International Doctoral Programme in Molecular Mechanisms of Disease

Project Information

iMED

Grant agreement ID: 801481

DOI 10.3030/801481

Project closed

EC signature date 23 March 2018

Start date 1 April 2019

End date 31 March 2024

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 3 767 040,00

EU contribution € 1 883 520,00

Coordinated by

KOBENHAVNS UNIVERSITET
Denmark

Publications

Peer reviewed articles (24)

Co-expression of YAP and TAZ associates with chromosomal instability in human cholangiocarcinoma

Author(s): Marcell Tóth, Lilija Wehling, Lena Thiess, Fabian Rose, Jennifer Schmitt, Sofia M. E. Weiler, Carsten Sticht, Carolina De La Torre, Melina Rausch, Thomas Albrecht, Niels Grabe, Lea Duwe, Jesper B. Andersen, Bruno C. Köhler, Christoph Springfeld, Arianeb Mehrabi, Yakup Kulu, Peter Schirmacher, Stephanie Roessler, Benjamin Goeppert & Kai Breuhahn
Published in: BMC Cancer, Issue 21, 2021, ISSN 1471-2407
Publisher: BioMed Central
DOI: 10.1186/s12885-021-08794-5

Combined Inhibition of Smoothened and the DNA Damage Checkpoint WEE1 Exerts Antitumor Activity in Cholangiocarcinoma

Author(s): Giulia Anichini; Chiara Raggi; Mirella Pastore; Laura Carrassa; Luisa Maresca; Enrica Crivaro; Tiziano Lottini; Lea Duwe; Jesper B. Andersen; Lorenzo Tofani; Luca Di Tommaso; Jesus M. Banales; Annarosa Arcangeli; Fabio Marra; Barbara Stecca
Published in: Mol Cancer Ther, 2023, Page(s) 343-356, ISSN 1535-7163
Publisher: American Association for Cancer Research
DOI: 10.1158/1535-7163.mct-22-0379

ANGPTL4 sensitizes lipoprotein lipase to PCSK3 cleavage by catalyzing its unfolding

Author(s): Lund Winther AM, Kumari A, Young SG, Ploug M
Published in: Journal of Lipid Research, Issue 62, 2021, ISSN 0022-2275
Publisher: Lipid Research, Inc.
DOI: 10.1016/j.jlr.2021.100071

Ribosomal RNA 2′-O-methylation dynamics impact cell fate decisions

Author(s): Häfner, Sophia Julia, Jansson, Martin David, Altinel, Kübra, Andersen, Kasper Langebjerg, Abay-Nørgaard, Zehra Caldwell, Ménard, Patrice, Fontenas, M., Sørensen, Daniel Madriz, Gay, David Michael, Arendrup, Frederic Schrøder, Tehler, D., Krogh, Nicolai, Nielsen, Henrik, Kraushar, M. L., Kirkeby, Agnete & Lund, Anders H.
Published in: Developmental Cell, 2023, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2023.06.007

The intrinsic instability of the hydrolase domain of lipoprotein lipase facilitates its inactivation by ANGPTL4-catalyzed unfolding

Author(s): Katrine Z. Leth-Espensen, Kristian K. Kristensen, Anni Kumari, Anne-Marie L. Winther, Stephen G. Young, Thomas J. D. Jørgensen and Michael Ploug
Published in: The Proceedings of the National Academy of Sciences, Issue 12, 2021, ISSN 1091-6490
Publisher: PNAS
DOI: 10.1073/pnas.2026650118

Multiparametric and accurate functional analysis of genetic sequence variants using CRISPR-Select

Author(s): Yiyuan Niu, Catarina A. Ferreira Azevedo, Xin Li, Elahe Kamali, Ole Haagen Nielsen, Claus Storgaard Sørensen & Morten Frödin
Published in: Nature Genetics, Issue 54, 2022, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-022-01224-7

GPIHBP1 and ANGPTL4 Utilize Protein Disorder to Orchestrate Order in Plasma Triglyceride Metabolism and Regulate Compartmentalization of LPL Activity

Author(s): Kristian Kølby Kristensen; Kristian Kølby Kristensen; Katrine Zinck Leth-Espensen; Katrine Zinck Leth-Espensen; Anni Kumari; Anni Kumari; Anne Louise Grønnemose; Anne Louise Grønnemose; Anne-Marie Lund-Winther; Anne-Marie Lund-Winther; Stephen G. Young; Stephen G. Young; Michael Ploug; Michael Ploug
Published in: Frontiers in Cell and Developmental Biology, Issue 9 (2021), 2021, ISSN 2296-634X
Publisher: Frontiers in Cell and Developmental Biology
DOI: 10.3389/fcell.2021.702508

