Training innovative future leaders in research and development of materials and implants for the spine

Project Information

NU-SPINE

Grant agreement ID: 812765

DOI

10.3030/812765

Project closed

EC signature date 13 September 2018

Start date 1 January 2019

End date 30 September 2023

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 4 272 380,36

EU contribution

€ 4 272 380,36

Coordinated by

UPPSALA UNIVERSITET
Sweden

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (12)

Assessment of the facet joint prosthesis incl. tribological testing

Assessment of the facet joint prosthesis incl tribological testing

Yearly publication lists
Testing standard for dynamic characterisation of Si3N4 implants
New testing protocols developed
Report on in vivo trials
Validation of ParFE optimization algorithm
Tribocorrosion and degradation mechanisms of coated implants
Method for wear particle isolation and full characterisation of wear products
Advanced 3D in vitro models for neurotoxicity assessment
Testing protocols deployed and validated
Neurotoxicity of wear products of SixNy
Yearly newsletters

Other (4)

Delivery of ESR courses 5 and 7
Report on network-wide ESR courses 1-4
Online introductory course to IPR 1
Report on network-wide ESR courses 5-7

Websites, patent fillings, videos etc. (2)

Public Engagement Seminar series delivered by ESRs
Website and online repository

Publications

Peer reviewed articles (29)

Comprehensive in vitro comparison of cellular and osteogenic response to alternative biomaterials for spinal implants

Author(s): Seung-Hun Lee; Stephanie Huber; Stephen J. Ferguson
Published in: Biomaterials Advances, 127, Issue 17, 2021, ISSN 0928-4931
Publisher: Elsevier BV
DOI: 10.1016/j.bas.2021.100006

In Vitro Biomechanics of the Cervical Spine: A Systematic Review.

Author(s): Hossein Ansaripour; Stephen J. Ferguson; Markus Flohr
Published in: Journal of Biomechanical Engineering, 144 (10), Issue 11, 2022, ISSN 0148-0731
Publisher: ASME
DOI: 10.1115/1.4054439

An ex-vivo model for the biomechanical assessment of cement discoplasty

Author(s): Ghandour S, Pazarlis K, Lewin S, Isaksson P, Försth P, Persson C.
Published in: Front Bioeng Biotechnol, 2022, ISSN 2296-4185
Publisher: PubMed
DOI: 10.3389/fbioe.2022.939717

Non-linear mechanical properties and dynamic response of silicon nitride bioceramic

Author(s): Xiaoyu Du, Gurdial Blugan, Tina Künniger, Seunghun S. Lee, Liliya Vladislavova, Stephen J. Ferguson
Published in: Ceramics International, Issue 47/23, 2021, Page(s) 33525-33536, ISSN 0272-8842
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.ceramint.2021.08.261

3D-Printed PEEK/Silicon Nitride Scaffolds with a Triply Periodic Minimal Surface Structure for Spinal Fusion Implants

Author(s): Xiaoyu Du; Sean Ronayne; Seunghun S. Lee; Jackson Hendry; Douglas Hoxworth; Ryan Bock; Stephen J. Ferguson
Published in: ACS Applied Bio Materials, 6 (8), Issue 11, 2023, ISSN 2576-6422
Publisher: ACS Appl. Bio Mater.
DOI: 10.1021/acsabm.3c00383

Structural Si3N4-SiO2 glass ceramics with bioactive and anti-bacterial properties

Author(s): Huasi Zhou, Cecilia Persson, Olivier Donzel-Gargand, Håkan Engqvist, Wei Xia
Published in: Journal of the European Ceramic Society, Issue 44, 2024, Page(s) 4260-4271, ISSN 0955-2219
Publisher: Elsevier BV
DOI: 10.1016/j.jeurceramsoc.2024.01.016

Bioactive silicon nitride implants through surface modification

Author(s): Ioannis Katsaros; Ken Welch; Wei Xia; Cecilia Persson; Håkan Engqvist
Published in: Brain and Spine, Vol 1, Iss , Pp 100124- (2021), Issue 13, 2021, ISSN 2772-5294
Publisher: Elsevier
DOI: 10.1016/j.bas.2021.100124

