Excel in Rare Diseases’ Research: Focus on LYSOsomal Disorders and CILiopathies

Livrables

D7.8 - LYSOCIL Final conference

Final conference at UNLNMSCEDOC ll the participants and steakholders related to RDs

D7.3 - Communication and promotional materials I

Informative brochures, presentations and movies on RDs

D7.2 - Project website launch and Visual Identity Guide

Creation of our Website with information on RDs and our visual logotype.

D7.6 - e-LYSOCIL RDs Research HUB launch

Website where partners can communicate, share and deposit research outputs for the general public.

D7.4 - Communication and promotional materials II

Informative brochures presentations and movies on RDs

D7.5 - Communication and promotional materials III

Informative brochures presentations and movies on RDs

Publications

SymmetryBreaking Cilia-Driven Flow in Embryogenesis

Auteurs: David J. Smith, Thomas D. Montenegro-Johnson, Susana S. Lopes
Publié dans: Annual Review of Fluid Mechanics, 2018, ISSN 0066-4189
Éditeur: Annual Reviews, Inc.
DOI: 10.1146/annurev-fluid-010518-040231

Pkd2 affects cilia length and impacts left-right flow dynamics and dand5 (project related publication after the start date of LYSOCIL project, RP2)

Auteurs: Raquel Jacinto, Pedro Sampaio, Mónica Roxo-Rosa, Sara Pestana, Susana S Lopes
Publié dans: Front Cell Dev Biol, 2021, ISSN 2296-634X
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fcell.2021.624531

Zebrafish motile cilia as a model for Primary Ciliary Dyskinesia (project related publication after the start date of LYSOCIL project, RP2)

Auteurs: Andreia L Pinto, Margarida Rasteiro, Catarina Bota, Sara Pestana, Pedro Sampaio, Claire Hogg, Thomas Burgoyne, Susana S Lopes
Publié dans: Int J Mol Sci, Numéro 22/16, 2021, ISSN 1661-6596
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22168361

Rab35 controls cilium length, function and membrane composition (project related publication after the start date of LYSOCIL project, RP1)

Auteurs: Stefanie Kuhns, Cecília Seixas, Sara Pestana, Bárbara Tavares, Renata Nogueira, Raquel Jacinto, José S Ramalho, Jeremy C Simpson, Jens S Andersen, Arnaud Echard, Susana S Lopes, Duarte C Barral, Oliver E Blacque
Publié dans: EMBO reports, Numéro 20/10, 2019, ISSN 1469-221X
Éditeur: Nature Publishing Group
DOI: 10.15252/embr.201847625

Rab11 is required for lysosome exocytosis through the interaction with Rab3a, Sec15 and GRAB (project related publication after the start date of LYSOCIL project, RP2)

Auteurs: Cristina Escrevente, Liliana Bento-Lopes, José S Ramalho, Duarte C Barral
Publié dans: J Cell Sci, Numéro 134/11, 2021, ISSN 0021-9533
Éditeur: The Company of Biologists Ltd.
DOI: 10.1242/jcs.246694

Formation of lipofuscin-like autofluorescent granules in the retinal pigment epithelium requires lysosome dysfunction (project related publication after the start date of LYSOCIL project, RP2)

Auteurs: Cristina Escrevente, Ana S Falcão, Michael J Hall, Mafalda Lopes-da-Silva, Pedro Antas, Miguel M Mesquita, Inês S Ferreira, M Helena Cardoso, Daniela Oliveira, Ana C Fradinho, Thomas Ciossek, Paul Nicklin, Clare E Futter, Sandra Tenreiro, Miguel C Seabra
Publié dans: Invest Ophthalmol Vis Sci, Numéro 62/9, 2021, ISSN 0146-0404
Éditeur: Association for Research in Vision and Ophthalmology
DOI: 10.1167/iovs.62.9.39

Melanocore uptake by keratinocytes occurs through phagocytosis and involves protease-activated receptor-2 internalization (project related publication after the start date of LYSOCIL project, RP2)

Auteurs: Hugo Moreiras ,Liliana Bento-Lopes, Matilde V. Neto, Cristina Escrevente, Luís C. Cabaço, Michael J. Hall, José S. Ramalho, Miguel C. Seabra, Duarte C. Barral
Publié dans: Traffic, Numéro 6, 2022, ISSN 1398-9219
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/tra.12843

Current methods to analyze lysosome morphology, positioning, motility and function (project related publication after the start date of LYSOCIL project, RP2)

Auteurs: Duarte C Barral, Leopoldo Staiano, Cláudia Guimas Almeida, Dan F Cutler, Emily R Eden, Clare E Futter, Antony Galione, André R A Marques, Diego Luis Medina, Gennaro Napolitano, Carmine Settembre, Otília V Vieira, Johannes M F G Aerts, Peace Atakpa-Adaji, Gemma Bruno, Antonella Capuozzo, Elvira De Leonibus, Chiara Di Malta, Cristina Escrevente, Alessandra Esposito, Paolo Grumati, Michael J Hall,
Publié dans: Traffic, Numéro 5, 2022, ISSN 1398-9219
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/tra.12839

Zebrafish model as a screen to prevent cyst inflation in Autosomal Dominant Polycystic Kidney Disease (project related publication after the start date of LYSOCIL project, RP2)

