Investigating Mechanisms and Models Predictive of Accessibility of Therapeutics (IM2PACT) Into The Brain

Project Information

IM2PACT

Grant agreement ID: 807015

DOI

10.3030/807015

Project closed

EC signature date 14 December 2018

Start date 1 January 2019

End date 31 December 2024

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 17 410 136,00

EU contribution

€ 9 000 000,00

Coordinated by

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (36)

Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody

Author(s): Rebecca Faresjö Dag Sehlin Stina Syvänen
Published in: Fluids and Barriers in the CNS, 2023, ISSN 2045-8118
Publisher: BioMed Central
DOI: 10.1186/s12987-023-00435-2

Tunneling Nanotubes: A New Target for Nanomedicine?

Author(s): Ottonelli, I.; Caraffi, R.; Tosi, G.; Vandelli, M.A.; Duskey, J.T.; Ruozi, B.
Published in: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23042237

Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood–brain barrier

Author(s): Dominika Luptáková, Theodosia Vallianatou, Anna Nilsson, Reza Shariatgorji, Margareta Hammarlund-Udenaes, Irena Loryan, Per E. Andrén
Published in: Molecular Psychiatry, 2021, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-021-01267-y

Region-independent active CNS net uptake of marketed H+/OC antiporter system substrates

Author(s): Frida Bällgren, Yang Hu, Shannuo Li, Lara van de Beek, Margareta Hammarlund-Udenaes, Irena Loryan
Published in: Frontiers in Cellular Neuroscience, Issue 18, 2024, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncel.2024.1493644

Hypoxia increases expression of selected blood–brain barrier transporters GLUT-1, P-gp, SLC7A5 and TFRC, while maintaining barrier integrity, in brain capillary endothelial monolayers

Author(s): Ozgür, Burak; Helms, Hans Christian Cederberg; Tornabene, Erica; Brodin, Birger
Published in: Fluids and Barriers of the CNS, 2022, ISSN 2045-8118
Publisher: BioMed Central
DOI: 10.1186/s12987-021-00297-6

Active CNS delivery of oxycodone in healthy and endotoxemic pigs

Author(s): Frida Bällgren, Tilda Bergfast, Aghavni Ginosyan, Jessica Mahajan, Miklós Lipcsey, Margareta Hammarlund-Udenaes, Stina Syvänen, Irena Loryan
Published in: Fluids and Barriers of the CNS, Issue 21, 2024, ISSN 2045-8118
Publisher: BioMed Central
DOI: 10.1186/s12987-024-00583-z

Brain endothelial LRP1 maintains blood–brain barrier integrity

Author(s): Steffen E. Storck, Magdalena Kurtyka, Claus U. Pietrzik
Published in: Fluids and Barriers of the CNS, Issue 18/1, 2021, ISSN 2045-8118
Publisher: BioMed Central
DOI: 10.1186/s12987-021-00260-5

Applications of the ROS-Responsive Thioketal Linker for the Production of Smart Nanomedicines

Author(s): Rinaldi, Arianna; Caraffi, Riccardo; Grazioli, Maria Vittoria; Oddone, Natalia; Giardino, Luciana; Tosi, Giovanni; Vandelli, Maria Angela; Calzà, Laura; Ruozi, Barbara; Duskey, Jason Thomas
Published in: Polymers, Issue 1, 2022, ISSN 2073-4360
Publisher: Basel MDPI
DOI: 10.3390/polym14040687

Reduced oxycodone brain delivery in rats due to lipopolysaccharide-induced inflammation: microdialysis insights into brain disposition and sex-specific pharmacokinetics

Author(s): Frida Bällgren, Margareta Hammarlund-Udenaes, Irena Loryan
Published in: Fluids and Barriers of the CNS, Issue 21, 2024, ISSN 2045-8118
Publisher: BioMed Central
DOI: 10.1186/s12987-024-00598-6

Modelling a Human Blood-Brain Barrier Co-Culture Using an Ultrathin Silicon Nitride Membrane-Based Microfluidic Device

Author(s): Hudecz, Diana; McCloskey, Molly C.; Vergo, Sandra; Christensen, Søren; McGrath, James L.; Nielsen, Morten S.
Published in: International Journal of Molecular Sciences, Issue 5, 2023, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24065624

Ex vivo nanoscale abluminal mapping of putative cargo receptors at the blood-brain barrier of expanded brain capillaries

