Zooming the link between diet and brain health: how phenolic metabolites modulate brain inflammation

Información del proyecto

LIMBo

Identificador del acuerdo de subvención: 804229

DOI

10.3030/804229

Fecha de la firma de la CE 17 Diciembre 2018

Fecha de inicio 1 Abril 2019

Fecha de finalización 31 Enero 2026

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 496 022,00

Aportación de la UE

€ 1 496 022,00

Coordinado por

UNIVERSIDADE NOVA DE LISBOA
Portugal

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (22)

Locomotor and gait changes in the LPS model of neuroinflammation are correlated with inflammatory cytokines in blood and brain

Autores: Diogo Carregosa, Natasa Loncarevic-Vasiljkovic, Raquel Feliciano, Diogo Moura-Louro, César S. Mendes, Cláudia Nunes dos Santos
Publicado en: Journal of Inflammation, Edición 21, 2024, ISSN 1476-9255
Editor: Springer Nature
DOI: 10.1186/s12950-024-00412-y

Dietary (Poly)phenols in Traumatic Brain Injury

Autores: Rafael Carecho, Diogo Carregosa, Bernardo Oliveira Ratilal, Inês Figueira, Maria Angeles Ávila-Gálvez, Cláudia Nunes dos Santos, Natasa Loncarevic-Vasiljkovic
Publicado en: International Journal of Molecular Sciences, Edición 24(10), 2023, Página(s) 8908, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24108908

Targeting the aryl hydrocarbon receptor by gut phenolic metabolites: A strategy towards gut inflammation

Autores: Catarina J.G. Pinto, María Ángeles Ávila-Gálvez, Yilong Lian, Pedro Moura-Alves, Cláudia Nunes dos Santos
Publicado en: Redox Biology, 2023, ISSN 2213-2317
Editor: Elsevier BV
DOI: 10.1016/j.redox.2023.102622

Overview of Beneficial Effects of (Poly)phenol Metabolites in the Context of Neurodegenerative Diseases on Model Organisms

Autores: Diogo Carregosa, Sara Mota, Sofia Ferreira, Beatriz Alves-Dias, Natasa Loncarevic-Vasiljkovic, Carolina Lage Crespo, Regina Menezes, Rita Teodoro, Cláudia Nunes dos Santos
Publicado en: Nutrients, Edición 13/9, 2021, Página(s) 2940, ISSN 2072-6643
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu13092940

Low Molecular Weight (poly)Phenol Metabolites Across the Blood-Brain Barrier: The Underexplored Journey

Autores: Rafael Carecho, Diogo Carregosa, Cláudia Nunes dos Santos
Publicado en: Brain Plasticity, 2020, Página(s) 1-22, ISSN 2213-6304
Editor: IOS Press
DOI: 10.3233/bpl-200099

How Healthy Eating Can Help Fight Parkinson’s Disease

Autores: Ana Filipa Raimundo, Carlos Pita, Inês P. Silva, Cláudia Nunes dos Santos, Natasa Loncarevic-Vasiljkovic
Publicado en: Frontiers for Young Minds, Edición 12, 2024, ISSN 2296-6846
Editor: Frontiers Media SA
DOI: 10.3389/frym.2024.1286574

Small Molecule Fisetin Modulates Alpha–Synuclein Aggregation

Autores: Rita Rosado-Ramos, Joana Godinho-Pereira, Daniela Marques, Inês Figueira, Tiago Fleming Outeiro, Regina Menezes, Cláudia Nunes dos Santos
Publicado en: Molecules, Edición 26/11, 2021, Página(s) 3353, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26113353

Bioaccessible Raspberry Extracts Enriched in Ellagitannins and Ellagic Acid Derivatives Have Anti-Neuroinflammatory Properties

Autores: Gonçalo Garcia, Teresa Faria Pais, Paula Pinto, Gary Dobson, Gordon J. McDougall, Derek Stewart, Cláudia Nunes Santos
Publicado en: Antioxidants, Edición 9/10, 2020, Página(s) 970, ISSN 2076-3921
Editor: MDPI
DOI: 10.3390/antiox9100970

Sesquiterpene Lactones: Promising Natural Compounds to Fight Inflammation

Autores: Melanie S. Matos, José D. Anastácio, Cláudia Nunes dos Santos
Publicado en: Pharmaceutics, Edición 13/7, 2021, Página(s) 991, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13070991

Costunolide and parthenolide: Novel blood-brain barrier permeable sesquiterpene lactones to improve barrier tightness

Autores: María Ángeles Ávila-Gálvez, Daniela Marques, Inês Figueira, Katarina Cankar, Dirk Bosch, Maria Alexandra Brito, Cláudia Nunes dos Santos
Publicado en: Biomedicine & Pharmacotherapy, 2023, Página(s) 115413, ISSN 0753-3322
Editor: Elsevier Masson
DOI: 10.1016/j.biopha.2023.115413

Polyphenol Metabolite Pyrogallol-O-Sulfate Decreases Microglial Activation and VEGF in Retinal Pigment Epithelium Cells and Diabetic Mouse Retina

