Periconceptional Programming of Health Training Network

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The Effect of an eHealth Coaching Program (Smarter Pregnancy)on Attitudes and Practices Toward Periconception LifestyleBehaviors in Women Attempting Pregnancy: Prospective Study

Autori: Hojeij B, Schoenmakers S, Willemsen S, van Rossem L, Dinnyes A, Rousian M, Steegers-Theunissen RP
Pubblicato in: Journal of Medical Internet Research, Numero Vol 25 (2023), 2023, ISSN 1438-8871
Editore: Journal of medical Internet Research
DOI: 10.2196/39321

Pig models for Duchenne muscular dystrophy – from disease mechanisms to validation of new diagnostic and therapeutic concepts

Autori: Michael Stirm, Lina Marie Fonteyne, Bachuki Shashikadze, Jan B. Stöckl, Mayuko Kurome, Barbara Kessler, Valeri Zakhartchenko, Elisabeth Kemter, Helmut Blum, Georg J. Arnold, Kaspar Matiasek, Rüdiger Wanke, Wolfgang Wurst, Hiroshi Nagashima, Ferdinand Knieling, Maggie C. Walter, Christian Kupatt, Thomas Fröhlich, Nikolai Klymiuk, Andreas Blutke, Eckhard Wolf
Pubblicato in: Neuromuscular Disorders, Numero VOLUME 32, ISSUE 7, 2022, Pagina/e P543-556, ISSN 0960-8966
Editore: Elsevier BV
DOI: 10.1016/j.nmd.2022.04.005

Structural and proteomic repercussions of growth hormone receptor deficiency on the pituitary gland: Lessons from a translational pig model

Autori: Bachuki Shashikadze, Sophie Franzmeier, Isabel Hofmann, Martin Kraetzl, Florian Flenkenthaler, Andreas Blutke, Thomas Fröhlich, Eckhard Wolf, Arne Hinrichs
Pubblicato in: Journal of Neuroendocrinology, 2023, ISSN 1365-2826
Editore: British Society for Neuroendocrinology
DOI: 10.1111/jne.13277

Transgenic pigs expressing near infrared fluorescent protein—A novel tool for noninvasive imaging of islet xenotransplants

Autori: Elisabeth Kemter, Antonio Citro, Lelia Wolf-van Buerck, Yi Qiu, Anika Böttcher Martina Policardi, Silvia Pellegrini, Libera Valla, Marianna Alunni-Fabbroni, Julianna Kobolák, Barbara Kessler, Mayuko Kurome, Valeri Zakhartchenko, Andras Dinnyes, Clemens C. Cyran, Heiko Lickert, Lorenzo Piemonti, Jochen Seissler, Eckhard Wolf
Pubblicato in: Xenotransplantation, 2021, ISSN 1399-3089
Editore: John Wiley & Sons A/S
DOI: 10.1111/xen.12719

The Rotterdam Periconceptional Cohort and embryonic and fetal measurements using 3D ultrasound and virtual reality techniques

Autori: Melek Rousian; Sam Schoenmakers; Alex J. Eggink; Dionne V Gootjes; Anton H. J. Koning; Maria P.H. Koster; Annemarie G.M.G.J. Mulders; Esther B. Baart; Irwin K.M. Reiss; Joop S.E. Laven; Eric A.P. Steegers; Régine P.M. Steegers-Theunissen
Pubblicato in: International Journal of Epidemiology, 50(5), 1426 - 1427L. Oxford University Press, Numero 2, 2021, Pagina/e 1426–1427L, ISSN 0300-5771
Editore: Oxford University Press
DOI: 10.1093/ije/dyab030

Epigenetic Mechanisms of ART-Related Imprinting Disorders: Lessons From iPSC and Mouse Models

Autori: Alex Horánszky, Jessica L. Becker, Melinda Zana, Anne C. Ferguson-Smith, András Dinnyés
Pubblicato in: Genes, Numero 12/11, 2021, Pagina/e 1704, ISSN 2073-4425
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes12111704

A high periconceptional maternal ultra-processed food consumption impairs embryonic growth: The Rotterdam periconceptional cohort.

