Inflammatory resolution and remodelling of the adipose extracellular matrix: key determinants of a metabolically healthy phenotype?

Información del proyecto

The MATRIX

Identificador del acuerdo de subvención: 804418

DOI

10.3030/804418

Fecha de la firma de la CE 6 Noviembre 2018

Fecha de inicio 1 Septiembre 2019

Fecha de finalización 28 Febrero 2026

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 700 002,00

Aportación de la UE

€ 1 700 002,00

Coordinado por

AARHUS UNIVERSITET
Denmark

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (17)

Healthy Subcutaneous and Omental Adipose Tissue Is Associated with High Expression of Extracellular Matrix Components

Autores: Matúš Soták; Meenu Rohini Rajan; Madison Clark; Christina Biörserud; Ville Wallenius; Carolina E. Hagberg; Emma Börgeson
Publicado en: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23010520

The immune checkpoint B7-H3 (CD276) regulates adipocyte progenitor metabolism and obesity development

Autores: Picarda E, Galbo PM Jr, Zong H, Rajan MR, Wallenius V, Zheng D, Börgeson E, Singh R, Pessin J, Zang X.
Publicado en: Sciences Advances, 2022, ISSN 2375-2548
Editor: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abm7012

Combined Loss of Obsc and Obsl1 in Murine Hearts Results in Diastolic Dysfunction, Altered Metabolism, and Deregulated Mitophagy

Autores: Kyohei Fujita, Patrick Desmond, Jordan Blondelle, Matúš Soták, Meenu Rohini Rajan, Madison Clark, Éric Estève, Yunghang Chan, Yusu Gu, Virginia Actis Dato, Valeria Marrocco, Nancy D. Dalton, Maji
Publicado en: Circulation: Heart Failure, Edición 18, 2025, ISSN 1941-3297
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circheartfailure.124.011867

Comparative analysis of obesity-related cardiometabolic and renal biomarkers in human plasma and serum.

Autores: Meenu Rohini Rajan; Matúš Soták; Fredrik Barrenäs; Fredrik Barrenäs; Tong Shen; Kamil Borkowski; Nicholas J. Ashton; Christina Biörserud; Tomas L. Lindahl; Sofia Ramström; Sofia Ramström; Michael Schöll; Michael Schöll; Per Lindahl; Oliver Fiehn; John W. Newman; John W. Newman; Rosie Perkins; Ville Wallenius; Stephan Lange; Stephan Lange; Emma Börgeson; Emma Börgeson
Publicado en: Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019), 2019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-019-51673-0

miR-486 is modulated by stretch and increases ventricular growth

Autores: Stephan Lange; Stephan Lange; Indroneal Banerjee; Katrina Carrion; Ricardo Serrano; Louisa Habich; Rebecca J Kameny; Luisa Lengenfelder; Nancy D. Dalton; Rudolph Meili; Emma Börgeson; Kirk L. Peterson; Marco Ricci; Joy Lincoln; Majid Ghassemian; Jeffery R. Fineman; Juan C. del Álamo; Vishal Nigam; Vishal Nigam; Vishal Nigam
Publicado en: JCI Insight, 2019, ISSN 2379-3708
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.125507

Of mice and men: Pinpointing species differences in adipose tissue biology

Autores: Emma Börgeson; Jeremie Boucher; Carolina E Hagberg
Publicado en: Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Editor: Frontiers Media S.A.
DOI: 10.3389/fcell.2022.1003118

Specialized Pro-Resolving Mediators and the Lymphatic System.

Autores: Jamie Kraft; Robert Blomgran; Iben Lundgaard; Marianne Quiding-Järbrink; Jonathan S. Bromberg; Emma Börgeson; Emma Börgeson
Publicado en: International Journal of Molecular Sciences, 2021, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22052750

The N2A region of titin has a unique structural configuration.

