Zooming the link between diet and brain health: how phenolic metabolites modulate brain inflammation

Informacje na temat projektu

LIMBo

Identyfikator umowy o grant: 804229

DOI

10.3030/804229

Data podpisania przez KE 17 Grudnia 2018

Data rozpoczęcia 1 Kwietnia 2019

Data zakończenia 31 Stycznia 2026

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity

€ 1 496 022,00

Wkład UE

€ 1 496 022,00

Koordynowany przez

UNIVERSIDADE NOVA DE LISBOA
Portugal

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Publikacje

Peer reviewed articles (22)

Locomotor and gait changes in the LPS model of neuroinflammation are correlated with inflammatory cytokines in blood and brain

Autorzy: Diogo Carregosa, Natasa Loncarevic-Vasiljkovic, Raquel Feliciano, Diogo Moura-Louro, César S. Mendes, Cláudia Nunes dos Santos
Opublikowane w: Journal of Inflammation, Numer 21, 2024, ISSN 1476-9255
Wydawca: Springer Nature
DOI: 10.1186/s12950-024-00412-y

Dietary (Poly)phenols in Traumatic Brain Injury

Autorzy: Rafael Carecho, Diogo Carregosa, Bernardo Oliveira Ratilal, Inês Figueira, Maria Angeles Ávila-Gálvez, Cláudia Nunes dos Santos, Natasa Loncarevic-Vasiljkovic
Opublikowane w: International Journal of Molecular Sciences, Numer 24(10), 2023, Strona(/y) 8908, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24108908

Targeting the aryl hydrocarbon receptor by gut phenolic metabolites: A strategy towards gut inflammation

Autorzy: Catarina J.G. Pinto, María Ángeles Ávila-Gálvez, Yilong Lian, Pedro Moura-Alves, Cláudia Nunes dos Santos
Opublikowane w: Redox Biology, 2023, ISSN 2213-2317
Wydawca: Elsevier BV
DOI: 10.1016/j.redox.2023.102622

Overview of Beneficial Effects of (Poly)phenol Metabolites in the Context of Neurodegenerative Diseases on Model Organisms

Autorzy: Diogo Carregosa, Sara Mota, Sofia Ferreira, Beatriz Alves-Dias, Natasa Loncarevic-Vasiljkovic, Carolina Lage Crespo, Regina Menezes, Rita Teodoro, Cláudia Nunes dos Santos
Opublikowane w: Nutrients, Numer 13/9, 2021, Strona(/y) 2940, ISSN 2072-6643
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu13092940

Low Molecular Weight (poly)Phenol Metabolites Across the Blood-Brain Barrier: The Underexplored Journey

Autorzy: Rafael Carecho, Diogo Carregosa, Cláudia Nunes dos Santos
Opublikowane w: Brain Plasticity, 2020, Strona(/y) 1-22, ISSN 2213-6304
Wydawca: IOS Press
DOI: 10.3233/bpl-200099

How Healthy Eating Can Help Fight Parkinson’s Disease

Autorzy: Ana Filipa Raimundo, Carlos Pita, Inês P. Silva, Cláudia Nunes dos Santos, Natasa Loncarevic-Vasiljkovic
Opublikowane w: Frontiers for Young Minds, Numer 12, 2024, ISSN 2296-6846
Wydawca: Frontiers Media SA
DOI: 10.3389/frym.2024.1286574

Small Molecule Fisetin Modulates Alpha–Synuclein Aggregation

Autorzy: Rita Rosado-Ramos, Joana Godinho-Pereira, Daniela Marques, Inês Figueira, Tiago Fleming Outeiro, Regina Menezes, Cláudia Nunes dos Santos
Opublikowane w: Molecules, Numer 26/11, 2021, Strona(/y) 3353, ISSN 1420-3049
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26113353

Bioaccessible Raspberry Extracts Enriched in Ellagitannins and Ellagic Acid Derivatives Have Anti-Neuroinflammatory Properties

