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SIGNALING PROPENSITY IN THE MICROENVIRONMENT OF B CELL CHRONIC LYMPHOCYTIC LEUKEMIA

Project description

The role of microenvironmental interactions in chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults in the western world. A critical component in CLL pathogenesis is the activation of the B-cell receptor signalling taking place in lymph nodes, and in the context of other microenvironmental interactions (such as CLL-T cell interaction). The EU-funded LeukemiaEnviron project is investigating how CLL cells behave in the microenvironment of immune niches. This includes analysis of CLL samples at various times during the disease course, during microenvironment-targeting therapies, and comparison of CLL cells in lymph nodes and peripheral blood. Results may have important clinical ramifications, and researchers also aim to develop a novel mouse model of the disease.

Host institution

Masarykova univerzita
Net EU contribution
€ 1 499 990,00
Address
Zerotinovo Namesti 9
601 77 Brno
Czechia

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Region
Jihovýchod Jihomoravský kraj
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Beneficiaries (1)

Masarykova univerzita
Czechia
Net EU contribution
€ 1 499 990,00
Address
Zerotinovo Namesti 9
601 77 Brno

See on map

Region
Jihovýchod Jihomoravský kraj
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00