Inflammatory resolution and remodelling of the adipose extracellular matrix: key determinants of a metabolically healthy phenotype?

Project Information

The MATRIX

Grant agreement ID: 804418

DOI

10.3030/804418

EC signature date 6 November 2018

Start date 1 September 2019

End date 28 February 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 700 002,00

EU contribution

€ 1 700 002,00

Coordinated by

AARHUS UNIVERSITET
Denmark

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (17)

Healthy Subcutaneous and Omental Adipose Tissue Is Associated with High Expression of Extracellular Matrix Components

Author(s): Matúš Soták; Meenu Rohini Rajan; Madison Clark; Christina Biörserud; Ville Wallenius; Carolina E. Hagberg; Emma Börgeson
Published in: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23010520

The immune checkpoint B7-H3 (CD276) regulates adipocyte progenitor metabolism and obesity development

Author(s): Picarda E, Galbo PM Jr, Zong H, Rajan MR, Wallenius V, Zheng D, Börgeson E, Singh R, Pessin J, Zang X.
Published in: Sciences Advances, 2022, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abm7012

Combined Loss of Obsc and Obsl1 in Murine Hearts Results in Diastolic Dysfunction, Altered Metabolism, and Deregulated Mitophagy

Author(s): Kyohei Fujita, Patrick Desmond, Jordan Blondelle, Matúš Soták, Meenu Rohini Rajan, Madison Clark, Éric Estève, Yunghang Chan, Yusu Gu, Virginia Actis Dato, Valeria Marrocco, Nancy D. Dalton, Maji
Published in: Circulation: Heart Failure, Issue 18, 2025, ISSN 1941-3297
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circheartfailure.124.011867

Comparative analysis of obesity-related cardiometabolic and renal biomarkers in human plasma and serum.

Author(s): Meenu Rohini Rajan; Matúš Soták; Fredrik Barrenäs; Fredrik Barrenäs; Tong Shen; Kamil Borkowski; Nicholas J. Ashton; Christina Biörserud; Tomas L. Lindahl; Sofia Ramström; Sofia Ramström; Michael Schöll; Michael Schöll; Per Lindahl; Oliver Fiehn; John W. Newman; John W. Newman; Rosie Perkins; Ville Wallenius; Stephan Lange; Stephan Lange; Emma Börgeson; Emma Börgeson
Published in: Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019), 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-51673-0

miR-486 is modulated by stretch and increases ventricular growth

Author(s): Stephan Lange; Stephan Lange; Indroneal Banerjee; Katrina Carrion; Ricardo Serrano; Louisa Habich; Rebecca J Kameny; Luisa Lengenfelder; Nancy D. Dalton; Rudolph Meili; Emma Börgeson; Kirk L. Peterson; Marco Ricci; Joy Lincoln; Majid Ghassemian; Jeffery R. Fineman; Juan C. del Álamo; Vishal Nigam; Vishal Nigam; Vishal Nigam
Published in: JCI Insight, 2019, ISSN 2379-3708
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.125507

Of mice and men: Pinpointing species differences in adipose tissue biology

Author(s): Emma Börgeson; Jeremie Boucher; Carolina E Hagberg
Published in: Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Publisher: Frontiers Media S.A.
DOI: 10.3389/fcell.2022.1003118

Specialized Pro-Resolving Mediators and the Lymphatic System.

Author(s): Jamie Kraft; Robert Blomgran; Iben Lundgaard; Marianne Quiding-Järbrink; Jonathan S. Bromberg; Emma Börgeson; Emma Börgeson
Published in: International Journal of Molecular Sciences, 2021, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22052750

The N2A region of titin has a unique structural configuration.

