Assessing the role of ribosomes and mRNA translation in shaping the inflammatory response

Informazioni relative al progetto

RiboInflam

ID dell’accordo di sovvenzione: 805500

DOI

10.3030/805500

Progetto chiuso

Data della firma CE 23 Ottobre 2018

Data di avvio 1 Gennaio 2019

Data di completamento 31 Dicembre 2024

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 499 720,00

Contributo UE

€ 1 499 720,00

Coordinato da

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Open Research Data Pilot (1)

Data Management Plan

Pubblicazioni

Peer reviewed articles (14)

Ribosome dynamics and mRNA turnover, a complex relationship under constant cellular scrutiny

Autori: Christelle Morris, David Cluet, Emiliano P. Ricci
Pubblicato in: WIREs RNA, 2021, ISSN 1757-7004
Editore: John Wiley and Sons Inc.
DOI: 10.1002/wrna.1658

Translation-dependent and -independent mRNA decay occur through mutually exclusive pathways defined by ribosome density during T cell activation

Autori: Blandine C. Mercier, Emmanuel Labaronne, David Cluet, Laura Guiguettaz, Nicolas Fontrodona, Alicia Bicknell, Antoine Corbin, Mélanie Wencker, Fabien Aube, Laurent Modolo, Karina Jouravleva, Didier Auboeuf, Melissa J. Moore, Emiliano P. Ricci
Pubblicato in: Genome Research, 2024, ISSN 1088-9051
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.277863.123

The DEAD box RNA helicase DDX42 is an intrinsic inhibitor of positive-strand RNA viruses

Autori: Boris Bonaventure, Antoine Rebendenne, Ana Luiza Chaves Valadão, Mary Arnaud-Arnould, Ségolène Gracias, Francisco Garcia de Gracia, Joe McKellar, Emmanuel Labaronne, Marine Tauziet, Valérie Vivet-Boudou, Eric Bernard, Laurence Briant, Nathalie Gros, Wassila Djilli, Valérie Courgnaud, Hugues Parrinello, Stéphanie Rialle, Mickaël Blaise, Laurent Lacroix, Marc Lavigne, Jean-Christophe Paillart
Pubblicato in: EMBO Reports, 2022, ISSN 1469-3178
Editore: EMBO Press
DOI: 10.15252/embr.202154061

The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans

Autori: Shiuli Agarwal, Tim Vierbuchen, Sreya Ghosh, Jennie Chan, Zhaozhao Jiang, Richard K. Kandasamy, Emiliano Ricci, Katherine A. Fitzgerald
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-20165-5

RSL24D1 sustains steady-state ribosome biogenesis and pluripotency translational programs in embryonic stem cells

Autori: Sébastien Durand, Marion Bruelle, Fleur Bourdelais, Bigitha Bennychen, Juliana Blin-Gonthier, Caroline Isaac, Aurélia Huyghe, Sylvie Martel, Antoine Seyve, Christophe Vanbelle, Annie Adrait, Yohann Couté, David Meyronet, Frédéric Catez, Jean-Jacques Diaz, Fabrice Lavial, Emiliano P. Ricci, François Ducray, Mathieu Gabut
Pubblicato in: Nature Communications, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-36037-7

Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease

Autori: Mehdi Eshraghi, Pabalu P. Karunadharma, Juliana Blin, Neelam Shahani, Emiliano P. Ricci, Audrey Michel, Nicolai T. Urban, Nicole Galli, Manish Sharma, Uri Nimrod Ramírez-Jarquín, Katie Florescu, Jennifer Hernandez, Srinivasa Subramaniam
Pubblicato in: Nature Communications, Numero 12/1, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-21637-y

Shaping the Innate Immune Response Through Post-Transcriptional Regulation of Gene Expression Mediated by RNA-Binding Proteins

Autori: Anissa Guillemin; Anuj Kumar; Mélanie Wencker; Mélanie Wencker; Emiliano P. Ricci
Pubblicato in: Frontiers in Immunology, Numero 10, 2022, ISSN 1664-3224
Editore: Frontiers Media S.A.
DOI: 10.3389/fimmu.2021.796012

