International Doctoral Programme in Molecular Mechanisms of Disease

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Publications

Co-expression of YAP and TAZ associates with chromosomal instability in human cholangiocarcinoma

Auteurs: Marcell Tóth, Lilija Wehling, Lena Thiess, Fabian Rose, Jennifer Schmitt, Sofia M. E. Weiler, Carsten Sticht, Carolina De La Torre, Melina Rausch, Thomas Albrecht, Niels Grabe, Lea Duwe, Jesper B. Andersen, Bruno C. Köhler, Christoph Springfeld, Arianeb Mehrabi, Yakup Kulu, Peter Schirmacher, Stephanie Roessler, Benjamin Goeppert & Kai Breuhahn
Publié dans: BMC Cancer, Numéro 21, 2021, ISSN 1471-2407
Éditeur: BioMed Central
DOI: 10.1186/s12885-021-08794-5

Combined Inhibition of Smoothened and the DNA Damage Checkpoint WEE1 Exerts Antitumor Activity in Cholangiocarcinoma

Auteurs: Giulia Anichini; Chiara Raggi; Mirella Pastore; Laura Carrassa; Luisa Maresca; Enrica Crivaro; Tiziano Lottini; Lea Duwe; Jesper B. Andersen; Lorenzo Tofani; Luca Di Tommaso; Jesus M. Banales; Annarosa Arcangeli; Fabio Marra; Barbara Stecca
Publié dans: Mol Cancer Ther, 2023, Page(s) 343-356, ISSN 1535-7163
Éditeur: American Association for Cancer Research
DOI: 10.1158/1535-7163.mct-22-0379

ANGPTL4 sensitizes lipoprotein lipase to PCSK3 cleavage by catalyzing its unfolding

Auteurs: Lund Winther AM, Kumari A, Young SG, Ploug M
Publié dans: Journal of Lipid Research, Numéro 62, 2021, ISSN 0022-2275
Éditeur: Lipid Research, Inc.
DOI: 10.1016/j.jlr.2021.100071

Ribosomal RNA 2′-O-methylation dynamics impact cell fate decisions

Auteurs: Häfner, Sophia Julia, Jansson, Martin David, Altinel, Kübra, Andersen, Kasper Langebjerg, Abay-Nørgaard, Zehra Caldwell, Ménard, Patrice, Fontenas, M., Sørensen, Daniel Madriz, Gay, David Michael, Arendrup, Frederic Schrøder, Tehler, D., Krogh, Nicolai, Nielsen, Henrik, Kraushar, M. L., Kirkeby, Agnete & Lund, Anders H.
Publié dans: Developmental Cell, 2023, ISSN 1534-5807
Éditeur: Cell Press
DOI: 10.1016/j.devcel.2023.06.007

The intrinsic instability of the hydrolase domain of lipoprotein lipase facilitates its inactivation by ANGPTL4-catalyzed unfolding

Auteurs: Katrine Z. Leth-Espensen, Kristian K. Kristensen, Anni Kumari, Anne-Marie L. Winther, Stephen G. Young, Thomas J. D. Jørgensen and Michael Ploug
Publié dans: The Proceedings of the National Academy of Sciences, Numéro 12, 2021, ISSN 1091-6490
Éditeur: PNAS
DOI: 10.1073/pnas.2026650118

Multiparametric and accurate functional analysis of genetic sequence variants using CRISPR-Select

Auteurs: Yiyuan Niu, Catarina A. Ferreira Azevedo, Xin Li, Elahe Kamali, Ole Haagen Nielsen, Claus Storgaard Sørensen & Morten Frödin
Publié dans: Nature Genetics, Numéro 54, 2022, ISSN 1061-4036
Éditeur: Nature Publishing Group
DOI: 10.1038/s41588-022-01224-7

GPIHBP1 and ANGPTL4 Utilize Protein Disorder to Orchestrate Order in Plasma Triglyceride Metabolism and Regulate Compartmentalization of LPL Activity

