Excel in Rare Diseases’ Research: Focus on LYSOsomal Disorders and CILiopathies

Resultado final

D7.8 - LYSOCIL Final conference

Final conference at UNLNMSCEDOC ll the participants and steakholders related to RDs

D7.3 - Communication and promotional materials I

Informative brochures, presentations and movies on RDs

D7.2 - Project website launch and Visual Identity Guide

Creation of our Website with information on RDs and our visual logotype.

D7.6 - e-LYSOCIL RDs Research HUB launch

Website where partners can communicate, share and deposit research outputs for the general public.

D7.4 - Communication and promotional materials II

Informative brochures presentations and movies on RDs

D7.5 - Communication and promotional materials III

Informative brochures presentations and movies on RDs

Publicaciones

SymmetryBreaking Cilia-Driven Flow in Embryogenesis

Autores: David J. Smith, Thomas D. Montenegro-Johnson, Susana S. Lopes
Publicado en: Annual Review of Fluid Mechanics, 2018, ISSN 0066-4189
Editor: Annual Reviews, Inc.
DOI: 10.1146/annurev-fluid-010518-040231

Pkd2 affects cilia length and impacts left-right flow dynamics and dand5 (project related publication after the start date of LYSOCIL project, RP2)

Autores: Raquel Jacinto, Pedro Sampaio, Mónica Roxo-Rosa, Sara Pestana, Susana S Lopes
Publicado en: Front Cell Dev Biol, 2021, ISSN 2296-634X
Editor: Frontiers Media S.A.
DOI: 10.3389/fcell.2021.624531

Zebrafish motile cilia as a model for Primary Ciliary Dyskinesia (project related publication after the start date of LYSOCIL project, RP2)

Autores: Andreia L Pinto, Margarida Rasteiro, Catarina Bota, Sara Pestana, Pedro Sampaio, Claire Hogg, Thomas Burgoyne, Susana S Lopes
Publicado en: Int J Mol Sci, Edición 22/16, 2021, ISSN 1661-6596
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22168361

Rab35 controls cilium length, function and membrane composition (project related publication after the start date of LYSOCIL project, RP1)

Autores: Stefanie Kuhns, Cecília Seixas, Sara Pestana, Bárbara Tavares, Renata Nogueira, Raquel Jacinto, José S Ramalho, Jeremy C Simpson, Jens S Andersen, Arnaud Echard, Susana S Lopes, Duarte C Barral, Oliver E Blacque
Publicado en: EMBO reports, Edición 20/10, 2019, ISSN 1469-221X
Editor: Nature Publishing Group
DOI: 10.15252/embr.201847625

Rab11 is required for lysosome exocytosis through the interaction with Rab3a, Sec15 and GRAB (project related publication after the start date of LYSOCIL project, RP2)

Autores: Cristina Escrevente, Liliana Bento-Lopes, José S Ramalho, Duarte C Barral
Publicado en: J Cell Sci, Edición 134/11, 2021, ISSN 0021-9533
Editor: The Company of Biologists Ltd.
DOI: 10.1242/jcs.246694

Formation of lipofuscin-like autofluorescent granules in the retinal pigment epithelium requires lysosome dysfunction (project related publication after the start date of LYSOCIL project, RP2)

Autores: Cristina Escrevente, Ana S Falcão, Michael J Hall, Mafalda Lopes-da-Silva, Pedro Antas, Miguel M Mesquita, Inês S Ferreira, M Helena Cardoso, Daniela Oliveira, Ana C Fradinho, Thomas Ciossek, Paul Nicklin, Clare E Futter, Sandra Tenreiro, Miguel C Seabra
Publicado en: Invest Ophthalmol Vis Sci, Edición 62/9, 2021, ISSN 0146-0404
Editor: Association for Research in Vision and Ophthalmology
DOI: 10.1167/iovs.62.9.39

Melanocore uptake by keratinocytes occurs through phagocytosis and involves protease-activated receptor-2 internalization (project related publication after the start date of LYSOCIL project, RP2)

Autores: Hugo Moreiras ,Liliana Bento-Lopes, Matilde V. Neto, Cristina Escrevente, Luís C. Cabaço, Michael J. Hall, José S. Ramalho, Miguel C. Seabra, Duarte C. Barral
Publicado en: Traffic, Edición 6, 2022, ISSN 1398-9219
Editor: Blackwell Publishing Inc.
DOI: 10.1111/tra.12843

Current methods to analyze lysosome morphology, positioning, motility and function (project related publication after the start date of LYSOCIL project, RP2)

Autores: Duarte C Barral, Leopoldo Staiano, Cláudia Guimas Almeida, Dan F Cutler, Emily R Eden, Clare E Futter, Antony Galione, André R A Marques, Diego Luis Medina, Gennaro Napolitano, Carmine Settembre, Otília V Vieira, Johannes M F G Aerts, Peace Atakpa-Adaji, Gemma Bruno, Antonella Capuozzo, Elvira De Leonibus, Chiara Di Malta, Cristina Escrevente, Alessandra Esposito, Paolo Grumati, Michael J Hall,
Publicado en: Traffic, Edición 5, 2022, ISSN 1398-9219
Editor: Blackwell Publishing Inc.
DOI: 10.1111/tra.12839

Zebrafish model as a screen to prevent cyst inflation in Autosomal Dominant Polycystic Kidney Disease (project related publication after the start date of LYSOCIL project, RP2)

