Inflammatory resolution and remodelling of the adipose extracellular matrix: key determinants of a metabolically healthy phenotype?

Informazioni relative al progetto

The MATRIX

ID dell’accordo di sovvenzione: 804418

DOI

10.3030/804418

Data della firma CE 6 Novembre 2018

Data di avvio 1 Settembre 2019

Data di completamento 28 Febbraio 2026

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 700 002,00

Contributo UE

€ 1 700 002,00

Coordinato da

AARHUS UNIVERSITET
Denmark

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (17)

Healthy Subcutaneous and Omental Adipose Tissue Is Associated with High Expression of Extracellular Matrix Components

Autori: Matúš Soták; Meenu Rohini Rajan; Madison Clark; Christina Biörserud; Ville Wallenius; Carolina E. Hagberg; Emma Börgeson
Pubblicato in: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23010520

The immune checkpoint B7-H3 (CD276) regulates adipocyte progenitor metabolism and obesity development

Autori: Picarda E, Galbo PM Jr, Zong H, Rajan MR, Wallenius V, Zheng D, Börgeson E, Singh R, Pessin J, Zang X.
Pubblicato in: Sciences Advances, 2022, ISSN 2375-2548
Editore: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abm7012

Combined Loss of Obsc and Obsl1 in Murine Hearts Results in Diastolic Dysfunction, Altered Metabolism, and Deregulated Mitophagy

Autori: Kyohei Fujita, Patrick Desmond, Jordan Blondelle, Matúš Soták, Meenu Rohini Rajan, Madison Clark, Éric Estève, Yunghang Chan, Yusu Gu, Virginia Actis Dato, Valeria Marrocco, Nancy D. Dalton, Maji
Pubblicato in: Circulation: Heart Failure, Numero 18, 2025, ISSN 1941-3297
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circheartfailure.124.011867

Comparative analysis of obesity-related cardiometabolic and renal biomarkers in human plasma and serum.

Autori: Meenu Rohini Rajan; Matúš Soták; Fredrik Barrenäs; Fredrik Barrenäs; Tong Shen; Kamil Borkowski; Nicholas J. Ashton; Christina Biörserud; Tomas L. Lindahl; Sofia Ramström; Sofia Ramström; Michael Schöll; Michael Schöll; Per Lindahl; Oliver Fiehn; John W. Newman; John W. Newman; Rosie Perkins; Ville Wallenius; Stephan Lange; Stephan Lange; Emma Börgeson; Emma Börgeson
Pubblicato in: Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019), 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-51673-0

miR-486 is modulated by stretch and increases ventricular growth

Autori: Stephan Lange; Stephan Lange; Indroneal Banerjee; Katrina Carrion; Ricardo Serrano; Louisa Habich; Rebecca J Kameny; Luisa Lengenfelder; Nancy D. Dalton; Rudolph Meili; Emma Börgeson; Kirk L. Peterson; Marco Ricci; Joy Lincoln; Majid Ghassemian; Jeffery R. Fineman; Juan C. del Álamo; Vishal Nigam; Vishal Nigam; Vishal Nigam
Pubblicato in: JCI Insight, 2019, ISSN 2379-3708
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.125507

Of mice and men: Pinpointing species differences in adipose tissue biology

Autori: Emma Börgeson; Jeremie Boucher; Carolina E Hagberg
Pubblicato in: Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Editore: Frontiers Media S.A.
DOI: 10.3389/fcell.2022.1003118

Specialized Pro-Resolving Mediators and the Lymphatic System.

Autori: Jamie Kraft; Robert Blomgran; Iben Lundgaard; Marianne Quiding-Järbrink; Jonathan S. Bromberg; Emma Börgeson; Emma Börgeson
Pubblicato in: International Journal of Molecular Sciences, 2021, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22052750

The N2A region of titin has a unique structural configuration.