Auteurs: Inês Oliveira, Raquel Jacinto, Sara Pestana, Fernando Nolasco, Joaquim Calado, Susana Santos Lopes, Mónica Roxo-Rosa
Publié dans: Int J Mol Sci, Numéro 22/16, 2021, ISSN 1661-6596
Éditeur: MDPI
DOI: 10.3390/ijms22169013

Carbon monoxide and mitochondria – modulation of cell metabolism, redox response and cell death

Auteurs: Ana S. Almeida, Cláudia Figueiredo-Pereira, Helena L. A. Vieira
Publié dans: Frontiers in Physiology, Numéro 6, 2015, ISSN 1664-042X
Éditeur: Frontiers Research Foundation

Carbon monoxide and the CNS: challenges and achievements

Auteurs: Cláudia S F Queiroga, Alessandro Vercelli, Helena L A Vieira
Publié dans: British Journal of Pharmacology, Numéro 172/6, 2015, Page(s) 1533-1545, ISSN 0007-1188
Éditeur: Wiley-Blackwell
DOI: 10.1111/bph.12729

New method to assess mitophagy flux by flow cytometry

Auteurs: Marta Mauro-Lizcano, Lorena Esteban-Martínez, Esther Seco, Ana Serrano-Puebla, Lucia Garcia-Ledo, Cláudia Figueiredo-Pereira, Helena L A Vieira, Patricia Boya
Publié dans: Autophagy, Numéro 11/5, 2015, Page(s) 833-843, ISSN 1554-8627
Éditeur: Landes Bioscience
DOI: 10.1080/15548627.2015.1034403

Rod disc renewal occurs by evagination of the ciliary plasma membrane that makes cadherin-based contacts with the inner segment

Auteurs: Thomas Burgoyne, Ingrid P. Meschede, Jemima J. Burden, Maryse Bailly, Miguel C. Seabra, Clare E. Futter
Publié dans: Proceedings of the National Academy of Sciences, Numéro 112/52, 2015, Page(s) 15922-15927, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.1509285113

Effect of carbon monoxide on gene expression in cerebrocortical astrocytes: Validation of reference genes for quantitative real-time PCR

Auteurs: Sara R. Oliveira, Helena L.A. Vieira, Carlos B. Duarte
Publié dans: Nitric Oxide, Numéro 49, 2015, Page(s) 80-89, ISSN 1089-8603
Éditeur: Academic Press
DOI: 10.1016/j.niox.2015.07.003

Mitochondria and carbon monoxide: cytoprotection and control of cell metabolism - a role for Ca2+?

Auteurs: Sara R. Oliveira, Cláudia S. F. Queiroga, Helena L. A. Vieira
Publié dans: The Journal of Physiology, 2015, ISSN 0022-3751
Éditeur: Blackwell Publishing Inc.

Host cell autophagy contributes to Plasmodium liver development

Auteurs: Carolina Thieleke‐Matos, Mafalda Lopes da Silva, Laura Cabrita‐Santos, Martim D. Portal, Inês P. Rodrigues, Vanessa Zuzarte‐Luis, José S. Ramalho, Clare E. Futter, Maria M. Mota, Duarte C. Barral, Miguel C. Seabra
Publié dans: Cellular Microbiology, 2015, ISSN 1462-5814
Éditeur: Blackwell Publishing Inc.

Photoreceptor phagosome processing defects and disturbed autophagy in retinal pigment epithelium of Cln3Δex1-6 mice modelling juvenile neuronal ceroid lipofuscinosis (Batten disease).

Auteurs: Silène T. Wavre-Shapton, Alessandra A. Calvi, Mark Turmaine, Miguel C. Seabra, Daniel F. Cutler, Clare E. Futter, Hannah M. Mitchison
Publié dans: Human Molecular Genetics, 2015, ISSN 0964-6906
Éditeur: Oxford University Press

Rab27a GTPase modulates L-type Ca(2+) channel function via interaction with the II-III linker of CaV1.3 subunit.

Auteurs: Nadine Reichhart, Magdalena Markowski, Shimpei Ishiyama, Andrea Wagner, Sergio Crespo-Garcia, Talitha Schorb, José S. Ramalho, Vladimir M. Milenkovic, Renate Föckler, Miguel C. Seabra, Olaf Strauß
Publié dans: Cellular Signalling, 2015, ISSN 0898-6568
Éditeur: Elsevier BV

Exosome-delivered microRNAs modulate the inflammatory response to endotoxin

Auteurs: Margaret Alexander, Ruozhen Hu, Marah C. Runtsch, Dominique A. Kagele, Timothy L. Mosbruger, Tanya Tolmachova, Miguel C. Seabra, June L. Round, Diane M. Ward, Ryan M. O’Connell
Publié dans: Nature Communications, Numéro 6/1, 2015, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/ncomms8321

Impact of the serum- and glucocorticoid-inducible kinase 1 on platelet dense granule biogenesis and secretion

Auteurs: B. Walker, E. Schmid, A. Russo, E.-M. Schmidt, O. Burk, P. Münzer, A. Velic, B. Macek, M. Schaller, M. Schwab, M. C. Seabra, M. Gawaz, F. Lang, O. Borst
Publié dans: Journal of Thrombosis and Haemostasis, Numéro 13/7, 2015, Page(s) 1325-1334, ISSN 1538-7933
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/jth.12998

Regulation of melanosome number, shape and movement in the zebrafish retinal pigment epithelium by OA1 and PMEL