Autores: Inês Oliveira, Raquel Jacinto, Sara Pestana, Fernando Nolasco, Joaquim Calado, Susana Santos Lopes, Mónica Roxo-Rosa
Publicado en: Int J Mol Sci, Edición 22/16, 2021, ISSN 1661-6596
Editor: MDPI
DOI: 10.3390/ijms22169013

Carbon monoxide and mitochondria – modulation of cell metabolism, redox response and cell death

Autores: Ana S. Almeida, Cláudia Figueiredo-Pereira, Helena L. A. Vieira
Publicado en: Frontiers in Physiology, Edición 6, 2015, ISSN 1664-042X
Editor: Frontiers Research Foundation

Carbon monoxide and the CNS: challenges and achievements

Autores: Cláudia S F Queiroga, Alessandro Vercelli, Helena L A Vieira
Publicado en: British Journal of Pharmacology, Edición 172/6, 2015, Página(s) 1533-1545, ISSN 0007-1188
Editor: Wiley-Blackwell
DOI: 10.1111/bph.12729

New method to assess mitophagy flux by flow cytometry

Autores: Marta Mauro-Lizcano, Lorena Esteban-Martínez, Esther Seco, Ana Serrano-Puebla, Lucia Garcia-Ledo, Cláudia Figueiredo-Pereira, Helena L A Vieira, Patricia Boya
Publicado en: Autophagy, Edición 11/5, 2015, Página(s) 833-843, ISSN 1554-8627
Editor: Landes Bioscience
DOI: 10.1080/15548627.2015.1034403

Rod disc renewal occurs by evagination of the ciliary plasma membrane that makes cadherin-based contacts with the inner segment

Autores: Thomas Burgoyne, Ingrid P. Meschede, Jemima J. Burden, Maryse Bailly, Miguel C. Seabra, Clare E. Futter
Publicado en: Proceedings of the National Academy of Sciences, Edición 112/52, 2015, Página(s) 15922-15927, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1509285113

Effect of carbon monoxide on gene expression in cerebrocortical astrocytes: Validation of reference genes for quantitative real-time PCR

Autores: Sara R. Oliveira, Helena L.A. Vieira, Carlos B. Duarte
Publicado en: Nitric Oxide, Edición 49, 2015, Página(s) 80-89, ISSN 1089-8603
Editor: Academic Press
DOI: 10.1016/j.niox.2015.07.003

Mitochondria and carbon monoxide: cytoprotection and control of cell metabolism - a role for Ca2+?

Autores: Sara R. Oliveira, Cláudia S. F. Queiroga, Helena L. A. Vieira
Publicado en: The Journal of Physiology, 2015, ISSN 0022-3751
Editor: Blackwell Publishing Inc.

Host cell autophagy contributes to Plasmodium liver development

Autores: Carolina Thieleke‐Matos, Mafalda Lopes da Silva, Laura Cabrita‐Santos, Martim D. Portal, Inês P. Rodrigues, Vanessa Zuzarte‐Luis, José S. Ramalho, Clare E. Futter, Maria M. Mota, Duarte C. Barral, Miguel C. Seabra
Publicado en: Cellular Microbiology, 2015, ISSN 1462-5814
Editor: Blackwell Publishing Inc.

Photoreceptor phagosome processing defects and disturbed autophagy in retinal pigment epithelium of Cln3Δex1-6 mice modelling juvenile neuronal ceroid lipofuscinosis (Batten disease).

Autores: Silène T. Wavre-Shapton, Alessandra A. Calvi, Mark Turmaine, Miguel C. Seabra, Daniel F. Cutler, Clare E. Futter, Hannah M. Mitchison
Publicado en: Human Molecular Genetics, 2015, ISSN 0964-6906
Editor: Oxford University Press

Rab27a GTPase modulates L-type Ca(2+) channel function via interaction with the II-III linker of CaV1.3 subunit.

Autores: Nadine Reichhart, Magdalena Markowski, Shimpei Ishiyama, Andrea Wagner, Sergio Crespo-Garcia, Talitha Schorb, José S. Ramalho, Vladimir M. Milenkovic, Renate Föckler, Miguel C. Seabra, Olaf Strauß
Publicado en: Cellular Signalling, 2015, ISSN 0898-6568
Editor: Elsevier BV

Exosome-delivered microRNAs modulate the inflammatory response to endotoxin

Autores: Margaret Alexander, Ruozhen Hu, Marah C. Runtsch, Dominique A. Kagele, Timothy L. Mosbruger, Tanya Tolmachova, Miguel C. Seabra, June L. Round, Diane M. Ward, Ryan M. O’Connell
Publicado en: Nature Communications, Edición 6/1, 2015, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/ncomms8321

Impact of the serum- and glucocorticoid-inducible kinase 1 on platelet dense granule biogenesis and secretion

Autores: B. Walker, E. Schmid, A. Russo, E.-M. Schmidt, O. Burk, P. Münzer, A. Velic, B. Macek, M. Schaller, M. Schwab, M. C. Seabra, M. Gawaz, F. Lang, O. Borst
Publicado en: Journal of Thrombosis and Haemostasis, Edición 13/7, 2015, Página(s) 1325-1334, ISSN 1538-7933
Editor: Blackwell Publishing Inc.
DOI: 10.1111/jth.12998