Conceptual design of compliant bone scaffolds by full-scale topology optimization

Author(s): Thijs Smit; Stijn Koppen; Stephen J. Ferguson; Benedikt Helgason
Published in: urn:issn:1751-6161, Issue 20, 2023, ISSN 1751-6161
Publisher: Elsevier BV
DOI: 10.1016/j.jmbbm.2023.105886

Scaffolds for bone-tissue engineering

Author(s): Seunghun S. Lee; Xiaoyu Du; Inseon Kim; Stephen J. Ferguson
Published in: Matter, 5 (9), Issue 1, 2022, ISSN 2590-2385
Publisher: ScienceDirect
DOI: 10.1016/j.matt.2022.06.003

Current status and future potential of wear-resistant coatings and articulating surfaces for hip and knee implants

Author(s): Charlotte Skjöldebrand; Joanne L. Tipper; Peter Hatto; Michael Bryant; Richard M. Hall; Cecilia Persson
Published in: Crossref, Issue 4, 2022, ISSN 2590-0064
Publisher: PubMed
DOI: 10.1016/j.mtbio.2022.100270

Correlation between mechanical properties and porosity in silicon nitride bioceramic

Author(s): Xiaoyu Du; Gurdial Blugan; Stephen J. Ferguson
Published in: Brain and Spine, Vol 1, Iss , Pp 100075- (2021), Issue 23, 2021, ISSN 2772-5294
Publisher: ELSEVIER
DOI: 10.1016/j.bas.2021.100075

Silicon Nitride as a Biomedical Material: An Overview

Author(s): Du, Xiaoyu; id_orcid0000-0003-2532-731X; Lee, Seunghun S.; Blugan, Gurdial; Ferguson, Stephen J.; id_orcid0000-0003-0650-5889
Published in: International Journal of Molecular Sciences, 23 (12), Issue 22, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23126551

Topology optimization using PETSc: a Python wrapper and extended functionality

Author(s): Thijs Smit; Niels Aage; Stephen J. Ferguson; Benedikt Helgason
Published in: Structural and Multidisciplinary Optimization, 64 (4), Issue 14, 2021, ISSN 1615-1488
Publisher: SpringerLink
DOI: 10.1007/s00158-021-03018-7

Silicon Nitride, a Bioceramic for Bone Tissue Engineering: A Reinforced Cryogel System With Antibiofilm and Osteogenic Effects

Author(s): Seunghun S. Lee; Leanid Laganenka; Xiaoyu Du; Wolf-Dietrich Hardt; Stephen J. Ferguson
Published in: Frontiers in Bioengineering and Biotechnology, Vol 9 (2021), Issue 3, 2021, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2021.794586

Bioactive Silicon Nitride Implant Surfaces with Maintained Antibacterial Properties

Author(s): Ioannis Katsaros; Yijun Zhou; Ken Welch; Wei Xia; Cecilia Persson; Håkan Engqvist
Published in: Journal of Functional Biomaterials; Volume 13; Issue 3; Pages: 129, Issue 10, 2022, ISSN 2079-4983
Publisher: National Library of Medicine
DOI: 10.3390/jfb13030129

The porous cantilever beam as a model for spinal implants: Experimental, analytical and finite element analysis of dynamic properties

Author(s): Xiaoyu Du; Yijun Zhou; Lingzhen Li; Cecilia Persson; Stephen J. Ferguson
Published in: Mathematical Biosciences and Engineering, 20 (4), Issue 7, 2023, ISSN 1551-0018
Publisher: AIMS Press
DOI: 10.3934/mbe.2023270

Hydroxyapatite particle shape affects screw attachment in cancellous bone when augmented with hydroxyapatite-containing hydrogels

Author(s): Yijun Zhou; Lisa Höglund; Ayan Samanta; Philip Procter; Cecilia Persson
Published in: Journal of the Mechanical Behavior of Biomedical Materials, 2024, ISSN 1751-6161
Publisher: Elsevier BV
DOI: 10.1016/j.jmbbm.2023.106241

