Well-Aging and the Tanycytic Control of Health

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Pubblicazioni

Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function

Autori: Natália da Silva Lima, Marcos F Fondevila, Eva Nóvoa, Xabier Buqué, Maria Mercado-Gómez, Sarah Gallet, Maria J González-Rellan, Uxia Fernandez, Anne Loyens, Maria Garcia-Vence, Maria Del Pilar Chantada-Vazquez, Susana B Bravo, Patricia Marañon, Ana Senra, Adriana Escudero, Magdalena Leiva, Diana Guallar, Miguel Fidalgo, Pedro Gomes, Marc Claret, Guadalupe Sabio, Marta Varela-Rey, Teresa C De
Pubblicato in: J. Hepatol., Numero 2022 Jan;76(1, 2022, Pagina/e 11-24, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2021.09.008

Obesity induces resistance to central action of BMP8B through a mechanism involving the BBSome

Autori: Eva Rial-Pensado, Oscar Freire-Agulleiro, Marcos Ríos, Deng Fu Guo, Cristina Contreras, Patricia Seoane-Collazo, Sulay Tovar, Rubén Nogueiras, Carlos Diéguez, Kamal Rahmouni, Miguel López
Pubblicato in: Molecular Metabolism, Numero 59, 2024, Pagina/e 101465, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2022.101465

Activation of Hypothalamic <scp>AMP‐Activated</scp> Protein Kinase Ameliorates Metabolic Complications of Experimental Arthritis

Autori: Patricia Seoane‐Collazo, Eva Rial‐Pensado, Ánxela Estévez‐Salguero, Edward Milbank, Lucía García‐Caballero, Marcos Ríos, Laura Liñares‐Pose, Morena Scotece, Rosalía Gallego, José Manuel Fernández‐Real, Rubén Nogueiras, Carlos Diéguez, Oreste Gualillo, Miguel López
Pubblicato in: Arthritis & Rheumatology, Numero 74, 2023, Pagina/e 212-222, ISSN 2326-5191
Editore: Wiley
DOI: 10.1002/art.41950

MS2 and LC libraries for untargeted metabolomics: Enhancing method development and identification confidence

Autori: Julica Folberth, Kimberly Begemann, Olaf Jöhren, Markus Schwaninger, Alaa Othman
Pubblicato in: Journal of Chromatography B, Numero 1145, 2020, Pagina/e 122105, ISSN 1570-0232
Editore: Elsevier BV
DOI: 10.1016/j.jchromb.2020.122105

Protocol for simultaneous patch-clamp recording from tanycytes and neurons in living mouse brain slices

Autori: Tori Lhomme, Vincent Prévot
Pubblicato in: STAR Protocols, Numero 4, 2025, Pagina/e 102571, ISSN 2666-1667
Editore: Elsevier BV
DOI: 10.1016/j.xpro.2023.102571

Melatonin drugs inhibit SARS-CoV-2 entry into the brain and virus-induced damage of cerebral small vessels.

Autori: Erika Cecon, Daniela Fernandois, Nicolas Renault, Caio Fernando Ferreira Coelho, Jan Wenzel, Corentin Bedart, Charlotte Izabelle, Sarah Gallet, Sophie Le Poder, Bernard Klonjkowski, Markus Schwaninger, Vincent Prevot, Julie Dam, Ralf Jockers
Pubblicato in: Cell Mol Life Sci, Numero 2022; 79(7), 2022, Pagina/e 361, ISSN 1420-682X
Editore: Birkhauser Verlag
DOI: 10.1007/s00018-022-04390-3

SF1-specific deletion of the energy sensor AMPKγ2 induces obesity

Autori: Óscar Freire-Agulleiro, Ánxela Estévez-Salguero, Vitor Ferreira, Cassie Lynn Holleman, Julia García-Currás, Ismael González-García, Rubén Nogueiras, Manuel Tena-Sempere, Cristina García-Cáceres, Carlos Diéguez, Miguel López
Pubblicato in: Molecular Metabolism, Numero 92, 2025, Pagina/e 102091, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2024.102091

Long-COVID cognitive impairments and reproductive hormone deficits in men may stem from GnRH neuronal death

Autori: Florent Sauve, Sreekala Nampoothiri, Sophie A. Clarke, Daniela Fernandois, Caio Fernando Ferreira Coêlho, Julie Dewisme, Edouard G. Mills, Gaetan Ternier, Ludovica Cotellessa, Cristina Iglesias-Garcia, Helge Mueller-Fielitz, Thibaud Lebouvier, Romain Perbet, Vincent Florent, Marc Baroncini, Ariane Sharif, June Ereño-Orbea, Maria Mercado-Gómez, Asis Palazon, Virginie Mattot, Florence Pasquier, S
Pubblicato in: eBioMedicine, Numero 96, 2024, Pagina/e 104784, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2023.104784

Gene therapy targeting the blood-brain barrier improves neurological symptoms in a model of genetic MCT8 deficiency

