Well-Aging and the Tanycytic Control of Health

Publicaciones

Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function

Autores: Natália da Silva Lima, Marcos F Fondevila, Eva Nóvoa, Xabier Buqué, Maria Mercado-Gómez, Sarah Gallet, Maria J González-Rellan, Uxia Fernandez, Anne Loyens, Maria Garcia-Vence, Maria Del Pilar Chantada-Vazquez, Susana B Bravo, Patricia Marañon, Ana Senra, Adriana Escudero, Magdalena Leiva, Diana Guallar, Miguel Fidalgo, Pedro Gomes, Marc Claret, Guadalupe Sabio, Marta Varela-Rey, Teresa C De
Publicado en: J. Hepatol., Edición 2022 Jan;76(1, 2022, Página(s) 11-24, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2021.09.008

Melatonin drugs inhibit SARS-CoV-2 entry into the brain and virus-induced damage of cerebral small vessels.

Autores: Erika Cecon, Daniela Fernandois, Nicolas Renault, Caio Fernando Ferreira Coelho, Jan Wenzel, Corentin Bedart, Charlotte Izabelle, Sarah Gallet, Sophie Le Poder, Bernard Klonjkowski, Markus Schwaninger, Vincent Prevot, Julie Dam, Ralf Jockers
Publicado en: Cell Mol Life Sci, Edición 2022; 79(7), 2022, Página(s) 361, ISSN 1420-682X
Editor: Birkhauser Verlag
DOI: 10.1007/s00018-022-04390-3

Gene therapy targeting the blood-brain barrier improves neurological symptoms in a model of genetic MCT8 deficiency

Autores: Sivaraj M Sundaram, Adriana Arrulo Pereira, Helge Müller-Fielitz, Hannes Köpke, Meri De Angelis, Timo D Müller, Heike Heuer, Jakob Körbelin, Markus Krohn, Jens Mittag, Ruben Nogueiras, Vincent Prevot, Markus Schwaninger
Publicado en: Brain, 2022, ISSN 0006-8950
Editor: Oxford University Press
DOI: 10.1093/brain/awac243

Short regulatory DNA sequences to target brain endothelial cells for gene therapy

Autores: Hanna Graßhoff, Helge Müller-Fielitz, Godwin K Dogbevia, Jakob Körbelin, Jacqueline Bannach, Carl MG Vahldieck, Kristina Kusche-Vihrog, Olaf Jöhren, Oliver J Müller, Ruben Nogueiras, Vincent Prevot, Markus Schwaninger
Publicado en: J Cereb Blood Flow Metab, Edición 2022 Jan; 42(1), 2022, Página(s) 104–120, ISSN 0271-678X
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x211039617

Hepatic p63 regulates glucose metabolism by repressing SIRT1

Autores: Maria J Gonzalez-Rellan, Eva Novoa, Natalia da Silva Lima, Amaia Rodriguez, Christelle Veyrat-Durebex, Samuel Seoane, Begoña Porteiro, Marcos F Fondevila, Uxia Fernandez,1 Marta Varela-Rey,6 Ana Senra,1 Cristina Iglesias,1 Adriana Escudero,1 Miguel Fidalgo,1 Diana Guallar,7 Roman Perez-Fernandez,1 Vincent Prevot,8 Markus Schwaninger,9 Miguel López,1,2 Carlos Dieguez,1,2 Roberto Coppari,4,5 Gema
Publicado en: Gut, Edición 2023 Mar; 72(3), 2023, Página(s) 472–483, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2021-326620

Cerebral angiogenesis ameliorates pathological disorders in Nemo -deficient mice with small-vessel disease

Autores: Yun Jiang, Kristin Müller, Mahtab A. Khan, Julian C. Assmann, Josephine Lampe, Knut Kilau, Marius Richter, Maximilian Kleint, Dirk A Ridder, Norbert Hübner, Marc Schmidt-Supprian, Jan Wenzel, Markus Schwaninger
Publicado en: Journal of Cerebral Blood Flow & Metabolism, Edición 41/2, 2021, Página(s) 219-235, ISSN 0271-678X
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x20910522