Autori: Ashley JP Smit, Batoul Hojeij, Melek Rousian, Sam Schoenmakers, Sten P Willemsen, Régine PM Steegers-Theunissen, Lenie van Rossem
Pubblicato in: Clinical Nutrition, Numero Volume 41, Numero 8, 2022, Pagina/e P1667-1675, ISSN 0261-5614
Editore: Churchill Livingstone
DOI: 10.1016/j.clnu.2022.06.006

Maternal One-Carbon Metabolism during the Periconceptional Period and Human Foetal Brain Growth: A Systematic Review

Autori: Eleonora Rubini, Inge M. M. Baijens, Alex Horánszky, Sam Schoenmakers, Kevin D. Sinclair, Melinda Zana, András Dinnyés, Régine P. M. Steegers-Theunissen, Melek Rousian
Pubblicato in: Genes, Numero 12/10, 2021, Pagina/e 1634, ISSN 2073-4425
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes12101634

Cleavage-stage or blastocyst-stage embryo biopsy has no impact on growth and health in children up to 2 years of age

Autori: F Belva, F Kondowe, A De Vos, K Keymolen, A Buysse, F Hes, W Verpoest, M De Rycke
Pubblicato in: Reproductive Biology and Endocrinology, Numero Volume 21, Article number: 87, 2023, ISSN 1477-7827
Editore: BioMed Central
DOI: 10.1186/s12958-023-01140-3

"""Directed self-assembly of a xenogeneic vascularized endocrine pancreas for type 1 diabetes"""

Autori: Antonio Citro, Alessia Neroni, Cataldo Pignatelli, Francesco Campo, Martina Policardi, Matteo Monieri, Silvia Pellegrini, Erica Dugnani, Fabio Manenti, Maria Chiara Maffia, Libera Valla, Elisabeth Kemter, Ilaria Marzinotto, Cristina Olgasi, Alessia Cucci, Antonia Follenzi, Vito Lampasona, Eckhard Wolf & Lorenzo Piemonti
Pubblicato in: Nature Communications, Numero volume 14, Article number: 878 , 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-36582-1

Growth of twins conceived using assisted reproductive treatments up to 5 years old: a national growth cohort

Autori: Fiskani J M Kondowe; Peter Clayton; Matthew Gittins; Stephen W D’Souza; Daniel R Brison; Stephen A Roberts
Pubblicato in: Human reproduction, Numero Volume 38, Numero 4,, 2023, Pagina/e Pages 751–761,, ISSN 0268-1161
Editore: Oxford University Press
DOI: 10.1093/humrep/dead018

Proteomics- and Metabolomics-Based Analysis of Metabolic Changes in a Swine Model of Pulmonary Hypertension

Autori: Payel Sen, Bachuki Shashikadze, Florian Flenkenthaler, Esther Van de Kamp, Siyu Tian, Chen Meng, Michael Gigl, Thomas Fröhlich, Daphne Merkus
Pubblicato in: IJMS, Numero Volume 24, Numero 5, 2023, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24054870

Network Approaches for Charting the Transcriptomic and Epigenetic Landscape of the Developmental Origins of Health and Disease

Autori: Salvo Danilo Lombardo; Ivan Fernando Wangsaputra; Jörg Menche; Adam Stevens
Pubblicato in: Genes 2022, 13(5), 764, Numero 2, 2022, ISSN 2073-4425
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes13050764

Developmental Effects of (Pre-)Gestational Diabetes on Offspring: Systematic Screening Using Omics Approaches

Autori: Bachuki Shashikadze, Florian Flenkenthaler, Jan B Stöckl, Libera Valla, Simone Renner, Elisabeth Kemter, Eckhard Wolf, Thomas Fröhlich
Pubblicato in: Genes, Numero 12/12, 2021, ISSN 2073-4425
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes12121991

Differential Effects of Insulin-Deficient Diabetes Mellitus on Visceral vs. Subcutaneous Adipose Tissue-Multi-omics Insights From the Munich MIDY Pig Model.

Autori: Florian Flenkenthaler, Erik Ländström, Bachuki Shashikadze, Mattias Backman, Andreas Blutke, Julia Philippou-Massier, Simone Renner, Martin Hrabe de Angelis, Rüdiger Wanke, Helmut Blum, Georg J Arnold, Eckhard Wolf, Thomas Fröhlich
Pubblicato in: Frontiers in Medicine, 2021, ISSN 2296-858X
Editore: Lausanne: Frontiers Media S.A., 2014-
DOI: 10.3389/fmed.2021.751277

High-fat diet fed to non-obese mothers during mouse preimplantation or gestation/lactation is sufficient to alter metabolism and hippocampal neurogenesis in adult offspring