Autorzy: Gonçalo Garcia, Teresa Faria Pais, Paula Pinto, Gary Dobson, Gordon J. McDougall, Derek Stewart, Cláudia Nunes Santos
Opublikowane w: Antioxidants, Numer 9/10, 2020, Strona(/y) 970, ISSN 2076-3921
Wydawca: MDPI
DOI: 10.3390/antiox9100970

Sesquiterpene Lactones: Promising Natural Compounds to Fight Inflammation

Autorzy: Melanie S. Matos, José D. Anastácio, Cláudia Nunes dos Santos
Opublikowane w: Pharmaceutics, Numer 13/7, 2021, Strona(/y) 991, ISSN 1999-4923
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13070991

Costunolide and parthenolide: Novel blood-brain barrier permeable sesquiterpene lactones to improve barrier tightness

Autorzy: María Ángeles Ávila-Gálvez, Daniela Marques, Inês Figueira, Katarina Cankar, Dirk Bosch, Maria Alexandra Brito, Cláudia Nunes dos Santos
Opublikowane w: Biomedicine & Pharmacotherapy, 2023, Strona(/y) 115413, ISSN 0753-3322
Wydawca: Elsevier Masson
DOI: 10.1016/j.biopha.2023.115413

Polyphenol Metabolite Pyrogallol-O-Sulfate Decreases Microglial Activation and VEGF in Retinal Pigment Epithelium Cells and Diabetic Mouse Retina

Autorzy: Daniela F. Santos, Mariana Pais, Cláudia N. Santos, Gabriela A. Silva
Opublikowane w: International Journal of Molecular Sciences, Numer 22/21, 2021, Strona(/y) 11402, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222111402

Urolithin B: Two-way attack on IAPP proteotoxicity with implications for diabetes

Autorzy: Ana F. Raimundo, Sofia Ferreira, Vânia Pobre, Mafalda Lopes-da-Silva, José A. Brito, Daniel J. V. A. dos Santos, Nuno Saraiva, Cláudia N. dos Santos, Regina Menezes
Opublikowane w: Frontiers in Endocrinology, 2022, ISSN 1664-2392
Wydawca: Lausanne: Frontiers Media S.A., 2010-
DOI: 10.3389/fendo.2022.1008418

Circulating (Poly)phenol Metabolites: Neuroprotection in a 3D Cell Model of Parkinson's Disease

Autorzy: Rafael Carecho, Inês Figueira, Ana Paula Terrasso, Joana Godinho-Pereira, Catarina de Oliveira Sequeira, Sofia Azeredo Pereira, Dragan Milenkovic, Marcel Leist, Catarina Brito, Cláudia Nunes dos Santos
Opublikowane w: Molecular Nutrition & Food Research, 2021, ISSN 1613-4125
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/mnfr.202100959

Identification and quantification of (poly)phenol and methylxanthine metabolites in human cerebrospinal fluid: evidence of their ability to cross the BBB

Autorzy: Melanie Le Sayec, Diogo Carregosa, Khadija Khalifa, Chiara de Lucia, Dag Aarsland, Cláudia N. Santos, Ana Rodriguez-Mateos
Opublikowane w: Food & Function, 2023, Strona(/y) 8893-8902, ISSN 2042-650X
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d3fo01913f

Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage

Autorzy: Rita Rosado-Ramos; Gonçalo M. Poças; Daniela Marques; Alexandre Foito; David M. Sevillano; Mafalda Lopes-da-Silva; Luís G. Gonçalves; Regina Menezes; Marcel Ottens; Derek Stewart; Alain Ibáñez de Opakua; Markus Zweckstetter; Miguel C. Seabra; César S. Mendes; Tiago Fleming Outeiro; Pedro M. Domingos; Cláudia N. Santos
Opublikowane w: Nature Communications, 2023, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-023-37561-2

Can exosomes transfer the preconditioning effects triggered by (poly)phenol compounds between cells?