Brain JNK and metabolic disease

Autores: Rubén Nogueiras, Guadalupe Sabio
Publicado en: Diabetologia, Edición 64/2, 2021, Página(s) 265-274, ISSN 0012-186X
Editor: Springer Verlag
DOI: 10.1007/s00125-020-05327-w

Leptin brain entry via a tanycytic LepR-EGFR shuttle controls lipid metabolism and pancreas function

Autores: Manon Duquenne, Cintia Folgueira, Cyril Bourouh, Marion Millet, Anisia Silva, Jérôme Clasadonte, Monica Imbernon, Daniela Fernandois, Ines Martinez-Corral, Soumya Kusumakshi, Emilie Caron, S. Rasika, Eleonora Deliglia, Nathalie Jouy, Asturo Oishi, Massimiliano Mazzone, Eric Trinquet, Jan Tavernier, Young-Bum Kim, Stéphane Ory, Ralf Jockers, Markus Schwaninger, Ulrich Boehm, Ruben Nogueiras, Jea
Publicado en: Nature Metabolism, 2021, ISSN 2522-5812
Editor: Nature Portfolio
DOI: 10.1038/s42255-021-00432-5

How COVID-19 affects microvessels in the brain

Autores: Jan Wenzel, Markus Schwaninger
Publicado en: Brain, 2022, ISSN 0006-8950
Editor: Oxford University Press
DOI: 10.1093/brain/awac211

Tanycytic networks mediate energy balance by feeding lactate to glucose-insensitive POMC neurons.

Autores: Tori Lhomme; Jerome Clasadonte; Monica Imbernon; Daniela Fernandois; Florent Sauve; Emilie Caron; Natália da Silva Lima; Violeta Heras; Ines Martinez-Corral; Helge Mueller-Fielitz; Sowmyalakshmi Rasika; Markus Schwaninger; Rubén Nogueiras; Vincent Prevot
Publicado en: J Clin Invest, Edición 8, 2021, ISSN 0021-9738
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci140521

NF-κB signaling in tanycytes mediates inflammation-induced anorexia

Autores: Mareike Böttcher, Helge Müller-Fielitz, Sivaraj M. Sundaram, Sarah Gallet, Vanessa Neve, Kiseko Shionoya, Adriano Zager, Ning Quan, Xiaoyu Liu, Ruth Schmidt-Ullrich, Ronny Haenold, Jan Wenzel, Anders Blomqvist, David Engblom, Vincent Prevot, Markus Schwaninger
Publicado en: Molecular Metabolism, Edición 39, 2020, Página(s) 101022, ISSN 2212-8778
Editor: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.101022

Acute changes in systemic glycemia gate access and action of GLP-1R agonist on brain structures controlling energy homeostasis.

Autores: Wineke Bakker; Monica Imbernon; Casper Gravesen Salinas; Daniela Herrera Moro Chao; Rim Hassouna; Chloe Morel; Claire Martin; Caroline Leger; Raphael G.P. Denis; Julien Castel; Andreas Peter; Martin Heni; Walter Maetzler; Heidi Solvang Nielsen; Manon Duquenne; Markus Schwaninger; Sofia Lundh; Wouter Frederic Johan Hogendorf; Giuseppe Gangarossa; Anna Secher; Jacob Hecksher-Sørensen; Thomas Åskov
Publicado en: Cell Rep. 41:111698 (2022), Edición 7, 2022, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2022.111698

The Role of Tanycytes in the Hypothalamus-Pituitary-Thyroid Axis and the Possibilities for Their Genetic Manipulation

Autores: Helge Müller-Fielitz, Markus Schwaninger
Publicado en: Experimental and Clinical Endocrinology & Diabetes, Edición 128/06/07, 2020, Página(s) 388-394, ISSN 0947-7349
Editor: Johann Ambrosius Barth
DOI: 10.1055/a-1065-1855

The SARS-CoV-2 main protease M-pro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