Auteurs: T. Burgoyne, M. N. O'Connor, M. C. Seabra, D. F. Cutler, C. E. Futter
Publié dans: Journal of Cell Science, Numéro 128/7, 2015, Page(s) 1400-1407, ISSN 0021-9533
Éditeur: The Company of Biologists Ltd.
DOI: 10.1242/jcs.164400

Overexpression of BDNF and Full-Length TrkB Receptor Ameliorate Striatal Neural Survival in Huntington's Disease

Auteurs: Ana Silva, Luana Naia, Alejandro Dominguez, Márcio Ribeiro, Joana Rodrigues, Otília V. Vieira, Volkmar Lessmann, Ana Cristina Rego
Publié dans: Neurodegenerative Diseases, Numéro 15/4, 2015, Page(s) 207-218, ISSN 1660-2854
Éditeur: S. Karger AG
DOI: 10.1159/000375447

Ischaemia-induced autophagy leads to degradation of gap junction protein connexin43 in cardiomyocytes

Auteurs: Tania Martins-Marques, Steve Catarino, Monica Zuzarte, Carla Marques, Paulo Matafome, Paulo Pereira, Henrique Girão
Publié dans: Biochemical Journal, Numéro 467/2, 2015, Page(s) 231-245, ISSN 0264-6021
Éditeur: Portland Press, Ltd.
DOI: 10.1042/BJ20141370

K63 linked ubiquitin chain formation is a signal for HIF1A degradation by Chaperone-Mediated Autophagy

Auteurs: Joao Vasco Ferreira, Ana Rosa Soares, Jose Silva Ramalho, Paulo Pereira, Henrique Girao
Publié dans: Scientific Reports, Numéro 5/1, 2015, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/srep10210

Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells

Auteurs: Ana Rosa Soares, Tania Martins-Marques, Teresa Ribeiro-Rodrigues, Joao Vasco Ferreira, Steve Catarino, Maria João Pinho, Monica Zuzarte, Sandra Isabel Anjo, Bruno Manadas, Joost P.G. Sluijter, Paulo Pereira, Henrique Girao
Publié dans: Scientific Reports, Numéro 5/1, 2015, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/srep13243

Interacting Network of the Gap Junction (GJ) Protein Connexin43 (Cx43) is Modulated by Ischemia and Reperfusion in the Heart

Auteurs: Tania Martins-Marques, Sandra Isabel Anjo, Paulo Pereira, Bruno Manadas, Henrique Girão
Publié dans: Molecular & Cellular Proteomics, Numéro 14/11, 2015, Page(s) 3040-3055, ISSN 1535-9476
Éditeur: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/mcp.M115.052894

Heart ischemia results in connexin43 ubiquitination localized at the intercalated discs

Auteurs: Tânia Martins-Marques, Steve Catarino, Carla Marques, Paulo Matafome, Teresa Ribeiro-Rodrigues, Rui Baptista, Paulo Pereira, Henrique Girão
Publié dans: Biochimie, Numéro 112, 2015, Page(s) 196-201, ISSN 0300-9084
Éditeur: Elsevier BV
DOI: 10.1016/j.biochi.2015.02.020

Connexin 43 ubiquitination determines the fate of gap junctions: restrict to survive

Auteurs: Teresa M. Ribeiro-Rodrigues, Steve Catarino, Maria J. Pinho, Paulo Pereira, Henrique Girao
Publié dans: Biochemical Society transactions, 2015, ISSN 0300-5127
Éditeur: Portland Press, Ltd.

To beat or not to beat: degradation of Cx43 imposes the heart rhythm

Auteurs: Tânia Martins-Marques, Steve Catarino, Carla Marques, Paulo Pereira, Henrique Girão
Publié dans: Biochemical Society transactions, 2015, ISSN 0300-5127
Éditeur: Portland Press, Ltd.

Autophagy and Ubiquitination in Cardiovascular Diseases

Auteurs: Tania Martins-Marques, Teresa Ribeiro-Rodrigues, Paulo Pereira, Patrice Codogno, Henrique Girao
Publié dans: DNA and Cell Biology, Numéro 34/4, 2015, Page(s) 243-251, ISSN 1044-5498
Éditeur: Mary Ann Liebert Inc.
DOI: 10.1089/dna.2014.2765

The zebrafish Kupffer's vesicle as a model system for the molecular mechanisms by which the lack of Polycystin-2 leads to stimulation of CFTR

Auteurs: M. Roxo-Rosa, R. Jacinto, P. Sampaio, S. S. Lopes
Publié dans: Biology Open, Numéro 4/11, 2015, Page(s) 1356-1366, ISSN 2046-6390
Éditeur: Company of Biologists Ltd
DOI: 10.1242/bio.014076

Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation

Auteurs: Quanlong Lu, Christine Insinna, Carolyn Ott, Jimmy Stauffer, Petra A. Pintado, Juliati Rahajeng, Ulrich Baxa, Vijay Walia, Adrian Cuenca, Yoo-Seok Hwang, Ira O. Daar, Susana Lopes, Jennifer Lippincott-Schwartz, Peter K. Jackson, Steve Caplan, Christopher J. Westlake
Publié dans: Nature Cell Biology, Numéro 17/3, 2015, Page(s) 228-240, ISSN 1465-7392
Éditeur: Nature Publishing Group
DOI: 10.1038/ncb3109