Autorzy: Inês Figueira, Paulo Bastos, Antonio González-Sarrías, Juan Carlos Espín, Bruno Costa-Silva, Cláudia Nunes dos Santos
Opublikowane w: Food & Function, 2023, ISSN 2042-650X
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d2fo00876a

Polyphenols and Their Metabolites in Renal Diseases: An Overview

Autorzy: Íris Guerreiro, Cíntia Ferreira-Pêgo, Diogo Carregosa, Cláudia N. Santos, Regina Menezes, Ana S. Fernandes, João G. Costa
Opublikowane w: Foods, 2022, ISSN 2304-8158
Wydawca: MDPI
DOI: 10.3390/foods11071060

Low-Molecular Weight Metabolites from Polyphenols as Effectors for Attenuating Neuroinflammation

Autorzy: Diogo Carregosa, Rafael Carecho, Inês Figueira, Cláudia N Santos
Opublikowane w: Journal of Agricultural and Food Chemistry, Numer 68/7, 2020, Strona(/y) 1790-1807, ISSN 0021-8561
Wydawca: American Chemical Society
DOI: 10.1021/acs.jafc.9b02155

Unlocking the potential of low-molecular-weight (Poly)phenol metabolites: Protectors at the blood-brain barrier frontier

Autorzy: Daniela Marques, Diogo Moura-Louro, Inês P. Silva, Sara Matos, Cláudia Nunes dos Santos, Inês Figueira
Opublikowane w: Neurochemistry International, Numer 179, 2024, Strona(/y) 105836, ISSN 0197-0186
Wydawca: Elsevier BV
DOI: 10.1016/j.neuint.2024.105836

A Dietary Cholesterol-Based Intestinal Inflammation Assay for Improving Drug-Discovery on Inflammatory Bowel Diseases

Autorzy: Nuno-Valério Silva, Diogo Carregosa, Catarina Gonçalves, Otília V Vieira, Cláudia Nunes Dos Santos, António Jacinto, Carolina Lage Crespo
Opublikowane w: Frontiers in Cell and Developmental Biology, 2021, ISSN 2296-634X
Wydawca: Lausanne: Frontiers Media S.A.
DOI: 10.3389/fcell.2021.674749

Circulating low-molecular-weight (poly)phenol metabolites in the brain: unveiling <i>in vitro</i> and <i>in vivo</i> blood–brain barrier transport

Autorzy: Rafael Carecho, Daniela Marques, Diogo Carregosa, Domenico Masuero, Mar Garcia-Aloy, Federica Tramer, Sabina Passamonti, Urska Vrhovsek, M. Rita Ventura, Maria Alexandra Brito, Cláudia Nunes dos Santos, Inês Figueira
Opublikowane w: Food &amp; Function, Numer 15, 2024, Strona(/y) 7812-7827, ISSN 2042-650X
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d4fo01396d

Assessing the Intestinal Permeability and Anti-Inflammatory Potential of Sesquiterpene Lactones from Chicory

Autorzy: Melanie S. Matos, José D. Anastácio, J. William Allwood, Diogo Carregosa, Daniela Marques, Julie Sungurtas, Gordon J. McDougall, Regina Menezes, Ana A. Matias, Derek Stewart, Cláudia Nunes dos Santos
Opublikowane w: Nutrients, Numer 12/11, 2020, Strona(/y) 3547, ISSN 2072-6643
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu12113547

Other (1)

Communicating Science Matters: Evidence from the BASCOE Study, a quantitative study from Brain Awareness Week outreach activities

Autorzy: Carlos Pita, Inês P. Silva, Ana Rita Colaço, Margarida Brotas, Beatriz Felgueiras, Beatriz Nogueira, Olga Carreira, Ana F. Fonseca, Mariana Castro, Adriana Capucho, Gonçalo Melo, Fatima O. Martins, Gabriela Ribeiro, Conceição Calhau, Sandra Tenreiro, Hugo Vicente Miranda, Silvia Vilares Conde, Cesar Mendes, Cláudia Nunes dos Santos, Nuno Mendonça, Maria Serrano Correia, Nuno Miguel Gonçalv
Opublikowane w: 2024
Wydawca: Center for Open Science
DOI: 10.31235/osf.io/ebr2k