Regulation of melanosome number, shape and movement in the zebrafish retinal pigment epithelium by OA1 and PMEL

Autores: T. Burgoyne, M. N. O'Connor, M. C. Seabra, D. F. Cutler, C. E. Futter
Publicado en: Journal of Cell Science, Edición 128/7, 2015, Página(s) 1400-1407, ISSN 0021-9533
Editor: The Company of Biologists Ltd.
DOI: 10.1242/jcs.164400

Overexpression of BDNF and Full-Length TrkB Receptor Ameliorate Striatal Neural Survival in Huntington's Disease

Autores: Ana Silva, Luana Naia, Alejandro Dominguez, Márcio Ribeiro, Joana Rodrigues, Otília V. Vieira, Volkmar Lessmann, Ana Cristina Rego
Publicado en: Neurodegenerative Diseases, Edición 15/4, 2015, Página(s) 207-218, ISSN 1660-2854
Editor: S. Karger AG
DOI: 10.1159/000375447

Ischaemia-induced autophagy leads to degradation of gap junction protein connexin43 in cardiomyocytes

Autores: Tania Martins-Marques, Steve Catarino, Monica Zuzarte, Carla Marques, Paulo Matafome, Paulo Pereira, Henrique Girão
Publicado en: Biochemical Journal, Edición 467/2, 2015, Página(s) 231-245, ISSN 0264-6021
Editor: Portland Press, Ltd.
DOI: 10.1042/BJ20141370

K63 linked ubiquitin chain formation is a signal for HIF1A degradation by Chaperone-Mediated Autophagy

Autores: Joao Vasco Ferreira, Ana Rosa Soares, Jose Silva Ramalho, Paulo Pereira, Henrique Girao
Publicado en: Scientific Reports, Edición 5/1, 2015, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep10210

Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells

Autores: Ana Rosa Soares, Tania Martins-Marques, Teresa Ribeiro-Rodrigues, Joao Vasco Ferreira, Steve Catarino, Maria João Pinho, Monica Zuzarte, Sandra Isabel Anjo, Bruno Manadas, Joost P.G. Sluijter, Paulo Pereira, Henrique Girao
Publicado en: Scientific Reports, Edición 5/1, 2015, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep13243

Interacting Network of the Gap Junction (GJ) Protein Connexin43 (Cx43) is Modulated by Ischemia and Reperfusion in the Heart

Autores: Tania Martins-Marques, Sandra Isabel Anjo, Paulo Pereira, Bruno Manadas, Henrique Girão
Publicado en: Molecular & Cellular Proteomics, Edición 14/11, 2015, Página(s) 3040-3055, ISSN 1535-9476
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/mcp.M115.052894

Heart ischemia results in connexin43 ubiquitination localized at the intercalated discs

Autores: Tânia Martins-Marques, Steve Catarino, Carla Marques, Paulo Matafome, Teresa Ribeiro-Rodrigues, Rui Baptista, Paulo Pereira, Henrique Girão
Publicado en: Biochimie, Edición 112, 2015, Página(s) 196-201, ISSN 0300-9084
Editor: Elsevier BV
DOI: 10.1016/j.biochi.2015.02.020

Connexin 43 ubiquitination determines the fate of gap junctions: restrict to survive

Autores: Teresa M. Ribeiro-Rodrigues, Steve Catarino, Maria J. Pinho, Paulo Pereira, Henrique Girao
Publicado en: Biochemical Society transactions, 2015, ISSN 0300-5127
Editor: Portland Press, Ltd.

To beat or not to beat: degradation of Cx43 imposes the heart rhythm

Autores: Tânia Martins-Marques, Steve Catarino, Carla Marques, Paulo Pereira, Henrique Girão
Publicado en: Biochemical Society transactions, 2015, ISSN 0300-5127
Editor: Portland Press, Ltd.

Autophagy and Ubiquitination in Cardiovascular Diseases

Autores: Tania Martins-Marques, Teresa Ribeiro-Rodrigues, Paulo Pereira, Patrice Codogno, Henrique Girao
Publicado en: DNA and Cell Biology, Edición 34/4, 2015, Página(s) 243-251, ISSN 1044-5498
Editor: Mary Ann Liebert Inc.
DOI: 10.1089/dna.2014.2765

The zebrafish Kupffer's vesicle as a model system for the molecular mechanisms by which the lack of Polycystin-2 leads to stimulation of CFTR

Autores: M. Roxo-Rosa, R. Jacinto, P. Sampaio, S. S. Lopes
Publicado en: Biology Open, Edición 4/11, 2015, Página(s) 1356-1366, ISSN 2046-6390
Editor: Company of Biologists Ltd
DOI: 10.1242/bio.014076

Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation

Autores: Quanlong Lu, Christine Insinna, Carolyn Ott, Jimmy Stauffer, Petra A. Pintado, Juliati Rahajeng, Ulrich Baxa, Vijay Walia, Adrian Cuenca, Yoo-Seok Hwang, Ira O. Daar, Susana Lopes, Jennifer Lippincott-Schwartz, Peter K. Jackson, Steve Caplan, Christopher J. Westlake
Publicado en: Nature Cell Biology, Edición 17/3, 2015, Página(s) 228-240, ISSN 1465-7392
Editor: Nature Publishing Group
DOI: 10.1038/ncb3109

