Well-Aging and the Tanycytic Control of Health

Pubblicazioni

Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function

Autori: Natália da Silva Lima, Marcos F Fondevila, Eva Nóvoa, Xabier Buqué, Maria Mercado-Gómez, Sarah Gallet, Maria J González-Rellan, Uxia Fernandez, Anne Loyens, Maria Garcia-Vence, Maria Del Pilar Chantada-Vazquez, Susana B Bravo, Patricia Marañon, Ana Senra, Adriana Escudero, Magdalena Leiva, Diana Guallar, Miguel Fidalgo, Pedro Gomes, Marc Claret, Guadalupe Sabio, Marta Varela-Rey, Teresa C De
Pubblicato in: J. Hepatol., Numero 2022 Jan;76(1, 2022, Pagina/e 11-24, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2021.09.008

Melatonin drugs inhibit SARS-CoV-2 entry into the brain and virus-induced damage of cerebral small vessels.

Autori: Erika Cecon, Daniela Fernandois, Nicolas Renault, Caio Fernando Ferreira Coelho, Jan Wenzel, Corentin Bedart, Charlotte Izabelle, Sarah Gallet, Sophie Le Poder, Bernard Klonjkowski, Markus Schwaninger, Vincent Prevot, Julie Dam, Ralf Jockers
Pubblicato in: Cell Mol Life Sci, Numero 2022; 79(7), 2022, Pagina/e 361, ISSN 1420-682X
Editore: Birkhauser Verlag
DOI: 10.1007/s00018-022-04390-3

Gene therapy targeting the blood-brain barrier improves neurological symptoms in a model of genetic MCT8 deficiency

Autori: Sivaraj M Sundaram, Adriana Arrulo Pereira, Helge Müller-Fielitz, Hannes Köpke, Meri De Angelis, Timo D Müller, Heike Heuer, Jakob Körbelin, Markus Krohn, Jens Mittag, Ruben Nogueiras, Vincent Prevot, Markus Schwaninger
Pubblicato in: Brain, 2022, ISSN 0006-8950
Editore: Oxford University Press
DOI: 10.1093/brain/awac243

Short regulatory DNA sequences to target brain endothelial cells for gene therapy

Autori: Hanna Graßhoff, Helge Müller-Fielitz, Godwin K Dogbevia, Jakob Körbelin, Jacqueline Bannach, Carl MG Vahldieck, Kristina Kusche-Vihrog, Olaf Jöhren, Oliver J Müller, Ruben Nogueiras, Vincent Prevot, Markus Schwaninger
Pubblicato in: J Cereb Blood Flow Metab, Numero 2022 Jan; 42(1), 2022, Pagina/e 104–120, ISSN 0271-678X
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x211039617

Hepatic p63 regulates glucose metabolism by repressing SIRT1

Autori: Maria J Gonzalez-Rellan, Eva Novoa, Natalia da Silva Lima, Amaia Rodriguez, Christelle Veyrat-Durebex, Samuel Seoane, Begoña Porteiro, Marcos F Fondevila, Uxia Fernandez,1 Marta Varela-Rey,6 Ana Senra,1 Cristina Iglesias,1 Adriana Escudero,1 Miguel Fidalgo,1 Diana Guallar,7 Roman Perez-Fernandez,1 Vincent Prevot,8 Markus Schwaninger,9 Miguel López,1,2 Carlos Dieguez,1,2 Roberto Coppari,4,5 Gema
Pubblicato in: Gut, Numero 2023 Mar; 72(3), 2023, Pagina/e 472–483, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2021-326620

Cerebral angiogenesis ameliorates pathological disorders in Nemo -deficient mice with small-vessel disease

Autori: Yun Jiang, Kristin Müller, Mahtab A. Khan, Julian C. Assmann, Josephine Lampe, Knut Kilau, Marius Richter, Maximilian Kleint, Dirk A Ridder, Norbert Hübner, Marc Schmidt-Supprian, Jan Wenzel, Markus Schwaninger
Pubblicato in: Journal of Cerebral Blood Flow & Metabolism, Numero 41/2, 2021, Pagina/e 219-235, ISSN 0271-678X
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x20910522

