Role of mTOR signaling dysregulation in the tumor suppressor networks in hepatocellular carcinoma

Información del proyecto

mTORmorS

Identificador del acuerdo de subvención: 797491

DOI

10.3030/797491

Proyecto finalizado el 4 Junio 2020

Fecha de la firma de la CE 17 Abril 2018

Fecha de inicio 15 Abril 2019

Fecha de finalización 14 Abril 2021

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 187 419,60

Aportación de la UE

€ 187 419,60

Coordinado por

UNIVERSITAT BASEL
Switzerland

Periodic Reporting for period 1 - mTORmorS (Role of mTOR signaling dysregulation in the tumor suppressor networks in hepatocellular carcinoma)

Período documentado: 2019-04-15 hasta 2021-04-14

Resumen del contexto y de los objetivos generales del proyecto

Mammalian target of rapamycin (mTOR) signaling is a central controller of cell growth and is commonly deregulated in cancer. Because the regulation of mTOR signaling is still not well defined, here we substantially profiled the interactors of mTOR signaling components using proteomics approach. Our data not only reconstructed the known mTOR signaling connections, but also identified putative novel binding partners. Together, our study provides a good resource to pursue the mTOR regulation mechanisms and suggests putative novel regulation nodes related to mTOR. This study could contribute to potential targeted therapy against conditions with dysregulated mTOR signaling.

Trabajo realizado desde el comienzo del proyecto hasta el final del período abarcado por el informe y los principales resultados hasta la fecha

1) The interacome profiling method were optimized in this study.
2) The interactome profillling reconstitutes the carnonical mTOR complexes.
3) Putative novel binding proteins of mTOR signaling componets were validated.
4) Putative mTOR substrates were identified.
Exploitation and dissemination of these results still remain further study.

Avances que van más allá del estado de la técnica e impacto potencial esperado (incluida la repercusión socioeconómica y las implicaciones sociales más amplias del proyecto hasta la fecha)

This study has identified many potential unexpected regulations linked to mTOR. These data were not fully examined in this projects, but future study based on these may unveil some novel nodes with therapeutic potential.

The interactome profilling reconstitutes the carnonical mTOR complexes.