Autori: Diego A. Ojeda, Oliver Hutton, Robert Hopkins, Felino Cagampang, Neil R. Smyth,Tom P Fleming, Judith Eckert, Sandrine Willaime-Morawek
Pubblicato in: Brain Communications, Numero Volume 5, Numero 2, 2023, ISSN 2632-1297
Editore: Oxford University Press
DOI: 10.1093/braincomms/fcad093

Environmental Alterations during Embryonic Development: Studying the Impact of Stressors on Pluripotent Stem Cell-Derived Cardiomyocytes

Autori: Federica Lamberto, Irene Peral-Sanchez, Suchitra Muenthaisong, Melinda Zana, Sandrine Willaime-Morawek, András Dinnyés
Pubblicato in: Genes, Numero 12/10, 2021, Pagina/e 1564, ISSN 2073-4425
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes12101564

Epigenetics in the Uterine Environment: How Maternal Diet and ART May Influence the Epigenome in the Offspring with Long-Term Health Consequences.

Autori: Peral-Sanchez I, Hojeij B, Ojeda DA, Steegers-Theunissen RPM, Willaime-Morawek S.
Pubblicato in: Genes, 2022, ISSN 2073-4425
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes13010031

A scalable, clinically severe pig model for Duchenne muscular dystrophy

Autori: Michael Stirm, Lina Marie Fonteyne, Bachuki Shashikadze, Magdalena Lindner, Maila Chirivi, Andreas Lange, Clara Kaufhold, Christian Mayer, Ivica Medugorac, Barbara Kessler, Mayuko Kurome, Valeri Zakhartchenko, Arne Hinrichs, Elisabeth Kemter, Sabine Krause, Rüdiger Wanke, Georg J. Arnold, Gerhard Wess, Hiroshi Nagashima, Martin Hrabĕ de Angelis, Florian Flenkenthaler, Levin Arne Kobelke, Claudia
Pubblicato in: Disease Models & Mechanisms, 2021, ISSN 1754-8411
Editore: Company of Biologists
DOI: 10.1242/dmm.049285

First Trimester Maternal Homocysteine and Embryonic and Fetal Growth: The Rotterdam Periconception Cohort

Autori: Eleonora Rubini; Katinka M. Snoek; Sam Schoenmakers; Sten P. Willemsen; Kevin D. Sinclair; Melek Rousian; Régine P. M. Steegers-Theunissen
Pubblicato in: Nutrients; Volume 14; Numero 6;, Numero 1, 2022, Pagina/e Pages: 1129, ISSN 2072-6643
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu14061129

the Rotterdam Periconception Cohort

Autori: Rosalieke E. Wiegel; Eleonora Rubini; Melek Rousian; Sam Schoenmakers; Joop S. E. Laven; Sten P. Willemsen; Esther B. Baart; Régine P. M. Steegers-Theunissen
Pubblicato in: Journal of Assisted Reproduction and Genetics, Numero volume 40, 2023, Pagina/e 1495–1506, ISSN 1058-0468
Editore: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10815-023-02803-1

The expression and activity of Toll-like receptors in the preimplantation human embryo suggest a new role for innate immunity

Autori: Wedad Aboussahoud; Wedad Aboussahoud; Helen Smith; Adam Stevens; Adam Stevens; Ivan Wangsaputra; Ivan Wangsaputra; Helen R. Hunter; Susan J. Kimber; Mourad W. Seif; Mourad W. Seif; Daniel R. Brison
Pubblicato in: Human Reproduction (Oxford, England), Numero 2021 Sep 18;36(10), 2021, Pagina/e 2661-2675, ISSN 0268-1161
Editore: Oxford University Press
DOI: 10.1093/humrep/deab188

Maternal obesity during pregnancy leads to derangements in one-carbon metabolism and the gut microbiota: implications for fetal development and offspring wellbeing

Autori: Eleonora RUBINI , Nicole SCHENKELAARS , Melek ROUSIAN , Kevin D. SINCLAIR, Lieske WEKEMA, Marijke M. FAAS, Régine P. M. STEEGERS-THEUNISSEN and Sam SCHOENMAKERS
Pubblicato in: American Journal of Obstetrics & Gynecology, 2022, ISSN 0002-9378
Editore: Mosby Inc.
DOI: 10.1016/j.ajog.2022.04.013

Maternal hyperglycemia induces alterations in hepatic amino acid, glucose and lipid metabolism of neonatal offspring: Multi-omics insights from a diabetic pig model

