Project description
Innovative solution for super-resolution imaging of living cells
Super-resolution (SR) microscopy surpasses the diffraction limit that restricts the optical resolution to 250 nm and allows the visualisation of subcellular organisation with unprecedented detail. SR imaging has been an integral tool for cell biologists, parasitologists and virologists. However, applications of SR technology have been limited by challenges that include potential damage to the biological objects by the intense light used for imaging as well as technical complexity and high costs. The EU-funded LiveCODIM project aims to apply the proprietary technology to expand the accessibility of SR microscopy by developing a plug-and-play system to study living cells. The solution will be cost-effective compared to current methods and will be able to turn any fluorescence microscope into the latest generation SR system.
Objective
In the last years, major advances in imaging have significantly contributed to the improvement of EU citizens’ quality of life,
from research to diagnostic and therapy. Super Resolution microscopy (SR) is a milestone discovery which goes beyond the
limits of optics, typically around 250nm, or ¼ of a μm (one can see inside a virus!). Nevertheless, SR has yet to become a
standard imaging modality, like the confocal or the widefield microscopes. Dissemination is still slowed by three critical
challenges
- damage to the biological tissue – it’s almost impossible to observe live cells
- technical complexity – only highly skilled operators can use the instruments
- cost of ownership – typically around half million euros for a complete solution
BioAxial, a Paris-based company, has developed the CODIM family of SR microscopes, using proprietary and well-patented
technology. After proof of concept, a 1st generation system has been acquired and is used by major players (Pasteur
Institute, Sanofi, Konica Minolta). Leveraging our core technology, LiveCODIM changes the game, scaling up SR
microscopy, with a breakthrough solution:
- specifically designed for the study of living cells
- a plug and play system requiring neither extensive, multi-skill staff training nor complex sample preparation
- 3x more cost-effective than the few other comparable solutions, with higher resolution
- which turns any fluorescence microscope into the latest generation SR system.
Not just an evolution, but a genuine revolution, LiveCODIM initially addresses the life science imaging market, a 1Bn€
playground, and has many other potential applications, in diagnostic (human tissue) and outside life science.
This project brings multiple benefits to EU citizens, by its contribution to life and environmental improvement.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences software
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering control systems
- natural sciences biological sciences microbiology virology
- natural sciences physical sciences optics microscopy super resolution microscopy
- social sciences political sciences political transitions revolutions
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.2.3. - INDUSTRIAL LEADERSHIP - Innovation In SMEs
MAIN PROGRAMME
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H2020-EU.3. - PRIORITY 'Societal challenges
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H2020-EU.2.1. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
SME-2 - SME instrument phase 2
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-EIC-SMEInst-2018-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75014 PARIS
France
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.