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An integrated hypothesis for cognitive and positive symptoms in schizophrenia

Project description

Improving quality of life with schizophrenia

Schizophrenia is a severe mental disorder characterised by extreme psychosis, hallucinations, delusions, impaired cognitive function and social behaviour. Currently, the only existing treatment – antipsychotics – targets specific symptoms, while the rest continue to affect patients. Under the common assumption that symptoms are caused by distinct pathophysiological mechanisms, the EU-funded INTEGRATE project aims to test the hypothesis that striatal hyperdopaminergia – an excess of the neurotransmitter dopamine in the central region of the brain commonly associated with psychosis – is caused by abnormal cortical inhibition. The project could lead the way to treatment that prevents psychosis and also address impaired cognitive function, thus significantly improving patients’ daily lives.


Net EU contribution
€ 208 400,40
Problemveien 5-7
0313 Oslo

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Norge Oslo og Viken Oslo
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00