Autori: Sivaraj M Sundaram, Adriana Arrulo Pereira, Helge Müller-Fielitz, Hannes Köpke, Meri De Angelis, Timo D Müller, Heike Heuer, Jakob Körbelin, Markus Krohn, Jens Mittag, Ruben Nogueiras, Vincent Prevot, Markus Schwaninger
Pubblicato in: Brain, 2022, ISSN 0006-8950
Editore: Oxford University Press
DOI: 10.1093/brain/awac243

Mitochondrial antiviral signaling protein enhances MASLD progression through the ERK/TNFα/NFκβ pathway

Autori: Eva Nóvoa, Natália da Silva Lima, Maria J. Gonzalez-Rellan, Maria D.P. Chantada-Vazquez, Joanne Verheij, Amaia Rodriguez, Eva M. Esquinas-Roman, Marcos F. Fondevila, Mirja Koning, Uxia Fernandez, Alba Cabaleiro, Tamara Parracho, Jose Iglesias-Moure, Samuel Seoane, Begoña Porteiro, Adriana Escudero, Ana Senra, Roman Perez-Fernandez, Miguel López, Miguel Fidalgo, Diana Guallar, Maria L. Martinez
Pubblicato in: Hepatology, Numero 81, 2025, Pagina/e 1535-1552, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1097/hep.0000000000000930

O-GlcNAcylated p53 in the liver modulates hepatic glucose production

Autori: Maria J. Gonzalez-Rellan, Marcos F. Fondevila, Uxia Fernandez, Amaia Rodríguez, Marta Varela-Rey, Christelle Veyrat-Durebex, Samuel Seoane, Ganeko Bernardo, Fernando Lopitz-Otsoa, David Fernández-Ramos, Jon Bilbao, Cristina Iglesias, Eva Novoa, Cristina Ameneiro, Ana Senra, Daniel Beiroa, Juan Cuñarro, Maria DP Chantada-Vazquez, Maria Garcia-Vence, Susana B. Bravo, Natalia Da Silva Lima, Begoñ
Pubblicato in: Nature Communications, Numero 12, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-25390-0

Removal of senescent cells reduces the viral load and attenuates pulmonary and systemic inflammation in SARS-CoV-2-infected, aged hamsters

Autori: Lou Delval, Aline Hantute-Ghesquier, Valentin Sencio, Jean Michel Flaman, Cyril Robil, Fabiola Silva Angulo, Larissa Lipskaia, Ozmen Çobanoğlu, Anne-Sophie Lacoste, Arnaud Machelart, Adeline Danneels, Mathieu Corbin, Lucie Deruyter, Séverine Heumel, Thierry Idziorek, Karin Séron, Florent Sauve, Antonino Bongiovanni, Vincent Prévot, Isabelle Wolowczuk, Sandrine Belouzard, Jean-Michel Saliou, P
Pubblicato in: Nature Aging, Numero 3, 2023, Pagina/e 829-845, ISSN 2662-8465
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s43587-023-00442-w

Orphan GPR50 Restrains Neurite Outgrowth and Cell Migration by Activating the G<sub>12/13</sub> Protein‐RhoA Pathway in Neural Progenitor Cells and Tanycytes

Autori: Raise Ahmad, Marine Luka, Anne‐Sophie Journe, Sarah Gallet, Alan Hegron, Marcio Do Cruzeiro, Mark J. Millan, Philippe Delagrange, Bernard Masri, Julie Dam, Vincent Prevot, Ralf Jockers
Pubblicato in: Journal of Pineal Research, Numero 77, 2025, ISSN 0742-3098
Editore: Blackwell Publishing Inc.
DOI: 10.1111/jpi.70041

Short regulatory DNA sequences to target brain endothelial cells for gene therapy

Autori: Hanna Graßhoff, Helge Müller-Fielitz, Godwin K Dogbevia, Jakob Körbelin, Jacqueline Bannach, Carl MG Vahldieck, Kristina Kusche-Vihrog, Olaf Jöhren, Oliver J Müller, Ruben Nogueiras, Vincent Prevot, Markus Schwaninger
Pubblicato in: J Cereb Blood Flow Metab, Numero 2022 Jan; 42(1), 2022, Pagina/e 104–120, ISSN 0271-678X
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x211039617

Nutritionally induced tanycytic plasticity in the hypothalamus of adult ewes

Autori: L.D. Prezotto, J.F. Thorson, V. Prevot, D.A. Redmer, A.T. Grazul-Bilska
Pubblicato in: Domestic Animal Endocrinology, Numero 72, 2023, Pagina/e 106438, ISSN 0739-7240
Editore: Elsevier BV
DOI: 10.1016/j.domaniend.2020.106438