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Autores: Daniel J Klionsky, Kotb Abdelmohsen, Akihisa Abe, Md Joynal Abedin, Hagai Abeliovich, Abraham Acevedo Arozena, Hiroaki Adachi, Christopher M Adams, Peter D Adams, Khosrow Adeli, Peter J Adhihetty, Sharon G Adler, Galila Agam, Rajesh Agarwal, Manish K Aghi, Maria Agnello, Patrizia Agostinis, Patricia V Aguilar, Julio Aguirre-Ghiso, Edoardo M Airoldi, Slimane Ait-Si-Ali, Takahiko Akematsu, Emmanuel
Publicado en: Autophagy, Edición 12/1, 2016, Página(s) 1-222, ISSN 1554-8627
Editor: Landes Bioscience
DOI: 10.1080/15548627.2015.1100356

Hippocampal neurogenesis response: What can we expect from two different models of hypertension?

Autores: Daniela Pedroso, Ana R. Nunes, Lucília N. Diogo, Carole Oudot, Emília C. Monteiro, Catherine Brenner, Helena L.A. Vieira
Publicado en: Brain Research, Edición 1646, 2016, Página(s) 199-206, ISSN 0006-8993
Editor: Elsevier BV
DOI: 10.1016/j.brainres.2016.05.044

Carbon monoxide improves neuronal differentiation and yield by increasing the functioning and number of mitochondria

Autores: Ana S. Almeida, Ursula Sonnewald, Paula M. Alves, Helena L.A. Vieira
Publicado en: Journal of Neurochemistry, Edición 138/3, 2016, Página(s) 423-435, ISSN 0022-3042
Editor: Blackwell Publishing Inc.
DOI: 10.1111/jnc.13653

Carbon Monoxide Releasing Molecule-A1 (CORM-A1) Improves Neurogenesis: Increase of Neuronal Differentiation Yield by Preventing Cell Death

Autores: Ana S. Almeida, Nuno L. Soares, Melissa Vieira, Jan Bert Gramsbergen, Helena L. A. Vieira
Publicado en: PLOS ONE, Edición 11/5, 2016, Página(s) e0154781, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0154781

Arl13b and the exocyst interact synergistically in ciliogenesis

Autores: Cecília Seixas, Soo Young Choi, Noemi Polgar, Nicole L. Umberger, Michael P. East, Xiaofeng Zuo, Hugo Moreiras, Rania Ghossoub, Alexandre Benmerah, Richard A. Kahn, Ben Fogelgren, Tamara Caspary, Joshua H. Lipschutz, Duarte C. Barral
Publicado en: Molecular Biology of the Cell, Edición 27/2, 2016, Página(s) 308-320, ISSN 1059-1524
Editor: American Society for Cell Biology
DOI: 10.1091/mbc.E15-02-0061

shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity

Autores: Susana A. Gonçalves, Diana Macedo, Helena Raquel, Pedro D. Simões, Flaviano Giorgini, José S. Ramalho, Duarte C. Barral, Luís Ferreira Moita, Tiago Fleming Outeiro
Publicado en: PLOS Genetics, Edición 12/4, 2016, Página(s) e1005995, ISSN 1553-7390
Editor: Public Library of Science
DOI: 10.1371/journal.pgen.1005995

A Rab3a-dependent complex essential for lysosome positioning and plasma membrane repair

Autores: Marisa Encarnação, Lília Espada, Cristina Escrevente, Denisa Mateus, José Ramalho, Xavier Michelet, Inês Santarino, Victor W. Hsu, Michael B. Brenner, Duarte C. Barral, Otília V. Vieira
Publicado en: The Journal of Cell Biology, Edición 213/6, 2016, Página(s) 631-640, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1083/jcb.201511093

Arf proteins in cancer cell migration

Autores: Cristina Casalou, Alexandra Faustino, Duarte C. Barral
Publicado en: Small GTPases, Edición 7/4, 2016, Página(s) 270-282, ISSN 2154-1248
Editor: Landes Bioscience
DOI: 10.1080/21541248.2016.1228792

Visual Acuity after Retinal Gene Therapy for Choroideremia

Autores: Thomas L. Edwards, Jasleen K. Jolly, Markus Groppe, Alun R. Barnard, Charles L. Cottriall, Tanya Tolmachova, Graeme C. Black, Andrew R. Webster, Andrew J. Lotery, Graham E. Holder, Kanmin Xue, Susan M. Downes, Matthew P. Simunovic, Miguel C. Seabra, Robert E. MacLaren
Publicado en: New England Journal of Medicine, Edición 374/20, 2016, Página(s) 1996-1998, ISSN 0028-4793
Editor: Massachusetts Medical Society
DOI: 10.1056/NEJMc1509501

Sequential and compartmentalized action of Rabs, SNAREs, and MAL in the apical delivery of fusiform vesicles in urothelial umbrella cells

Autores: Bret Wankel, Jiangyong Ouyang, Xuemei Guo, Krassimira Hadjiolova, Jeremy Miller, Yi Liao, Daniel Kai Long Tham, Rok Romih, Leonardo R. Andrade, Iwona Gumper, Jean-Pierre Simon, Rakhee Sachdeva, Tanya Tolmachova, Miguel C. Seabra, Mitsunori Fukuda, Nicole Schaeren-Wiemers, Wan Jin Hong, David D. Sabatini, Xue-Ru Wu, Xiangpeng Kong, Gert Kreibich, Michael J. Rindler, Tung-Tien Sun
Publicado en: Molecular Biology of the Cell, Edición 27/10, 2016, Página(s) 1621-1634, ISSN 1059-1524
Editor: American Society for Cell Biology
DOI: 10.1091/mbc.E15-04-0230