Autores: Josephine Lampe; Jan Wenzel; Helge Müller-Fielitz; Kristin Müller; Raphael Schuster; Linlin Zhang; Marietta Zille; Markus Krohn; Ümit Özorhan; Yun Jiang; Vanessa Neve; Anke Fähnrich; Fabian Ott; Sonja Binder; Hauke Busch; Ludovic Collin; Roberto Villasenor; Olaf Jöhren; Hermann Altmeppen; Manolis Pasparakis; Ruben Nogueiras; Vincent Prevot; Rolf Hilgenfeld; Markus Glatzel; Markus Schwaninger
Publicado en: Nature neuroscience, Edición 10, 2021, ISSN 1097-6256
Editor: Nature Publishing Group
DOI: 10.21203/rs.3.rs-86988/v1

Is LRP2 Involved in Leptin Transport over the Blood-Brain Barrier and Development of Obesity?

Autores: Elvira S. Sandin; Julica Folberth; Helge Müller-Fielitz; Claus U. Pietrzik; Elisabeth Herold; Thomas E. Willnow; Paul T. Pfluger; Ruben Nogueiras; Vincent Prevot; Thomas Krey; Markus Schwaninger
Publicado en: reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela, Edición 4, 2021, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22094998

The L‐α‐lysophosphatidylinositol/GPR55 system induces the development of non‐alcoholic steatosis and steatohepatitis

Autores: Marcos F. Fondevila, Uxia Fernandez, Maria J. Gonzalez‐Rellan, Natalia Da Silva Lima, Xabier Buque, Agueda Gonzalez‐Rodriguez, Cristina Alonso, Marta Iruarrizaga‐Lejarreta, Teresa C. Delgado, Marta Varela‐Rey, Ana Senra, Vera Garcia‐Outeiral, Eva Novoa, Cristina Iglesias, Begoña Porteiro, Daniel Beiroa, Cintia Folgueira, Marta Tojo, Jorge L. Torres, Lourdes Hernández‐Cosido, Óscar B
Publicado en: Hepatology, 2020, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hep.31290

Nicotine’ actions on energy balance: Friend or foe?

Autores: Patricia Seoane-Collazo, Carlos Diéguez, Rubén Nogueiras, Kamal Rahmouni, José Manuel Fernández-Real, Miguel López
Publicado en: Pharmacology & Therapeutics, 2020, Página(s) 107693, ISSN 0163-7258
Editor: Pergamon Press
DOI: 10.1016/j.pharmthera.2020.107693

Impaired endothelium-mediated cerebrovascular reactivity promotes anxiety and respiration disorders in mice

Autores: Jan Wenzel, Cathrin E. Hansen, Carla Bettoni, Miriam A. Vogt, Beate Lembrich, Rentsenkhand Natsagdorj, Gianna Huber, Josefine Brands, Kjestine Schmidt, Julian C. Assmann, Ines Stölting, Kathrin Saar, Jan Sedlacik, Jens Fiehler, Peter Ludewig, Michael Wegmann, Nina Feller, Marius Richter, Helge Müller-Fielitz, Thomas Walther, Gabriele M. König, Evi Kostenis, Walter Raasch, Norbert Hübner, Peter
Publicado en: Proceedings of the National Academy of Sciences, Edición 117/3, 2020, Página(s) 1753-1761, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1907467117

Hypothalamic bile acid-TGR5 signaling protects from obesity

Autores: Ashley Castellanos-Jankiewicz, Omar Guzmán-Quevedo, Valérie S. Fénelon, Philippe Zizzari, Carmelo Quarta, Luigi Bellocchio, Anne Tailleux, Julie Charton, Daniela Fernandois, Marcus Henricsson, Catherine Piveteau, Vincent Simon, Camille Allard, Sandrine Quemener, Valentine Guinot, Nathalie Hennuyer, Alessia Perino, Alexia Duveau, Marlène Maitre, Thierry Leste-Lasserre, Samantha Clark, Nathalie
Publicado en: Cell Metabolism, 2021, ISSN 1550-4131
Editor: Cell Press
DOI: 10.1016/j.cmet.2021.04.009