Brain JNK and metabolic disease

Autori: Rubén Nogueiras, Guadalupe Sabio
Pubblicato in: Diabetologia, Numero 64/2, 2021, Pagina/e 265-274, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-020-05327-w

Leptin brain entry via a tanycytic LepR-EGFR shuttle controls lipid metabolism and pancreas function

Autori: Manon Duquenne, Cintia Folgueira, Cyril Bourouh, Marion Millet, Anisia Silva, Jérôme Clasadonte, Monica Imbernon, Daniela Fernandois, Ines Martinez-Corral, Soumya Kusumakshi, Emilie Caron, S. Rasika, Eleonora Deliglia, Nathalie Jouy, Asturo Oishi, Massimiliano Mazzone, Eric Trinquet, Jan Tavernier, Young-Bum Kim, Stéphane Ory, Ralf Jockers, Markus Schwaninger, Ulrich Boehm, Ruben Nogueiras, Jea
Pubblicato in: Nature Metabolism, 2021, ISSN 2522-5812
Editore: Nature Portfolio
DOI: 10.1038/s42255-021-00432-5

How COVID-19 affects microvessels in the brain

Autori: Jan Wenzel, Markus Schwaninger
Pubblicato in: Brain, 2022, ISSN 0006-8950
Editore: Oxford University Press
DOI: 10.1093/brain/awac211

Tanycytic networks mediate energy balance by feeding lactate to glucose-insensitive POMC neurons.

Autori: Tori Lhomme; Jerome Clasadonte; Monica Imbernon; Daniela Fernandois; Florent Sauve; Emilie Caron; Natália da Silva Lima; Violeta Heras; Ines Martinez-Corral; Helge Mueller-Fielitz; Sowmyalakshmi Rasika; Markus Schwaninger; Rubén Nogueiras; Vincent Prevot
Pubblicato in: J Clin Invest, Numero 8, 2021, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci140521

NF-κB signaling in tanycytes mediates inflammation-induced anorexia

Autori: Mareike Böttcher, Helge Müller-Fielitz, Sivaraj M. Sundaram, Sarah Gallet, Vanessa Neve, Kiseko Shionoya, Adriano Zager, Ning Quan, Xiaoyu Liu, Ruth Schmidt-Ullrich, Ronny Haenold, Jan Wenzel, Anders Blomqvist, David Engblom, Vincent Prevot, Markus Schwaninger
Pubblicato in: Molecular Metabolism, Numero 39, 2020, Pagina/e 101022, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.101022

Acute changes in systemic glycemia gate access and action of GLP-1R agonist on brain structures controlling energy homeostasis.

Autori: Wineke Bakker; Monica Imbernon; Casper Gravesen Salinas; Daniela Herrera Moro Chao; Rim Hassouna; Chloe Morel; Claire Martin; Caroline Leger; Raphael G.P. Denis; Julien Castel; Andreas Peter; Martin Heni; Walter Maetzler; Heidi Solvang Nielsen; Manon Duquenne; Markus Schwaninger; Sofia Lundh; Wouter Frederic Johan Hogendorf; Giuseppe Gangarossa; Anna Secher; Jacob Hecksher-Sørensen; Thomas Åskov
Pubblicato in: Cell Rep. 41:111698 (2022), Numero 7, 2022, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2022.111698

The Role of Tanycytes in the Hypothalamus-Pituitary-Thyroid Axis and the Possibilities for Their Genetic Manipulation

Autori: Helge Müller-Fielitz, Markus Schwaninger
Pubblicato in: Experimental and Clinical Endocrinology & Diabetes, Numero 128/06/07, 2020, Pagina/e 388-394, ISSN 0947-7349
Editore: Johann Ambrosius Barth
DOI: 10.1055/a-1065-1855

The SARS-CoV-2 main protease M-pro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

