Descripción del proyecto
Cómo retrasan los fenólicos alimentarios las enfermedades neurodegenerativas
Existe la creencia de que una dieta rica en fenólicos retrasa las enfermedades neurodegenerativas entre la población de edad avanzada. Sin embargo, aún se están examinando las acciones mecanicistas de los fenólicos sobre la salud cerebral. El proyecto LIMBo, financiado con fondos europeos, tiene por objeto analizar la capacidad de los fenólicos alimentarios para prevenir y retrasar la neuroinflamación, proceso central de las enfermedades neurodegenerativas. El proyecto se centrará en los metabolitos derivados de los fenólicos alimentarios e investigará sus efectos en las rutas tanto determinadas como desconocidas de las células microgliales. Con LIMBo se obtendrán conocimientos esenciales que mejorarán la comprensión de la diversidad de los metabolitos fenólicos, su impacto específico en la neuroinflamación y su uso potencial como profármacos. Además, se extraerán conocimientos científicos valiosos de cara a la futura aplicación de dietas saludables para el cerebro.
Objetivo
Currently a big concern of our aging society is to efficiently delay the onset of neurodegenerative diseases which are progressively rising in incidence. The paradigm that a diet rich in the phenolics, prevalent e.g. in fruits, is beneficial to brain health has reached the public. However their mechanistic actions in brain functions remain to be seen, particularly since the nature of those acting in the brain remains overlooked. I wish to address this gap by identifying candidate compounds that can support development of effective strategies to delay neurodegeneration.
Specifically, I will be analysing the potential of dietary phenolics in both prevention and treatment (i.e delay) of neuroinflammation – key process shared in neurodegenerative diseases. To break down the current indeterminate status of “cause vs effect”, my vision is to focus my research on metabolites derived from dietary phenolics that reach the brain. I will be investigating their effects in both established and unknown response pathways of microglia cells - the innate immune cells of the central nervous system, either alone or when communicating with other brain cells. Ultimately, to attain an integrated view of their effects I will establish nutrition trials in mice. LIMBo considers both pro- and anti- inflammatory processes to preliminary validate the action of any promising metabolite in prevention and/or therapeutics.
LIMBo provides valuable scientific insights for future implementation of healthy brain diets. My group is in a unique position to address LIMBo objectives due to multidisciplinary expertise in organic synthesis, metabolomics and molecular and cellular biology, together with our previous data on novel neuroactive metabolites.
LIMBo also creates far-reaching opportunities by generating knowledge that impacts our fundamental understanding on the diversity of phenolic metabolites and their specific influences in neuroinflammation and potential use as prodrugs.
Ámbito científico
Palabras clave
Programa(s)
Régimen de financiación
ERC-STG - Starting GrantInstitución de acogida
1099 085 Lisboa
Portugal