International Doctoral Programme in Molecular Mechanisms of Disease

Información del proyecto

iMED

Identificador del acuerdo de subvención: 801481

DOI

10.3030/801481

Proyecto cerrado

Fecha de la firma de la CE 23 Marzo 2018

Fecha de inicio 1 Abril 2019

Fecha de finalización 31 Marzo 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 3 767 040,00

Aportación de la UE

€ 1 883 520,00

Coordinado por

KOBENHAVNS UNIVERSITET
Denmark

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (28)

Co-expression of YAP and TAZ associates with chromosomal instability in human cholangiocarcinoma

Autores: Marcell Tóth, Lilija Wehling, Lena Thiess, Fabian Rose, Jennifer Schmitt, Sofia M. E. Weiler, Carsten Sticht, Carolina De La Torre, Melina Rausch, Thomas Albrecht, Niels Grabe, Lea Duwe, Jesper B. Andersen, Bruno C. Köhler, Christoph Springfeld, Arianeb Mehrabi, Yakup Kulu, Peter Schirmacher, Stephanie Roessler, Benjamin Goeppert & Kai Breuhahn
Publicado en: BMC Cancer, Edición 21, 2021, ISSN 1471-2407
Editor: BioMed Central
DOI: 10.1186/s12885-021-08794-5

Combined Inhibition of Smoothened and the DNA Damage Checkpoint WEE1 Exerts Antitumor Activity in Cholangiocarcinoma

Autores: Giulia Anichini; Chiara Raggi; Mirella Pastore; Laura Carrassa; Luisa Maresca; Enrica Crivaro; Tiziano Lottini; Lea Duwe; Jesper B. Andersen; Lorenzo Tofani; Luca Di Tommaso; Jesus M. Banales; Annarosa Arcangeli; Fabio Marra; Barbara Stecca
Publicado en: Mol Cancer Ther, 2023, Página(s) 343-356, ISSN 1535-7163
Editor: American Association for Cancer Research
DOI: 10.1158/1535-7163.mct-22-0379

ANGPTL4 sensitizes lipoprotein lipase to PCSK3 cleavage by catalyzing its unfolding

Autores: Lund Winther AM, Kumari A, Young SG, Ploug M
Publicado en: Journal of Lipid Research, Edición 62, 2021, ISSN 0022-2275
Editor: Lipid Research, Inc.
DOI: 10.1016/j.jlr.2021.100071

Ribosomal RNA 2′-O-methylation dynamics impact cell fate decisions

Autores: Häfner, Sophia Julia, Jansson, Martin David, Altinel, Kübra, Andersen, Kasper Langebjerg, Abay-Nørgaard, Zehra Caldwell, Ménard, Patrice, Fontenas, M., Sørensen, Daniel Madriz, Gay, David Michael, Arendrup, Frederic Schrøder, Tehler, D., Krogh, Nicolai, Nielsen, Henrik, Kraushar, M. L., Kirkeby, Agnete & Lund, Anders H.
Publicado en: Developmental Cell, 2023, ISSN 1534-5807
Editor: Cell Press
DOI: 10.1016/j.devcel.2023.06.007

The intrinsic instability of the hydrolase domain of lipoprotein lipase facilitates its inactivation by ANGPTL4-catalyzed unfolding

Autores: Katrine Z. Leth-Espensen, Kristian K. Kristensen, Anni Kumari, Anne-Marie L. Winther, Stephen G. Young, Thomas J. D. Jørgensen and Michael Ploug
Publicado en: The Proceedings of the National Academy of Sciences, Edición 12, 2021, ISSN 1091-6490
Editor: PNAS
DOI: 10.1073/pnas.2026650118

Multiparametric and accurate functional analysis of genetic sequence variants using CRISPR-Select

Autores: Yiyuan Niu, Catarina A. Ferreira Azevedo, Xin Li, Elahe Kamali, Ole Haagen Nielsen, Claus Storgaard Sørensen & Morten Frödin
Publicado en: Nature Genetics, Edición 54, 2022, ISSN 1061-4036
Editor: Nature Publishing Group
DOI: 10.1038/s41588-022-01224-7