Autori: Josephine Lampe; Jan Wenzel; Helge Müller-Fielitz; Kristin Müller; Raphael Schuster; Linlin Zhang; Marietta Zille; Markus Krohn; Ümit Özorhan; Yun Jiang; Vanessa Neve; Anke Fähnrich; Fabian Ott; Sonja Binder; Hauke Busch; Ludovic Collin; Roberto Villasenor; Olaf Jöhren; Hermann Altmeppen; Manolis Pasparakis; Ruben Nogueiras; Vincent Prevot; Rolf Hilgenfeld; Markus Glatzel; Markus Schwaninger
Pubblicato in: Nature neuroscience, Numero 10, 2021, ISSN 1097-6256
Editore: Nature Publishing Group
DOI: 10.21203/rs.3.rs-86988/v1

Is LRP2 Involved in Leptin Transport over the Blood-Brain Barrier and Development of Obesity?

Autori: Elvira S. Sandin; Julica Folberth; Helge Müller-Fielitz; Claus U. Pietrzik; Elisabeth Herold; Thomas E. Willnow; Paul T. Pfluger; Ruben Nogueiras; Vincent Prevot; Thomas Krey; Markus Schwaninger
Pubblicato in: reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela, Numero 4, 2021, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22094998

The L‐α‐lysophosphatidylinositol/GPR55 system induces the development of non‐alcoholic steatosis and steatohepatitis

Autori: Marcos F. Fondevila, Uxia Fernandez, Maria J. Gonzalez‐Rellan, Natalia Da Silva Lima, Xabier Buque, Agueda Gonzalez‐Rodriguez, Cristina Alonso, Marta Iruarrizaga‐Lejarreta, Teresa C. Delgado, Marta Varela‐Rey, Ana Senra, Vera Garcia‐Outeiral, Eva Novoa, Cristina Iglesias, Begoña Porteiro, Daniel Beiroa, Cintia Folgueira, Marta Tojo, Jorge L. Torres, Lourdes Hernández‐Cosido, Óscar B
Pubblicato in: Hepatology, 2020, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hep.31290

Nicotine’ actions on energy balance: Friend or foe?

Autori: Patricia Seoane-Collazo, Carlos Diéguez, Rubén Nogueiras, Kamal Rahmouni, José Manuel Fernández-Real, Miguel López
Pubblicato in: Pharmacology & Therapeutics, 2020, Pagina/e 107693, ISSN 0163-7258
Editore: Pergamon Press
DOI: 10.1016/j.pharmthera.2020.107693

Impaired endothelium-mediated cerebrovascular reactivity promotes anxiety and respiration disorders in mice

Autori: Jan Wenzel, Cathrin E. Hansen, Carla Bettoni, Miriam A. Vogt, Beate Lembrich, Rentsenkhand Natsagdorj, Gianna Huber, Josefine Brands, Kjestine Schmidt, Julian C. Assmann, Ines Stölting, Kathrin Saar, Jan Sedlacik, Jens Fiehler, Peter Ludewig, Michael Wegmann, Nina Feller, Marius Richter, Helge Müller-Fielitz, Thomas Walther, Gabriele M. König, Evi Kostenis, Walter Raasch, Norbert Hübner, Peter
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 117/3, 2020, Pagina/e 1753-1761, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1907467117

Hypothalamic bile acid-TGR5 signaling protects from obesity

Autori: Ashley Castellanos-Jankiewicz, Omar Guzmán-Quevedo, Valérie S. Fénelon, Philippe Zizzari, Carmelo Quarta, Luigi Bellocchio, Anne Tailleux, Julie Charton, Daniela Fernandois, Marcus Henricsson, Catherine Piveteau, Vincent Simon, Camille Allard, Sandrine Quemener, Valentine Guinot, Nathalie Hennuyer, Alessia Perino, Alexia Duveau, Marlène Maitre, Thierry Leste-Lasserre, Samantha Clark, Nathalie
Pubblicato in: Cell Metabolism, 2021, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2021.04.009