In vitro activity of quaternary ammonium surfactants against streptococcal, chlamydial, and gonococcal infective agents

Autores: Ângela S. Inácio, Alexandra Nunes, Catarina Milho, Luís Jaime Mota, Maria J. Borrego, João P. Gomes, Winchil L. C. Vaz, Otília V. Vieira
Publicado en: Antimicrobial agents and chemotherapy, 2016, ISSN 0066-4804
Editor: American Society for Microbiology

Quaternary ammonium surfactant structure determines selective toxicity towards bacteria: mechanisms of action and clinical implications in antibacterial prophylaxis

Autores: Ângela S. Inácio, Neuza S. Domingues, Alexandra Nunes, Patrícia T. Martins, Maria J. Moreno, Luís M. Estronca, Rui Fernandes, António J. M. Moreno, Maria J. Borrego, João P. Gomes, Winchil L. C. Vaz, Otília V. Vieira
Publicado en: Journal of Antimicrobial Chemotherapy, Edición 71/3, 2016, Página(s) 641-654, ISSN 0305-7453
Editor: Oxford University Press
DOI: 10.1093/jac/dkv405

Presence of Cx43 in extracellular vesicles reduces the cardiotoxicity of the anti-tumour therapeutic approach with doxorubicin

Autores: Tania Martins-Marques, Maria Joao Pinho, Monica Zuzarte, Carla Oliveira, Paulo Pereira, Joost P. G. Sluijter, Celia Gomes, Henrique Girao
Publicado en: Journal of Extracellular Vesicles, Edición 5/1, 2016, Página(s) 32538, ISSN 2001-3078
Editor: Taylor & Francis
DOI: 10.3402/jev.v5.32538

Accelerated age-related olfactory decline among type 1 Usher patients

Autores: João Carlos Ribeiro, Bárbara Oliveiros, Paulo Pereira, Natália António, Thomas Hummel, António Paiva, Eduardo D. Silva
Publicado en: Scientific Reports, Edición 6/1, 2016, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep28309

Three-dimensional flow in Kupffer’s Vesicle

Autores: T. D. Montenegro-Johnson, D. I. Baker, D. J. Smith, S. S. Lopes
Publicado en: Journal of Mathematical Biology, Edición 73/3, 2016, Página(s) 705-725, ISSN 0303-6812
Editor: Springer Verlag
DOI: 10.1007/s00285-016-0967-7

Report of the 4th European Zebrafish Principal Investigator Meeting

Autores: Susana S. Lopes, Martin Distel, Claudia Linker, Rita Fior, Rui Monteiro, Isaac H. Bianco, Ruben Portugues, Uwe Strähle, Leonor Saúde
Publicado en: Zebrafish, Edición 13/6, 2016, Página(s) 590-595, ISSN 1545-8547
Editor: Mary Ann Liebert Inc.
DOI: 10.1089/zeb.2016.1364

Role of Cell Metabolism and Mitochondrial Function During Adult Neurogenesis

Autores: Ana S. Almeida, Helena L. A. Vieira
Publicado en: Neurochemical Research, Edición 42/6, 2017, Página(s) 1787-1794, ISSN 0364-3190
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11064-016-2150-3

Mitochondrion: a common organelle for distinct cell deaths?

Autores: Z. Wang, C. Figueiredo-Pereira, C. Oudot, H.L.A. Vieira, C. Brenner
Publicado en: International review of cell and molecular biology, 2017, ISSN 1937-6448
Editor: Elsevier BV

Carbon monoxide reverses the metabolic adaptation of microglia cells to an inflammatory stimulus

Autores: Jayne Louise Wilson, Frédéric Bouillaud, Ana S. Almeida, Helena L. Vieira, Mohand Ouidir Ouidja, Jean-Luc Dubois-Randé, Roberta Foresti, Roberto Motterlini
Publicado en: Free Radical Biology and Medicine, Edición 104, 2017, Página(s) 311-323, ISSN 0891-5849
Editor: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2017.01.022

Commensal-to-pathogen transition: One-single transposon insertion results in two pathoadaptive traits in Escherichia coli -macrophage interaction

Autores: João T. Proença, Duarte C. Barral, Isabel Gordo
Publicado en: Scientific Reports, Edición 7/1, 2017, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-017-04081-1

Rab27-Dependent Exosome Production Inhibits Chronic Inflammation and Enables Acute Responses to Inflammatory Stimuli

Autores: Margaret Alexander, Andrew G. Ramstead, Kaylyn M. Bauer, Soh-Hyun Lee, Marah C. Runtsch, Jared Wallace, Thomas B. Huffaker, Dane K. Larsen, Tanya Tolmachova, Miguel C. Seabra, June L. Round, Diane M. Ward, Ryan M. O’Connell
Publicado en: The Journal of Immunology, Edición 199/10, 2017, Página(s) 3559-3570, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.1700904