GPIHBP1 and ANGPTL4 Utilize Protein Disorder to Orchestrate Order in Plasma Triglyceride Metabolism and Regulate Compartmentalization of LPL Activity

Autores: Kristian Kølby Kristensen; Kristian Kølby Kristensen; Katrine Zinck Leth-Espensen; Katrine Zinck Leth-Espensen; Anni Kumari; Anni Kumari; Anne Louise Grønnemose; Anne Louise Grønnemose; Anne-Marie Lund-Winther; Anne-Marie Lund-Winther; Stephen G. Young; Stephen G. Young; Michael Ploug; Michael Ploug
Publicado en: Frontiers in Cell and Developmental Biology, Edición 9 (2021), 2021, ISSN 2296-634X
Editor: Frontiers in Cell and Developmental Biology
DOI: 10.3389/fcell.2021.702508

Loss of the KN Motif and AnKyrin Repeat Domain 1 (KANK1) Leads to Lymphoid Compartment Dysregulation in Murine Model

Autores: Marwa Almosailleakh; Sofia Bentivegna; Samuele Narcisi; Sébasitien J. Benquet; Linn Gillberg; Carmen P. Montaño-Almendras; Simonas Savickas; Erwin M. Schoof; Amelie Wegener; Hérve Luche
Publicado en: Genes, 2023, ISSN 2073-4425
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes14101947

The histone demethylase KDM5C functions as a tumor suppressor in AML by repression of bivalently marked immature genes

Autores: Mette Louise Trempenau; Mikkel Bruhn Schuster; Sachin Pundhir; Mafalda Araujo Pereira; Adrija Kalvisa; Marta Tapia; Jinyu Su; Ying Ge; Bauke de Boer; Alexander Balhuizen; Frederik Otzen Bagger; Pavel Shliaha; Patrycja Sroczynska; Julian Walfridsson; Kirsten Grønbæk; Kim Theilgaard-Mönch; Ole N. Jensen; Kristian Helin; Bo T. Porse
Publicado en: Leukemia, Edición 6, 2023, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/s41375-023-01810-6

The Importance of Lipoprotein Lipase Regulation in Atherosclerosis.

Autores: Anni Kumari; Kristian Kølby Kristensen; Kristian Kølby Kristensen; Michael Ploug; Michael Ploug; Anne-Marie Lund Winther; Anne-Marie Lund Winther
Publicado en: Biomedicines, Edición 7, 2021, ISSN 2227-9059
Editor: MDPI
DOI: 10.3390/biomedicines9070782

MicroRNA-27a-3p targets FoxO signalling to induce tumour-like phenotypes in bile duct cells

Autores: Lea Duwe, Patricia Munoz-Garrido, Monika Lewinska, Juan Lafuente-Barquero, Letizia Satriano, Dan Høgdall, Andrzej Taranta, Boye S. Nielsen, Awaisa Ghazal, Matthias S. Matter, Jesus M. Banales, Blanca I. Aldana, Yu-Tang Gao, Jens U. Marquardt, Lewis R. Roberts, Rui C. Oliveira, Jill Koshiol, Colm J. O'Rourke, Jesper B. Andersen
Publicado en: Journal of Hepatology, 2022, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2022.10.012

Regulation of translation by site-specific ribosomal RNA methylation

Autores: Martin D. Jansson, Sophia J. Häfner, Kübra Altinel, Disa Tehler, Nicolai Krogh, Emil Jakobsen, Jens V. Andersen, Kasper L. Andersen, Erwin M. Schoof, Patrice Ménard, Henrik Nielsen & Anders H. Lund
Publicado en: Nature Structural & Molecular Biology, Edición 28, 2021, ISSN 1545-9993
Editor: Nature Publishing Group
DOI: 10.1038/s41594-021-00669-4

Extracellular Signal-Regulated Kinase 5 Regulates the Malignant Phenotype of Cholangiocarcinoma Cells

