Project description
The role of microenvironmental interactions in chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults in the western world. A critical component in CLL pathogenesis is the activation of the B-cell receptor signalling taking place in lymph nodes, and in the context of other microenvironmental interactions (such as CLL-T cell interaction). The EU-funded LeukemiaEnviron project is investigating how CLL cells behave in the microenvironment of immune niches. This includes analysis of CLL samples at various times during the disease course, during microenvironment-targeting therapies, and comparison of CLL cells in lymph nodes and peripheral blood. Results may have important clinical ramifications, and researchers also aim to develop a novel mouse model of the disease.
Fields of science
Programme(s)
Topic(s)
Funding Scheme
ERC-STG - Starting Grant
Host institution
601 77 Brno
Czechia
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Beneficiaries (1)
601 77 Brno
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