Hepatic p63 regulates glucose metabolism by repressing SIRT1

Autori: Maria J Gonzalez-Rellan, Eva Novoa, Natalia da Silva Lima, Amaia Rodriguez, Christelle Veyrat-Durebex, Samuel Seoane, Begoña Porteiro, Marcos F Fondevila, Uxia Fernandez,1 Marta Varela-Rey,6 Ana Senra,1 Cristina Iglesias,1 Adriana Escudero,1 Miguel Fidalgo,1 Diana Guallar,7 Roman Perez-Fernandez,1 Vincent Prevot,8 Markus Schwaninger,9 Miguel López,1,2 Carlos Dieguez,1,2 Roberto Coppari,4,5 Gema
Pubblicato in: Gut, Numero 2023 Mar; 72(3), 2023, Pagina/e 472–483, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2021-326620

Hypothalamic Structural and Functional Imbalances in Anorexia Nervosa

Autori: Vincent Florent, Marc Baroncini, Patrice Jissendi-Tchofo, Renaud Lopes, Matthieu Vanhoutte, Sowmyalakshmi Rasika, Jean-Pierre Pruvo, Jean Vignau, Stephane Verdun, Jeanette E. Johansen, Marie Pigeyre, Sebastien G. Bouret, Ida A.K. Nilsson, Vincent Prevot
Pubblicato in: Neuroendocrinology, Numero 110, 2025, Pagina/e 552-562, ISSN 0028-3835
Editore: S. Karger AG
DOI: 10.1159/000503147

Diet-Induced Obesity and NASH Impair Disease Recovery in SARS-CoV-2-Infected Golden Hamsters

Autori: François Briand, Valentin Sencio, Cyril Robil, Séverine Heumel, Lucie Deruyter, Arnaud Machelart, Johanna Barthelemy, Gemma Bogard, Eik Hoffmann, Fabrice Infanti, Oliver Domenig, Audrey Chabrat, Virgile Richard, Vincent Prévot, Ruben Nogueiras, Isabelle Wolowczuk, Florence Pinet, Thierry Sulpice, François Trottein
Pubblicato in: Viruses, Numero 14, 2025, Pagina/e 2067, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v14092067

Small extracellular vesicle targeting of hypothalamic AMPKα1 promotes weight loss in leptin receptor deficient mice

Autori: Edward Milbank, Nathalia Dragano, Xavi Vidal-Gómez, Verónica Rivas-Limeres, Pablo Garrido-Gil, Mireille Wertheimer, Sylvain Recoquillon, María P. Pata, José Luis Labandeira-Garcia, Carlos Diéguez, Rubén Nogueiras, M. Carmen Martínez, Ramaroson Andriantsitohaina, Miguel López
Pubblicato in: Metabolism, Numero 139, 2024, Pagina/e 155350, ISSN 0026-0495
Editore: Elsevier BV
DOI: 10.1016/j.metabol.2022.155350

Orally Induced Hyperthyroidism Regulates Hypothalamic AMP-Activated Protein Kinase

Autori: Valentina Capelli, Carmen Grijota-Martínez, Nathalia R. V. Dragano, Eval Rial-Pensado, Johan Fernø, Rubén Nogueiras, Jens Mittag, Carlos Diéguez, Miguel López
Pubblicato in: Nutrients, Numero 13, 2024, Pagina/e 4204, ISSN 2072-6643
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu13124204

Tanycytic transcytosis inhibition disrupts energy balance, glucose homeostasis and cognitive function in male mice

Autori: Manon Duquenne, Eleonora Deligia, Cintia Folgueira, Cyril Bourouh, Emilie Caron, Frank Pfrieger, Markus Schwaninger, Ruben Nogueiras, Jean-Sébastien Annicotte, Monica Imbernon, Vincent Prévot
Pubblicato in: Molecular Metabolism, Numero 87, 2024, Pagina/e 101996, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2024.101996

κ-Opioid Signaling in the Lateral Hypothalamic Area Modulates Nicotine-Induced Negative Energy Balance

Autori: Patricia Seoane-Collazo, Amparo Romero-Picó, Eva Rial-Pensado, Laura Liñares-Pose, Ánxela Estévez-Salguero, Johan Fernø, Rubén Nogueiras, Carlos Diéguez, Miguel López
Pubblicato in: International Journal of Molecular Sciences, Numero 22, 2024, Pagina/e 1515, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22041515

Neuroprotective effect of small extracellular vesicle-mediated targeting of AMPKα2 in cerebral ischemia

Autori: Alberto Ouro, Amanda Rodríguez-Díaz, Tania López-González, Daniel Romaus-Sanjurjo, Ánxela Estévez-Salguero, Ramón Iglesias-Rey, Mariña Rodríguez-Arrizabalaga, Paola Fernández-Sanmartín, Mónica Castro-Mosquera, Manuel Debasa-Mouce, Antía Custodia, Marta Aramburu-Núñez, María Muñoz-González, Pablo Aguiar, Ismael González-García, Marc Schneeberger, Rubén Nogueiras, Carlos Diégue
Pubblicato in: Metabolism, Numero 167, 2025, Pagina/e 156160, ISSN 0026-0495
Editore: Elsevier BV
DOI: 10.1016/j.metabol.2025.156160

Estrogen receptor-α signaling in tanycytes lies at the crossroads of fertility and metabolism