Endogenous THBD (Thrombomodulin) Mediates Angiogenesis in the Ischemic Brain

Autori: Jan Wenzel, Dimitrios Spyropoulos, Julian Christopher Assmann, Mahtab Ahmad Khan, Ines Stölting, Beate Lembrich, Sara Kreißig, Dirk Andreas Ridder, Berend Isermann, Markus Schwaninger
Pubblicato in: Arteriosclerosis, Thrombosis, and Vascular Biology, 2020, ISSN 1079-5642
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.120.315061

Sirt3 in POMC neurons controls energy balance in a sex- and diet-dependent manner

Autori: Mar Quiñones, René Hernández-Bautista, Daniel Beiroa, Violeta Heras, Francisco L. Torres-Leal, Brian Y.H. Lam, Ana Senra, Johan Fernø, Alicia García Gómez-Valadés, Markus Schwaninger, Vincent Prevot, Giles Yeo, Marc Claret, Miguel López, Carlos Diéguez, Omar Al-Massadi, Ruben Nogueiras
Pubblicato in: Redox Biology, Numero 41, 2021, Pagina/e 101945, ISSN 2213-2317
Editore: Elsevier BV
DOI: 10.1016/j.redox.2021.101945

Obese patients with NASH have increased hepatic expression of SARS-CoV-2 critical entry points

Autori: Marcos F. Fondevila, Maria Mercado-Gómez, Amaia Rodríguez, Maria J. Gonzalez-Rellan, Paula Iruzubieta, Víctor Valentí, Javier Escalada, Markus Schwaninger, Vincent Prevot, Carlos Dieguez, Javier Crespo, Gema Frühbeck, Maria L. Martinez- Chantar, Ruben Nogueiras
Pubblicato in: Journal of Hepatology, 2020, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2020.09.027

Bitter taste cells in the ventricular walls of the murine brain regulate glucose homeostasis

Autori: Qiang Yu, Igor Gamayun, Philipp Wartenberg, Qian Zhang, Sen Qiao, Soumya Kusumakshi, Sarah Candlish, Viktoria Götz, Shuping Wen, Debajyoti Das, Amanda Wyatt, Vanessa Wahl, Fabien Ectors, Kathrin Kattler, Daniela Yildiz, Vincent Prevot, Markus Schwaninger, Gaetan Ternier, Paolo Giacobini Philippe Ciofi, Timo D Müller, Ulrich Boehm
Pubblicato in: Nat Commun ., Numero 2023 Mar 22;14(1):1588, 2023, ISSN 2041-1723
Editore: Nature Publishing Group

MCH Neurons Regulate Permeability of the Median Eminence Barrier

Autori: Hong Jiang, Sarah Gallet, Paul Klemm, Pia Scholl, Kat Folz-Donahue, Janine Altmüller, Jens Alber, Christian Heilinger, Christian Kukat, Anne Loyens, Helge Müller-Fielitz, Sivaraj Sundaram, Markus Schwaninger, Vincent Prevot, Jens C. Brüning
Pubblicato in: Neuron, Numero 107/2, 2020, Pagina/e 306-319.e9, ISSN 0896-6273
Editore: Cell Press
DOI: 10.1016/j.neuron.2020.04.020

Central nicotine induces browning through hypothalamic κ opioid receptor

Autori: Patricia Seoane-Collazo, Laura Liñares-Pose, Eva Rial-Pensado, Amparo Romero-Picó, José María Moreno-Navarrete, Noelia Martínez-Sánchez, Pablo Garrido-Gil, Ramón Iglesias-Rey, Donald A. Morgan, Naoki Tomasini, Samuel Andrew Malone, Ana Senra, Cintia Folgueira, Gema Medina-Gomez, Tomás Sobrino, José L. Labandeira-García, Rubén Nogueiras, Ana I. Domingos, José-Manuel Fernández-Real, Kam
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-12004-z

