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Investigating Mechanisms and Models Predictive of Accessibility of Therapeutics (IM2PACT) Into The Brain

Project description

The blood–brain barrier and delivery of biopharmaceuticals to the brain

The overall goal of the EU-funded IM2PACT project is to further our understanding of the blood–brain barrier (BBB) in health and disease in order to develop innovative systems for the delivery of biopharmaceuticals to the brain and identify novel drug targets for Alzheimer’s disease, multiple sclerosis and metabolic disease. Researchers will identify specific genes altered in brain endothelial cells in disease and establish new disease genetic models followed by the generation and characterisation of robust and predictive stem cell-derived BBB models. Next, they aim to develop efficacious and safe mechanisms and technologies for brain delivery, employing neurotropic virus-mediated BBB selective penetration systems and establishing in silico models to predict BBB penetration for therapeutics and pharmacokinetics in different compartments of the neural system.

Coordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Net EU contribution
€ 2 462 486,25
Address
Wellington Square University Offices
OX1 2JD Oxford
United Kingdom
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire

Participants (26)

UPPSALA UNIVERSITET
Sweden
Net EU contribution
€ 1 113 250,00
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Östra Sverige Östra Mellansverige Uppsala län
STICHTING VUMC
Netherlands
Net EU contribution
€ 290 437,50
Address
De Boelelaan 1117
1081 HV Amsterdam
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERSITY OF DUNDEE
United Kingdom
Net EU contribution
€ 354 008,75
Address
Nethergate
DD1 4HN Dundee
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
Net EU contribution
€ 297 500,00
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek
KOBENHAVNS UNIVERSITET
Denmark
Net EU contribution
€ 532 198,75
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
AARHUS UNIVERSITET
Denmark
Net EU contribution
€ 483 966,25
Address
Nordre Ringgade 1
8000 Aarhus C
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ
Germany
Net EU contribution
€ 288 661,25
Address
Langenbeckstrasse 1
55131 Mainz
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Rheinland-Pfalz Rheinhessen-Pfalz Mainz, Kreisfreie Stadt
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Germany
Net EU contribution
€ 290 187,50
Address
Seminarstrasse 2
69117 Heidelberg
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis
AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH
Austria
Net EU contribution
€ 582 292,50
Address
Giefinggasse 4
1210 Wien
Activity type
Research Organisations
Non-EU contribution
€ 0,00
MIMETAS BV
Netherlands
Net EU contribution
€ 251 812,50
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
De Limes 7
2342 DH Oegstgeest
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Region
West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek
THE OPEN UNIVERSITY
United Kingdom
Net EU contribution
€ 232 283,75
Address
Walton Hall
MK7 6AA Milton Keynes
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Milton Keynes
UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT
Germany
Net EU contribution
€ 213 718,75
Address
Josef-schneider-strasse 2
97080 Wurzburg
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Bayern Unterfranken Würzburg, Kreisfreie Stadt
STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER
Germany
Net EU contribution
€ 290 312,50
Address
Bunteweg 2
30559 Hannover
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ARTEMIS BIO-SUPPORT B.V.
Netherlands
Net EU contribution
€ 290 380,00
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
Molengraaffsingel 10
2629 JD Delft
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Region
West-Nederland Zuid-Holland Delft en Westland
NEUWAY PHARMA GMBH
Germany
Net EU contribution
€ 112 500,00
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
Ludwig-erhard-allee 2
53175 Bonn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Region
Nordrhein-Westfalen Köln Bonn, Kreisfreie Stadt
 
THE UNIVERSITY OF SHEFFIELD
United Kingdom
Net EU contribution
€ 249 305,00
Address
Firth Court Western Bank
S10 2TN Sheffield
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Yorkshire and the Humber South Yorkshire Sheffield
UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA
Italy
Net EU contribution
€ 67 565,00
Address
Via Universita 4
41121 Modena
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
PHARMACOIDEA FEJLESZTO ES SZOLGALTATO KFT
Hungary
Net EU contribution
€ 300 058,75
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
Derkovits Fasor 7-11
6726 Szeged
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
CARDIFF UNIVERSITY
United Kingdom
Net EU contribution
€ 297 075,00
Address
Newport Road 30 36
CF24 0DE Cardiff
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Wales East Wales Cardiff and Vale of Glamorgan
SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT
France
Net EU contribution
€ 0,00
Address
Pierre Brossolette 1
91380 Chilly Mazarin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 1 500 000,00
PFIZER LIMITED
United Kingdom
Net EU contribution
€ 0,00
Address
Ramsgate Road
CT13 9NJ Sandwich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 796 120,00
NOVARTIS PHARMA AG
Switzerland
Net EU contribution
€ 0,00
Address
Lichtstrasse 35
4056 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 1 800 000,00
Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
NOVO NORDISK A/S
Denmark
Net EU contribution
€ 0,00
Address
Novo Alle 1
2880 Bagsvaerd
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 714 016,00
FUJIFILM CELLULAR DYNAMICS INC
United States
Net EU contribution
€ 0,00
Address
Science Drive 525 Suite 200
53711 Madison Wi
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 1 900 000,00
JANSSEN PHARMACEUTICA NV
Belgium
Net EU contribution
€ 0,00
Address
Turnhoutseweg 30
2340 Beerse
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 1 100 000,00
H. LUNDBECK AS
Denmark
Net EU contribution
€ 0,00
Address
Ottiliavej 7-9
2500 Valby
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 600 000,00