Autori: Daniela Fernandois, Mariam Rusidzé, Helge Mueller-Fielitz, Florent Sauve, Eleonora Deligia, Mauro S.B. Silva, Florence Evrard, Aurelio Franco-García, Daniele Mazur, Ines Martinez-Corral, Nathalie Jouy, S. Rasika, Claude-Alain Maurage, Paolo Giacobini, Ruben Nogueiras, Benedicte Dehouck, Markus Schwaninger, Francoise Lenfant, Vincent Prevot
Pubblicato in: Metabolism, Numero 158, 2024, Pagina/e 155976, ISSN 0026-0495
Editore: Elsevier BV
DOI: 10.1016/j.metabol.2024.155976

O-GlcNAcylation: A Sweet Hub in the Regulation of Glucose Metabolism in Health and Disease

Autori: Maria J. Gonzalez-Rellan, Marcos F. Fondevila, Carlos Dieguez, Ruben Nogueiras
Pubblicato in: Frontiers in Endocrinology, Numero 13, 2022, ISSN 1664-2392
Editore: Frontiers Media SA
DOI: 10.3389/fendo.2022.873513

Inhibition of hepatic p63 ameliorates steatohepatitis with fibrosis in mice

Autori: Marcos F. Fondevila, Eva Novoa, Uxia Fernandez, Valentina Dorta, Tamara Parracho, Henriette Kreimeyer, Maria Garcia-Vence, Maria P. Chantada-Vazquez, Susana B. Bravo, Begoña Porteiro, Alba Cabaleiro, Mijra Koning, Ana Senra, Yara Souto, Joanne Verheij, Diana Guallar, Miguel Fidalgo, Abraham S. Meijnikman, Natalia da Silva Lima, Carlos Dieguez, Maria J. Gonzalez-Rellan, Ruben Nogueiras
Pubblicato in: Molecular Metabolism, Numero 85, 2024, Pagina/e 101962, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2024.101962

Cerebral angiogenesis ameliorates pathological disorders in Nemo -deficient mice with small-vessel disease

Autori: Yun Jiang, Kristin Müller, Mahtab A. Khan, Julian C. Assmann, Josephine Lampe, Knut Kilau, Marius Richter, Maximilian Kleint, Dirk A Ridder, Norbert Hübner, Marc Schmidt-Supprian, Jan Wenzel, Markus Schwaninger
Pubblicato in: Journal of Cerebral Blood Flow & Metabolism, Numero 41/2, 2021, Pagina/e 219-235, ISSN 0271-678X
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x20910522

Glial endozepines and energy balance: Old peptides with new tricks

Autori: Bruno Lebrun, Manon Barbot, Marie‐Christine Tonon, Vincent Prévot, Jérôme Leprince, Jean‐Denis Troadec
Pubblicato in: Glia, Numero 69, 2023, Pagina/e 1079-1093, ISSN 0894-1491
Editore: John Wiley & Sons Inc.
DOI: 10.1002/glia.23927

The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes

Autori: Maria Mercado-Gómez, Endika Prieto-Fernández, Naroa Goikoetxea-Usandizaga, Laura Vila-Vecilla, Mikel Azkargorta, Miren Bravo, Marina Serrano-Maciá, Leire Egia-Mendikute, Rubén Rodríguez-Agudo, Sofia Lachiondo-Ortega, So Young Lee, Alvaro Eguileor Giné, Clàudia Gil-Pitarch, Irene González-Recio, Jorge Simón, Petar Petrov, Ramiro Jover, Luis Alfonso Martínez-Cruz, June Ereño-Orbea, Teresa
Pubblicato in: Communications Biology, Numero 5, 2022, ISSN 2399-3642
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s42003-022-03789-9

Glial Endozepines Reverse High-Fat Diet-Induced Obesity by Enhancing Hypothalamic Response to Peripheral Leptin

Autori: Florent Guillebaud, Manon Duquenne, Mehdi Djelloul, Clément Pierre, Kevin Poirot, Guenièvre Roussel, Seddik Riad, Damien Lanfray, Fabrice Morin, André Jean, Marie-Christine Tonon, Stéphanie Gaigé, Bruno Lebrun, Michel Dallaporta, Jérôme Leprince, Vincent Prevot, Jean-Denis Troadec
Pubblicato in: Molecular Neurobiology, Numero 57, 2021, Pagina/e 3307-3333, ISSN 0893-7648
Editore: Humana Press, Inc.
DOI: 10.1007/s12035-020-01944-z

Brain JNK and metabolic disease

Autori: Rubén Nogueiras, Guadalupe Sabio
Pubblicato in: Diabetologia, Numero 64/2, 2021, Pagina/e 265-274, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-020-05327-w

Leptin brain entry via a tanycytic LepR-EGFR shuttle controls lipid metabolism and pancreas function