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Auteurs: Daniel J Klionsky, Kotb Abdelmohsen, Akihisa Abe, Md Joynal Abedin, Hagai Abeliovich, Abraham Acevedo Arozena, Hiroaki Adachi, Christopher M Adams, Peter D Adams, Khosrow Adeli, Peter J Adhihetty, Sharon G Adler, Galila Agam, Rajesh Agarwal, Manish K Aghi, Maria Agnello, Patrizia Agostinis, Patricia V Aguilar, Julio Aguirre-Ghiso, Edoardo M Airoldi, Slimane Ait-Si-Ali, Takahiko Akematsu, Emmanuel
Publié dans: Autophagy, Numéro 12/1, 2016, Page(s) 1-222, ISSN 1554-8627
Éditeur: Landes Bioscience
DOI: 10.1080/15548627.2015.1100356

Hippocampal neurogenesis response: What can we expect from two different models of hypertension?

Auteurs: Daniela Pedroso, Ana R. Nunes, Lucília N. Diogo, Carole Oudot, Emília C. Monteiro, Catherine Brenner, Helena L.A. Vieira
Publié dans: Brain Research, Numéro 1646, 2016, Page(s) 199-206, ISSN 0006-8993
Éditeur: Elsevier BV
DOI: 10.1016/j.brainres.2016.05.044

Carbon monoxide improves neuronal differentiation and yield by increasing the functioning and number of mitochondria

Auteurs: Ana S. Almeida, Ursula Sonnewald, Paula M. Alves, Helena L.A. Vieira
Publié dans: Journal of Neurochemistry, Numéro 138/3, 2016, Page(s) 423-435, ISSN 0022-3042
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/jnc.13653

Carbon Monoxide Releasing Molecule-A1 (CORM-A1) Improves Neurogenesis: Increase of Neuronal Differentiation Yield by Preventing Cell Death

Auteurs: Ana S. Almeida, Nuno L. Soares, Melissa Vieira, Jan Bert Gramsbergen, Helena L. A. Vieira
Publié dans: PLOS ONE, Numéro 11/5, 2016, Page(s) e0154781, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0154781

Arl13b and the exocyst interact synergistically in ciliogenesis

Auteurs: Cecília Seixas, Soo Young Choi, Noemi Polgar, Nicole L. Umberger, Michael P. East, Xiaofeng Zuo, Hugo Moreiras, Rania Ghossoub, Alexandre Benmerah, Richard A. Kahn, Ben Fogelgren, Tamara Caspary, Joshua H. Lipschutz, Duarte C. Barral
Publié dans: Molecular Biology of the Cell, Numéro 27/2, 2016, Page(s) 308-320, ISSN 1059-1524
Éditeur: American Society for Cell Biology
DOI: 10.1091/mbc.E15-02-0061

shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity

Auteurs: Susana A. Gonçalves, Diana Macedo, Helena Raquel, Pedro D. Simões, Flaviano Giorgini, José S. Ramalho, Duarte C. Barral, Luís Ferreira Moita, Tiago Fleming Outeiro
Publié dans: PLOS Genetics, Numéro 12/4, 2016, Page(s) e1005995, ISSN 1553-7390
Éditeur: Public Library of Science
DOI: 10.1371/journal.pgen.1005995

A Rab3a-dependent complex essential for lysosome positioning and plasma membrane repair

Auteurs: Marisa Encarnação, Lília Espada, Cristina Escrevente, Denisa Mateus, José Ramalho, Xavier Michelet, Inês Santarino, Victor W. Hsu, Michael B. Brenner, Duarte C. Barral, Otília V. Vieira
Publié dans: The Journal of Cell Biology, Numéro 213/6, 2016, Page(s) 631-640, ISSN 0021-9525
Éditeur: Rockefeller University Press
DOI: 10.1083/jcb.201511093

Arf proteins in cancer cell migration

Auteurs: Cristina Casalou, Alexandra Faustino, Duarte C. Barral
Publié dans: Small GTPases, Numéro 7/4, 2016, Page(s) 270-282, ISSN 2154-1248
Éditeur: Landes Bioscience
DOI: 10.1080/21541248.2016.1228792

Visual Acuity after Retinal Gene Therapy for Choroideremia

Auteurs: Thomas L. Edwards, Jasleen K. Jolly, Markus Groppe, Alun R. Barnard, Charles L. Cottriall, Tanya Tolmachova, Graeme C. Black, Andrew R. Webster, Andrew J. Lotery, Graham E. Holder, Kanmin Xue, Susan M. Downes, Matthew P. Simunovic, Miguel C. Seabra, Robert E. MacLaren
Publié dans: New England Journal of Medicine, Numéro 374/20, 2016, Page(s) 1996-1998, ISSN 0028-4793
Éditeur: Massachusetts Medical Society
DOI: 10.1056/NEJMc1509501

Sequential and compartmentalized action of Rabs, SNAREs, and MAL in the apical delivery of fusiform vesicles in urothelial umbrella cells

Auteurs: Bret Wankel, Jiangyong Ouyang, Xuemei Guo, Krassimira Hadjiolova, Jeremy Miller, Yi Liao, Daniel Kai Long Tham, Rok Romih, Leonardo R. Andrade, Iwona Gumper, Jean-Pierre Simon, Rakhee Sachdeva, Tanya Tolmachova, Miguel C. Seabra, Mitsunori Fukuda, Nicole Schaeren-Wiemers, Wan Jin Hong, David D. Sabatini, Xue-Ru Wu, Xiangpeng Kong, Gert Kreibich, Michael J. Rindler, Tung-Tien Sun
Publié dans: Molecular Biology of the Cell, Numéro 27/10, 2016, Page(s) 1621-1634, ISSN 1059-1524
Éditeur: American Society for Cell Biology
DOI: 10.1091/mbc.E15-04-0230