Auteurs: Kristian Kølby Kristensen; Kristian Kølby Kristensen; Katrine Zinck Leth-Espensen; Katrine Zinck Leth-Espensen; Anni Kumari; Anni Kumari; Anne Louise Grønnemose; Anne Louise Grønnemose; Anne-Marie Lund-Winther; Anne-Marie Lund-Winther; Stephen G. Young; Stephen G. Young; Michael Ploug; Michael Ploug
Publié dans: Frontiers in Cell and Developmental Biology, Numéro 9 (2021), 2021, ISSN 2296-634X
Éditeur: Frontiers in Cell and Developmental Biology
DOI: 10.3389/fcell.2021.702508

Loss of the KN Motif and AnKyrin Repeat Domain 1 (KANK1) Leads to Lymphoid Compartment Dysregulation in Murine Model

Auteurs: Marwa Almosailleakh; Sofia Bentivegna; Samuele Narcisi; Sébasitien J. Benquet; Linn Gillberg; Carmen P. Montaño-Almendras; Simonas Savickas; Erwin M. Schoof; Amelie Wegener; Hérve Luche
Publié dans: Genes, 2023, ISSN 2073-4425
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes14101947

The histone demethylase KDM5C functions as a tumor suppressor in AML by repression of bivalently marked immature genes

Auteurs: Mette Louise Trempenau; Mikkel Bruhn Schuster; Sachin Pundhir; Mafalda Araujo Pereira; Adrija Kalvisa; Marta Tapia; Jinyu Su; Ying Ge; Bauke de Boer; Alexander Balhuizen; Frederik Otzen Bagger; Pavel Shliaha; Patrycja Sroczynska; Julian Walfridsson; Kirsten Grønbæk; Kim Theilgaard-Mönch; Ole N. Jensen; Kristian Helin; Bo T. Porse
Publié dans: Leukemia, Numéro 6, 2023, ISSN 0887-6924
Éditeur: Nature Publishing Group
DOI: 10.1038/s41375-023-01810-6

The Importance of Lipoprotein Lipase Regulation in Atherosclerosis.

Auteurs: Anni Kumari; Kristian Kølby Kristensen; Kristian Kølby Kristensen; Michael Ploug; Michael Ploug; Anne-Marie Lund Winther; Anne-Marie Lund Winther
Publié dans: Biomedicines, Numéro 7, 2021, ISSN 2227-9059
Éditeur: MDPI
DOI: 10.3390/biomedicines9070782

MicroRNA-27a-3p targets FoxO signalling to induce tumour-like phenotypes in bile duct cells

Auteurs: Lea Duwe, Patricia Munoz-Garrido, Monika Lewinska, Juan Lafuente-Barquero, Letizia Satriano, Dan Høgdall, Andrzej Taranta, Boye S. Nielsen, Awaisa Ghazal, Matthias S. Matter, Jesus M. Banales, Blanca I. Aldana, Yu-Tang Gao, Jens U. Marquardt, Lewis R. Roberts, Rui C. Oliveira, Jill Koshiol, Colm J. O'Rourke, Jesper B. Andersen
Publié dans: Journal of Hepatology, 2022, ISSN 0168-8278
Éditeur: Elsevier BV
DOI: 10.1016/j.jhep.2022.10.012

Regulation of translation by site-specific ribosomal RNA methylation

Auteurs: Martin D. Jansson, Sophia J. Häfner, Kübra Altinel, Disa Tehler, Nicolai Krogh, Emil Jakobsen, Jens V. Andersen, Kasper L. Andersen, Erwin M. Schoof, Patrice Ménard, Henrik Nielsen & Anders H. Lund
Publié dans: Nature Structural & Molecular Biology, Numéro 28, 2021, ISSN 1545-9993
Éditeur: Nature Publishing Group
DOI: 10.1038/s41594-021-00669-4

Extracellular Signal-Regulated Kinase 5 Regulates the Malignant Phenotype of Cholangiocarcinoma Cells

