Description du projet
Une solution innovante pour l’imagerie des cellules vivantes à super-résolution
La microscopie à super-résolution (SR) surpasse la limite de diffraction qui restreint la résolution optique à 250 nm et permet de visualiser l’organisation subcellulaire avec des détails sans précédent. L’imagerie SR est un outil essentiel pour les biologistes cellulaires, les parasitologues et les virologues. Cependant, les applications de la technologie SR ont été limitées par divers problèmes, notamment les dommages potentiels causés aux objets biologiques par la lumière intense utilisée pour l’imagerie, mais aussi par sa complexité technique et son coût élevé. Le projet LiveCODIM, financé par l’UE, a pour ambition d’appliquer la technologie propriétaire pour élargir l’accessibilité de la microscopie SR en développant un système prêt à l’emploi destiné à étudier les cellules vivantes. La solution sera rentable par rapport aux méthodes actuelles et pourra transformer n’importe quel microscope à fluorescence en un système SR de dernière génération.
Objectif
In the last years, major advances in imaging have significantly contributed to the improvement of EU citizens’ quality of life,
from research to diagnostic and therapy. Super Resolution microscopy (SR) is a milestone discovery which goes beyond the
limits of optics, typically around 250nm, or ¼ of a μm (one can see inside a virus!). Nevertheless, SR has yet to become a
standard imaging modality, like the confocal or the widefield microscopes. Dissemination is still slowed by three critical
challenges
- damage to the biological tissue – it’s almost impossible to observe live cells
- technical complexity – only highly skilled operators can use the instruments
- cost of ownership – typically around half million euros for a complete solution
BioAxial, a Paris-based company, has developed the CODIM family of SR microscopes, using proprietary and well-patented
technology. After proof of concept, a 1st generation system has been acquired and is used by major players (Pasteur
Institute, Sanofi, Konica Minolta). Leveraging our core technology, LiveCODIM changes the game, scaling up SR
microscopy, with a breakthrough solution:
- specifically designed for the study of living cells
- a plug and play system requiring neither extensive, multi-skill staff training nor complex sample preparation
- 3x more cost-effective than the few other comparable solutions, with higher resolution
- which turns any fluorescence microscope into the latest generation SR system.
Not just an evolution, but a genuine revolution, LiveCODIM initially addresses the life science imaging market, a 1Bn€
playground, and has many other potential applications, in diagnostic (human tissue) and outside life science.
This project brings multiple benefits to EU citizens, by its contribution to life and environmental improvement.
Champ scientifique
- natural sciencescomputer and information sciencessoftware
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringcontrol systems
- natural sciencesbiological sciencesmicrobiologyvirology
- natural sciencesphysical sciencesopticsmicroscopysuper resolution microscopy
- social sciencespolitical sciencespolitical transitionsrevolutions
Programme(s)
Régime de financement
SME-2 - SME instrument phase 2Coordinateur
75014 PARIS
France
L’entreprise s’est définie comme une PME (petite et moyenne entreprise) au moment de la signature de la convention de subvention.