International Doctoral Programme in Molecular Mechanisms of Disease

Informacje na temat projektu

iMED

Identyfikator umowy o grant: 801481

DOI

10.3030/801481

Projekt został zamknięty

Data podpisania przez KE 23 Marca 2018

Data rozpoczęcia 1 Kwietnia 2019

Data zakończenia 31 Marca 2024

Finansowanie w ramach

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Koszt całkowity

€ 3 767 040,00

Wkład UE

€ 1 883 520,00

Koordynowany przez

KOBENHAVNS UNIVERSITET
Denmark

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Publikacje

Peer reviewed articles (28)

Co-expression of YAP and TAZ associates with chromosomal instability in human cholangiocarcinoma

Autorzy: Marcell Tóth, Lilija Wehling, Lena Thiess, Fabian Rose, Jennifer Schmitt, Sofia M. E. Weiler, Carsten Sticht, Carolina De La Torre, Melina Rausch, Thomas Albrecht, Niels Grabe, Lea Duwe, Jesper B. Andersen, Bruno C. Köhler, Christoph Springfeld, Arianeb Mehrabi, Yakup Kulu, Peter Schirmacher, Stephanie Roessler, Benjamin Goeppert & Kai Breuhahn
Opublikowane w: BMC Cancer, Numer 21, 2021, ISSN 1471-2407
Wydawca: BioMed Central
DOI: 10.1186/s12885-021-08794-5

Combined Inhibition of Smoothened and the DNA Damage Checkpoint WEE1 Exerts Antitumor Activity in Cholangiocarcinoma

Autorzy: Giulia Anichini; Chiara Raggi; Mirella Pastore; Laura Carrassa; Luisa Maresca; Enrica Crivaro; Tiziano Lottini; Lea Duwe; Jesper B. Andersen; Lorenzo Tofani; Luca Di Tommaso; Jesus M. Banales; Annarosa Arcangeli; Fabio Marra; Barbara Stecca
Opublikowane w: Mol Cancer Ther, 2023, Strona(/y) 343-356, ISSN 1535-7163
Wydawca: American Association for Cancer Research
DOI: 10.1158/1535-7163.mct-22-0379

ANGPTL4 sensitizes lipoprotein lipase to PCSK3 cleavage by catalyzing its unfolding

Autorzy: Lund Winther AM, Kumari A, Young SG, Ploug M
Opublikowane w: Journal of Lipid Research, Numer 62, 2021, ISSN 0022-2275
Wydawca: Lipid Research, Inc.
DOI: 10.1016/j.jlr.2021.100071

Ribosomal RNA 2′-O-methylation dynamics impact cell fate decisions

Autorzy: Häfner, Sophia Julia, Jansson, Martin David, Altinel, Kübra, Andersen, Kasper Langebjerg, Abay-Nørgaard, Zehra Caldwell, Ménard, Patrice, Fontenas, M., Sørensen, Daniel Madriz, Gay, David Michael, Arendrup, Frederic Schrøder, Tehler, D., Krogh, Nicolai, Nielsen, Henrik, Kraushar, M. L., Kirkeby, Agnete & Lund, Anders H.
Opublikowane w: Developmental Cell, 2023, ISSN 1534-5807
Wydawca: Cell Press
DOI: 10.1016/j.devcel.2023.06.007

The intrinsic instability of the hydrolase domain of lipoprotein lipase facilitates its inactivation by ANGPTL4-catalyzed unfolding

Autorzy: Katrine Z. Leth-Espensen, Kristian K. Kristensen, Anni Kumari, Anne-Marie L. Winther, Stephen G. Young, Thomas J. D. Jørgensen and Michael Ploug
Opublikowane w: The Proceedings of the National Academy of Sciences, Numer 12, 2021, ISSN 1091-6490
Wydawca: PNAS
DOI: 10.1073/pnas.2026650118

Multiparametric and accurate functional analysis of genetic sequence variants using CRISPR-Select

Autorzy: Yiyuan Niu, Catarina A. Ferreira Azevedo, Xin Li, Elahe Kamali, Ole Haagen Nielsen, Claus Storgaard Sørensen & Morten Frödin
Opublikowane w: Nature Genetics, Numer 54, 2022, ISSN 1061-4036
Wydawca: Nature Publishing Group
DOI: 10.1038/s41588-022-01224-7