Involvement of the p62/NRF2 signal transduction pathway on erythrophagocytosis

Autores: Inês B. Santarino, Michelle S. Viegas, Neuza S. Domingues, Ana M. Ribeiro, Miguel P. Soares, Otília V. Vieira
Publicado en: Scientific Reports, Edición 7/1, 2017, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-017-05687-1

Maturation of phagosomes containing different erythrophagocytic particles in primary macrophages

Autores: Inês B. Santarino, Otília V. Vieira
Publicado en: FEBS Open Bio, Edición 7/9, 2017, Página(s) 1281-1290, ISSN 2211-5463
Editor: Elsevier BV
DOI: 10.1002/2211-5463.12262

Cholesteryl hemiesters alter lysosome structure and function and induce proinflammatory cytokine production in macrophages

Autores: Neuza Domingues, Luís M.B.B. Estronca, João Silva, Marisa R. Encarnação, Rita Mateus, Diogo Silva, Inês B. Santarino, Margarida Saraiva, Maria I.L. Soares, Teresa M.V.D. Pinho e Melo, António Jacinto, Winchil L.C. Vaz, Otília V. Vieira
Publicado en: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Edición 1862/2, 2017, Página(s) 210-220, ISSN 1388-1981
Editor: Elsevier BV
DOI: 10.1016/j.bbalip.2016.10.009

Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis

Autores: Teresa M. Ribeiro-Rodrigues, Tiago L. Laundos, Rita Pereira-Carvalho, Daniela Batista-Almeida, Ricardo Pereira, Vanessa Coelho-Santos, Ana P. Silva, Rosa Fernandes, Monica Zuzarte, Francisco J. Enguita, Marina C. Costa, Perpetua Pinto-do-Ó, Marta T. Pinto, Pedro Gouveia, Lino Ferreira, Justin C. Mason, Paulo Pereira, Brenda R. Kwak, Diana S. Nascimento, Henrique Girão
Publicado en: Cardiovascular Research, Edición 113/11, 2017, Página(s) 1338-1350, ISSN 0008-6363
Editor: Elsevier BV
DOI: 10.1093/cvr/cvx118

Molecular control of chaperone-mediated autophagy

Autores: Steve Catarino, Paulo Pereira, Henrique Girão
Publicado en: Essays In Biochemistry, Edición 61/6, 2017, Página(s) 663-674, ISSN 0071-1365
Editor: Portland Press, Ltd.
DOI: 10.1042/EBC20170057

Hyperglycemia-induced degradation of HIF-1α contributes to impaired response of cardiomyocytes to hypoxia

Autores: Ana Rita Ramalho, Adriana Toscano, Paulo Pereira, Henrique Girão, Lino Gonçalves, Carla Marques
Publicado en: Revista Portuguesa de Cardiologia, Edición 36/5, 2017, Página(s) 367-373, ISSN 0870-2551
Editor: Sociedade Portuguesa De Cardiologia
DOI: 10.1016/j.repc.2016.09.018

Elucidation of the dynamic nature of interactome networks: A practical tutorial

Autores: Sandra I. Anjo, Tania Martins-Marques, Paulo Pereira, Henrique Girão, Bruno Manadas
Publicado en: Journal of Proteomics, Edición 171, 2018, Página(s) 116-126, ISSN 1874-3919
Editor: Elsevier BV
DOI: 10.1016/j.jprot.2017.04.011

Bin1 and CD2AP polarise the endocytic generation of beta‐amyloid

Autores: Florent Ubelmann, Tatiana Burrinha, Laura Salavessa, Ricardo Gomes, Cláudio Ferreira, Nuno Moreno, Cláudia Guimas Almeida
Publicado en: EMBO reports, Edición 18/1, 2017, Página(s) 102-122, ISSN 1469-221X
Editor: Nature Publishing Group
DOI: 10.15252/embr.201642738

A Novel Protocol to Quantitatively Measure the Endocytic Trafficking of Amyloid Precursor Protein (APP) in Polarized Primary Neurons with Sub-cellular Resolution

Autores: Florent Ubelmann, Tatiana Burrinha, Cláudia Guimas Almeida
Publicado en: BIO-PROTOCOL, Edición 7/23, 2017, ISSN 2331-8325
Editor: Bio-protocol LLC
DOI: 10.21769/BioProtoc.2629

Measuring the Endocytic Recycling of Amyloid Precursor Protein (APP) in Neuro2a Cells

Autores: Florent Ubelmann, Tatiana Burrinha, Cláudia Guimas Almeida
Publicado en: BIO-PROTOCOL, Edición 7/23, 2017, ISSN 2331-8325
Editor: Bio-protocol LLC
DOI: 10.21769/BioProtoc.2635

Usefulness of zebrafish larvae to evaluate drug-induced functional and morphological renal tubular alterations

Autores: Rita Gorgulho, Raquel Jacinto, Susana S. Lopes, Sofia A. Pereira, Erin M. Tranfield, Gabriel G. Martins, Emilio J. Gualda, Rico J. E. Derks, Ana C. Correia, Evelyne Steenvoorden, Petra Pintado, Oleg A. Mayboroda, Emilia C. Monteiro, Judit Morello
Publicado en: Archives of Toxicology, Edición 92/1, 2018, Página(s) 411-423, ISSN 0340-5761
Editor: Springer Verlag
DOI: 10.1007/s00204-017-2063-1