Endogenous THBD (Thrombomodulin) Mediates Angiogenesis in the Ischemic Brain

Autores: Jan Wenzel, Dimitrios Spyropoulos, Julian Christopher Assmann, Mahtab Ahmad Khan, Ines Stölting, Beate Lembrich, Sara Kreißig, Dirk Andreas Ridder, Berend Isermann, Markus Schwaninger
Publicado en: Arteriosclerosis, Thrombosis, and Vascular Biology, 2020, ISSN 1079-5642
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.120.315061

Sirt3 in POMC neurons controls energy balance in a sex- and diet-dependent manner

Autores: Mar Quiñones, René Hernández-Bautista, Daniel Beiroa, Violeta Heras, Francisco L. Torres-Leal, Brian Y.H. Lam, Ana Senra, Johan Fernø, Alicia García Gómez-Valadés, Markus Schwaninger, Vincent Prevot, Giles Yeo, Marc Claret, Miguel López, Carlos Diéguez, Omar Al-Massadi, Ruben Nogueiras
Publicado en: Redox Biology, Edición 41, 2021, Página(s) 101945, ISSN 2213-2317
Editor: Elsevier BV
DOI: 10.1016/j.redox.2021.101945

Obese patients with NASH have increased hepatic expression of SARS-CoV-2 critical entry points

Autores: Marcos F. Fondevila, Maria Mercado-Gómez, Amaia Rodríguez, Maria J. Gonzalez-Rellan, Paula Iruzubieta, Víctor Valentí, Javier Escalada, Markus Schwaninger, Vincent Prevot, Carlos Dieguez, Javier Crespo, Gema Frühbeck, Maria L. Martinez- Chantar, Ruben Nogueiras
Publicado en: Journal of Hepatology, 2020, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2020.09.027

Bitter taste cells in the ventricular walls of the murine brain regulate glucose homeostasis

Autores: Qiang Yu, Igor Gamayun, Philipp Wartenberg, Qian Zhang, Sen Qiao, Soumya Kusumakshi, Sarah Candlish, Viktoria Götz, Shuping Wen, Debajyoti Das, Amanda Wyatt, Vanessa Wahl, Fabien Ectors, Kathrin Kattler, Daniela Yildiz, Vincent Prevot, Markus Schwaninger, Gaetan Ternier, Paolo Giacobini Philippe Ciofi, Timo D Müller, Ulrich Boehm
Publicado en: Nat Commun ., Edición 2023 Mar 22;14(1):1588, 2023, ISSN 2041-1723
Editor: Nature Publishing Group

MCH Neurons Regulate Permeability of the Median Eminence Barrier

Autores: Hong Jiang, Sarah Gallet, Paul Klemm, Pia Scholl, Kat Folz-Donahue, Janine Altmüller, Jens Alber, Christian Heilinger, Christian Kukat, Anne Loyens, Helge Müller-Fielitz, Sivaraj Sundaram, Markus Schwaninger, Vincent Prevot, Jens C. Brüning
Publicado en: Neuron, Edición 107/2, 2020, Página(s) 306-319.e9, ISSN 0896-6273
Editor: Cell Press
DOI: 10.1016/j.neuron.2020.04.020

Central nicotine induces browning through hypothalamic κ opioid receptor

Autores: Patricia Seoane-Collazo, Laura Liñares-Pose, Eva Rial-Pensado, Amparo Romero-Picó, José María Moreno-Navarrete, Noelia Martínez-Sánchez, Pablo Garrido-Gil, Ramón Iglesias-Rey, Donald A. Morgan, Naoki Tomasini, Samuel Andrew Malone, Ana Senra, Cintia Folgueira, Gema Medina-Gomez, Tomás Sobrino, José L. Labandeira-García, Rubén Nogueiras, Ana I. Domingos, José-Manuel Fernández-Real, Kam
Publicado en: Nature Communications, Edición 10/1, 2019, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-12004-z

