Zooming the link between diet and brain health: how phenolic metabolites modulate brain inflammation

Project Information

LIMBo

Grant agreement ID: 804229

DOI 10.3030/804229

EC signature date 17 December 2018

Start date 1 April 2019

End date 30 September 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 496 022,00

EU contribution € 1 496 022,00

Coordinated by

UNIVERSIDADE NOVA DE LISBOA
Portugal

Publications

Peer reviewed articles (18)

Dietary (Poly)phenols in Traumatic Brain Injury

Author(s): Rafael Carecho, Diogo Carregosa, Bernardo Oliveira Ratilal, Inês Figueira, Maria Angeles Ávila-Gálvez, Cláudia Nunes dos Santos, Natasa Loncarevic-Vasiljkovic
Published in: International Journal of Molecular Sciences, Issue 24(10), 2023, Page(s) 8908, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24108908

Targeting the aryl hydrocarbon receptor by gut phenolic metabolites: A strategy towards gut inflammation

Author(s): Catarina J.G. Pinto, María Ángeles Ávila-Gálvez, Yilong Lian, Pedro Moura-Alves, Cláudia Nunes dos Santos
Published in: Redox Biology, 2023, ISSN 2213-2317
Publisher: Elsevier BV
DOI: 10.1016/j.redox.2023.102622

Overview of Beneficial Effects of (Poly)phenol Metabolites in the Context of Neurodegenerative Diseases on Model Organisms

Author(s): Diogo Carregosa, Sara Mota, Sofia Ferreira, Beatriz Alves-Dias, Natasa Loncarevic-Vasiljkovic, Carolina Lage Crespo, Regina Menezes, Rita Teodoro, Cláudia Nunes dos Santos
Published in: Nutrients, Issue 13/9, 2021, Page(s) 2940, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu13092940

Low Molecular Weight (poly)Phenol Metabolites Across the Blood-Brain Barrier: The Underexplored Journey

Author(s): Rafael Carecho, Diogo Carregosa, Cláudia Nunes dos Santos
Published in: Brain Plasticity, 2020, Page(s) 1-22, ISSN 2213-6304
Publisher: IOS Press
DOI: 10.3233/bpl-200099

Small Molecule Fisetin Modulates Alpha–Synuclein Aggregation

Author(s): Rita Rosado-Ramos, Joana Godinho-Pereira, Daniela Marques, Inês Figueira, Tiago Fleming Outeiro, Regina Menezes, Cláudia Nunes dos Santos
Published in: Molecules, Issue 26/11, 2021, Page(s) 3353, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26113353

Bioaccessible Raspberry Extracts Enriched in Ellagitannins and Ellagic Acid Derivatives Have Anti-Neuroinflammatory Properties

Author(s): Gonçalo Garcia, Teresa Faria Pais, Paula Pinto, Gary Dobson, Gordon J. McDougall, Derek Stewart, Cláudia Nunes Santos
Published in: Antioxidants, Issue 9/10, 2020, Page(s) 970, ISSN 2076-3921
Publisher: MDPI
DOI: 10.3390/antiox9100970

Sesquiterpene Lactones: Promising Natural Compounds to Fight Inflammation

Author(s): Melanie S. Matos, José D. Anastácio, Cláudia Nunes dos Santos
Published in: Pharmaceutics, Issue 13/7, 2021, Page(s) 991, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13070991

Costunolide and parthenolide: Novel blood-brain barrier permeable sesquiterpene lactones to improve barrier tightness

Author(s): María Ángeles Ávila-Gálvez, Daniela Marques, Inês Figueira, Katarina Cankar, Dirk Bosch, Maria Alexandra Brito, Cláudia Nunes dos Santos
Published in: Biomedicine & Pharmacotherapy, 2023, Page(s) 115413, ISSN 0753-3322
Publisher: Elsevier Masson
DOI: 10.1016/j.biopha.2023.115413

Polyphenol Metabolite Pyrogallol-O-Sulfate Decreases Microglial Activation and VEGF in Retinal Pigment Epithelium Cells and Diabetic Mouse Retina

Author(s): Daniela F. Santos, Mariana Pais, Cláudia N. Santos, Gabriela A. Silva
Published in: International Journal of Molecular Sciences, Issue 22/21, 2021, Page(s) 11402, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222111402

Urolithin B: Two-way attack on IAPP proteotoxicity with implications for diabetes

Author(s): Ana F. Raimundo, Sofia Ferreira, Vânia Pobre, Mafalda Lopes-da-Silva, José A. Brito, Daniel J. V. A. dos Santos, Nuno Saraiva, Cláudia N. dos Santos, Regina Menezes
Published in: Frontiers in Endocrinology, 2022, ISSN 1664-2392
Publisher: Lausanne: Frontiers Media S.A., 2010-
DOI: 10.3389/fendo.2022.1008418