Autores: Alessandra Gentilini, Giulia Lori, Alessandra Caligiuri, Chiara Raggi, Giovanni Di Maira, Mirella Pastore, Benedetta Piombanti, Tiziano Lottini, Annarosa Arcangeli, Stefania Madiai, Nadia Navari, Jesus M. Banales, Sabina Di Matteo, Domenico Alvaro, Lea Duwe, Jesper B. Andersen, Alessandro Tubita, Ignazia Tusa, Luca Di Tommaso, Claudia Campani, Elisabetta Rovida, Fabio Marra
Publicado en: Hepatology, Edición 74, 2021, ISSN 1527-3350
Editor: John Wiley & Sons, Inc.
DOI: 10.1002/hep.31888

Transcriptional and epigenomic profiling identifies YAP signaling as a key regulator of intestinal epithelium maturation

Autores: Pikkupeura, Laura Maarit, Bardini Bressan, Raul, Guiu, J., Chen, Y., Maimets, Martti, Mayer, Daniela, Schweiger, P. J., Hansen, Stine Lind, Maciag, Grzegorz Jerzy, Larsen, Hjalte List, Lõhmussaar, Kadi, Pedersen, M. T., Teves, Joji Marie Yap, Lange, Jette Bornholdt, Benes, V., Sandelin, Albin Gustav & Jensen, Kim Bak
Publicado en: Science Advances, 2023, ISSN 2375-2548
Editor: American Association for the Advancement of Science
DOI: 10.1126/sciadv.adf9460

Lactate receptor GPR81 drives breast cancer growth and invasiveness through regulation of ECM properties and Notch ligand DLL4

Autores: Kathrine Lundø, Oksana Dmytriyeva, Louise Spøhr, Eliana Goncalves-Alves, Jiayi Yao, Laia P. Blasco, Mette Trauelsen, Muthulakshmi Ponniah, Marc Severin, Albin Sandelin, Marie Kveiborg, Thue W. Schwartz & Stine F. Pedersen
Publicado en: BMC Cancer, 2023, ISSN 1471-2407
Editor: BioMed Central
DOI: 10.1186/s12885-023-11631-6

Loss of cancer cell-derived ADAM15 alters the tumor microenvironment in colorectal tumors

Autores: Laia Puig Blasco, Krzysztof B. Piotrowski, Signe R. Michaelsen, Nicolai S. Bager, Aušrinė Areškevičiūtiė, Marie-Louise Thorseth, Xiao-Feng Sun, Ulrich auf dem Keller, Bjarne W. Kristensen, Daniel H. Madsen, Sebastian P. Gnosa, Marie Kveiborg
Publicado en: International Journal of Cancer, 2023, ISSN 0020-7136
Editor: John Wiley & Sons Inc.
DOI: 10.1002/ijc.34695

Inverse effects of APOC2 and ANGPTL4 on the conformational dynamics of lid-anchoring structures in lipoprotein lipase

Autores: Kumari, Anni; Grønnemose, A. L.; Kristensen, Kristian Kølby; Winther, Anne-Marie Lund; Young, S. G.; Jørgensen, T. J. D. & Ploug, Michael
Publicado en: Proceedings of the National Academy of Sciences of the United States of America, 2023, ISSN 1091-6490
Editor: P NATL ACAD SCI USA
DOI: 10.1073/pnas.2221888120

ADAM12 expression is upregulated in cancer cells upon radiation and constitutes a prognostic factor in rectal cancer patients following radiotherapy

Autores: Krzysztof Bartłomiej Piotrowski, Laia Puig Blasco, Jacob Samsøe-Petersen, Rikke Løvendahl Eefsen, Martin Illemann, Victor Oginga Oria, Karla Iveth Aguilera Campos, Alexia Mélanie Lopresti, Reidar Albrechtsen, Claus Storgaard Sørensen, Xiao-Feng Sun, Marie Kveiborg & Sebastian Gnosa
Publicado en: Cancer Gene Ther, 2023, ISSN 0929-1903
Editor: Nature Publishing Group
DOI: 10.1038/s41417-023-00643-w