Parvocellular Oxytocin Neurons and Autism Spectrum Disorders

Autores: Sivaraj Mohana Sundaram, Markus Schwaninger
Publicado en: Trends in Endocrinology and Metabolism, 2021, Página(s) 195-197, ISSN 1043-2760
Editor: Elsevier BV
DOI: 10.1016/j.tem.2021.01.004

MCH Regulates SIRT1/FoxO1 and Reduces POMC Neuronal Activity to Induce Hyperphagia, Adiposity, and Glucose Intolerance

Autores: Omar Al-Massadi, Mar Quiñones, Jerome Clasadonte, René Hernandez-Bautista, Amparo Romero-Picó, Cintia Folgueira, Donald A. Morgan, Imre Kalló, Violeta Heras, Ana Senra, Samuel C. Funderburk, Michael J. Krashes, Yara Souto, Miguel Fidalgo, Serge Luquet, Melissa J. Chee, Monica Imbernon, Daniel Beiroa, Lucía García-Caballero, Rosalia Gallego, Brian Y.H. Lam, Giles Yeo, Miguel Lopez, Zsolt Lipo
Publicado en: Diabetes, Edición 68/12, 2019, Página(s) 2210-2222, ISSN 0012-1797
Editor: American Diabetes Association
DOI: 10.2337/db19-0029

Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21

Autores: Veronica Pena-Leon, Cintia Folgueira, Silvia Barja-Fernández, Raquel Pérez-Lois, Natália Da Silva Lima, Marion Martin, Violeta Heras, Sara Martinez-Martinez, Paola Valero, Cristina Iglesias, Mannon Duquenne, Omar Al-Massadi, Daniel Beiroa, Yara Souto, Miguel Fidalgo, Rasika Sowmyalakshmi, Diana Guallar, Juan Cunarro, Cecilia Castelao, Ana Senra, Patricia González-Saenz, Rocío Vázquez-Cobela,
Publicado en: Nat Metab ., Edición 2022 Jul;4(7), 2022, Página(s) 901-917, ISSN 2522-5812
Editor: Nature Portfolio
DOI: 10.1038/s42255-022-00602-z

Hypothalamic dopamine signalling regulates brown fat thermogenesis

Autores: Cintia Folgueira, Daniel Beiroa, Begoña Porteiro, Manon Duquenne, Emma Puighermanal, Marcos F. Fondevila, Silvia Barja-Fernández, Rosalia Gallego, René Hernández-Bautista, Cecilia Castelao, Ana Senra, Patricia Seoane-Collazo, Noemi Gómez-Lado, Pablo Aguiar, Diana Guallar, Miguel Fidalgo, Amparo Romero-Pico, Roger Adan, Clemence Blouet, Jose Luís Labandeira-García, Françoise Jeanrenaud, Imr
Publicado en: Nature Metabolism, Edición 1/8, 2019, Página(s) 811-829, ISSN 2522-5812
Editor: Nature
DOI: 10.1038/s42255-019-0099-7

Glial cells as integrators of peripheral and central signals in the regulation of energy homeostasis

Autores: Sreekala Nampoothiri, Ruben Nogueiras, Markus Schwaninger, Vincent Prevot
Publicado en: Nat Metab ., Edición 2022 Jul;4(7), 2022, Página(s) 813-825, ISSN 2522-5812
Editor: Nature Portfolio
DOI: 10.1038/s42255-022-00610-z

Inhibition of carnitine palmitoyltransferase 1A in hepatic stellate cells protects against fibrosis

Autores: Marcos F. Fondevila, Uxia Fernandez, Violeta Heras, Tamara Parracho, Maria J. Gonzalez-Rellan, Eva Novoa, Begoña Porteiro, Cristina Alonso, Rebeca Mayo, Natalia da Silva Lima, Cristina Iglesias, Aveline A. Filliol, Ana Senra, Teresa C. Delgado, Ashwin Woodhoo, Laura Herrero, Dolors Serra, Vincent Prevot, Markus Schwaninger, Miguel López, Ruben Nogueiras
Publicado en: J. Hepatol., Edición Volume 77, Edición 1, July 2022, 2022, Página(s) 15-28, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2022.02.003

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