Non-peer reviewed articles (2)

Low molecular weight gut polyphenols metabolites and its nutritional relevance as effectors for attenuating neuroinflammation

Autorzy: Diogo Carregosa, Rafael Carecho, Inês Figueira, Cláudia Nunes dos Santos
Opublikowane w: Proceedings of the Nutrition Society, Numer 79, 2020, ISSN 0029-6651
Wydawca: CABI Publishing
DOI: 10.1017/s0029665120002359

From berries to brain: Assessing the impact of (poly)phenols in the MPTP mouse model of Parkinson’s disease

Autorzy: Rafael Carecho, Ana Filipa Raimundo, María Ángeles Ávila-Gálvez, Hugo Tainha Lopes, Catarina de Oliveira Sequeira, Carlos Pita, Catarina Pinto, Diogo Carregosa, Alicia Marín, Antonio González-Sarrías, Juan Carlos Espín, Sofia Azeredo Pereira, Andreia Neves Carvalho, Teresa F. Pais, Natasa Loncarevic-Vasiljkovic, Cláudia Nunes dos Santos
Opublikowane w: BioRXiv, 2025, ISSN 2692-8205
Wydawca: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.08.16.670034

Conference proceedings (1)

Development and Validation of a Food Frequency Questionnaire to Assess Polyphenol Intake and Its Association with Inflammation in the Portuguese Population: Study Plan

Autorzy: Lizaveta Hilman, Cláudia Nunes Santos, Nuno Mendonça
Opublikowane w: The 14th European Nutrition Conference FENS 2023, 2024, Strona(/y) 360
Wydawca: MDPI
DOI: 10.3390/proceedings2023091360

Thesis and dissertations (6)

From diet to neuronal cells: Investigating the effects of circulating (poly)phenol metabolites on Parkinson's disease

Autorzy: Rafael Carecho, Teresa Pais, Cláudia Nunes dos Santos
Opublikowane w: 2024
Wydawca: NMS-Universidade Nova de Lisboa

Berry-enriched diet suppress neuroinflammation by modulating microglia

Autorzy: Diogo Louro, Cláudia Nunes dos Santos
Opublikowane w: 2024
Wydawca: Nova Medical School - Universidade NOVA de Lisboa

A new paradigm to study NF-kB in vivo and the role of dietary phenolic metabolites using drosophila

Autorzy: Sara Mota, Rita Teodoro, Cláudia Nunes dos Santos
Opublikowane w: 2022
Wydawca: NMS-NOVA

(Poly)Phenol metabolites antinflammatory role in blood-brain barrier – microglia crosstalk

Autorzy: Sara Matos, Inês Figueira
Opublikowane w: 2025
Wydawca: Nova Medical School - Universidade NOVA de Lisboa

SYNTHESIS AND EVALUATION OF PHENOLIC METABOLITES AND ANALOGUES

Autorzy: Diogo Cardoso Mendes, Rita Ventura, Cláudia Nunes dos Santos
Opublikowane w: 2022
Wydawca: Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa.

Microbiota derived metabolites from dietary phenolics and their potential to mitigate neuroinflammation

Autorzy: Diogo Carregosa, Maria Rita Ventura, Cláudia Nunes dos Santos
Opublikowane w: 2025
Wydawca: Nova Medical School - Universidade NOVA de Lisboa

Prawa własności intelektualnej

Other (1)

OMPOUNDS AND COMPOSITIONS FOR NEURODEGENERATIVE DISEASES

Numer wniosku/publikacji: WO 2023156983A1
Data: 2023-02-20
Wnioskodawca/wnioskodawcy: UNIVERSIDADE NOVA DE LISBOA