Parvocellular Oxytocin Neurons and Autism Spectrum Disorders

Autori: Sivaraj Mohana Sundaram, Markus Schwaninger
Pubblicato in: Trends in Endocrinology and Metabolism, 2021, Pagina/e 195-197, ISSN 1043-2760
Editore: Elsevier BV
DOI: 10.1016/j.tem.2021.01.004

MCH Regulates SIRT1/FoxO1 and Reduces POMC Neuronal Activity to Induce Hyperphagia, Adiposity, and Glucose Intolerance

Autori: Omar Al-Massadi, Mar Quiñones, Jerome Clasadonte, René Hernandez-Bautista, Amparo Romero-Picó, Cintia Folgueira, Donald A. Morgan, Imre Kalló, Violeta Heras, Ana Senra, Samuel C. Funderburk, Michael J. Krashes, Yara Souto, Miguel Fidalgo, Serge Luquet, Melissa J. Chee, Monica Imbernon, Daniel Beiroa, Lucía García-Caballero, Rosalia Gallego, Brian Y.H. Lam, Giles Yeo, Miguel Lopez, Zsolt Lipo
Pubblicato in: Diabetes, Numero 68/12, 2019, Pagina/e 2210-2222, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/db19-0029

Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21

Autori: Veronica Pena-Leon, Cintia Folgueira, Silvia Barja-Fernández, Raquel Pérez-Lois, Natália Da Silva Lima, Marion Martin, Violeta Heras, Sara Martinez-Martinez, Paola Valero, Cristina Iglesias, Mannon Duquenne, Omar Al-Massadi, Daniel Beiroa, Yara Souto, Miguel Fidalgo, Rasika Sowmyalakshmi, Diana Guallar, Juan Cunarro, Cecilia Castelao, Ana Senra, Patricia González-Saenz, Rocío Vázquez-Cobela,
Pubblicato in: Nat Metab ., Numero 2022 Jul;4(7), 2022, Pagina/e 901-917, ISSN 2522-5812
Editore: Nature Portfolio
DOI: 10.1038/s42255-022-00602-z

Hypothalamic dopamine signalling regulates brown fat thermogenesis

Autori: Cintia Folgueira, Daniel Beiroa, Begoña Porteiro, Manon Duquenne, Emma Puighermanal, Marcos F. Fondevila, Silvia Barja-Fernández, Rosalia Gallego, René Hernández-Bautista, Cecilia Castelao, Ana Senra, Patricia Seoane-Collazo, Noemi Gómez-Lado, Pablo Aguiar, Diana Guallar, Miguel Fidalgo, Amparo Romero-Pico, Roger Adan, Clemence Blouet, Jose Luís Labandeira-García, Françoise Jeanrenaud, Imr
Pubblicato in: Nature Metabolism, Numero 1/8, 2019, Pagina/e 811-829, ISSN 2522-5812
Editore: Nature
DOI: 10.1038/s42255-019-0099-7

Glial cells as integrators of peripheral and central signals in the regulation of energy homeostasis

Autori: Sreekala Nampoothiri, Ruben Nogueiras, Markus Schwaninger, Vincent Prevot
Pubblicato in: Nat Metab ., Numero 2022 Jul;4(7), 2022, Pagina/e 813-825, ISSN 2522-5812
Editore: Nature Portfolio
DOI: 10.1038/s42255-022-00610-z

Inhibition of carnitine palmitoyltransferase 1A in hepatic stellate cells protects against fibrosis

Autori: Marcos F. Fondevila, Uxia Fernandez, Violeta Heras, Tamara Parracho, Maria J. Gonzalez-Rellan, Eva Novoa, Begoña Porteiro, Cristina Alonso, Rebeca Mayo, Natalia da Silva Lima, Cristina Iglesias, Aveline A. Filliol, Ana Senra, Teresa C. Delgado, Ashwin Woodhoo, Laura Herrero, Dolors Serra, Vincent Prevot, Markus Schwaninger, Miguel López, Ruben Nogueiras
Pubblicato in: J. Hepatol., Numero Volume 77, Numero 1, July 2022, 2022, Pagina/e 15-28, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2022.02.003

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