Notch/Her12 signalling modulates, motile/immotile cilia ratio downstream of Foxj1a in zebrafish left-right organizer

Autores: Barbara Tavares, Raquel Jacinto, Pedro Sampaio, Sara Pestana, Andreia Pinto, Andreia Vaz, Mónica Roxo-Rosa, Rui Gardner, Telma Lopes, Britta Schilling, Ian Henry, Leonor Saúde, Susana Santos Lopes
Publicado en: eLife, Edición 6, 2017, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/eLife.25165

Dynamics of cilia length in left–right development

Autores: P. Pintado, P. Sampaio, B. Tavares, T. D. Montenegro-Johnson, D. J. Smith, S. S. Lopes
Publicado en: Royal Society Open Science, Edición 4/3, 2017, Página(s) 161102, ISSN 2054-5703
Editor: Royal Society Publishing
DOI: 10.1098/rsos.161102

Pure Polyphenols Applications for Cardiac Health and Disease

Autores: Claudia N. Santos, Andreia Gomes, Carole Oudot, Daniela Dias-Pedroso, Ana Rodriguez-Mateos, Helena L.A. Vieira, Catherine Brenner
Publicado en: Current Pharmaceutical Design, Edición 24/19, 2018, Página(s) 2137-2156, ISSN 1381-6128
Editor: Bentham Science Publishers
DOI: 10.2174/1381612824666180608102344

Intermittent, low dose carbon monoxide exposure enhances survival and dopaminergic differentiation of human neural stem cells

Autores: Nanna Dreyer-Andersen, Ana Sofia Almeida, Pia Jensen, Morad Kamand, Justyna Okarmus, Tine Rosenberg, Stig Düring Friis, Alberto Martínez Serrano, Morten Blaabjerg, Bjarne Winther Kristensen, Troels Skrydstrup, Jan Bert Gramsbergen, Helena L. A. Vieira, Morten Meyer
Publicado en: PLOS ONE, Edición 13/1, 2018, Página(s) e0191207, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0191207

Improvement of neuronal differentiation by carbon monoxide: Role of pentose phosphate pathway

Autores: Ana S. Almeida, Nuno L. Soares, Catarina O. Sequeira, Sofia A. Pereira, Ursula Sonnewald, Helena L.A. Vieira
Publicado en: Redox Biology, Edición 17, 2018, Página(s) 338-347, ISSN 2213-2317
Editor: Elsevier BV
DOI: 10.1016/j.redox.2018.05.004

P2X7 Receptors Mediate CO-Induced Alterations in Gene Expression in Cultured Cortical Astrocytes—Transcriptomic Study

Autores: Sara R. Oliveira, Cláudia Figueiredo-Pereira, Carlos B. Duarte, Helena L. A. Vieira
Publicado en: Molecular Neurobiology, 2018, ISSN 0893-7648
Editor: Humana Press, Inc.
DOI: 10.1007/s12035-018-1302-7

Phenolic Metabolites Modulate Cardiomyocyte Beating in Response to Isoproterenol

Autores: Daniela Dias-Pedroso, Joel Guerra, Andreia Gomes, Carole Oudot, Catherine Brenner, Cláudia N. Santos, Helena L. A. Vieira
Publicado en: Cardiovascular Toxicology, 2018, ISSN 1530-7905
Editor: Humana Press, Inc.
DOI: 10.1007/s12012-018-9485-8

Melanin Transferred to Keratinocytes Resides in Nondegradative Endocytic Compartments

Autores: Maria S. Correia, Hugo Moreiras, Francisco J.C. Pereira, Matilde V. Neto, Tiago C. Festas, Abul K. Tarafder, José S. Ramalho, Miguel C. Seabra, Duarte C. Barral
Publicado en: Journal of Investigative Dermatology, Edición 138/3, 2018, Página(s) 637-646, ISSN 0022-202X
Editor: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2017.09.042

Rab GTPase regulation of bacteria and protozoa phagocytosis occurs through the modulation of phagocytic receptor surface expression

Autores: Elsa Seixas, Cristina Escrevente, Miguel C. Seabra, Duarte C. Barral
Publicado en: Scientific Reports, Edición 8/1, 2018, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-31171-5

Beneficial effects on vision in patients undergoing retinal gene therapy for choroideremia

Autores: Kanmin Xue, Jasleen K Jolly, Alun R. Barnard, Anna Rudenko, Anna P. Salvetti, Maria I. Patrício, Thomas L. Edwards, Markus Groppe, Harry O. Orlans, Tanya Tolmachova, Graeme C. Black, Andrew R. Webster, Andrew J. Lotery, Graham E. Holder, Susan M. Downes, Miguel C. Seabra, Robert E. MacLaren
Publicado en: Nature Medicine, Edición 24/10, 2018, Página(s) 1507-1512, ISSN 1078-8956
Editor: Nature Publishing Group
DOI: 10.1038/s41591-018-0185-5

Two-Year Results After AAV2-Mediated Gene Therapy for Choroideremia: The Alberta Experience

Autores: Ioannis S. Dimopoulos, Stephanie C. Hoang, Alina Radziwon, Natalia M. Binczyk, Miguel C. Seabra, Robert E. MacLaren, Rizwan Somani, Matthew T.S. Tennant, Ian M. MacDonald
Publicado en: American Journal of Ophthalmology, Edición 193, 2018, Página(s) 130-142, ISSN 0002-9394
Editor: Elsevier BV
DOI: 10.1016/j.ajo.2018.06.011