Autori: Manon Duquenne, Cintia Folgueira, Cyril Bourouh, Marion Millet, Anisia Silva, Jérôme Clasadonte, Monica Imbernon, Daniela Fernandois, Ines Martinez-Corral, Soumya Kusumakshi, Emilie Caron, S. Rasika, Eleonora Deliglia, Nathalie Jouy, Asturo Oishi, Massimiliano Mazzone, Eric Trinquet, Jan Tavernier, Young-Bum Kim, Stéphane Ory, Ralf Jockers, Markus Schwaninger, Ulrich Boehm, Ruben Nogueiras, Jea
Pubblicato in: Nature Metabolism, 2021, ISSN 2522-5812
Editore: Nature Portfolio
DOI: 10.1038/s42255-021-00432-5

Cell proliferation and glial cell marker expression in the wall of the third ventricle in the tuberal region of the male mouse hypothalamus during postnatal development

Autori: Adrian Coutteau‐Robles, Vincent Prevot, Ariane Sharif
Pubblicato in: Journal of Neuroendocrinology, Numero 35, 2023, Pagina/e 35(3):e13239, ISSN 0953-8194
Editore: Blackwell Publishing Inc.
DOI: 10.1111/jne.13239

Hepatocyte-specific O-GlcNAc transferase downregulation ameliorates nonalcoholic steatohepatitis by improving mitochondrial function

Autori: Maria J. Gonzalez-Rellan, Tamara Parracho, Violeta Heras, Amaia Rodriguez, Marcos F. Fondevila, Eva Novoa, Natalia Lima, Marta Varela-Rey, Ana Senra, Maria D.P. Chantada-Vazquez, Cristina Ameneiro, Ganeko Bernardo, David Fernandez-Ramos, Fernando Lopitz-Otsoa, Jon Bilbao, Diana Guallar, Miguel Fidalgo, Susana Bravo, Carlos Dieguez, Maria L. Martinez-Chantar, Oscar Millet, Jose M. Mato, Markus Schw
Pubblicato in: Molecular Metabolism, Numero 75, 2023, Pagina/e 101776, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2023.101776

Novel insights into minipuberty and <scp>GnRH</scp>: Implications on neurodevelopment, cognition, and <scp>COVID</scp>‐19 therapeutics

Autori: Konstantina Chachlaki, Kevin Le Duc, Laurent Storme, Vincent Prevot
Pubblicato in: Journal of Neuroendocrinology, Numero 36, 2024, ISSN 0953-8194
Editore: Blackwell Publishing Inc.
DOI: 10.1111/jne.13387

Glial control of neuronal function

Autori: Vincent Prevot
Pubblicato in: Nature Reviews Endocrinology, Numero 18, 2022, Pagina/e 195-195, ISSN 1759-5029
Editore: Nature Publishing Group
DOI: 10.1038/s41574-022-00640-3

Alteration of the gut microbiota following SARS-CoV-2 infection correlates with disease severity in hamsters

Autori: Valentin Sencio, Arnaud Machelart, Cyril Robil, Nicolas Benech, Eik Hoffmann, Chloé Galbert, Lucie Deryuter, Séverine Heumel, Aline Hantute-Ghesquier, Anne Flourens, Priscille Brodin, Fabrice Infanti, Virgile Richard, Jean Dubuisson, Corinne Grangette, Thierry Sulpice, Isabelle Wolowczuk, Florence Pinet, Vincent Prévot, Sandrine Belouzard, François Briand, Martine Duterque-Coquillaud, Harry So
Pubblicato in: Gut Microbes, Numero 14, 2025, Pagina/e 14(1):2018900, ISSN 1949-0976
Editore: Landes Bioscience
DOI: 10.1080/19490976.2021.2018900

BMP8 and activated brown adipose tissue in human newborns

Autori: Adela Urisarri, Ismael González-García, Ánxela Estévez-Salguero, María P. Pata, Edward Milbank, Noemi López, Natalia Mandiá, Carmen Grijota-Martinez, Carlos A. Salgado, Rubén Nogueiras, Carlos Diéguez, Francesc Villarroya, José-Manuel Fernández-Real, María L. Couce, Miguel López
Pubblicato in: Nature Communications, Numero 12, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-25456-z

Tanycytic networks mediate energy balance by feeding lactate to glucose-insensitive POMC neurons.

Autori: Tori Lhomme; Jerome Clasadonte; Monica Imbernon; Daniela Fernandois; Florent Sauve; Emilie Caron; Natália da Silva Lima; Violeta Heras; Ines Martinez-Corral; Helge Mueller-Fielitz; Sowmyalakshmi Rasika; Markus Schwaninger; Rubén Nogueiras; Vincent Prevot
Pubblicato in: J Clin Invest, Numero 8, 2021, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci140521

Angiocrine polyamine production regulates adiposity

Autori: Erika Monelli, Pilar Villacampa, Amaia Zabala-Letona, Anabel Martinez-Romero, Judith Llena, Daniel Beiroa, Leonor Gouveia, Iñigo Chivite, Sebastián Zagmutt, Pau Gama-Perez, Oscar Osorio-Conles, Laia Muixi, Ainara Martinez-Gonzalez, Sandra D. Castillo, Natalia Martín-Martín, Pau Castel, Lorea Valcarcel-Jimenez, Irene Garcia-Gonzalez, Josep A. Villena, Sonia Fernandez-Ruiz, Dolors Serra, Laura H
Pubblicato in: Nature Metabolism, Numero 4, 2022, Pagina/e 327-343, ISSN 2522-5812
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s42255-022-00544-6