GPIHBP1 and ANGPTL4 Utilize Protein Disorder to Orchestrate Order in Plasma Triglyceride Metabolism and Regulate Compartmentalization of LPL Activity

Autorzy: Kristian Kølby Kristensen; Kristian Kølby Kristensen; Katrine Zinck Leth-Espensen; Katrine Zinck Leth-Espensen; Anni Kumari; Anni Kumari; Anne Louise Grønnemose; Anne Louise Grønnemose; Anne-Marie Lund-Winther; Anne-Marie Lund-Winther; Stephen G. Young; Stephen G. Young; Michael Ploug; Michael Ploug
Opublikowane w: Frontiers in Cell and Developmental Biology, Numer 9 (2021), 2021, ISSN 2296-634X
Wydawca: Frontiers in Cell and Developmental Biology
DOI: 10.3389/fcell.2021.702508

Loss of the KN Motif and AnKyrin Repeat Domain 1 (KANK1) Leads to Lymphoid Compartment Dysregulation in Murine Model

Autorzy: Marwa Almosailleakh; Sofia Bentivegna; Samuele Narcisi; Sébasitien J. Benquet; Linn Gillberg; Carmen P. Montaño-Almendras; Simonas Savickas; Erwin M. Schoof; Amelie Wegener; Hérve Luche
Opublikowane w: Genes, 2023, ISSN 2073-4425
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes14101947

The histone demethylase KDM5C functions as a tumor suppressor in AML by repression of bivalently marked immature genes

Autorzy: Mette Louise Trempenau; Mikkel Bruhn Schuster; Sachin Pundhir; Mafalda Araujo Pereira; Adrija Kalvisa; Marta Tapia; Jinyu Su; Ying Ge; Bauke de Boer; Alexander Balhuizen; Frederik Otzen Bagger; Pavel Shliaha; Patrycja Sroczynska; Julian Walfridsson; Kirsten Grønbæk; Kim Theilgaard-Mönch; Ole N. Jensen; Kristian Helin; Bo T. Porse
Opublikowane w: Leukemia, Numer 6, 2023, ISSN 0887-6924
Wydawca: Nature Publishing Group
DOI: 10.1038/s41375-023-01810-6

The Importance of Lipoprotein Lipase Regulation in Atherosclerosis.

Autorzy: Anni Kumari; Kristian Kølby Kristensen; Kristian Kølby Kristensen; Michael Ploug; Michael Ploug; Anne-Marie Lund Winther; Anne-Marie Lund Winther
Opublikowane w: Biomedicines, Numer 7, 2021, ISSN 2227-9059
Wydawca: MDPI
DOI: 10.3390/biomedicines9070782

MicroRNA-27a-3p targets FoxO signalling to induce tumour-like phenotypes in bile duct cells

Autorzy: Lea Duwe, Patricia Munoz-Garrido, Monika Lewinska, Juan Lafuente-Barquero, Letizia Satriano, Dan Høgdall, Andrzej Taranta, Boye S. Nielsen, Awaisa Ghazal, Matthias S. Matter, Jesus M. Banales, Blanca I. Aldana, Yu-Tang Gao, Jens U. Marquardt, Lewis R. Roberts, Rui C. Oliveira, Jill Koshiol, Colm J. O'Rourke, Jesper B. Andersen
Opublikowane w: Journal of Hepatology, 2022, ISSN 0168-8278
Wydawca: Elsevier BV
DOI: 10.1016/j.jhep.2022.10.012

Regulation of translation by site-specific ribosomal RNA methylation

Autorzy: Martin D. Jansson, Sophia J. Häfner, Kübra Altinel, Disa Tehler, Nicolai Krogh, Emil Jakobsen, Jens V. Andersen, Kasper L. Andersen, Erwin M. Schoof, Patrice Ménard, Henrik Nielsen & Anders H. Lund
Opublikowane w: Nature Structural & Molecular Biology, Numer 28, 2021, ISSN 1545-9993
Wydawca: Nature Publishing Group
DOI: 10.1038/s41594-021-00669-4