The histone demethylase KDM5C functions as a tumor suppressor in AML by repression of bivalently marked immature genes

Author(s): Mette Louise Trempenau; Mikkel Bruhn Schuster; Sachin Pundhir; Mafalda Araujo Pereira; Adrija Kalvisa; Marta Tapia; Jinyu Su; Ying Ge; Bauke de Boer; Alexander Balhuizen; Frederik Otzen Bagger; Pavel Shliaha; Patrycja Sroczynska; Julian Walfridsson; Kirsten Grønbæk; Kim Theilgaard-Mönch; Ole N. Jensen; Kristian Helin; Bo T. Porse
Published in: Leukemia, Issue 6, 2023, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/s41375-023-01810-6

The Importance of Lipoprotein Lipase Regulation in Atherosclerosis.

Author(s): Anni Kumari; Kristian Kølby Kristensen; Kristian Kølby Kristensen; Michael Ploug; Michael Ploug; Anne-Marie Lund Winther; Anne-Marie Lund Winther
Published in: Biomedicines, Issue 7, 2021, ISSN 2227-9059
Publisher: MDPI
DOI: 10.3390/biomedicines9070782

MicroRNA-27a-3p targets FoxO signalling to induce tumour-like phenotypes in bile duct cells

Author(s): Lea Duwe, Patricia Munoz-Garrido, Monika Lewinska, Juan Lafuente-Barquero, Letizia Satriano, Dan Høgdall, Andrzej Taranta, Boye S. Nielsen, Awaisa Ghazal, Matthias S. Matter, Jesus M. Banales, Blanca I. Aldana, Yu-Tang Gao, Jens U. Marquardt, Lewis R. Roberts, Rui C. Oliveira, Jill Koshiol, Colm J. O'Rourke, Jesper B. Andersen
Published in: Journal of Hepatology, 2022, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2022.10.012

Regulation of translation by site-specific ribosomal RNA methylation

Author(s): Martin D. Jansson, Sophia J. Häfner, Kübra Altinel, Disa Tehler, Nicolai Krogh, Emil Jakobsen, Jens V. Andersen, Kasper L. Andersen, Erwin M. Schoof, Patrice Ménard, Henrik Nielsen & Anders H. Lund
Published in: Nature Structural & Molecular Biology, Issue 28, 2021, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-021-00669-4

Extracellular Signal-Regulated Kinase 5 Regulates the Malignant Phenotype of Cholangiocarcinoma Cells

Author(s): Alessandra Gentilini, Giulia Lori, Alessandra Caligiuri, Chiara Raggi, Giovanni Di Maira, Mirella Pastore, Benedetta Piombanti, Tiziano Lottini, Annarosa Arcangeli, Stefania Madiai, Nadia Navari, Jesus M. Banales, Sabina Di Matteo, Domenico Alvaro, Lea Duwe, Jesper B. Andersen, Alessandro Tubita, Ignazia Tusa, Luca Di Tommaso, Claudia Campani, Elisabetta Rovida, Fabio Marra
Published in: Hepatology, Issue 74, 2021, ISSN 1527-3350
Publisher: John Wiley & Sons, Inc.
DOI: 10.1002/hep.31888

Lactate receptor GPR81 drives breast cancer growth and invasiveness through regulation of ECM properties and Notch ligand DLL4

Author(s): Kathrine Lundø, Oksana Dmytriyeva, Louise Spøhr, Eliana Goncalves-Alves, Jiayi Yao, Laia P. Blasco, Mette Trauelsen, Muthulakshmi Ponniah, Marc Severin, Albin Sandelin, Marie Kveiborg, Thue W. Schwartz & Stine F. Pedersen
Published in: BMC Cancer, 2023, ISSN 1471-2407
Publisher: BioMed Central
DOI: 10.1186/s12885-023-11631-6

Loss of cancer cell-derived ADAM15 alters the tumor microenvironment in colorectal tumors

Author(s): Laia Puig Blasco, Krzysztof B. Piotrowski, Signe R. Michaelsen, Nicolai S. Bager, Aušrinė Areškevičiūtiė, Marie-Louise Thorseth, Xiao-Feng Sun, Ulrich auf dem Keller, Bjarne W. Kristensen, Daniel H. Madsen, Sebastian P. Gnosa, Marie Kveiborg
Published in: International Journal of Cancer, 2023, ISSN 0020-7136
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ijc.34695