NF-κB signaling in tanycytes mediates inflammation-induced anorexia

Autori: Mareike Böttcher, Helge Müller-Fielitz, Sivaraj M. Sundaram, Sarah Gallet, Vanessa Neve, Kiseko Shionoya, Adriano Zager, Ning Quan, Xiaoyu Liu, Ruth Schmidt-Ullrich, Ronny Haenold, Jan Wenzel, Anders Blomqvist, David Engblom, Vincent Prevot, Markus Schwaninger
Pubblicato in: Molecular Metabolism, Numero 39, 2020, Pagina/e 101022, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.101022

Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis

Autori: Eva Rial-Pensado, Verónica Rivas-Limeres, Carmen Grijota-Martínez, Amanda Rodríguez-Díaz, Valentina Capelli, Olga Barca-Mayo, Rubén Nogueiras, Jens Mittag, Carlos Diéguez, Miguel López
Pubblicato in: Frontiers in Physiology, Numero 13, 2022, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2022.1017381

Acute changes in systemic glycemia gate access and action of GLP-1R agonist on brain structures controlling energy homeostasis.

Autori: Wineke Bakker; Monica Imbernon; Casper Gravesen Salinas; Daniela Herrera Moro Chao; Rim Hassouna; Chloe Morel; Claire Martin; Caroline Leger; Raphael G.P. Denis; Julien Castel; Andreas Peter; Martin Heni; Walter Maetzler; Heidi Solvang Nielsen; Manon Duquenne; Markus Schwaninger; Sofia Lundh; Wouter Frederic Johan Hogendorf; Giuseppe Gangarossa; Anna Secher; Jacob Hecksher-Sørensen; Thomas Åskov
Pubblicato in: Cell Rep. 41:111698 (2022), Numero 7, 2022, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2022.111698

The Role of Tanycytes in the Hypothalamus-Pituitary-Thyroid Axis and the Possibilities for Their Genetic Manipulation

Autori: Helge Müller-Fielitz, Markus Schwaninger
Pubblicato in: Experimental and Clinical Endocrinology & Diabetes, Numero 128/06/07, 2020, Pagina/e 388-394, ISSN 0947-7349
Editore: Johann Ambrosius Barth
DOI: 10.1055/a-1065-1855

The SARS-CoV-2 main protease M-pro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

Autori: Josephine Lampe; Jan Wenzel; Helge Müller-Fielitz; Kristin Müller; Raphael Schuster; Linlin Zhang; Marietta Zille; Markus Krohn; Ümit Özorhan; Yun Jiang; Vanessa Neve; Anke Fähnrich; Fabian Ott; Sonja Binder; Hauke Busch; Ludovic Collin; Roberto Villasenor; Olaf Jöhren; Hermann Altmeppen; Manolis Pasparakis; Ruben Nogueiras; Vincent Prevot; Rolf Hilgenfeld; Markus Glatzel; Markus Schwaninger
Pubblicato in: Nature neuroscience, Numero 10, 2021, ISSN 1097-6256
Editore: Nature Publishing Group
DOI: 10.21203/rs.3.rs-86988/v1

Hypothalamic free fatty acid receptor-1 regulates whole-body energy balance

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Is LRP2 Involved in Leptin Transport over the Blood-Brain Barrier and Development of Obesity?

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Nicotine’ actions on energy balance: Friend or foe?

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Regulation of Thyroid Hormone Gatekeepers by Thyrotropin in Tanycytes

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Hypothalamic bile acid-TGR5 signaling protects from obesity

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Seeing through the fog: a neuroendocrine explanation for post-COVID cognitive deficits

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The hypothalamic–pituitary–gonadal axis and the enigma of Alzheimer disease sex differences

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Kappa-Opioid Receptor Blockade Ameliorates Obesity Caused by Estrogen Withdrawal via Promotion of Energy Expenditure through mTOR Pathway

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Endogenous THBD (Thrombomodulin) Mediates Angiogenesis in the Ischemic Brain

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Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone

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COVID-19 could worsen cerebral amyloid angiopathy

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The reactive pyruvate metabolite dimethylglyoxal mediates neurological consequences of diabetes

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Sirt3 in POMC neurons controls energy balance in a sex- and diet-dependent manner

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Distinct Actions of the Thyroid Hormone Transporters Mct8 and Oatp1c1 in Murine Adult Hippocampal Neurogenesis

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Bitter taste cells in the ventricular walls of the murine brain regulate glucose homeostasis

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Metabolic control of puberty: 60 years in the footsteps of Kennedy and Mitra’s seminal work

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MCH Neurons Regulate Permeability of the Median Eminence Barrier