Auteurs: Alessandra Gentilini, Giulia Lori, Alessandra Caligiuri, Chiara Raggi, Giovanni Di Maira, Mirella Pastore, Benedetta Piombanti, Tiziano Lottini, Annarosa Arcangeli, Stefania Madiai, Nadia Navari, Jesus M. Banales, Sabina Di Matteo, Domenico Alvaro, Lea Duwe, Jesper B. Andersen, Alessandro Tubita, Ignazia Tusa, Luca Di Tommaso, Claudia Campani, Elisabetta Rovida, Fabio Marra
Publié dans: Hepatology, Numéro 74, 2021, ISSN 1527-3350
Éditeur: John Wiley & Sons, Inc.
DOI: 10.1002/hep.31888

Transcriptional and epigenomic profiling identifies YAP signaling as a key regulator of intestinal epithelium maturation

Auteurs: Pikkupeura, Laura Maarit, Bardini Bressan, Raul, Guiu, J., Chen, Y., Maimets, Martti, Mayer, Daniela, Schweiger, P. J., Hansen, Stine Lind, Maciag, Grzegorz Jerzy, Larsen, Hjalte List, Lõhmussaar, Kadi, Pedersen, M. T., Teves, Joji Marie Yap, Lange, Jette Bornholdt, Benes, V., Sandelin, Albin Gustav & Jensen, Kim Bak
Publié dans: Science Advances, 2023, ISSN 2375-2548
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/sciadv.adf9460

Lactate receptor GPR81 drives breast cancer growth and invasiveness through regulation of ECM properties and Notch ligand DLL4

Auteurs: Kathrine Lundø, Oksana Dmytriyeva, Louise Spøhr, Eliana Goncalves-Alves, Jiayi Yao, Laia P. Blasco, Mette Trauelsen, Muthulakshmi Ponniah, Marc Severin, Albin Sandelin, Marie Kveiborg, Thue W. Schwartz & Stine F. Pedersen
Publié dans: BMC Cancer, 2023, ISSN 1471-2407
Éditeur: BioMed Central
DOI: 10.1186/s12885-023-11631-6

Loss of cancer cell-derived ADAM15 alters the tumor microenvironment in colorectal tumors

Auteurs: Laia Puig Blasco, Krzysztof B. Piotrowski, Signe R. Michaelsen, Nicolai S. Bager, Aušrinė Areškevičiūtiė, Marie-Louise Thorseth, Xiao-Feng Sun, Ulrich auf dem Keller, Bjarne W. Kristensen, Daniel H. Madsen, Sebastian P. Gnosa, Marie Kveiborg
Publié dans: International Journal of Cancer, 2023, ISSN 0020-7136
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/ijc.34695

Inverse effects of APOC2 and ANGPTL4 on the conformational dynamics of lid-anchoring structures in lipoprotein lipase

Auteurs: Kumari, Anni; Grønnemose, A. L.; Kristensen, Kristian Kølby; Winther, Anne-Marie Lund; Young, S. G.; Jørgensen, T. J. D. & Ploug, Michael
Publié dans: Proceedings of the National Academy of Sciences of the United States of America, 2023, ISSN 1091-6490
Éditeur: P NATL ACAD SCI USA
DOI: 10.1073/pnas.2221888120

ADAM12 expression is upregulated in cancer cells upon radiation and constitutes a prognostic factor in rectal cancer patients following radiotherapy

Auteurs: Krzysztof Bartłomiej Piotrowski, Laia Puig Blasco, Jacob Samsøe-Petersen, Rikke Løvendahl Eefsen, Martin Illemann, Victor Oginga Oria, Karla Iveth Aguilera Campos, Alexia Mélanie Lopresti, Reidar Albrechtsen, Claus Storgaard Sørensen, Xiao-Feng Sun, Marie Kveiborg & Sebastian Gnosa
Publié dans: Cancer Gene Ther, 2023, ISSN 0929-1903
Éditeur: Nature Publishing Group
DOI: 10.1038/s41417-023-00643-w