Autores: Daniela F. Santos, Mariana Pais, Cláudia N. Santos, Gabriela A. Silva
Publicado en: International Journal of Molecular Sciences, Edición 22/21, 2021, Página(s) 11402, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222111402

Urolithin B: Two-way attack on IAPP proteotoxicity with implications for diabetes

Autores: Ana F. Raimundo, Sofia Ferreira, Vânia Pobre, Mafalda Lopes-da-Silva, José A. Brito, Daniel J. V. A. dos Santos, Nuno Saraiva, Cláudia N. dos Santos, Regina Menezes
Publicado en: Frontiers in Endocrinology, 2022, ISSN 1664-2392
Editor: Lausanne: Frontiers Media S.A., 2010-
DOI: 10.3389/fendo.2022.1008418

Circulating (Poly)phenol Metabolites: Neuroprotection in a 3D Cell Model of Parkinson's Disease

Autores: Rafael Carecho, Inês Figueira, Ana Paula Terrasso, Joana Godinho-Pereira, Catarina de Oliveira Sequeira, Sofia Azeredo Pereira, Dragan Milenkovic, Marcel Leist, Catarina Brito, Cláudia Nunes dos Santos
Publicado en: Molecular Nutrition & Food Research, 2021, ISSN 1613-4125
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/mnfr.202100959

Identification and quantification of (poly)phenol and methylxanthine metabolites in human cerebrospinal fluid: evidence of their ability to cross the BBB

Autores: Melanie Le Sayec, Diogo Carregosa, Khadija Khalifa, Chiara de Lucia, Dag Aarsland, Cláudia N. Santos, Ana Rodriguez-Mateos
Publicado en: Food & Function, 2023, Página(s) 8893-8902, ISSN 2042-650X
Editor: Royal Society of Chemistry
DOI: 10.1039/d3fo01913f

Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage

Autores: Rita Rosado-Ramos; Gonçalo M. Poças; Daniela Marques; Alexandre Foito; David M. Sevillano; Mafalda Lopes-da-Silva; Luís G. Gonçalves; Regina Menezes; Marcel Ottens; Derek Stewart; Alain Ibáñez de Opakua; Markus Zweckstetter; Miguel C. Seabra; César S. Mendes; Tiago Fleming Outeiro; Pedro M. Domingos; Cláudia N. Santos
Publicado en: Nature Communications, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-37561-2

Can exosomes transfer the preconditioning effects triggered by (poly)phenol compounds between cells?

Autores: Inês Figueira, Paulo Bastos, Antonio González-Sarrías, Juan Carlos Espín, Bruno Costa-Silva, Cláudia Nunes dos Santos
Publicado en: Food & Function, 2023, ISSN 2042-650X
Editor: Royal Society of Chemistry
DOI: 10.1039/d2fo00876a

Polyphenols and Their Metabolites in Renal Diseases: An Overview

Autores: Íris Guerreiro, Cíntia Ferreira-Pêgo, Diogo Carregosa, Cláudia N. Santos, Regina Menezes, Ana S. Fernandes, João G. Costa
Publicado en: Foods, 2022, ISSN 2304-8158
Editor: MDPI
DOI: 10.3390/foods11071060

Low-Molecular Weight Metabolites from Polyphenols as Effectors for Attenuating Neuroinflammation

Autores: Diogo Carregosa, Rafael Carecho, Inês Figueira, Cláudia N Santos
Publicado en: Journal of Agricultural and Food Chemistry, Edición 68/7, 2020, Página(s) 1790-1807, ISSN 0021-8561
Editor: American Chemical Society
DOI: 10.1021/acs.jafc.9b02155

Unlocking the potential of low-molecular-weight (Poly)phenol metabolites: Protectors at the blood-brain barrier frontier

Autores: Daniela Marques, Diogo Moura-Louro, Inês P. Silva, Sara Matos, Cláudia Nunes dos Santos, Inês Figueira
Publicado en: Neurochemistry International, Edición 179, 2024, Página(s) 105836, ISSN 0197-0186
Editor: Elsevier BV
DOI: 10.1016/j.neuint.2024.105836

A Dietary Cholesterol-Based Intestinal Inflammation Assay for Improving Drug-Discovery on Inflammatory Bowel Diseases

Autores: Nuno-Valério Silva, Diogo Carregosa, Catarina Gonçalves, Otília V Vieira, Cláudia Nunes Dos Santos, António Jacinto, Carolina Lage Crespo
Publicado en: Frontiers in Cell and Developmental Biology, 2021, ISSN 2296-634X
Editor: Lausanne: Frontiers Media S.A.
DOI: 10.3389/fcell.2021.674749

Circulating low-molecular-weight (poly)phenol metabolites in the brain: unveiling <i>in vitro</i> and <i>in vivo</i> blood–brain barrier transport

Autores: Rafael Carecho, Daniela Marques, Diogo Carregosa, Domenico Masuero, Mar Garcia-Aloy, Federica Tramer, Sabina Passamonti, Urska Vrhovsek, M. Rita Ventura, Maria Alexandra Brito, Cláudia Nunes dos Santos, Inês Figueira
Publicado en: Food &amp; Function, Edición 15, 2024, Página(s) 7812-7827, ISSN 2042-650X
Editor: Royal Society of Chemistry
DOI: 10.1039/d4fo01396d