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Central nicotine induces browning through hypothalamic κ opioid receptor

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Nesfatin-1 decreases the motivational and rewarding value of food

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Parvocellular Oxytocin Neurons and Autism Spectrum Disorders

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A functional cerebral endothelium is necessary to protect against cognitive decline

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Multifaceted actions of melanin-concentrating hormone on mammalian energy homeostasis

Autori: Omar Al-Massadi, Carlos Dieguez, Marc Schneeberger, Miguel López, Markus Schwaninger, Vincent Prevot, Ruben Nogueiras
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Activity-Based Anorexia Induces Browning of Adipose Tissue Independent of Hypothalamic AMPK

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Diet modulates the therapeutic effects of dimethyl fumarate mediated by the immunometabolic neutrophil receptor HCAR

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Tanycytes control hypothalamic liraglutide uptake and its anti-obesity actions

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GLP-1 and GIP agonism has no direct actions in human hepatocytes or hepatic stellate cells

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MCH Regulates SIRT1/FoxO1 and Reduces POMC Neuronal Activity to Induce Hyperphagia, Adiposity, and Glucose Intolerance

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A plastic aggrecan barrier modulated by peripheral energy state gates metabolic signal access to arcuate neurons

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Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21

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Circulating ghrelin crosses the blood-cerebrospinal fluid barrier via growth hormone secretagogue receptor dependent and independent mechanisms

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Hypothalamic dopamine signalling regulates brown fat thermogenesis

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PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism

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p63 controls metabolic activation of hepatic stellate cells and fibrosis via an HER2-ACC1 pathway

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The polygamous GnRH neuron: Astrocytic and tanycytic communication with a neuroendocrine neuronal population

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Selective Depletion of Adult GFAP-Expressing Tanycytes Leads to Hypogonadotropic Hypogonadism in Males

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Preventing and correcting polycystic ovary syndrome by targeting anti-Müllerian hormone signaling in minipuberty and adulthood in mice

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Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity

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Astrogenesis in the hypothalamus: A life-long process contributing to the development and plasticity of neuroendocrine networks

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Rapid modulation of gut microbiota composition by hypothalamic circuits in mice

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Serum Metabolites as Potential Markers and Predictors of Depression-like Behavior and Effective Fluoxetine Treatment in Chronically Socially Isolated Rats

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Glial cells as integrators of peripheral and central signals in the regulation of energy homeostasis

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A brainstem–hypothalamus neuronal circuit reduces feeding upon heat exposure

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Hypothalamic SIRT1-mediated regulation of the hormonal trigger of ovulation and its repression in energy deficit

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Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism

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DOI: 10.1038/s41593-018-0286-y

Inhibition of carnitine palmitoyltransferase 1A in hepatic stellate cells protects against fibrosis

Autori: Marcos F. Fondevila, Uxia Fernandez, Violeta Heras, Tamara Parracho, Maria J. Gonzalez-Rellan, Eva Novoa, Begoña Porteiro, Cristina Alonso, Rebeca Mayo, Natalia da Silva Lima, Cristina Iglesias, Aveline A. Filliol, Ana Senra, Teresa C. Delgado, Ashwin Woodhoo, Laura Herrero, Dolors Serra, Vincent Prevot, Markus Schwaninger, Miguel López, Ruben Nogueiras
Pubblicato in: J. Hepatol., Numero Volume 77, Numero 1, July 2022, 2022, Pagina/e 15-28, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2022.02.003

MECHANISMS IN ENDOCRINOLOGY: The gut–brain axis: regulating energy balance independent of food intake

Autori: Ruben Nogueiras
Pubblicato in: European Journal of Endocrinology, Numero 185, 2023, Pagina/e R75-R91, ISSN 0804-4643
Editore: BioScientifica Ltd.
DOI: 10.1530/eje-21-0277

Bridging brain barriers for gene therapy

Autori: Markus Schwaninger, Vincent Prevot, Ruben Nogueiras
Pubblicato in: Open Access Government, Numero 42, 2024, Pagina/e 210-211, ISSN 2516-3817
Editore: Adjacent Digital Politics Ltd
DOI: 10.56367/oag-042-10410

Feed or breed: Hypothalamic mechanisms linking energy availability to puberty onset

Autori: Alicia Sicardi, Daniela Fernandois, Vincent Prevot
Pubblicato in: Neuron, Numero 113, 2025, Pagina/e 968-970, ISSN 0896-6273
Editore: Cell Press
DOI: 10.1016/j.neuron.2025.03.012

How COVID-19 affects microvessels in the brain

Autori: Jan Wenzel, Markus Schwaninger
Pubblicato in: Brain, 2022, ISSN 0006-8950
Editore: Oxford University Press
DOI: 10.1093/brain/awac211

Glycemic control: Tanycytes march to the beat of the suprachiasmatic drummer

Autori: Monica Imbernon, Benedicte Dehouck, Vincent Prevot
Pubblicato in: Current Biology, Numero 32, 2024, Pagina/e R173-R176, ISSN 0960-9822
Editore: Cell Press
DOI: 10.1016/j.cub.2022.01.038