Autores: Chiara Stronczek; Stephan Lange; Stephan Lange; Belinda Bullard; Sebastian Wolniak; Emma Börgeson; Olga Mayans; Jennifer R. Fleming
Publicado en: The Journal of General Physiology, 2021, ISSN 0022-1295
Editor: Rockefeller University Press
DOI: 10.1085/jgp.202012766

Inflammation and resolution in obesity

Autores: Matúš Soták, Madison Clark, Bianca E. Suur, Emma Börgeson
Publicado en: Nature Reviews Endocrinology, Edición 21, 2024, Página(s) 45-61, ISSN 1759-5029
Editor: Nature Publishing Group
DOI: 10.1038/s41574-024-01047-y

Intestinal sodium/glucose cotransporter 3 expression is epithelial and downregulated in obesity

Autores: Soták M, Casselbrant A, Rath E, Zietek T, Strömstedt M, Adingupu DD, Karlsson D, Fritsch Fredin M, Ergang P, Pácha J, Batorsky A, Alpers CE, Börgeson E, Hansen PBL, Ericsson A, Björnson Granqvist A, Wallenius V, Fändriks L, Unwin RJ
Publicado en: Life Sciences, 2021, ISSN 0024-3205
Editor: Elsevier BV
DOI: 10.1016/j.lfs.2020.118974

The evolving functions of the vasculature in regulating adipose tissue biology in health and obesity

Autores: Ibrahim AlZaim; Laura P M H de Rooij; Bilal N Sheikh; Emma Börgeson; Joanna Kalucka
Publicado en: Nature Reviews Endocrinology, 2023, Página(s) 19(12): 691-707, ISSN 1759-5029
Editor: Nature Publishing Group
DOI: 10.1038/s41574-023-00893-6

Exploring Obscurin and SPEG Kinase Biology.

Autores: Jennifer R. Fleming; Alankrita Rani; Jamie Kraft; Sanja Zenker; Emma Börgeson; Emma Börgeson; Stephan Lange; Stephan Lange
Publicado en: Journal of Clinical Medicine, 2021, ISSN 2077-0383
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm10050984

Lipoxins modulate neutrophil oxidative burst, integrin expression and lymphatic transmigration differentially in human health and atherosclerosis

Autores: Jamie D. Kraft; Robert Blomgran; Ida Bergström; Matúš Soták; Madison Clark; Alankrita Rani; Meenu Rohini Rajan; Jesmond Dalli; Sofia Nyström; Marianne Quiding‐Järbrink; Jonathan Bromberg; Per Skoog; Emma Börgeson
Publicado en: Crossref, 2022, ISSN 0892-6638
Editor: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202101219rr

Challenges in PhD education due to COVID-19 - disrupted supervision or business as usual: a cross-sectional survey of Swedish biomedical sciences graduate students.

Autores: Emma Börgeson; Matúš Soták; Jamie Kraft; Grace Bagunu; Christina Biörserud; Stephan Lange; Stephan Lange
Publicado en: BMC Medical Education, Vol 21, Iss 1, Pp 1-11 (2021), 2021, ISSN 1472-6920
Editor: BioMed Central
DOI: 10.21203/rs.3.rs-318234/v1

Molecular Characterisation of Titin N2A and Its Binding of CARP Reveals a Titin/Actin Cross-linking Mechanism

Autores: Zhou T, Fleming JR, Lange S, Hessel AL, Bogomolovas J, Stronczek C, Grundei D, Ghassemian M, Biju A, Börgeson E, Bullard B, Linke WA, Chen J, Kovermann M, Mayans O.
Publicado en: The Journal of Molecular Biology, 2021, ISSN 0022-2836
Editor: Academic Press
DOI: 10.1016/j.jmb.2021.166901

Students at a crossroad: A cross-sectional survey gauging the impact of COVID-19 on medical and biomedical graduates in the United States and Sweden

Autores: Stephan Lange; Matúš Soták; Carolina E Hagberg; Grace Bagunu; Sylvi Vigmo; Emma Börgeson
Publicado en: Biochemistry and Molecular Biology Education, 2023, ISSN 1470-8175
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1002/bmb.21761

Lipoxins reduce obesity-induced adipose tissue inflammation in 3D-cultured human adipocytes and explant cultures

Autores: Matúš Soták, Meenu Rohini Rajan, Madison Clark, Matthew Harms, Alankrita Rani, Jamie D. Kraft, David Tandio, Tong Shen, Kamil Borkowski, Oliver Fiehn, John W. Newman, Marianne Quiding-Järbrink, Ch
Publicado en: iScience, Edición 25, 2025, Página(s) 104602, ISSN 2589-0042
Editor: Elsevier BV
DOI: 10.1016/j.isci.2022.104602