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Investigating Mechanisms and Models Predictive of Accessibility of Therapeutics (IM2PACT) Into The Brain

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Publications

Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood–brain barrier

Author(s): Dominika Luptáková, Theodosia Vallianatou, Anna Nilsson, Reza Shariatgorji, Margareta Hammarlund-Udenaes, Irena Loryan, Per E. Andrén
Published in: Molecular Psychiatry, 2021, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-021-01267-y

Novel peptide-conjugated nanomedicines for brain targeting: In vivo evidence

Author(s): Jason T Duskey, Ilaria Ottonelli, Federica Da Ros, Antonietta Vilella, Michele Zoli, Sandra Kovachka, Francesca Spyrakis, Maria A Vandelli, Giovanni Tosi, Barbara Ruozi
Published in: Nanomedicine: Nanotechnology, Biology and Medicine, 28, 2020, Page(s) 102226, ISSN 1549-9634
Publisher: Elsevier BV
DOI: 10.1016/j.nano.2020.102226

Brain endothelial LRP1 maintains blood–brain barrier integrity

Author(s): Steffen E. Storck, Magdalena Kurtyka, Claus U. Pietrzik
Published in: Fluids and Barriers of the CNS, 18/1, 2021, ISSN 2045-8118
Publisher: BioMed Central
DOI: 10.1186/s12987-021-00260-5

Human induced pluripotent stem cells (BIONi010-C) generate tight cell monolayers with blood-brain barrier traits and functional expression of large neutral amino acid transporter 1 (SLC7A5)

Author(s): C. Goldeman, M. Andersen, A. Al-Robai, T. Buchholtz, N. Svane, B. Ozgür, B. Holst, E. Shusta, V.J. Hall, L. Saaby, P. Hyttel, B. Brodin
Published in: European Journal of Pharmaceutical Sciences, 156, 2021, Page(s) 105577, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2020.105577

Vesicular Transport Machinery in Brain Endothelial Cells: What We Know and What We Do not

Author(s): Andrea E. Toth, Mikkel R. Holst, Morten S. Nielsen
Published in: Current Pharmaceutical Design, 26/13, 2020, Page(s) 1405-1416, ISSN 1381-6128
Publisher: Bentham Science Publishers
DOI: 10.2174/1381612826666200212113421

PLGA-PEG-ANG-2 Nanoparticles for Blood–Brain Barrier Crossing: Proof-of-Concept Study

Author(s): Gina P. Hoyos-Ceballos, Barbara Ruozi, Ilaria Ottonelli, Federica Da Ros, Maria Angela Vandelli, Flavio Forni, Eleonora Daini, Antonietta Vilella, Michele Zoli, Giovanni Tosi, Jason T. Duskey, Betty L. López-Osorio
Published in: Pharmaceutics, 12/1, 2020, Page(s) 72, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12010072

Global proteomic analysis of extracellular matrix in mouse and human brain highlights relevance to cerebrovascular disease

Author(s): Alexandra Pokhilko, Gaia Brezzo, Lahiru Handunnetthi, Raphael Heilig, Rachel Lennon, Colin Smith, Stuart M Allan, Alessandra Granata, Sanjay Sinha, Tao Wang, Hugh S Markus, Alexandra Naba, Roman Fischer, Tom Van Agtmael, Karen Horsburgh, M Zameel Cader
Published in: Journal of Cerebral Blood Flow & Metabolism, 41/9, 2021, Page(s) 2423-2438, ISSN 0271-678X
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x211004307

Targeted single-cell RNA sequencing of transcription factors enhances the identification of cell types and trajectories

Author(s): Alexandra Pokhilko, Adam E. Handel, Fabiola Curion, Viola Volpato, Emma S. Whiteley, Sunniva Bøstrand, Sarah E. Newey, Colin J. Akerman, Caleb Webber, Michael B. Clark, Rory Bowden, M. Zameel Cader
Published in: Genome Research, 31/6, 2021, Page(s) 1069-1081, ISSN 1088-9051
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.273961.120

Transendothelial Electrical Resistance Measurement across the Blood–Brain Barrier: A Critical Review of Methods

Author(s): Judit P. Vigh, András Kincses, Burak Ozgür, Fruzsina R. Walter, Ana Raquel Santa-Maria, Sándor Valkai, Mónika Vastag, Winfried Neuhaus, Birger Brodin, András Dér, Mária A. Deli
Published in: Micromachines, 12/6, 2021, Page(s) 685, ISSN 2072-666X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/mi12060685

Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss

Author(s): Maarja A. Mäe, Liqun He, Sofia Nordling, Elisa Vazquez-Liebanas, Khayrun Nahar, Bongnam Jung, Xidan Li, Bryan C. Tan, Juat Chin Foo, Amaury Cazenave-Gassiot, Markus R. Wenk, Yvette Zarb, Barbara Lavina, Susan E. Quaggin, Marie Jeansson, Chengua Gu, David L. Silver, Michael Vanlandewijck, Eugene C. Butcher, Annika Keller, Christer Betsholtz
Published in: Circulation Research, 128/4, 2021, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.120.317473

Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size

Author(s): Rebecca Faresjö, Gillian Bonvicini, Xiaotian T. Fang, Ximena Aguilar, Dag Sehlin, Stina Syvänen
Published in: Fluids and Barriers of the CNS, 18/1, 2021, ISSN 2045-8118
Publisher: BioMed Central
DOI: 10.1186/s12987-021-00257-0

The Role of Sphingolipids and Specialized Pro-Resolving Mediators in Alzheimer’s Disease

Author(s): Nienke M. de Wit, Kevin Mol, Sabela Rodríguez-Lorenzo, Helga E. de Vries, Gijs Kooij
Published in: Frontiers in Immunology, 11, 2021, ISSN 1664-3224
Publisher: Frontiersin
DOI: 10.3389/fimmu.2020.620348

A Microfluidic Multisize Spheroid Array for Multiparametric Screening of Anticancer Drugs and Blood–Brain Barrier Transport Properties

Author(s): Christoph Eilenberger, Mario Rothbauer, Florian Selinger, Anna Gerhartl, Christian Jordan, Michael Harasek, Barbara Schädl, Johannes Grillari, Julian Weghuber, Winfried Neuhaus, Seta Küpcü, Peter Ertl
Published in: Advanced Science, 8/11, 2021, Page(s) 2004856, ISSN 2198-3844
Publisher: Wiley-VCH
DOI: 10.1002/advs.202004856

Mapping Receptor Antibody Endocytosis and Trafficking in Brain Endothelial Cells

Author(s): Mikkel R. Holst, Simone S. E. Nielsen, Morten S. Nielsen
Published in: Permeability Barrier - Methods and Protocols, 2367, 2021, Page(s) 193-205, ISBN 978-1-0716-1672-7
Publisher: Springer US
DOI: 10.1007/7651_2020_312

Drug Delivery Strategies to Overcome the Blood–Brain Barrier (BBB)

Author(s): Hans Christian Cederberg Helms, Mie Kristensen, Lasse Saaby, Gert Fricker, Birger Brodin
Published in: Handbook of Experimental Pharmacology, 2020
Publisher: Springer Berlin Heidelberg
DOI: 10.1007/164_2020_403