Author(s): Chiara Stronczek; Stephan Lange; Stephan Lange; Belinda Bullard; Sebastian Wolniak; Emma Börgeson; Olga Mayans; Jennifer R. Fleming
Published in: The Journal of General Physiology, 2021, ISSN 0022-1295
Publisher: Rockefeller University Press
DOI: 10.1085/jgp.202012766

Inflammation and resolution in obesity

Author(s): Matúš Soták, Madison Clark, Bianca E. Suur, Emma Börgeson
Published in: Nature Reviews Endocrinology, Issue 21, 2024, Page(s) 45-61, ISSN 1759-5029
Publisher: Nature Publishing Group
DOI: 10.1038/s41574-024-01047-y

Intestinal sodium/glucose cotransporter 3 expression is epithelial and downregulated in obesity

Author(s): Soták M, Casselbrant A, Rath E, Zietek T, Strömstedt M, Adingupu DD, Karlsson D, Fritsch Fredin M, Ergang P, Pácha J, Batorsky A, Alpers CE, Börgeson E, Hansen PBL, Ericsson A, Björnson Granqvist A, Wallenius V, Fändriks L, Unwin RJ
Published in: Life Sciences, 2021, ISSN 0024-3205
Publisher: Elsevier BV
DOI: 10.1016/j.lfs.2020.118974

The evolving functions of the vasculature in regulating adipose tissue biology in health and obesity

Author(s): Ibrahim AlZaim; Laura P M H de Rooij; Bilal N Sheikh; Emma Börgeson; Joanna Kalucka
Published in: Nature Reviews Endocrinology, 2023, Page(s) 19(12): 691-707, ISSN 1759-5029
Publisher: Nature Publishing Group
DOI: 10.1038/s41574-023-00893-6

Exploring Obscurin and SPEG Kinase Biology.

Author(s): Jennifer R. Fleming; Alankrita Rani; Jamie Kraft; Sanja Zenker; Emma Börgeson; Emma Börgeson; Stephan Lange; Stephan Lange
Published in: Journal of Clinical Medicine, 2021, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm10050984

Lipoxins modulate neutrophil oxidative burst, integrin expression and lymphatic transmigration differentially in human health and atherosclerosis

Author(s): Jamie D. Kraft; Robert Blomgran; Ida Bergström; Matúš Soták; Madison Clark; Alankrita Rani; Meenu Rohini Rajan; Jesmond Dalli; Sofia Nyström; Marianne Quiding‐Järbrink; Jonathan Bromberg; Per Skoog; Emma Börgeson
Published in: Crossref, 2022, ISSN 0892-6638
Publisher: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202101219rr

Challenges in PhD education due to COVID-19 - disrupted supervision or business as usual: a cross-sectional survey of Swedish biomedical sciences graduate students.

Author(s): Emma Börgeson; Matúš Soták; Jamie Kraft; Grace Bagunu; Christina Biörserud; Stephan Lange; Stephan Lange
Published in: BMC Medical Education, Vol 21, Iss 1, Pp 1-11 (2021), 2021, ISSN 1472-6920
Publisher: BioMed Central
DOI: 10.21203/rs.3.rs-318234/v1

Molecular Characterisation of Titin N2A and Its Binding of CARP Reveals a Titin/Actin Cross-linking Mechanism

Author(s): Zhou T, Fleming JR, Lange S, Hessel AL, Bogomolovas J, Stronczek C, Grundei D, Ghassemian M, Biju A, Börgeson E, Bullard B, Linke WA, Chen J, Kovermann M, Mayans O.
Published in: The Journal of Molecular Biology, 2021, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2021.166901

Students at a crossroad: A cross-sectional survey gauging the impact of COVID-19 on medical and biomedical graduates in the United States and Sweden

Author(s): Stephan Lange; Matúš Soták; Carolina E Hagberg; Grace Bagunu; Sylvi Vigmo; Emma Börgeson
Published in: Biochemistry and Molecular Biology Education, 2023, ISSN 1470-8175
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1002/bmb.21761

Lipoxins reduce obesity-induced adipose tissue inflammation in 3D-cultured human adipocytes and explant cultures

Author(s): Matúš Soták, Meenu Rohini Rajan, Madison Clark, Matthew Harms, Alankrita Rani, Jamie D. Kraft, David Tandio, Tong Shen, Kamil Borkowski, Oliver Fiehn, John W. Newman, Marianne Quiding-Järbrink, Ch
Published in: iScience, Issue 25, 2025, Page(s) 104602, ISSN 2589-0042
Publisher: Elsevier BV
DOI: 10.1016/j.isci.2022.104602