In vitro activity of quaternary ammonium surfactants against streptococcal, chlamydial, and gonococcal infective agents

Auteurs: Ângela S. Inácio, Alexandra Nunes, Catarina Milho, Luís Jaime Mota, Maria J. Borrego, João P. Gomes, Winchil L. C. Vaz, Otília V. Vieira
Publié dans: Antimicrobial agents and chemotherapy, 2016, ISSN 0066-4804
Éditeur: American Society for Microbiology

Quaternary ammonium surfactant structure determines selective toxicity towards bacteria: mechanisms of action and clinical implications in antibacterial prophylaxis

Auteurs: Ângela S. Inácio, Neuza S. Domingues, Alexandra Nunes, Patrícia T. Martins, Maria J. Moreno, Luís M. Estronca, Rui Fernandes, António J. M. Moreno, Maria J. Borrego, João P. Gomes, Winchil L. C. Vaz, Otília V. Vieira
Publié dans: Journal of Antimicrobial Chemotherapy, Numéro 71/3, 2016, Page(s) 641-654, ISSN 0305-7453
Éditeur: Oxford University Press
DOI: 10.1093/jac/dkv405

Presence of Cx43 in extracellular vesicles reduces the cardiotoxicity of the anti-tumour therapeutic approach with doxorubicin

Auteurs: Tania Martins-Marques, Maria Joao Pinho, Monica Zuzarte, Carla Oliveira, Paulo Pereira, Joost P. G. Sluijter, Celia Gomes, Henrique Girao
Publié dans: Journal of Extracellular Vesicles, Numéro 5/1, 2016, Page(s) 32538, ISSN 2001-3078
Éditeur: Taylor & Francis
DOI: 10.3402/jev.v5.32538

Accelerated age-related olfactory decline among type 1 Usher patients

Auteurs: João Carlos Ribeiro, Bárbara Oliveiros, Paulo Pereira, Natália António, Thomas Hummel, António Paiva, Eduardo D. Silva
Publié dans: Scientific Reports, Numéro 6/1, 2016, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/srep28309

Three-dimensional flow in Kupffer’s Vesicle

Auteurs: T. D. Montenegro-Johnson, D. I. Baker, D. J. Smith, S. S. Lopes
Publié dans: Journal of Mathematical Biology, Numéro 73/3, 2016, Page(s) 705-725, ISSN 0303-6812
Éditeur: Springer Verlag
DOI: 10.1007/s00285-016-0967-7

Report of the 4th European Zebrafish Principal Investigator Meeting

Auteurs: Susana S. Lopes, Martin Distel, Claudia Linker, Rita Fior, Rui Monteiro, Isaac H. Bianco, Ruben Portugues, Uwe Strähle, Leonor Saúde
Publié dans: Zebrafish, Numéro 13/6, 2016, Page(s) 590-595, ISSN 1545-8547
Éditeur: Mary Ann Liebert Inc.
DOI: 10.1089/zeb.2016.1364

Role of Cell Metabolism and Mitochondrial Function During Adult Neurogenesis

Auteurs: Ana S. Almeida, Helena L. A. Vieira
Publié dans: Neurochemical Research, Numéro 42/6, 2017, Page(s) 1787-1794, ISSN 0364-3190
Éditeur: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11064-016-2150-3

Mitochondrion: a common organelle for distinct cell deaths?

Auteurs: Z. Wang, C. Figueiredo-Pereira, C. Oudot, H.L.A. Vieira, C. Brenner
Publié dans: International review of cell and molecular biology, 2017, ISSN 1937-6448
Éditeur: Elsevier BV

Carbon monoxide reverses the metabolic adaptation of microglia cells to an inflammatory stimulus

Auteurs: Jayne Louise Wilson, Frédéric Bouillaud, Ana S. Almeida, Helena L. Vieira, Mohand Ouidir Ouidja, Jean-Luc Dubois-Randé, Roberta Foresti, Roberto Motterlini
Publié dans: Free Radical Biology and Medicine, Numéro 104, 2017, Page(s) 311-323, ISSN 0891-5849
Éditeur: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2017.01.022

Commensal-to-pathogen transition: One-single transposon insertion results in two pathoadaptive traits in Escherichia coli -macrophage interaction

Auteurs: João T. Proença, Duarte C. Barral, Isabel Gordo
Publié dans: Scientific Reports, Numéro 7/1, 2017, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-017-04081-1

Rab27-Dependent Exosome Production Inhibits Chronic Inflammation and Enables Acute Responses to Inflammatory Stimuli

Auteurs: Margaret Alexander, Andrew G. Ramstead, Kaylyn M. Bauer, Soh-Hyun Lee, Marah C. Runtsch, Jared Wallace, Thomas B. Huffaker, Dane K. Larsen, Tanya Tolmachova, Miguel C. Seabra, June L. Round, Diane M. Ward, Ryan M. O’Connell
Publié dans: The Journal of Immunology, Numéro 199/10, 2017, Page(s) 3559-3570, ISSN 0022-1767
Éditeur: American Association of Immunologists
DOI: 10.4049/jimmunol.1700904

