Towards Realistic Modelling of Nucleosome Organization Inside Functional Chromatin Domains

Información del proyecto

InsideChromatin

Identificador del acuerdo de subvención: 803326

DOI

10.3030/803326

Proyecto cerrado

Fecha de la firma de la CE 17 Octubre 2018

Fecha de inicio 1 Abril 2019

Fecha de finalización 31 Marzo 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 490 380,00

Aportación de la UE

€ 1 490 380,00

Coordinado por

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Non-peer reviewed articles (1)

Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions

Autores: Georg Krainer, Timothy J. Welsh, Jerelle A. Joseph, Jorge R. Espinosa, Sina Wittmann, Ella de Csilléry, Akshay Sridhar, Zenon Toprakcioglu, Giedre Gudiškytė, Magdalena A. Czekalska, William E. Arter, Peter St George-Hyslop, Anthony A. Hyman, Rosana Collepardo-Guevara, Simon Alberti, Tuomas P.J. Knowles
Publicado en: Nature Communications, Edición 12, 2021, Página(s) 1085, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-21181-9

Peer reviewed articles (13)

Nucleosome plasticity is a critical element of chromatin liquid–liquid phase separation and multivalent nucleosome interactions

Autores: Stephen E Farr, Esmae J Woods, Jerelle A Joseph, Adiran Garaizar, Rosana Collepardo-Guevara
Publicado en: Nature Communications, Edición 12, 2021, Página(s) 2883, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-23090-3

Valency and Binding Affinity Variations Can Regulate the Multilayered Organization of Protein Condensates with Many Components

Autores: Ignacio Sanchez-Burgos, Jorge R. Espinosa, Jerelle A. Joseph, Rosana Collepardo-Guevara
Publicado en: Biomolecules, Edición 11, 2021, Página(s) 278, ISSN 2218-273X
Editor: MDPI
DOI: 10.3390/biom11020278

Targeted modulation of protein liquid-liquid phase separation by evolution of amino-acid sequence

Autores: Simon M Lichtinger, Adiran Garaizar, Rosana Collepardo-Guevara, Aleks Reinhardt
Publicado en: Plos Computational Biology, Edición 17(8), 2021, Página(s) e1009328, ISSN 1553-734X
Editor: Public Library of Science
DOI: 10.1371/journal.pcbi.1009328

Physics-driven coarse-grained model for biomolecular phase separation with near-quantitative accuracy

Autores: Jerelle A. Joseph, Aleks Reinhardt, Anne Aguirre, Pin Yu Chew, Kieran O. Russell, Jorge R. Espinosa, Adiran Garaizar, Rosana Collepardo-Guevara
Publicado en: Nature Computational Science, Edición 1, 2021, Página(s) 732–743, ISSN 2662-8457
Editor: Nature Publishing Group
DOI: 10.1038/s43588-021-00155-3

Size conservation emerges spontaneously in biomolecular condensates formed by scaffolds and surfactant clients

Autores: Ignacio Sanchez-Burgos, Jerelle A. Joseph, Rosana Collepardo-Guevara, Jorge R. Espinosa
Publicado en: Scientific Reports, Edición 11, 2021, Página(s) 15241, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-021-94309-y

Liquid-like chromatin in the cell: What can we learn from imaging and computational modeling?

Autores: Yuji Itoh, Esmae J. Woods, Katsuhiko Minami, Kazuhiro Maeshima, Rosana Collepardo-Guevara
Publicado en: Current Opinion in Structural Biology, Edición 71, 2021, Página(s) 123-135, ISSN 0959-440X
Editor: Elsevier BV
DOI: 10.1016/j.sbi.2021.06.004

Protein disorder-to-order transition enhances the nucleosome-binding affinity of H1

Autores: Akshay Sridhar, Modesto Orozco, Rosana Collepardo-Guevara
Publicado en: Nucleic Acids Research, Edición 48/10, 2020, Página(s) 5318–5331, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkaa285

Liquid network connectivity regulates the stability and composition of biomolecular condensates with many components

Autores: Jorge R. Espinosa, Jerelle A. Joseph, Ignacio Sanchez-Burgos, Adiran Garaizar, Daan Frenkel, Rosana Collepardo-Guevara
Publicado en: Proceedings of the National Academy of Sciences, Edición 117/24, 2020, Página(s) 13238-13247, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1917569117

Expansion of Intrinsically Disordered Proteins Increases the Range of Stability of Liquid–Liquid Phase Separation

Autores: Adiran Garaizar, Ignacio Sanchez-Burgos, Rosana Collepardo-Guevara, Jorge R. Espinosa
Publicado en: Molecules, Edición 25/20, 2020, Página(s) 4705, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25204705

