Role of mTOR signaling dysregulation in the tumor suppressor networks in hepatocellular carcinoma

Projektinformationen

mTORmorS

ID Finanzhilfevereinbarung: 797491

DOI

10.3030/797491

Das Projekt endete am 4 Juni 2020

EK-Unterschriftsdatum 17 April 2018

Startdatum 15 April 2019

Enddatum 14 April 2021

Finanziert unter

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Gesamtkosten

€ 187 419,60

EU-Beitrag

€ 187 419,60

Koordiniert durch

UNIVERSITAT BASEL
Switzerland

Periodic Reporting for period 1 - mTORmorS (Role of mTOR signaling dysregulation in the tumor suppressor networks in hepatocellular carcinoma)

Berichtszeitraum: 2019-04-15 bis 2021-04-14

Zusammenfassung vom Kontext und den Gesamtzielen des Projekts

Mammalian target of rapamycin (mTOR) signaling is a central controller of cell growth and is commonly deregulated in cancer. Because the regulation of mTOR signaling is still not well defined, here we substantially profiled the interactors of mTOR signaling components using proteomics approach. Our data not only reconstructed the known mTOR signaling connections, but also identified putative novel binding partners. Together, our study provides a good resource to pursue the mTOR regulation mechanisms and suggests putative novel regulation nodes related to mTOR. This study could contribute to potential targeted therapy against conditions with dysregulated mTOR signaling.

Arbeit, die ab Beginn des Projekts bis zum Ende des durch den Bericht erfassten Berichtszeitraums geleistet wurde, und die wichtigsten bis dahin erzielten Ergebnisse

1) The interacome profiling method were optimized in this study.
2) The interactome profillling reconstitutes the carnonical mTOR complexes.
3) Putative novel binding proteins of mTOR signaling componets were validated.
4) Putative mTOR substrates were identified.
Exploitation and dissemination of these results still remain further study.

Fortschritte, die über den aktuellen Stand der Technik hinausgehen und voraussichtliche potenzielle Auswirkungen (einschließlich der bis dato erzielten sozioökonomischen Auswirkungen und weiter gefassten gesellschaftlichen Auswirkungen des Projekts)

This study has identified many potential unexpected regulations linked to mTOR. These data were not fully examined in this projects, but future study based on these may unveil some novel nodes with therapeutic potential.

The interactome profilling reconstitutes the carnonical mTOR complexes.