Involvement of the p62/NRF2 signal transduction pathway on erythrophagocytosis

Auteurs: Inês B. Santarino, Michelle S. Viegas, Neuza S. Domingues, Ana M. Ribeiro, Miguel P. Soares, Otília V. Vieira
Publié dans: Scientific Reports, Numéro 7/1, 2017, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-017-05687-1

Maturation of phagosomes containing different erythrophagocytic particles in primary macrophages

Auteurs: Inês B. Santarino, Otília V. Vieira
Publié dans: FEBS Open Bio, Numéro 7/9, 2017, Page(s) 1281-1290, ISSN 2211-5463
Éditeur: Elsevier BV
DOI: 10.1002/2211-5463.12262

Cholesteryl hemiesters alter lysosome structure and function and induce proinflammatory cytokine production in macrophages

Auteurs: Neuza Domingues, Luís M.B.B. Estronca, João Silva, Marisa R. Encarnação, Rita Mateus, Diogo Silva, Inês B. Santarino, Margarida Saraiva, Maria I.L. Soares, Teresa M.V.D. Pinho e Melo, António Jacinto, Winchil L.C. Vaz, Otília V. Vieira
Publié dans: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Numéro 1862/2, 2017, Page(s) 210-220, ISSN 1388-1981
Éditeur: Elsevier BV
DOI: 10.1016/j.bbalip.2016.10.009

Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis

Auteurs: Teresa M. Ribeiro-Rodrigues, Tiago L. Laundos, Rita Pereira-Carvalho, Daniela Batista-Almeida, Ricardo Pereira, Vanessa Coelho-Santos, Ana P. Silva, Rosa Fernandes, Monica Zuzarte, Francisco J. Enguita, Marina C. Costa, Perpetua Pinto-do-Ó, Marta T. Pinto, Pedro Gouveia, Lino Ferreira, Justin C. Mason, Paulo Pereira, Brenda R. Kwak, Diana S. Nascimento, Henrique Girão
Publié dans: Cardiovascular Research, Numéro 113/11, 2017, Page(s) 1338-1350, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvx118

Molecular control of chaperone-mediated autophagy

Auteurs: Steve Catarino, Paulo Pereira, Henrique Girão
Publié dans: Essays In Biochemistry, Numéro 61/6, 2017, Page(s) 663-674, ISSN 0071-1365
Éditeur: Portland Press, Ltd.
DOI: 10.1042/EBC20170057

Hyperglycemia-induced degradation of HIF-1α contributes to impaired response of cardiomyocytes to hypoxia

Auteurs: Ana Rita Ramalho, Adriana Toscano, Paulo Pereira, Henrique Girão, Lino Gonçalves, Carla Marques
Publié dans: Revista Portuguesa de Cardiologia, Numéro 36/5, 2017, Page(s) 367-373, ISSN 0870-2551
Éditeur: Sociedade Portuguesa De Cardiologia
DOI: 10.1016/j.repc.2016.09.018

Elucidation of the dynamic nature of interactome networks: A practical tutorial

Auteurs: Sandra I. Anjo, Tania Martins-Marques, Paulo Pereira, Henrique Girão, Bruno Manadas
Publié dans: Journal of Proteomics, Numéro 171, 2018, Page(s) 116-126, ISSN 1874-3919
Éditeur: Elsevier BV
DOI: 10.1016/j.jprot.2017.04.011

Bin1 and CD2AP polarise the endocytic generation of beta‐amyloid

Auteurs: Florent Ubelmann, Tatiana Burrinha, Laura Salavessa, Ricardo Gomes, Cláudio Ferreira, Nuno Moreno, Cláudia Guimas Almeida
Publié dans: EMBO reports, Numéro 18/1, 2017, Page(s) 102-122, ISSN 1469-221X
Éditeur: Nature Publishing Group
DOI: 10.15252/embr.201642738

A Novel Protocol to Quantitatively Measure the Endocytic Trafficking of Amyloid Precursor Protein (APP) in Polarized Primary Neurons with Sub-cellular Resolution

Auteurs: Florent Ubelmann, Tatiana Burrinha, Cláudia Guimas Almeida
Publié dans: BIO-PROTOCOL, Numéro 7/23, 2017, ISSN 2331-8325
Éditeur: Bio-protocol LLC
DOI: 10.21769/BioProtoc.2629

Measuring the Endocytic Recycling of Amyloid Precursor Protein (APP) in Neuro2a Cells

Auteurs: Florent Ubelmann, Tatiana Burrinha, Cláudia Guimas Almeida
Publié dans: BIO-PROTOCOL, Numéro 7/23, 2017, ISSN 2331-8325
Éditeur: Bio-protocol LLC
DOI: 10.21769/BioProtoc.2635

Usefulness of zebrafish larvae to evaluate drug-induced functional and morphological renal tubular alterations

Auteurs: Rita Gorgulho, Raquel Jacinto, Susana S. Lopes, Sofia A. Pereira, Erin M. Tranfield, Gabriel G. Martins, Emilio J. Gualda, Rico J. E. Derks, Ana C. Correia, Evelyne Steenvoorden, Petra Pintado, Oleg A. Mayboroda, Emilia C. Monteiro, Judit Morello
Publié dans: Archives of Toxicology, Numéro 92/1, 2018, Page(s) 411-423, ISSN 0340-5761
Éditeur: Springer Verlag
DOI: 10.1007/s00204-017-2063-1