Emergence of chromatin hierarchical loops from protein disorder and nucleosome asymmetry

Autores: Akshay Sridhar, Stephen E. Farr, Guillem Portella, Tamar Schlick, Modesto Orozco, Rosana Collepardo-Guevara
Publicado en: Proceedings of the National Academy of Sciences, Edición 117/13, 2020, Página(s) 7216-7224, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1910044117

DNA binds to a specific site of the adhesive blood-protein von Willebrand factor guided by electrostatic interactions

Autores: Angélica Sandoval-Pérez, Ricarda M L Berger, Adiran Garaizar, Stephen E Farr, Maria A Brehm, Gesa König, Stefan W Schneider, Rosana Collepardo-Guevara, Volker Huck, Joachim O Rädler, Camilo Aponte-Santamaría
Publicado en: Nucleic Acids Research, Edición 48/13, 2020, Página(s) 7333-7344, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkaa466

Thermodynamics and kinetics of phase separation of protein-RNA mixtures by a minimal model

Autores: Jerelle A Joseph, Jorge R Espinosa, Ignacio Sanchez-Burgos, Adiran Garaizar, Daan Frenkel, Rosana Collepardo-Guevara
Publicado en: Biophysical Journal, Edición 120/7, 2021, Página(s) 1219-1230, ISSN 0006-3495
Editor: Biophysical Society
DOI: 10.1016/j.bpj.2021.01.031

Breakdown of the law of rectilinear diameter and related surprises in the liquid-vapor coexistence in systems of patchy particles

Autores: Jorge R. Espinosa, Adiran Garaizar, Carlos Vega, Daan Frenkel, Rosana Collepardo-Guevara
Publicado en: The Journal of Chemical Physics, Edición 150/22, 2019, Página(s) 224510, ISSN 0021-9606
Editor: American Institute of Physics
DOI: 10.1063/1.5098551

Other (6)

Intermolecular reorganisation of single-component condensates during ageing promotes multiphase architectures

Autores: Adiran Garaizar, Jorge R Espinosa, Jerelle A Joseph, Georg Krainer, Yi Shen, Tuomas PJ Knowles, Rosana Collepardo-Guevara
Publicado en: bioRxiv, 2021
Editor: Cold Spring Harbour
DOI: 10.1101/2021.10.09.463670

The chromatin regulator HMGA1a undergoes phase separation in the nucleus

Autores: Hongjia Zhu, Masako Narita, Jerelle A. Joseph, Georg Krainer, Will Arter, Kadi L. Saar, Niklas Ermann, Jorge R. Espinosa, Yi Shen, Masami Ando Kuri, Runzhang Qi, Yufan Xu, Rosana Collepardo-Guevara, Masashi Narita, Tuomas P. J. Knowles
Publicado en: bioRxiv, 2021
Editor: Cold Spring Harbor
DOI: 10.1101/2021.10.14.464384

Oligonucleotides can act as superscaffolds that enhance liquid-liquid phase separation of intracellular mixtures

Autores: Jerelle A. Joseph, Jorge R. Espinosa, Ignacio Sanchez-Burgos, Adiran Garaizar, Daan Frenkel, Rosana Collepardo-Guevara
Publicado en: bioRxiv, 2020
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2020.01.24.916858

Kinetic interplay between droplet maturation and coalescence modulates shape of aged protein condensates

Autores: Adiran Garaizar, Jorge R. Espinosa, Jerelle A. Joseph, Rosana Collepardo-Guevara
Publicado en: bioRxiv, 2021
Editor: Cold Spring Harbor
DOI: 10.1101/2021.10.07.463530

Surface electrostatics govern the emulsion stability of biomolecular condensates

Autores: Timothy J. Welsh, Georg Krainer, Jorge R. Espinosa, Jerelle A. Joseph, Akshay Sridhar, Marcus Jahnel, William E. Arter, Kadi L. Saar, Simon Alberti, Rosana Collepardo-Guevara, Tuomas P.J. Knowles
Publicado en: bioRxiv, 2020
Editor: Cold Spring Harbor Labortory
DOI: 10.1101/2020.04.20.047910

RNA length has a non-trivial effect in the stability of biomolecular condensates formed by RNA-binding proteins

Autores: Ignacio Sanchez-Burgos, Jorge R Espinosa, Jerelle A Joseph, Rosana Collepardo-Guevara
Publicado en: bioRxiv, 2021
Editor: Cold Spring Harbour
DOI: 10.1101/2021.10.07.463486