Author(s): Mikkel Roland Holst, Mette Richner, Pernille Olsgaard Arenshøj, Parvez Alam, Kathrine Hyldig, Morten Schallburg Nielsen
Published in: Fluids and Barriers of the CNS, Issue 21, 2024, ISSN 2045-8118
Publisher: BioMed Central
DOI: 10.1186/s12987-024-00585-x

Optimization of an Injectable Hydrogel Depot System for the Controlled Release of Retinal-Targeted Hybrid Nanoparticles

Author(s): Ilaria Ottonelli; Andrea Bighinati; Elisa Adani; François Loll; Riccardo Caraffi; Maria Angela Vandelli; Frank Boury; Giovanni Tosi; Jason Thomas Duskey; Valeria Marigo; Barbara Ruozi
Published in: Pharmaceutics, 2022, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15010025

Brain pharmacokinetics of mono- and bispecific amyloid-β antibodies in wild-type and Alzheimer’s disease mice measured by high cut-off microdialysis

Author(s): Julku U, Xiong M, Wik E, Roshanbin S, Sehlin D, Syvänen S
Published in: Fluids Barriers CNS, 2022, ISSN 2045-8118
Publisher: BioMed Central
DOI: 10.1186/s12987-022-00398-w

Contribution of Syndecans to the Cellular Entry of SARS-CoV-2

Author(s): Anett Hudák; Annamária Letoha; László Szilák; Tamás Letoha
Published in: International Journal of Molecular Sciences, Issue 4, 2021, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22105336

The Interplay of Apoes with Syndecans in Influencing Key Cellular Events of Amyloid Pathology.

Author(s): Anett Hudák; Katalin Jósvay; Ildikó Domonkos; Annamária Letoha; László Szilák; Tamás Letoha
Published in: International Journal of Molecular Sciences, Issue 5, 2021, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22137070

A hydrogel model of the human blood-brain barrier using differentiated stem cells

Author(s): Nandita Rahatekar Singh, Radka Gromnicova, Andreas Brachner, Igor Kraev, Ignacio A. Romero, Winfried Neuhaus, David Male
Published in: Plos One, 2023, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0283954

PCSK9 acts as a key regulator of Aβ clearance across the blood–brain barrier

Author(s): Alexander D. Mazura; Anke Ohler; Steffen E. Storck; Magdalena Kurtyka; Franka Scharfenberg; Sascha Weggen; Christoph Becker-Pauly; Claus U. Pietrzik
Published in: Cellular and Molecular Life Sciences, 2022, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-022-04237-x

Applications of the ROS responsive Thioketal linker for the production of smart nanomedicines

Author(s): Rinaldi A.,Caraffi R., Grazioli M.V., Oddone N., Giardino L., Tosi G., Vandelli M.A., Calzà L., Ruozi B. and Duskey J.T.,
Published in: Polymers, 2022, ISSN 2073-4360
Publisher: MDPI
DOI: 10.3390/polym14040687

Generation of Advanced Blood–Brain Barrier Spheroids Using Human‐Induced Pluripotent Stem Cell‐Derived Brain Capillary Endothelial‐Like Cells

Author(s): Sanjana Mathew‐Schmitt, Sabrina Oerter, Evelin Reitenbach, Sabine Gätzner, Alevtina Höchner, Heinz‐Georg Jahnke, Jörg Piontek, Winfried Neuhaus, Andreas Brachner, Marco Metzger, Antje Appelt‐Menzel
Published in: Advanced Biology, Issue 9, 2025, ISSN 2701-0198
Publisher: Wiley
DOI: 10.1002/adbi.202400442

PLGA-PEG-ANG-2 Nanoparticles for Blood–Brain Barrier Crossing: Proof-of-Concept Study

Author(s): Gina P. Hoyos-Ceballos, Barbara Ruozi, Ilaria Ottonelli, Federica Da Ros, Maria Angela Vandelli, Flavio Forni, Eleonora Daini, Antonietta Vilella, Michele Zoli, Giovanni Tosi, Jason T. Duskey, Betty L. López-Osorio
Published in: Pharmaceutics, Issue 12/1, 2020, Page(s) 72, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12010072

Global proteomic analysis of extracellular matrix in mouse and human brain highlights relevance to cerebrovascular disease

Author(s): Alexandra Pokhilko, Gaia Brezzo, Lahiru Handunnetthi, Raphael Heilig, Rachel Lennon, Colin Smith, Stuart M Allan, Alessandra Granata, Sanjay Sinha, Tao Wang, Hugh S Markus, Alexandra Naba, Roman Fischer, Tom Van Agtmael, Karen Horsburgh, M Zameel Cader
Published in: Journal of Cerebral Blood Flow & Metabolism, Issue 41/9, 2021, Page(s) 2423-2438, ISSN 0271-678X
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x211004307