The WATCH project: Tanycytes in health and disease

Autori: Vincent Prevot, Markus Schwaninger, Ruben Nogueiras
Pubblicato in: Open Access Government, Numero 37, 2023, Pagina/e 132-133, ISSN 2516-3817
Editore: Adjacent Digital Politics Ltd
DOI: 10.56367/oag-037-10410

Prolonged lactation: Preventing obesity since infancy

Autori: Vincent Prevot, Markus Schwaninger, Ruben Nogueiras
Pubblicato in: Open Access Government, Numero 43, 2024, Pagina/e 106-107, ISSN 2516-3817
Editore: Adjacent Digital Politics Ltd
DOI: 10.56367/oag-043-10410

L’IRM hypothalamique, un nouvel outil diagnostique dans l’anorexie mentale ?

Autori: Vincent Florent, Marc Baroncini, Vincent Prévot
Pubblicato in: médecine/sciences, Numero 36, 2020, Pagina/e 115-117, ISSN 0767-0974
Editore: Editions E D K
DOI: 10.1051/medsci/2020007

Seasonal biology: Tanycytes give the hypothalamus a spring makeover

Autori: Manon Rivagorda, Vincent Prevot, Markus Schwaninger
Pubblicato in: Current Biology, Numero 34, 2025, Pagina/e R209-R211, ISSN 0960-9822
Editore: Cell Press
DOI: 10.1016/j.cub.2024.01.055

Food odour recognition adjusts systemic metabolism to nutrient availability

Autori: Vincent Prevot, Ruben Nogueiras
Pubblicato in: Nature Reviews Endocrinology, Numero 19, 2023, Pagina/e 130-131, ISSN 1759-5029
Editore: Nature Publishing Group
DOI: 10.1038/s41574-022-00801-4

Sowing SARS-CoV-2 to reap neurodegeneration: A hamster study

Autori: S. Rasika, Daniela Fernandois, Vincent Prévot
Pubblicato in: eBioMedicine, Numero 80, 2022, Pagina/e 104071, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2022.104071

Obese patients with NASH have increased hepatic expression of SARS-CoV-2 critical entry points

Autori: Marcos F. Fondevila, Maria Mercado-Gómez, Amaia Rodríguez, Maria J. Gonzalez-Rellan, Paula Iruzubieta, Víctor Valentí, Javier Escalada, Markus Schwaninger, Vincent Prevot, Carlos Dieguez, Javier Crespo, Gema Frühbeck, Maria L. Martinez- Chantar, Ruben Nogueiras
Pubblicato in: Journal of Hepatology, 2020, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2020.09.027

Brain infection by SARS-CoV-2: Lifelong consequences

Autori: Vincent Prévot
Pubblicato in: Open Access Government, Numero 41, 2024, Pagina/e 22-23, ISSN 2516-3817
Editore: Adjacent Digital Politics Ltd
DOI: 10.56367/oag-041-10397

Les neurones produisant l’hormone de mélano-concentration régulent la fenestration des anses vasculaires de l’éminence médiane

Autori: Alicia Sicardi, Vincent Prévot
Pubblicato in: médecine/sciences, Numero 38, 2022, Pagina/e 248-251, ISSN 0767-0974
Editore: Editions E D K
DOI: 10.1051/medsci/2022016

Les neurones produisant la gonadolibérine sculptent leur environnement neuroglial dans la petite enfance

Autori: Ariane Sharif, Vincent Prévot
Pubblicato in: médecine/sciences, Numero 38, 2022, Pagina/e 428-430, ISSN 0767-0974
Editore: Editions E D K
DOI: 10.1051/medsci/2022047

Unveiling the Importance of Tanycytes in the Control of the Dialogue Between the Brain and the Periphery

Autori: Sreekala Nampoothiri, Manon Duquenne, Vincent Prevot
Pubblicato in: Masterclass in Neuroendocrinology, Glial-Neuronal Signaling in Neuroendocrine Systems, Numero Numero 11, pp 255-284, 2023, Pagina/e 255-284
Editore: Springer International Publishing
DOI: 10.1007/978-3-030-62383-8_11

Tanycytes in the infundibular nucleus and median eminence and their role in the blood–brain barrier

Autori: Vincent Prevot, Ruben Nogueiras, Markus Schwaninger
Pubblicato in: Handbook of Clinical Neurology, The Human Hypothalamus - Middle and Posterior Region, Numero 180:253-273, 2022, Pagina/e 253-273
Editore: Elsevier
DOI: 10.1016/b978-0-12-820107-7.00016-1

Gene therapy targeting the blood-brain barrier

Autori: Jakob Körbelin, Adriana Arrulo, Markus Schwaninger
Pubblicato in: Vitamins and Hormones, Blood-Brain Barrier, Numero 126, 2024, Pagina/e 191-217
Editore: Elsevier
DOI: 10.1016/bs.vh.2024.03.001

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