Inverse effects of APOC2 and ANGPTL4 on the conformational dynamics of lid-anchoring structures in lipoprotein lipase

Author(s): Kumari, Anni; Grønnemose, A. L.; Kristensen, Kristian Kølby; Winther, Anne-Marie Lund; Young, S. G.; Jørgensen, T. J. D. & Ploug, Michael
Published in: Proceedings of the National Academy of Sciences of the United States of America, 2023, ISSN 1091-6490
Publisher: P NATL ACAD SCI USA
DOI: 10.1073/pnas.2221888120

ADAM12 expression is upregulated in cancer cells upon radiation and constitutes a prognostic factor in rectal cancer patients following radiotherapy

Author(s): Krzysztof Bartłomiej Piotrowski, Laia Puig Blasco, Jacob Samsøe-Petersen, Rikke Løvendahl Eefsen, Martin Illemann, Victor Oginga Oria, Karla Iveth Aguilera Campos, Alexia Mélanie Lopresti, Reidar Albrechtsen, Claus Storgaard Sørensen, Xiao-Feng Sun, Marie Kveiborg & Sebastian Gnosa
Published in: Cancer Gene Ther, 2023, ISSN 0929-1903
Publisher: Nature Publishing Group
DOI: 10.1038/s41417-023-00643-w

Frequency and Functional Characterization of RUNX1 Germline Variants in Myeloid Neoplasms

Author(s): Nikolaj Juul Nitschke, Marwa Almosailleakh, Yiyuan Niu, Jakob Werner Hansen, Klas Raaschou-Jensen, Jakob Schmidt Jespersen, Marianne Tang Severinsen, Anne Stidsholt Roug, Morten Frödin, Joachim Lütken Weischenfeldt, Mette Klarskov Andersen,and Kirsten Grønbæk
Published in: Human mutation, 2023, ISSN 1098-1004
Publisher: Wiley Periodicals
DOI: 10.1155/2023/4738660

Unraveling the actin cytoskeleton in the malignant transformation of cholangiocyte biology

Author(s): Lea Duwe, Laura Fouassier, Juan Lafuente-Barquero and Jesper B. Andersen
Published in: Translational Oncology, Issue 26, 2022, ISSN 1936-5233
Publisher: Neoplasia Press
DOI: 10.1016/j.tranon.2022.101531

The Urokinase Receptor (uPAR) as a “Trojan Horse” in Targeted Cancer Therapy: Challenges and Opportunities

Author(s): Metrangolo, V.; Ploug, M.; Engelholm, L.H
Published in: Cancers, Issue 13, 2021, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13215376

ADAM17-mediated EGFR ligand shedding directs macrophage-promoted cancer cell invasion

Author(s): Sebastian P. Gnosa, Laia Puig Blasco, Krzysztof B. Piotrowski, Marie L. Freiberg, Simonas Savickas, Daniel H. Madsen, Ulrich auf dem Keller, Pauliina Kronqvist, and Marie Kveiborg
Published in: The Journal of Clinical Investigation Insight, Issue 18, 2022, ISSN 2379-3708
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.155296

Mapping cellular coordinates through advances in spatial transcriptomics technology.

Author(s): Joji Marie Teves and Kyoung Jae Won
Published in: Molecules and Cells, Issue 43(7), 2020, Page(s) 591-599, ISSN 1016-8478
Publisher: Springer Verlag
DOI: 10.14348/molcells.2020.0020

Lipid alterations in chronic liver disease and liver cancer

Author(s): Bichitra Paul, Monika Lewinska, Jesper B. Andersen
Published in: JHEP Reports, Issue 6, 2022, ISSN 2589-5559
Publisher: Elsevier B.V.
DOI: 10.1016/j.jhepr.2022.100479

The Collagen Receptor uPARAP in Malignant Mesothelioma: A Potential Diagnostic Marker and Therapeutic Target.

Author(s): Pınar Çakılkaya; Rikke Raagaard Sørensen; Henrik J. Jürgensen; Oliver Krigslund; Henrik Gårdsvoll; Christoffer Nielsen; Eric Santoni-Rugiu; Niels Behrendt; Lars H. Engelholm
Published in: International Journal of Molecular Sciences, Issue 21, 2021, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222111452

Antibody–Drug Conjugates: The Dynamic Evolution from Conventional to Next-Generation Constructs

Author(s): Virginia Metrangolo, Lars H. Engelholm
Published in: Cancers, 2024, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers16020447