Extracellular Signal-Regulated Kinase 5 Regulates the Malignant Phenotype of Cholangiocarcinoma Cells

Autorzy: Alessandra Gentilini, Giulia Lori, Alessandra Caligiuri, Chiara Raggi, Giovanni Di Maira, Mirella Pastore, Benedetta Piombanti, Tiziano Lottini, Annarosa Arcangeli, Stefania Madiai, Nadia Navari, Jesus M. Banales, Sabina Di Matteo, Domenico Alvaro, Lea Duwe, Jesper B. Andersen, Alessandro Tubita, Ignazia Tusa, Luca Di Tommaso, Claudia Campani, Elisabetta Rovida, Fabio Marra
Opublikowane w: Hepatology, Numer 74, 2021, ISSN 1527-3350
Wydawca: John Wiley & Sons, Inc.
DOI: 10.1002/hep.31888

Transcriptional and epigenomic profiling identifies YAP signaling as a key regulator of intestinal epithelium maturation

Autorzy: Pikkupeura, Laura Maarit, Bardini Bressan, Raul, Guiu, J., Chen, Y., Maimets, Martti, Mayer, Daniela, Schweiger, P. J., Hansen, Stine Lind, Maciag, Grzegorz Jerzy, Larsen, Hjalte List, Lõhmussaar, Kadi, Pedersen, M. T., Teves, Joji Marie Yap, Lange, Jette Bornholdt, Benes, V., Sandelin, Albin Gustav & Jensen, Kim Bak
Opublikowane w: Science Advances, 2023, ISSN 2375-2548
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/sciadv.adf9460

Lactate receptor GPR81 drives breast cancer growth and invasiveness through regulation of ECM properties and Notch ligand DLL4

Autorzy: Kathrine Lundø, Oksana Dmytriyeva, Louise Spøhr, Eliana Goncalves-Alves, Jiayi Yao, Laia P. Blasco, Mette Trauelsen, Muthulakshmi Ponniah, Marc Severin, Albin Sandelin, Marie Kveiborg, Thue W. Schwartz & Stine F. Pedersen
Opublikowane w: BMC Cancer, 2023, ISSN 1471-2407
Wydawca: BioMed Central
DOI: 10.1186/s12885-023-11631-6

Loss of cancer cell-derived ADAM15 alters the tumor microenvironment in colorectal tumors

Autorzy: Laia Puig Blasco, Krzysztof B. Piotrowski, Signe R. Michaelsen, Nicolai S. Bager, Aušrinė Areškevičiūtiė, Marie-Louise Thorseth, Xiao-Feng Sun, Ulrich auf dem Keller, Bjarne W. Kristensen, Daniel H. Madsen, Sebastian P. Gnosa, Marie Kveiborg
Opublikowane w: International Journal of Cancer, 2023, ISSN 0020-7136
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/ijc.34695

Inverse effects of APOC2 and ANGPTL4 on the conformational dynamics of lid-anchoring structures in lipoprotein lipase

Autorzy: Kumari, Anni; Grønnemose, A. L.; Kristensen, Kristian Kølby; Winther, Anne-Marie Lund; Young, S. G.; Jørgensen, T. J. D. & Ploug, Michael
Opublikowane w: Proceedings of the National Academy of Sciences of the United States of America, 2023, ISSN 1091-6490
Wydawca: P NATL ACAD SCI USA
DOI: 10.1073/pnas.2221888120

ADAM12 expression is upregulated in cancer cells upon radiation and constitutes a prognostic factor in rectal cancer patients following radiotherapy

Autorzy: Krzysztof Bartłomiej Piotrowski, Laia Puig Blasco, Jacob Samsøe-Petersen, Rikke Løvendahl Eefsen, Martin Illemann, Victor Oginga Oria, Karla Iveth Aguilera Campos, Alexia Mélanie Lopresti, Reidar Albrechtsen, Claus Storgaard Sørensen, Xiao-Feng Sun, Marie Kveiborg & Sebastian Gnosa
Opublikowane w: Cancer Gene Ther, 2023, ISSN 0929-1903
Wydawca: Nature Publishing Group
DOI: 10.1038/s41417-023-00643-w