Autori: Bachuki Shashikadze, Libera Valla, Salvo Danilo Lombardo, Cornelia Prehn, Mark Haid, Fabien Riols, Jan Bernd Stöckl, Radwa Elkhateib, Simone Renner, Birgit Rathkolb, Jörg Menche, Martin Hrabĕ de Angelis, Eckhard Wolf, Elisabeth Kemter, Thomas Fröhlich
Pubblicato in: Molecular Metabolism, Numero Volume 75, 2023, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2023.101768

Periconceptional biomarkers for maternal obesity: a systematic review

Autori: Batoul Hojeij, Melek Rousian, Kevin D. Sinclair, Andras Dinnyes, Régine P.M. Steegers Theunissen and Sam Schoenmakers
Pubblicato in: Rev Endocr Metab Disord, Numero 24, 2023, Pagina/e 139–175, ISSN 1389-9155
Editore: Kluwer Academic Publishers
DOI: 10.1007/s11154-022-09762-5

Systemic deletion of DMD exon 51 rescues clinically severe Duchenne muscular dystrophy in a pig model lacking DMD exon 52

Autori: Michael Stirm, Bachuki Shashikadze, Andreas Blutke , Andreas Lange, Mayuko Kurome, Barbara Keßler, Valeri Zakhartchenko, Andrea Bähr, Nikolai Klymiuk, Hiroshi Nagashima, Elisabeth Kemter, Maggie C. Walterg, Wolfgang Wursth, Christian Kupatte, Thomas Fröhlich, Eckhard Wolf
Pubblicato in: PNAS, Numero 120 (29) e2301250120, 2023, ISSN 1091-6490
Editore: Proceedings of the National Academy of Sciences of the United States of America.
DOI: 10.1073/pnas.2301250120

Regenerative Neurology and Regenerative Cardiology: Shared Hurdles and Achievements

Autori: Dinko Mitrečić; Valentina Hribljan; Denis Jagečić; Jasmina Isaković; Federica Lamberto; Alex Horánszky; Melinda Zana; Gabor Foldes; Barbara Zavan; Augustas Pivoriūnas; Salvador Martinez; Letizia Mazzini; Lidija Radenovic; Jelena Milasin; Juan Carlos Chachques; Leonora Buzanska; Min Suk Song; András Dinnyés
Pubblicato in: International Journal of Molecular Sciences, Numero Vol. 23, issue 2, 2022, Pagina/e 855, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23020855

Proteomics and disease network associations evaluation of environmentally relevant Bisphenol A concentrations in a human 3D neural stem cell model

Autori: Horánszky A., B. Shashikadze, R. Elkhateib, S. D. Lombardo, F. Lamberto, M. Zana, J. Menche, T. Fröhlich, A. Dinnyés
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero Volume 11 - 2023, 2023, ISSN 2296-634X
Editore: Frontiers Media S.A.
DOI: 10.3389/fcell.2023.1236243

Low-dose Bisphenol A exposure alters the functionality and cellular environment in a human cardiomyocyte model

Autori: Lamberto F., B. Shashikadze, R. Elkhateib, S. D. Lombardo, A. Horánszky, A. Balogh, K. Kistamás, M. Zana, J. Menche, T. Fröhlich, A. Dinnyés
Pubblicato in: Environmental Pollution, Numero Volume 335, 2023, ISSN 0269-7491
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2023.122359

Multifactorial approaches to enhance maturation of human iPSC-derived cardiomyocytes

Autori: Kornél Kistamás, Anna Müller, Suchitra Muenthaisong, Federica Lamberto, Melinda Zana, Martin Dulac, Filipa Leal, Ali Maziz, Pedro Costa, Eiva Bernotiene, Christian Bergaud, András Dinnyés
Pubblicato in: Journal of Molecular Liquids, Numero Volume 387, 2023, ISSN 0167-7322
Editore: Elsevier BV
DOI: 10.1016/j.molliq.2023.122668

Variably methylated retrotransposons are refractory to a range of environmental perturbations

Autori: Tessa M. Bertozzi, Jessica L. Becker, Georgina E. T. Blake, Amita Bansal, Duy K. Nguyen, Denise S. Fernandez-Twinn, Susan E. Ozanne, Marisa S. Bartolomei, Rebecca A. Simmons, Erica D. Watson, Anne C. Ferguson-Smith
Pubblicato in: Nature Genetics, 2021, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-021-00898-9

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