Assessing the Intestinal Permeability and Anti-Inflammatory Potential of Sesquiterpene Lactones from Chicory

Autores: Melanie S. Matos, José D. Anastácio, J. William Allwood, Diogo Carregosa, Daniela Marques, Julie Sungurtas, Gordon J. McDougall, Regina Menezes, Ana A. Matias, Derek Stewart, Cláudia Nunes dos Santos
Publicado en: Nutrients, Edición 12/11, 2020, Página(s) 3547, ISSN 2072-6643
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu12113547

Other (1)

Communicating Science Matters: Evidence from the BASCOE Study, a quantitative study from Brain Awareness Week outreach activities

Autores: Carlos Pita, Inês P. Silva, Ana Rita Colaço, Margarida Brotas, Beatriz Felgueiras, Beatriz Nogueira, Olga Carreira, Ana F. Fonseca, Mariana Castro, Adriana Capucho, Gonçalo Melo, Fatima O. Martins, Gabriela Ribeiro, Conceição Calhau, Sandra Tenreiro, Hugo Vicente Miranda, Silvia Vilares Conde, Cesar Mendes, Cláudia Nunes dos Santos, Nuno Mendonça, Maria Serrano Correia, Nuno Miguel Gonçalv
Publicado en: 2024
Editor: Center for Open Science
DOI: 10.31235/osf.io/ebr2k

Non-peer reviewed articles (2)

Low molecular weight gut polyphenols metabolites and its nutritional relevance as effectors for attenuating neuroinflammation

Autores: Diogo Carregosa, Rafael Carecho, Inês Figueira, Cláudia Nunes dos Santos
Publicado en: Proceedings of the Nutrition Society, Edición 79, 2020, ISSN 0029-6651
Editor: CABI Publishing
DOI: 10.1017/s0029665120002359

From berries to brain: Assessing the impact of (poly)phenols in the MPTP mouse model of Parkinson’s disease

Autores: Rafael Carecho, Ana Filipa Raimundo, María Ángeles Ávila-Gálvez, Hugo Tainha Lopes, Catarina de Oliveira Sequeira, Carlos Pita, Catarina Pinto, Diogo Carregosa, Alicia Marín, Antonio González-Sarrías, Juan Carlos Espín, Sofia Azeredo Pereira, Andreia Neves Carvalho, Teresa F. Pais, Natasa Loncarevic-Vasiljkovic, Cláudia Nunes dos Santos
Publicado en: BioRXiv, 2025, ISSN 2692-8205
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.08.16.670034

Conference proceedings (1)

Development and Validation of a Food Frequency Questionnaire to Assess Polyphenol Intake and Its Association with Inflammation in the Portuguese Population: Study Plan

Autores: Lizaveta Hilman, Cláudia Nunes Santos, Nuno Mendonça
Publicado en: The 14th European Nutrition Conference FENS 2023, 2024, Página(s) 360
Editor: MDPI
DOI: 10.3390/proceedings2023091360

Thesis and dissertations (6)

From diet to neuronal cells: Investigating the effects of circulating (poly)phenol metabolites on Parkinson's disease

Autores: Rafael Carecho, Teresa Pais, Cláudia Nunes dos Santos
Publicado en: 2024
Editor: NMS-Universidade Nova de Lisboa

Berry-enriched diet suppress neuroinflammation by modulating microglia

Autores: Diogo Louro, Cláudia Nunes dos Santos
Publicado en: 2024
Editor: Nova Medical School - Universidade NOVA de Lisboa

A new paradigm to study NF-kB in vivo and the role of dietary phenolic metabolites using drosophila

Autores: Sara Mota, Rita Teodoro, Cláudia Nunes dos Santos
Publicado en: 2022
Editor: NMS-NOVA

(Poly)Phenol metabolites antinflammatory role in blood-brain barrier – microglia crosstalk

Autores: Sara Matos, Inês Figueira
Publicado en: 2025
Editor: Nova Medical School - Universidade NOVA de Lisboa

SYNTHESIS AND EVALUATION OF PHENOLIC METABOLITES AND ANALOGUES

Autores: Diogo Cardoso Mendes, Rita Ventura, Cláudia Nunes dos Santos
Publicado en: 2022
Editor: Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa.

Microbiota derived metabolites from dietary phenolics and their potential to mitigate neuroinflammation

Autores: Diogo Carregosa, Maria Rita Ventura, Cláudia Nunes dos Santos
Publicado en: 2025
Editor: Nova Medical School - Universidade NOVA de Lisboa

Derechos de propiedad intelectual

Other (1)

OMPOUNDS AND COMPOSITIONS FOR NEURODEGENERATIVE DISEASES

Número de solicitud/publicación: WO 2023156983A1
Fecha: 2023-02-20
Solicitante(s): UNIVERSIDADE NOVA DE LISBOA