Circulating (Poly)phenol Metabolites: Neuroprotection in a 3D Cell Model of Parkinson's Disease

Author(s): Rafael Carecho, Inês Figueira, Ana Paula Terrasso, Joana Godinho-Pereira, Catarina de Oliveira Sequeira, Sofia Azeredo Pereira, Dragan Milenkovic, Marcel Leist, Catarina Brito, Cláudia Nunes dos Santos
Published in: Molecular Nutrition & Food Research, 2021, ISSN 1613-4125
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/mnfr.202100959

Identification and quantification of (poly)phenol and methylxanthine metabolites in human cerebrospinal fluid: evidence of their ability to cross the BBB

Author(s): Melanie Le Sayec, Diogo Carregosa, Khadija Khalifa, Chiara de Lucia, Dag Aarsland, Cláudia N. Santos, Ana Rodriguez-Mateos
Published in: Food & Function, 2023, Page(s) 8893-8902, ISSN 2042-650X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3fo01913f

Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage

Author(s): Rita Rosado-Ramos; Gonçalo M. Poças; Daniela Marques; Alexandre Foito; David M. Sevillano; Mafalda Lopes-da-Silva; Luís G. Gonçalves; Regina Menezes; Marcel Ottens; Derek Stewart; Alain Ibáñez de Opakua; Markus Zweckstetter; Miguel C. Seabra; César S. Mendes; Tiago Fleming Outeiro; Pedro M. Domingos; Cláudia N. Santos
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-37561-2

Can exosomes transfer the preconditioning effects triggered by (poly)phenol compounds between cells?

Author(s): Inês Figueira, Paulo Bastos, Antonio González-Sarrías, Juan Carlos Espín, Bruno Costa-Silva, Cláudia Nunes dos Santos
Published in: Food & Function, 2023, ISSN 2042-650X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2fo00876a

Polyphenols and Their Metabolites in Renal Diseases: An Overview

Author(s): Íris Guerreiro, Cíntia Ferreira-Pêgo, Diogo Carregosa, Cláudia N. Santos, Regina Menezes, Ana S. Fernandes, João G. Costa
Published in: Foods, 2022, ISSN 2304-8158
Publisher: MDPI
DOI: 10.3390/foods11071060

Low-Molecular Weight Metabolites from Polyphenols as Effectors for Attenuating Neuroinflammation

Author(s): Diogo Carregosa, Rafael Carecho, Inês Figueira, Cláudia N Santos
Published in: Journal of Agricultural and Food Chemistry, Issue 68/7, 2020, Page(s) 1790-1807, ISSN 0021-8561
Publisher: American Chemical Society
DOI: 10.1021/acs.jafc.9b02155

A Dietary Cholesterol-Based Intestinal Inflammation Assay for Improving Drug-Discovery on Inflammatory Bowel Diseases

Author(s): Nuno-Valério Silva, Diogo Carregosa, Catarina Gonçalves, Otília V Vieira, Cláudia Nunes Dos Santos, António Jacinto, Carolina Lage Crespo
Published in: Frontiers in Cell and Developmental Biology, 2021, ISSN 2296-634X
Publisher: Lausanne: Frontiers Media S.A.
DOI: 10.3389/fcell.2021.674749

Assessing the Intestinal Permeability and Anti-Inflammatory Potential of Sesquiterpene Lactones from Chicory

Author(s): Melanie S. Matos, José D. Anastácio, J. William Allwood, Diogo Carregosa, Daniela Marques, Julie Sungurtas, Gordon J. McDougall, Regina Menezes, Ana A. Matias, Derek Stewart, Cláudia Nunes dos Santos
Published in: Nutrients, Issue 12/11, 2020, Page(s) 3547, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu12113547

Thesis and dissertations (2)

A new paradigm to study NF-kB in vivo and the role of dietary phenolic metabolites using drosophila

Author(s): Sara Mota, Rita Teodoro, Cláudia Nunes dos Santos
Published in: 2022
Publisher: NMS-NOVA

SYNTHESIS AND EVALUATION OF PHENOLIC METABOLITES AND ANALOGUES

Author(s): Diogo Cardoso Mendes, Rita Ventura, Cláudia Nunes dos Santos
Published in: 2022
Publisher: Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa.

Intellectual Property Rights

Other (1)

OMPOUNDS AND COMPOSITIONS FOR NEURODEGENERATIVE DISEASES

Application/Publication number: WO 2023156983A1
Date: 2023-02-20