Skip to main content

Investigating Mechanisms and Models Predictive of Accessibility of Therapeutics (IM2PACT) Into The Brain

Project description

The blood–brain barrier and delivery of biopharmaceuticals to the brain

The overall goal of the EU-funded IM2PACT project is to further our understanding of the blood–brain barrier (BBB) in health and disease in order to develop innovative systems for the delivery of biopharmaceuticals to the brain and identify novel drug targets for Alzheimer’s disease, multiple sclerosis and metabolic disease. Researchers will identify specific genes altered in brain endothelial cells in disease and establish new disease genetic models followed by the generation and characterisation of robust and predictive stem cell-derived BBB models. Next, they aim to develop efficacious and safe mechanisms and technologies for brain delivery, employing neurotropic virus-mediated BBB selective penetration systems and establishing in silico models to predict BBB penetration for therapeutics and pharmacokinetics in different compartments of the neural system.

Coordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Net EU contribution
€ 2 462 486,25
Address
Wellington Square University Offices
OX1 2JD Oxford
United Kingdom

See on map

Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Participants (26)

UPPSALA UNIVERSITET
Sweden
Net EU contribution
€ 1 113 250,00
Address
Von Kraemers Alle 4
751 05 Uppsala

See on map

Region
Östra Sverige Östra Mellansverige Uppsala län
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
STICHTING VUMC
Netherlands
Net EU contribution
€ 290 437,50
Address
De Boelelaan 1117
1081 HV Amsterdam

See on map

Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Research Organisations
Other funding
€ 0,00
UNIVERSITY OF DUNDEE
United Kingdom
Net EU contribution
€ 354 008,75
Address
Nethergate
DD1 4HN Dundee

See on map

Region
Eastern Scotland Angus and Dundee City
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
Net EU contribution
€ 297 500,00
Address
Albinusdreef 2
2333 ZA Leiden

See on map

Region
West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
KOBENHAVNS UNIVERSITET
Denmark
Net EU contribution
€ 532 198,75
Address
Norregade 10
1165 Kobenhavn

See on map

Region
Danmark Hovedstaden Byen København
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
AARHUS UNIVERSITET
Denmark
Net EU contribution
€ 483 966,25
Address
Nordre Ringgade 1
8000 Aarhus C

See on map

Region
Danmark Midtjylland Østjylland
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ
Germany
Net EU contribution
€ 288 661,25
Address
Langenbeckstrasse 1
55131 Mainz

See on map

Region
Rheinland-Pfalz Rheinhessen-Pfalz Mainz, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Germany
Net EU contribution
€ 290 187,50
Address
Seminarstrasse 2
69117 Heidelberg

See on map

Region
Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH
Austria
Net EU contribution
€ 582 292,50
Other funding
€ 0,00
MIMETAS BV
Netherlands
Net EU contribution
€ 251 812,50
Address
De Limes 7
2342 DH Oegstgeest

See on map

SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
THE OPEN UNIVERSITY
United Kingdom
Net EU contribution
€ 232 283,75
Address
Walton Hall
MK7 6AA Milton Keynes

See on map

Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Milton Keynes
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT
Germany
Net EU contribution
€ 213 718,75
Address
Josef-schneider-strasse 2
97080 Wurzburg

See on map

Region
Bayern Unterfranken Würzburg, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER
Germany
Net EU contribution
€ 290 312,50
Address
Bunteweg 2
30559 Hannover

See on map

Region
Niedersachsen Hannover Region Hannover
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
ARTEMIS BIO-SUPPORT B.V.
Netherlands
Net EU contribution
€ 290 380,00
Address
Molengraaffsingel 10
2629 JD Delft

See on map

SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
West-Nederland Zuid-Holland Delft en Westland
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
NEUWAY PHARMA GMBH
Germany
Net EU contribution
€ 112 500,00
Address
Ludwig-erhard-allee 2
53175 Bonn

See on map

SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Nordrhein-Westfalen Köln Bonn, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
THE UNIVERSITY OF SHEFFIELD
United Kingdom
Net EU contribution
€ 249 305,00
Address
Firth Court Western Bank
S10 2TN Sheffield

See on map

Region
Yorkshire and the Humber South Yorkshire Sheffield
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA
Italy
Net EU contribution
€ 67 565,00
Address
Via Universita 4
41121 Modena

See on map

Region
Nord-Est Emilia-Romagna Modena
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
PHARMACOIDEA FEJLESZTO ES SZOLGALTATO KFT
Hungary
Net EU contribution
€ 300 058,75
Address
Derkovits Fasor 7-11
6726 Szeged

See on map

SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Alföld és Észak Dél-Alföld Csongrád
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
CARDIFF UNIVERSITY
United Kingdom
Net EU contribution
€ 297 075,00
Address
Newport Road 30 36
CF24 0DE Cardiff

See on map

Region
Wales East Wales Cardiff and Vale of Glamorgan
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT
France
Net EU contribution
€ 0,00
Address
Pierre Brossolette 1
91380 Chilly Mazarin

See on map

Region
Ile-de-France Ile-de-France Essonne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 1 500 000,00
PFIZER LIMITED
United Kingdom
Net EU contribution
€ 0,00
Address
Ramsgate Road
CT13 9NJ Sandwich

See on map

Region
South East (England) Kent East Kent
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 796 120,00
NOVARTIS PHARMA AG
Switzerland
Net EU contribution
€ 0,00
Address
Lichtstrasse 35
4056 Basel

See on map

Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 1 800 000,00
NOVO NORDISK A/S
Denmark
Net EU contribution
€ 0,00
Address
Novo Alle 1
2880 Bagsvaerd

See on map

Region
Danmark Hovedstaden Københavns omegn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 714 016,00
FUJIFILM CELLULAR DYNAMICS INC
United States
Net EU contribution
€ 0,00
Address
Science Drive 525 Suite 200
53711 Madison Wi

See on map

Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 1 900 000,00
JANSSEN PHARMACEUTICA NV
Belgium
Net EU contribution
€ 0,00
Address
Turnhoutseweg 30
2340 Beerse

See on map

Region
Vlaams Gewest Prov. Antwerpen Arr. Turnhout
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 1 100 000,00
H. LUNDBECK AS
Denmark
Net EU contribution
€ 0,00
Address
Ottiliavej 7-9
2500 Valby

See on map

Region
Danmark Hovedstaden Byen København
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 600 000,00