Evolution and medical significance of LU domain−containing proteins

Auteurs: Leth, J. M., Leth-Espensen, K. Z., Kristensen, K. K., Kumari, A., Winther, A. M. L., Young, S. G., & Ploug, M.
Publié dans: International Journal of Molecular Sciences, 2019, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20112760

Frequency and Functional Characterization of RUNX1 Germline Variants in Myeloid Neoplasms

Auteurs: Nikolaj Juul Nitschke, Marwa Almosailleakh, Yiyuan Niu, Jakob Werner Hansen, Klas Raaschou-Jensen, Jakob Schmidt Jespersen, Marianne Tang Severinsen, Anne Stidsholt Roug, Morten Frödin, Joachim Lütken Weischenfeldt, Mette Klarskov Andersen,and Kirsten Grønbæk
Publié dans: Human mutation, 2023, ISSN 1098-1004
Éditeur: Wiley Periodicals
DOI: 10.1155/2023/4738660

Unraveling the actin cytoskeleton in the malignant transformation of cholangiocyte biology

Auteurs: Lea Duwe, Laura Fouassier, Juan Lafuente-Barquero and Jesper B. Andersen
Publié dans: Translational Oncology, Numéro 26, 2022, ISSN 1936-5233
Éditeur: Neoplasia Press
DOI: 10.1016/j.tranon.2022.101531

The Urokinase Receptor (uPAR) as a “Trojan Horse” in Targeted Cancer Therapy: Challenges and Opportunities

Auteurs: Metrangolo, V.; Ploug, M.; Engelholm, L.H
Publié dans: Cancers, Numéro 13, 2021, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13215376

INDEL detection, the ‘Achilles heel’ of precise genome editing: a survey of methods for accurate profiling of gene editing induced indels

Auteurs: Eric Paul Bennett, Bent Larsen Petersen, Ida Elisabeth Johansen, Yiyuan Niu, Zhang Yang, Christopher Aled Chamberlain, Özcan Met, Hans H Wandall, Morten Frödin
Publié dans: Nucleic Acids Research, 2020, ISSN 0305-1048
Éditeur: Oxford University Press
DOI: 10.1093/nar/gkaa975

ADAM17-mediated EGFR ligand shedding directs macrophage-promoted cancer cell invasion

Auteurs: Sebastian P. Gnosa, Laia Puig Blasco, Krzysztof B. Piotrowski, Marie L. Freiberg, Simonas Savickas, Daniel H. Madsen, Ulrich auf dem Keller, Pauliina Kronqvist, and Marie Kveiborg
Publié dans: The Journal of Clinical Investigation Insight, Numéro 18, 2022, ISSN 2379-3708
Éditeur: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.155296

Mapping cellular coordinates through advances in spatial transcriptomics technology.

Auteurs: Joji Marie Teves and Kyoung Jae Won
Publié dans: Molecules and Cells, Numéro 43(7), 2020, Page(s) 591-599, ISSN 1016-8478
Éditeur: Springer Verlag
DOI: 10.14348/molcells.2020.0020

Lipid alterations in chronic liver disease and liver cancer

Auteurs: Bichitra Paul, Monika Lewinska, Jesper B. Andersen
Publié dans: JHEP Reports, Numéro 6, 2022, ISSN 2589-5559
Éditeur: Elsevier B.V.
DOI: 10.1016/j.jhepr.2022.100479

The Collagen Receptor uPARAP in Malignant Mesothelioma: A Potential Diagnostic Marker and Therapeutic Target.

Auteurs: Pınar Çakılkaya; Rikke Raagaard Sørensen; Henrik J. Jürgensen; Oliver Krigslund; Henrik Gårdsvoll; Christoffer Nielsen; Eric Santoni-Rugiu; Niels Behrendt; Lars H. Engelholm
Publié dans: International Journal of Molecular Sciences, Numéro 21, 2021, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222111452

Antibody–Drug Conjugates: The Dynamic Evolution from Conventional to Next-Generation Constructs

Auteurs: Virginia Metrangolo, Lars H. Engelholm
Publié dans: Cancers, 2024, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers16020447

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