Evolution and medical significance of LU domain−containing proteins

Autorzy: Leth, J. M., Leth-Espensen, K. Z., Kristensen, K. K., Kumari, A., Winther, A. M. L., Young, S. G., & Ploug, M.
Opublikowane w: International Journal of Molecular Sciences, 2019, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20112760

Frequency and Functional Characterization of RUNX1 Germline Variants in Myeloid Neoplasms

Autorzy: Nikolaj Juul Nitschke, Marwa Almosailleakh, Yiyuan Niu, Jakob Werner Hansen, Klas Raaschou-Jensen, Jakob Schmidt Jespersen, Marianne Tang Severinsen, Anne Stidsholt Roug, Morten Frödin, Joachim Lütken Weischenfeldt, Mette Klarskov Andersen,and Kirsten Grønbæk
Opublikowane w: Human mutation, 2023, ISSN 1098-1004
Wydawca: Wiley Periodicals
DOI: 10.1155/2023/4738660

Unraveling the actin cytoskeleton in the malignant transformation of cholangiocyte biology

Autorzy: Lea Duwe, Laura Fouassier, Juan Lafuente-Barquero and Jesper B. Andersen
Opublikowane w: Translational Oncology, Numer 26, 2022, ISSN 1936-5233
Wydawca: Neoplasia Press
DOI: 10.1016/j.tranon.2022.101531

The Urokinase Receptor (uPAR) as a “Trojan Horse” in Targeted Cancer Therapy: Challenges and Opportunities

Autorzy: Metrangolo, V.; Ploug, M.; Engelholm, L.H
Opublikowane w: Cancers, Numer 13, 2021, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13215376

INDEL detection, the ‘Achilles heel’ of precise genome editing: a survey of methods for accurate profiling of gene editing induced indels

Autorzy: Eric Paul Bennett, Bent Larsen Petersen, Ida Elisabeth Johansen, Yiyuan Niu, Zhang Yang, Christopher Aled Chamberlain, Özcan Met, Hans H Wandall, Morten Frödin
Opublikowane w: Nucleic Acids Research, 2020, ISSN 0305-1048
Wydawca: Oxford University Press
DOI: 10.1093/nar/gkaa975

ADAM17-mediated EGFR ligand shedding directs macrophage-promoted cancer cell invasion

Autorzy: Sebastian P. Gnosa, Laia Puig Blasco, Krzysztof B. Piotrowski, Marie L. Freiberg, Simonas Savickas, Daniel H. Madsen, Ulrich auf dem Keller, Pauliina Kronqvist, and Marie Kveiborg
Opublikowane w: The Journal of Clinical Investigation Insight, Numer 18, 2022, ISSN 2379-3708
Wydawca: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.155296

Mapping cellular coordinates through advances in spatial transcriptomics technology.

Autorzy: Joji Marie Teves and Kyoung Jae Won
Opublikowane w: Molecules and Cells, Numer 43(7), 2020, Strona(/y) 591-599, ISSN 1016-8478
Wydawca: Springer Verlag
DOI: 10.14348/molcells.2020.0020

Lipid alterations in chronic liver disease and liver cancer

Autorzy: Bichitra Paul, Monika Lewinska, Jesper B. Andersen
Opublikowane w: JHEP Reports, Numer 6, 2022, ISSN 2589-5559
Wydawca: Elsevier B.V.
DOI: 10.1016/j.jhepr.2022.100479

The Collagen Receptor uPARAP in Malignant Mesothelioma: A Potential Diagnostic Marker and Therapeutic Target.

Autorzy: Pınar Çakılkaya; Rikke Raagaard Sørensen; Henrik J. Jürgensen; Oliver Krigslund; Henrik Gårdsvoll; Christoffer Nielsen; Eric Santoni-Rugiu; Niels Behrendt; Lars H. Engelholm
Opublikowane w: International Journal of Molecular Sciences, Numer 21, 2021, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222111452

Antibody–Drug Conjugates: The Dynamic Evolution from Conventional to Next-Generation Constructs

Autorzy: Virginia Metrangolo, Lars H. Engelholm
Opublikowane w: Cancers, 2024, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers16020447