Metabolism-dependent secondary effect of anti-MAPK cancer therapy on DNA repair

Autori: Fabien Aubé, Nicolas Fontrodona, Laura Guiguettaz, Elodie Vallin, Lucilla Fabbri, Audrey Lapendry, Stephan Vagner, Emiliano P Ricci, Didier Auboeuf
Pubblicato in: NAR Cancer, Numero 6, 2024, ISSN 2632-8674
Editore: Oxford Academic
DOI: 10.1093/narcan/zcae019

System-wide Profiling of RNA-Binding Proteins Uncovers Key Regulators of Virus Infection

Autori: Manuel Garcia-Moreno, Marko Noerenberg, Shuai Ni, Aino I. Järvelin, Esther González-Almela, Caroline E. Lenz, Marcel Bach-Pages, Victoria Cox, Rosario Avolio, Thomas Davis, Svenja Hester, Thibault J.M. Sohier, Bingnan Li, Gregory Heikel, Gracjan Michlewski, Miguel A. Sanz, Luis Carrasco, Emiliano P. Ricci, Vicent Pelechano, Ilan Davis, Bernd Fischer, Shabaz Mohammed, Alfredo Castello
Pubblicato in: Molecular Cell, Numero 74/1, 2019, Pagina/e 196-211.e11, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2019.01.017

Genome editing in primary cells and in vivo using viral-derived Nanoblades loaded with Cas9-sgRNA ribonucleoproteins

Autori: Philippe E. Mangeot, Valérie Risson, Floriane Fusil, Aline Marnef, Emilie Laurent, Juliana Blin, Virginie Mournetas, Emmanuelle Massouridès, Thibault J. M. Sohier, Antoine Corbin, Fabien Aubé, Marie Teixeira, Christian Pinset, Laurent Schaeffer, Gaëlle Legube, François-Loïc Cosset, Els Verhoeyen, Théophile Ohlmann, Emiliano P. Ricci
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-07845-z

Non-AUG HIV-1 uORF translation elicits specific T cell immune response and regulates viral transcript expression

Autori: Emmanuel Labaronne, Didier Décimo, Lisa Bertrand, Laura Guiguettaz, Thibault J. M. Sohier, David Cluet, Valérie Vivet-Boudou, Ana Luiza Chaves Valadão, Clara Dahoui, Pauline François, Isabelle Hatin, Olivier Lambotte, Assia Samri, Brigitte Autran, Lucie Etienne, Caroline Goujon, Jean-Christophe Paillart, Olivier Namy, Bertha Cecilia Ramirez, Théophile Ohlmann, Arnaud Moris, Emiliano P. Ricci
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-025-56772-3

"Delivery of the Cas9/sgRNA Ribonucleoprotein Complex in Immortalized and Primary Cells via Virus-like Particles (""Nanoblades"")"

Autori: Philippe E. Mangeot, Laura Guiguettaz, Thibault J. M. Sohier, Emiliano P. Ricci
Pubblicato in: Journal of Visualized Experiments, Numero 169, 2021, ISSN 1940-087X
Editore: MYJoVE Corporation
DOI: 10.3791/62245

Pseudomonas aeruginosa cleaves the decoding center of Caenorhabditis elegans ribosomes

Autori: Alejandro Vasquez-Rifo, Emiliano P. Ricci, Victor Ambros
Pubblicato in: PLOS Biology, Numero 18/12, 2020, Pagina/e e3000969, ISSN 1545-7885
Editore: Plos
DOI: 10.1371/journal.pbio.3000969

Ribosomes guide pachytene piRNA formation on long intergenic piRNA precursors

Autori: Yu H. Sun, Jiang Zhu, Li Huitong Xie, Ziwei Li, Rajyalakshmi Meduri, Xiaopeng Zhu, Chi Song, Chen Chen, Emiliano P. Ricci, Zhiping Weng, Xin Zhiguo Li
Pubblicato in: Nature Cell Biology, Numero 22/2, 2020, Pagina/e 200-212, ISSN 1465-7392
Editore: Nature Publishing Group
DOI: 10.1038/s41556-019-0457-4