The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier

Author(s): Magdalena Kurtyka, Frank Wessely, Sarah Bau, Eseoghene Ifie, Liqun He, Nienke M. de Wit, Alberte Bay Villekjær Pedersen, Maximilian Keller, Caleb Webber, Helga E. de Vries, Olaf Ansorge, Christer Betsholtz, Marijke De Bock, Catarina Chaves, Birger Brodin, Morten S. Nielsen, Winfried Neuhaus, Robert D. Bell, Tamás Letoha, Axel H. Meyer, Germán Leparc, Martin Lenter, Dominique Lesuisse, Zameel M.
Published in: European Journal of Cell Biology, Issue 103, 2025, Page(s) 151406, ISSN 0171-9335
Publisher: Elsevier BV
DOI: 10.1016/j.ejcb.2024.151406

Recent Advances on Surface-Modified GBM Targeted Nanoparticles: Targeting Strategies and Surface Characterization

Author(s): Francesca Rodà; Riccardo Caraffi; Silvia Picciolini; Giovanni Tosi; Maria Angela Vandelli; Barbara Ruozi; Marzia Bedoni; Ilaria Ottonelli; Jason Thomas Duskey
Published in: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24032496

Differential Blood–Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro

Author(s): Melander, Erik; Eriksson, Camilla; Wellens, Sara; Hosseini, Kimia; Fredriksson, Robert; Gosselet, Fabien; Culot, Maxime; Göransson, Ulf; Hammarlund-Udenaes, Margareta; Loryan, Irena
Published in: Pharmaceutics, Issue 1, 2023, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15051507

Targeted single-cell RNA sequencing of transcription factors enhances the identification of cell types and trajectories

Author(s): Alexandra Pokhilko, Adam E. Handel, Fabiola Curion, Viola Volpato, Emma S. Whiteley, Sunniva Bøstrand, Sarah E. Newey, Colin J. Akerman, Caleb Webber, Michael B. Clark, Rory Bowden, M. Zameel Cader
Published in: Genome Research, Issue 31/6, 2021, Page(s) 1069-1081, ISSN 1088-9051
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.273961.120

Transendothelial Electrical Resistance Measurement across the Blood–Brain Barrier: A Critical Review of Methods

Author(s): Judit P. Vigh, András Kincses, Burak Ozgür, Fruzsina R. Walter, Ana Raquel Santa-Maria, Sándor Valkai, Mónika Vastag, Winfried Neuhaus, Birger Brodin, András Dér, Mária A. Deli
Published in: Micromachines, Issue 12/6, 2021, Page(s) 685, ISSN 2072-666X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/mi12060685

Endocrine Regulation of Microvascular Receptor—Mediated Transcytosis and Its Therapeutic Opportunities: Insights by PCSK9—Mediated Regulation

Author(s): Mazura, Alexander, Pietrzik, Claus
Published in: Pharmaceutics, 2023, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15041268

A single nuclear transcriptomic characterisation of mechanisms responsible for impaired angiogenesis and blood-brain barrier function in Alzheimer’s disease

Author(s): Stergios Tsartsalis, Hannah Sleven, Nurun Fancy, Frank Wessely, Amy M. Smith, Nanet Willumsen, To Ka Dorcas Cheung, Michal J. Rokicki, Vicky Chau, Eseoghene Ifie, Combiz Khozoie, Olaf Ansorge, Xin Yang, Marion H. Jenkyns, Karen Davey, Aisling McGarry, Robert C. J. Muirhead, Stephanie Debette, Johanna S. Jackson, Axel Montagne, David R. Owen, J. Scott Miners, Seth Love, Caleb Webber, M. Zameel Cade
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-46630-z

Glioblastoma Multiforme Selective Nanomedicines for Improved Anti-Cancer Treatments

Author(s): Jason Thomas Duskey; Arianna Rinaldi; Ilaria Ottonelli; Riccardo Caraffi; Chiara Alessia De Benedictis; Ann Katrin Sauer; Giovanni Tosi; Maria Angela Vandelli; Barbara Ruozi; Andreas Martin Grabrucker
Published in: Pharmaceutics;, Issue Volume 14; Issue 7, 2022, Page(s) 1450, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14071450

Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss

Author(s): Maarja A. Mäe, Liqun He, Sofia Nordling, Elisa Vazquez-Liebanas, Khayrun Nahar, Bongnam Jung, Xidan Li, Bryan C. Tan, Juat Chin Foo, Amaury Cazenave-Gassiot, Markus R. Wenk, Yvette Zarb, Barbara Lavina, Susan E. Quaggin, Marie Jeansson, Chengua Gu, David L. Silver, Michael Vanlandewijck, Eugene C. Butcher, Annika Keller, Christer Betsholtz
Published in: Circulation Research, Issue 128/4, 2021, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.120.317473

Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size

Author(s): Rebecca Faresjö, Gillian Bonvicini, Xiaotian T. Fang, Ximena Aguilar, Dag Sehlin, Stina Syvänen
Published in: Fluids and Barriers of the CNS, Issue 18/1, 2021, ISSN 2045-8118
Publisher: BioMed Central
DOI: 10.1186/s12987-021-00257-0

Regional distribution of unbound eletriptan and sumatriptan in the CNS and PNS in rats: implications for a potential central action

Author(s): Nana Svane, Frida Bällgren, Aghavni Ginosyan, Mie Kristensen, Birger Brodin, Irena Loryan
Published in: The Journal of Headache and Pain, Issue 25, 2024, ISSN 1129-2377
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/s10194-024-01894-0

Sortilin regulates blood-brain barrier integrity.

Author(s): Andrea E. Tóth; Andrea E. Tóth; Hans C. Helms; Hans C. Helms; Andras Harazin; Kasper B. Johnsen; Kasper B. Johnsen; Charlotte Goldeman; Charlotte Goldeman; Annette Burkhart; Annette Burkhart; Maj S. Thomsen; Maj S. Thomsen; Paul J. Kempen; Paul J. Kempen; Adrian Klepe; Dora V. Lipka; Peter L. Møller; Thomas Lars Andresen; Thomas Lars Andresen; Mette Nyegaard; Torben Moos; Torben Moos; Birger Br
Published in: The FEBS journal, Issue 1, 2022, ISSN 1742-464X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/febs.16225

Microfluidic Technology for the Production of Hybrid Nanomedicines.

Author(s): Ottonelli, Ilaria; Duskey, Jason Thomas; Rinaldi, Arianna; Grazioli, Maria Vittoria; Parmeggiani, Irene; Vandelli, Maria Angela; Wang, Leon Z.; Prud’homme, Robert K.; Tosi, Giovanni; Ruozi, Barbara
Published in: Pharmaceutics, 2021, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13091495

Transferrin Receptor Binding BBB-shuttle facilitates brain delivery of anti-Aβ affibodies

Author(s): Faresjö R, Lindberg H, Ståhl S, Löfblom J, Syvänen S, Sehlin D.
Published in: Pharmaceutical Research, 2022, ISSN 0724-8741
Publisher: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11095-022-03282-2

A Microfluidic Multisize Spheroid Array for Multiparametric Screening of Anticancer Drugs and Blood–Brain Barrier Transport Properties

Author(s): Christoph Eilenberger, Mario Rothbauer, Florian Selinger, Anna Gerhartl, Christian Jordan, Michael Harasek, Barbara Schädl, Johannes Grillari, Julian Weghuber, Winfried Neuhaus, Seta Küpcü, Peter Ertl
Published in: Advanced Science, Issue 8/11, 2021, Page(s) 2004856, ISSN 2198-3844
Publisher: Wiley-VCH
DOI: 10.1002/advs.202004856

Book chapters (1)

Drug Delivery Strategies to Overcome the Blood–Brain Barrier (BBB)

Author(s): Cederberg Helms, Hans Christian Kristensen, Mie Saaby, Lasse Fricker, Gert Brodin, Birger
Published in: Physiology, Pharmacology and Pathology of the Blood-Brain Barrier, 2020, ISSN 0171-2004
Publisher: Springer Cham
DOI: 10.1007/164_2020_403

Other (1)

Amino acid and viral binding by the high-affinity Cationic Amino acidTransporter 1 (CAT1) from Mus musculus

Author(s): David Sauer, Mingda Ye, Zhu Liang, Daming Zhou, Ashley Pike, SiYi Wang, Dong Wang, Souvika Bakshi, Laurent Brooke, Eleanor Williams, Jon Elkins, Benedikt Kessler, David Stuart
Published in: 2024
Publisher: Springer Science and Business Media LLC
DOI: 10.21203/rs.3.rs-4673967/v1