Autori: Chiara Stronczek; Stephan Lange; Stephan Lange; Belinda Bullard; Sebastian Wolniak; Emma Börgeson; Olga Mayans; Jennifer R. Fleming
Pubblicato in: The Journal of General Physiology, 2021, ISSN 0022-1295
Editore: Rockefeller University Press
DOI: 10.1085/jgp.202012766

Inflammation and resolution in obesity

Autori: Matúš Soták, Madison Clark, Bianca E. Suur, Emma Börgeson
Pubblicato in: Nature Reviews Endocrinology, Numero 21, 2024, Pagina/e 45-61, ISSN 1759-5029
Editore: Nature Publishing Group
DOI: 10.1038/s41574-024-01047-y

Intestinal sodium/glucose cotransporter 3 expression is epithelial and downregulated in obesity

Autori: Soták M, Casselbrant A, Rath E, Zietek T, Strömstedt M, Adingupu DD, Karlsson D, Fritsch Fredin M, Ergang P, Pácha J, Batorsky A, Alpers CE, Börgeson E, Hansen PBL, Ericsson A, Björnson Granqvist A, Wallenius V, Fändriks L, Unwin RJ
Pubblicato in: Life Sciences, 2021, ISSN 0024-3205
Editore: Elsevier BV
DOI: 10.1016/j.lfs.2020.118974

The evolving functions of the vasculature in regulating adipose tissue biology in health and obesity

Autori: Ibrahim AlZaim; Laura P M H de Rooij; Bilal N Sheikh; Emma Börgeson; Joanna Kalucka
Pubblicato in: Nature Reviews Endocrinology, 2023, Pagina/e 19(12): 691-707, ISSN 1759-5029
Editore: Nature Publishing Group
DOI: 10.1038/s41574-023-00893-6

Exploring Obscurin and SPEG Kinase Biology.

Autori: Jennifer R. Fleming; Alankrita Rani; Jamie Kraft; Sanja Zenker; Emma Börgeson; Emma Börgeson; Stephan Lange; Stephan Lange
Pubblicato in: Journal of Clinical Medicine, 2021, ISSN 2077-0383
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm10050984

Lipoxins modulate neutrophil oxidative burst, integrin expression and lymphatic transmigration differentially in human health and atherosclerosis

Autori: Jamie D. Kraft; Robert Blomgran; Ida Bergström; Matúš Soták; Madison Clark; Alankrita Rani; Meenu Rohini Rajan; Jesmond Dalli; Sofia Nyström; Marianne Quiding‐Järbrink; Jonathan Bromberg; Per Skoog; Emma Börgeson
Pubblicato in: Crossref, 2022, ISSN 0892-6638
Editore: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202101219rr

Challenges in PhD education due to COVID-19 - disrupted supervision or business as usual: a cross-sectional survey of Swedish biomedical sciences graduate students.

Autori: Emma Börgeson; Matúš Soták; Jamie Kraft; Grace Bagunu; Christina Biörserud; Stephan Lange; Stephan Lange
Pubblicato in: BMC Medical Education, Vol 21, Iss 1, Pp 1-11 (2021), 2021, ISSN 1472-6920
Editore: BioMed Central
DOI: 10.21203/rs.3.rs-318234/v1

Molecular Characterisation of Titin N2A and Its Binding of CARP Reveals a Titin/Actin Cross-linking Mechanism

Autori: Zhou T, Fleming JR, Lange S, Hessel AL, Bogomolovas J, Stronczek C, Grundei D, Ghassemian M, Biju A, Börgeson E, Bullard B, Linke WA, Chen J, Kovermann M, Mayans O.
Pubblicato in: The Journal of Molecular Biology, 2021, ISSN 0022-2836
Editore: Academic Press
DOI: 10.1016/j.jmb.2021.166901

Students at a crossroad: A cross-sectional survey gauging the impact of COVID-19 on medical and biomedical graduates in the United States and Sweden

Autori: Stephan Lange; Matúš Soták; Carolina E Hagberg; Grace Bagunu; Sylvi Vigmo; Emma Börgeson
Pubblicato in: Biochemistry and Molecular Biology Education, 2023, ISSN 1470-8175
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1002/bmb.21761

Lipoxins reduce obesity-induced adipose tissue inflammation in 3D-cultured human adipocytes and explant cultures

Autori: Matúš Soták, Meenu Rohini Rajan, Madison Clark, Matthew Harms, Alankrita Rani, Jamie D. Kraft, David Tandio, Tong Shen, Kamil Borkowski, Oliver Fiehn, John W. Newman, Marianne Quiding-Järbrink, Ch
Pubblicato in: iScience, Numero 25, 2025, Pagina/e 104602, ISSN 2589-0042
Editore: Elsevier BV
DOI: 10.1016/j.isci.2022.104602