with dysregulated mTOR signaling.

Lavoro eseguito dall’inizio del progetto fino alla fine del periodo coperto dalla relazione e principali risultati finora ottenuti

1) The interacome profiling method were optimized in this study.
2) The interactome profillling reconstitutes the carnonical mTOR complexes.
3) Putative novel binding proteins of mTOR signaling componets were validated.
4) Putative mTOR substrates were identified.
Exploitation and dissemination of these results still remain further study.

Progressi oltre lo stato dell’arte e potenziale impatto previsto (incluso l’impatto socioeconomico e le implicazioni sociali più ampie del progetto fino ad ora)

This study has identified many potential unexpected regulations linked to mTOR. These data were not fully examined in this projects, but future study based on these may unveil some novel nodes with therapeutic potential.

The interactome profilling reconstitutes the carnonical mTOR complexes.