Evolution and medical significance of LU domain−containing proteins

Autores: Leth, J. M., Leth-Espensen, K. Z., Kristensen, K. K., Kumari, A., Winther, A. M. L., Young, S. G., & Ploug, M.
Publicado en: International Journal of Molecular Sciences, 2019, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20112760

Frequency and Functional Characterization of RUNX1 Germline Variants in Myeloid Neoplasms

Autores: Nikolaj Juul Nitschke, Marwa Almosailleakh, Yiyuan Niu, Jakob Werner Hansen, Klas Raaschou-Jensen, Jakob Schmidt Jespersen, Marianne Tang Severinsen, Anne Stidsholt Roug, Morten Frödin, Joachim Lütken Weischenfeldt, Mette Klarskov Andersen,and Kirsten Grønbæk
Publicado en: Human mutation, 2023, ISSN 1098-1004
Editor: Wiley Periodicals
DOI: 10.1155/2023/4738660

Unraveling the actin cytoskeleton in the malignant transformation of cholangiocyte biology

Autores: Lea Duwe, Laura Fouassier, Juan Lafuente-Barquero and Jesper B. Andersen
Publicado en: Translational Oncology, Edición 26, 2022, ISSN 1936-5233
Editor: Neoplasia Press
DOI: 10.1016/j.tranon.2022.101531

The Urokinase Receptor (uPAR) as a “Trojan Horse” in Targeted Cancer Therapy: Challenges and Opportunities

Autores: Metrangolo, V.; Ploug, M.; Engelholm, L.H
Publicado en: Cancers, Edición 13, 2021, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13215376

INDEL detection, the ‘Achilles heel’ of precise genome editing: a survey of methods for accurate profiling of gene editing induced indels

Autores: Eric Paul Bennett, Bent Larsen Petersen, Ida Elisabeth Johansen, Yiyuan Niu, Zhang Yang, Christopher Aled Chamberlain, Özcan Met, Hans H Wandall, Morten Frödin
Publicado en: Nucleic Acids Research, 2020, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkaa975

ADAM17-mediated EGFR ligand shedding directs macrophage-promoted cancer cell invasion

Autores: Sebastian P. Gnosa, Laia Puig Blasco, Krzysztof B. Piotrowski, Marie L. Freiberg, Simonas Savickas, Daniel H. Madsen, Ulrich auf dem Keller, Pauliina Kronqvist, and Marie Kveiborg
Publicado en: The Journal of Clinical Investigation Insight, Edición 18, 2022, ISSN 2379-3708
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.155296

Mapping cellular coordinates through advances in spatial transcriptomics technology.

Autores: Joji Marie Teves and Kyoung Jae Won
Publicado en: Molecules and Cells, Edición 43(7), 2020, Página(s) 591-599, ISSN 1016-8478
Editor: Springer Verlag
DOI: 10.14348/molcells.2020.0020

Lipid alterations in chronic liver disease and liver cancer

Autores: Bichitra Paul, Monika Lewinska, Jesper B. Andersen
Publicado en: JHEP Reports, Edición 6, 2022, ISSN 2589-5559
Editor: Elsevier B.V.
DOI: 10.1016/j.jhepr.2022.100479

The Collagen Receptor uPARAP in Malignant Mesothelioma: A Potential Diagnostic Marker and Therapeutic Target.

Autores: Pınar Çakılkaya; Rikke Raagaard Sørensen; Henrik J. Jürgensen; Oliver Krigslund; Henrik Gårdsvoll; Christoffer Nielsen; Eric Santoni-Rugiu; Niels Behrendt; Lars H. Engelholm
Publicado en: International Journal of Molecular Sciences, Edición 21, 2021, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222111452

Antibody–Drug Conjugates: The Dynamic Evolution from Conventional to Next-Generation Constructs

Autores: Virginia Metrangolo, Lars H. Engelholm
Publicado en: Cancers, 2024, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers16020447