Rab3a and Rab10 are regulators of lysosome exocytosis and plasma membrane repair

Autores: Otilia V. Vieira
Publicado en: Small GTPases, Edición 9/4, 2016, Página(s) 349-351, ISSN 2154-1248
Editor: Landes Bioscience
DOI: 10.1080/21541248.2016.1235004

Lipid and Non-lipid Factors Affecting Macrophage Dysfunction and Inflammation in Atherosclerosis

Autores: Mark S. Gibson, Neuza Domingues, Otilia V. Vieira
Publicado en: Frontiers in Physiology, Edición 9, 2018, ISSN 1664-042X
Editor: Frontiers Research Foundation
DOI: 10.3389/fphys.2018.00654

Cholesterol is Inefficiently Converted to Cholesteryl Esters in the Blood of Cardiovascular Disease Patients

Autores: Mathias J. Gerl, Winchil L. C. Vaz, Neuza Domingues, Christian Klose, Michal A. Surma, Júlio L. Sampaio, Manuel S. Almeida, Gustavo Rodrigues, Pedro Araújo-Gonçalves, Jorge Ferreira, Claudia Borbinha, João Pedro Marto, Miguel Viana-Baptista, Kai Simons, Otilia V. Vieira
Publicado en: Scientific Reports, Edición 8/1, 2018, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-33116-4

MicroRNA-424(322) as a new marker of disease progression in pulmonary arterial hypertension and its role in right ventricular hypertrophy by targeting SMURF1

Autores: Rui Baptista, Carla Marques, Steve Catarino, Francisco J Enguita, Marina C Costa, Paulo Matafome, Mónica Zuzarte, Graça Castro, Abílio Reis, Pedro Monteiro, Mariano Pêgo, Paulo Pereira, Henrique Girão
Publicado en: Cardiovascular Research, Edición 114/1, 2017, Página(s) 53-64, ISSN 0008-6363
Editor: Elsevier BV
DOI: 10.1093/cvr/cvx187

The Endolysosomal System and Proteostasis: From Development to Degeneration

Autores: Bettina Winckler, Victor Faundez, Sandra Maday, Qian Cai, Cláudia Guimas Almeida, Huaye Zhang
Publicado en: The Journal of Neuroscience, Edición 38/44, 2018, Página(s) 9364-9374, ISSN 0270-6474
Editor: Society for Neuroscience
DOI: 10.1523/JNEUROSCI.1665-18.2018

Impact of late-onset Alzheimer’s genetic risk factors on beta-amyloid endocytic production

Autores: Cláudia Guimas Almeida, Farzaneh Sadat Mirfakhar, Catarina Perdigão, Tatiana Burrinha
Publicado en: Cellular and Molecular Life Sciences, Edición 75/14, 2018, Página(s) 2577-2589, ISSN 1420-682X
Editor: Birkhauser Verlag
DOI: 10.1007/s00018-018-2825-9

Wall stress enhanced exocytosis of extracellular vesicles as a possible mechanism of left-right symmetry-breaking in vertebrate development

Autores: J. Solowiej-Wedderburn, D.J. Smith, S.S. Lopes, T.D. Montenegro-Johnson
Publicado en: Journal of Theoretical Biology, Edición 460, 2019, Página(s) 220-226, ISSN 0022-5193
Editor: Academic Press
DOI: 10.1016/j.jtbi.2018.10.015

Zebrafish Larvae Are a Suitable Model to Investigate the Metabolic Phenotype of Drug-Induced Renal Tubular Injury

Autores: Judit Morello, Rico J. E. Derks, Susana S. Lopes, Evelyne Steenvoorden, Emilia C. Monteiro, Oleg A. Mayboroda, Sofia A. Pereira
Publicado en: Frontiers in Pharmacology, Edición 9, 2018, ISSN 1663-9812
Editor: Frontiers Media S.A.
DOI: 10.3389/fphar.2018.01193

Crosstalk between cilia and autophagy: implication for human diseases (project related publication after the start date of LYSOCIL project, RP2)

Autores: Manuela Morleo, Helena L A Vieira, Petra Pennekamp, Alessandro Palma, Liliana Bento-Lopes, Heymut Omran, Susana S Lopes, Duarte C Barral, Brunella Franco
Publicado en: Autophagy, Edición 1/20, 2022, ISSN 1554-8627
Editor: Landes Bioscience
DOI: 10.1080/15548627.2022.2067383

Lysosome (dys)function in atherosclerosis – a big weight on the shoulders of a small organelle (project related publication after the start date of LYSOCIL project, RP2)

Autores: André R A Marques, Cristiano Ramos, Gisela Machado-Oliveira, Otília V Vieira
Publicado en: Front Cell Dev Biol, 2021, ISSN 2296-634X
Editor: Frontiers Media S.A.
DOI: 10.3389/fcell.2021.658995

Assessment of Mitochondrial Protein Glutathionylation as Signaling for CO Pathway

Autores: Ana S. Almeida, Helena L. A. Vieira
Publicado en: Mitochondrial Medicine, Edición 1264, 2015, Página(s) 343-350, ISBN 978-1-4939-2256-7
Editor: Springer New York
DOI: 10.1007/978-1-4939-2257-4_30

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