Notch/Her12 signalling modulates, motile/immotile cilia ratio downstream of Foxj1a in zebrafish left-right organizer

Auteurs: Barbara Tavares, Raquel Jacinto, Pedro Sampaio, Sara Pestana, Andreia Pinto, Andreia Vaz, Mónica Roxo-Rosa, Rui Gardner, Telma Lopes, Britta Schilling, Ian Henry, Leonor Saúde, Susana Santos Lopes
Publié dans: eLife, Numéro 6, 2017, ISSN 2050-084X
Éditeur: eLife Sciences Publications
DOI: 10.7554/eLife.25165

Dynamics of cilia length in left–right development

Auteurs: P. Pintado, P. Sampaio, B. Tavares, T. D. Montenegro-Johnson, D. J. Smith, S. S. Lopes
Publié dans: Royal Society Open Science, Numéro 4/3, 2017, Page(s) 161102, ISSN 2054-5703
Éditeur: Royal Society Publishing
DOI: 10.1098/rsos.161102

Pure Polyphenols Applications for Cardiac Health and Disease

Auteurs: Claudia N. Santos, Andreia Gomes, Carole Oudot, Daniela Dias-Pedroso, Ana Rodriguez-Mateos, Helena L.A. Vieira, Catherine Brenner
Publié dans: Current Pharmaceutical Design, Numéro 24/19, 2018, Page(s) 2137-2156, ISSN 1381-6128
Éditeur: Bentham Science Publishers
DOI: 10.2174/1381612824666180608102344

Intermittent, low dose carbon monoxide exposure enhances survival and dopaminergic differentiation of human neural stem cells

Auteurs: Nanna Dreyer-Andersen, Ana Sofia Almeida, Pia Jensen, Morad Kamand, Justyna Okarmus, Tine Rosenberg, Stig Düring Friis, Alberto Martínez Serrano, Morten Blaabjerg, Bjarne Winther Kristensen, Troels Skrydstrup, Jan Bert Gramsbergen, Helena L. A. Vieira, Morten Meyer
Publié dans: PLOS ONE, Numéro 13/1, 2018, Page(s) e0191207, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0191207

Improvement of neuronal differentiation by carbon monoxide: Role of pentose phosphate pathway

Auteurs: Ana S. Almeida, Nuno L. Soares, Catarina O. Sequeira, Sofia A. Pereira, Ursula Sonnewald, Helena L.A. Vieira
Publié dans: Redox Biology, Numéro 17, 2018, Page(s) 338-347, ISSN 2213-2317
Éditeur: Elsevier BV
DOI: 10.1016/j.redox.2018.05.004

P2X7 Receptors Mediate CO-Induced Alterations in Gene Expression in Cultured Cortical Astrocytes—Transcriptomic Study

Auteurs: Sara R. Oliveira, Cláudia Figueiredo-Pereira, Carlos B. Duarte, Helena L. A. Vieira
Publié dans: Molecular Neurobiology, 2018, ISSN 0893-7648
Éditeur: Humana Press, Inc.
DOI: 10.1007/s12035-018-1302-7

Phenolic Metabolites Modulate Cardiomyocyte Beating in Response to Isoproterenol

Auteurs: Daniela Dias-Pedroso, Joel Guerra, Andreia Gomes, Carole Oudot, Catherine Brenner, Cláudia N. Santos, Helena L. A. Vieira
Publié dans: Cardiovascular Toxicology, 2018, ISSN 1530-7905
Éditeur: Humana Press, Inc.
DOI: 10.1007/s12012-018-9485-8

Melanin Transferred to Keratinocytes Resides in Nondegradative Endocytic Compartments

Auteurs: Maria S. Correia, Hugo Moreiras, Francisco J.C. Pereira, Matilde V. Neto, Tiago C. Festas, Abul K. Tarafder, José S. Ramalho, Miguel C. Seabra, Duarte C. Barral
Publié dans: Journal of Investigative Dermatology, Numéro 138/3, 2018, Page(s) 637-646, ISSN 0022-202X
Éditeur: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2017.09.042

Rab GTPase regulation of bacteria and protozoa phagocytosis occurs through the modulation of phagocytic receptor surface expression

Auteurs: Elsa Seixas, Cristina Escrevente, Miguel C. Seabra, Duarte C. Barral
Publié dans: Scientific Reports, Numéro 8/1, 2018, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-31171-5

Beneficial effects on vision in patients undergoing retinal gene therapy for choroideremia

Auteurs: Kanmin Xue, Jasleen K Jolly, Alun R. Barnard, Anna Rudenko, Anna P. Salvetti, Maria I. Patrício, Thomas L. Edwards, Markus Groppe, Harry O. Orlans, Tanya Tolmachova, Graeme C. Black, Andrew R. Webster, Andrew J. Lotery, Graham E. Holder, Susan M. Downes, Miguel C. Seabra, Robert E. MacLaren
Publié dans: Nature Medicine, Numéro 24/10, 2018, Page(s) 1507-1512, ISSN 1078-8956
Éditeur: Nature Publishing Group
DOI: 10.1038/s41591-018-0185-5

Two-Year Results After AAV2-Mediated Gene Therapy for Choroideremia: The Alberta Experience

