Our society is based on "systems of systems", namely, large-scale and interconnected infrastructures, such as power grids and transportation systems, with network structure and interacting subsystems. These systems are "complex', due to the rationality and autonomy of their subsystems, and in fact require advanced coordination and control actions for their safe and efficient operation, for example to mitigate grid overloading and traffic congestion. Unfortunately, standard multi-agent optimisation is inappropriate and ineffective for systems with noncooperative (selfish) subsystems, virtually all modern systems of systems. In order to ensure safe and efficient operation despite the presence of selfish parties, this project will develop dynamic game theory towards a unifying framework for the analysis and control of complex systems of systems and for supporting automated decision making.