Auteurs: Ioannis S. Dimopoulos, Stephanie C. Hoang, Alina Radziwon, Natalia M. Binczyk, Miguel C. Seabra, Robert E. MacLaren, Rizwan Somani, Matthew T.S. Tennant, Ian M. MacDonald
Publié dans: American Journal of Ophthalmology, Numéro 193, 2018, Page(s) 130-142, ISSN 0002-9394
Éditeur: Elsevier BV
DOI: 10.1016/j.ajo.2018.06.011

Rab3a and Rab10 are regulators of lysosome exocytosis and plasma membrane repair

Auteurs: Otilia V. Vieira
Publié dans: Small GTPases, Numéro 9/4, 2016, Page(s) 349-351, ISSN 2154-1248
Éditeur: Landes Bioscience
DOI: 10.1080/21541248.2016.1235004

Lipid and Non-lipid Factors Affecting Macrophage Dysfunction and Inflammation in Atherosclerosis

Auteurs: Mark S. Gibson, Neuza Domingues, Otilia V. Vieira
Publié dans: Frontiers in Physiology, Numéro 9, 2018, ISSN 1664-042X
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fphys.2018.00654

Cholesterol is Inefficiently Converted to Cholesteryl Esters in the Blood of Cardiovascular Disease Patients

Auteurs: Mathias J. Gerl, Winchil L. C. Vaz, Neuza Domingues, Christian Klose, Michal A. Surma, Júlio L. Sampaio, Manuel S. Almeida, Gustavo Rodrigues, Pedro Araújo-Gonçalves, Jorge Ferreira, Claudia Borbinha, João Pedro Marto, Miguel Viana-Baptista, Kai Simons, Otilia V. Vieira
Publié dans: Scientific Reports, Numéro 8/1, 2018, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-33116-4

MicroRNA-424(322) as a new marker of disease progression in pulmonary arterial hypertension and its role in right ventricular hypertrophy by targeting SMURF1

Auteurs: Rui Baptista, Carla Marques, Steve Catarino, Francisco J Enguita, Marina C Costa, Paulo Matafome, Mónica Zuzarte, Graça Castro, Abílio Reis, Pedro Monteiro, Mariano Pêgo, Paulo Pereira, Henrique Girão
Publié dans: Cardiovascular Research, Numéro 114/1, 2017, Page(s) 53-64, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvx187

The Endolysosomal System and Proteostasis: From Development to Degeneration

Auteurs: Bettina Winckler, Victor Faundez, Sandra Maday, Qian Cai, Cláudia Guimas Almeida, Huaye Zhang
Publié dans: The Journal of Neuroscience, Numéro 38/44, 2018, Page(s) 9364-9374, ISSN 0270-6474
Éditeur: Society for Neuroscience
DOI: 10.1523/JNEUROSCI.1665-18.2018

Impact of late-onset Alzheimer’s genetic risk factors on beta-amyloid endocytic production

Auteurs: Cláudia Guimas Almeida, Farzaneh Sadat Mirfakhar, Catarina Perdigão, Tatiana Burrinha
Publié dans: Cellular and Molecular Life Sciences, Numéro 75/14, 2018, Page(s) 2577-2589, ISSN 1420-682X
Éditeur: Birkhauser Verlag
DOI: 10.1007/s00018-018-2825-9

Wall stress enhanced exocytosis of extracellular vesicles as a possible mechanism of left-right symmetry-breaking in vertebrate development

Auteurs: J. Solowiej-Wedderburn, D.J. Smith, S.S. Lopes, T.D. Montenegro-Johnson
Publié dans: Journal of Theoretical Biology, Numéro 460, 2019, Page(s) 220-226, ISSN 0022-5193
Éditeur: Academic Press
DOI: 10.1016/j.jtbi.2018.10.015

Zebrafish Larvae Are a Suitable Model to Investigate the Metabolic Phenotype of Drug-Induced Renal Tubular Injury

Auteurs: Judit Morello, Rico J. E. Derks, Susana S. Lopes, Evelyne Steenvoorden, Emilia C. Monteiro, Oleg A. Mayboroda, Sofia A. Pereira
Publié dans: Frontiers in Pharmacology, Numéro 9, 2018, ISSN 1663-9812
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fphar.2018.01193

Crosstalk between cilia and autophagy: implication for human diseases (project related publication after the start date of LYSOCIL project, RP2)

Auteurs: Manuela Morleo, Helena L A Vieira, Petra Pennekamp, Alessandro Palma, Liliana Bento-Lopes, Heymut Omran, Susana S Lopes, Duarte C Barral, Brunella Franco
Publié dans: Autophagy, Numéro 1/20, 2022, ISSN 1554-8627
Éditeur: Landes Bioscience
DOI: 10.1080/15548627.2022.2067383

Lysosome (dys)function in atherosclerosis – a big weight on the shoulders of a small organelle (project related publication after the start date of LYSOCIL project, RP2)

Auteurs: André R A Marques, Cristiano Ramos, Gisela Machado-Oliveira, Otília V Vieira
Publié dans: Front Cell Dev Biol, 2021, ISSN 2296-634X
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fcell.2021.658995

Assessment of Mitochondrial Protein Glutathionylation as Signaling for CO Pathway

Auteurs: Ana S. Almeida, Helena L. A. Vieira
Publié dans: Mitochondrial Medicine, Numéro 1264, 2015, Page(s) 343-350, ISBN 978-1-4939-2256-7
Éditeur: Springer New York
DOI: 10.1007/978-1-4939-2257-4_30

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