SiNx Coating Deposition on CoCr by Plasma-Enhanced Chemical Vapor Deposition

Author(s): Huasi Zhou, Cecilia Persson, Wei Xia, Håkan Engqvist
Published in: Biomedical Materials & Devices, Issue 2, 2024, Page(s) 376-383, ISSN 2731-4812
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s44174-023-00083-y

A Biomimetic Macroporous Hybrid Scaffold with Sustained Drug Delivery for Enhanced Bone Regeneration

Author(s): Seung-Hun Lee; Matthias Santschi; Stephen J. Ferguson
Published in: Biomacromolecules, 22 (6), Issue 5, 2022, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.3929/ethz-b-000493840

Ceramics in total disc replacements: A scoping review

Author(s): Lucia Kölle; Dominika Ignasiak; Stephen J. Ferguson; Benedikt Helgason
Published in: Clinical Biomechanics, 100, Issue 5, 2022, ISSN 0268-0033
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.clinbiomech.2022.105796

Comprehensive in vitro comparison of cellular and osteogenic response to alternative biomaterials for spinal implants

Author(s): Seunghun S. Lee, Stephanie Huber, Stephen J. Ferguson
Published in: Materials Science and Engineering: C, Issue 127, 2021, Page(s) 112251, ISSN 0928-4931
Publisher: Elsevier BV
DOI: 10.1016/j.msec.2021.112251

Correction to “A Biomimetic Macroporous Hybrid Scaffold with Sustained Drug Delivery for Enhanced Bone Regeneration”

Author(s): Seunghun S. Lee; Matthias Santschi; Stephen J. Ferguson
Published in: Crossref, Issue 4, 2023, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.2c00203

A Biomimetic Macroporous Hybrid Scaffold with Sustained Drug Delivery for Enhanced Bone Regeneration

Author(s): Seunghun S. Lee, Matthias Santschi, Stephen J. Ferguson
Published in: Biomacromolecules, 2021, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.1c00241

A 3D-Printed Assemblable Bespoke Scaffold as a Versatile Microcryogel Carrier for Site-Specific Regenerative Medicine

Author(s): Lee, Seunghun S.; Kleger, Nicole; Kuhn, Gisela A.; Greutert, Helen; Du, Xiaoyu; Smit, Thijs; Studart, André R.; Ferguson, Stephen J.
Published in: Advanced Materials, Issue 7, 2023, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.3929/ethz-b-000634325

Fe and C additions decrease the dissolution rate of silicon nitride coatings and are compatible with microglial viability in 3D collagen hydrogels

Author(s): Estefanía Echeverri; Charlotte Skjöldebrand; Paul O'Callaghan; Anders Palmquist; Johan Kreuger; Gry Hulsart-Billström; Cecilia Persson
Published in: Crossref, Issue 5, 2023, ISSN 2047-4830
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2bm02074b

A self-renewing biomimetic skeletal muscle construct engineered using induced myogenic progenitor cells

Author(s): Inseon Kim; Seunghun S. Lee; Adhideb Ghosh; Stephen J. Ferguson; Ori Bar‐Nur
Published in: Advanced Functional Materials, Issue 11, 2024, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1101/2023.04.10.534929

Tailoring the dissolution rate and in vitro cell response of silicon nitride coatings through combinatorial sputtering with chromium and niobium

Author(s): Charlotte Skjöldebrand; Estefanía Echeverri; Gry Hulsart-Billström; Cecilia Persson
Published in: Crossref, Issue 4, 2022, ISSN 2047-4830
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1bm01978c

3D-printed LEGO®-inspired titanium scaffolds for patient-specific regenerative medicine

Author(s): Seunghun S. Lee; Xiaoyu Du; Thijs Smit; Elisa G. Bissacco; Daniel Seiler; Michael de Wild; Stephen J. Ferguson
Published in: Crossref, Issue 4, 2023, ISSN 2772-9508
Publisher: ScienceDirect
DOI: 10.1016/j.bioadv.2023.213617

Quasi-static and dynamic mechanical properties of a linoleic acid-modified, low-modulus bone cement for spinal applications

Author(s): Salim Ghandour, Iain Christie, Caroline Öhman Mägi, Cecilia Persson
Published in: Open Research Europe, Issue 3, 2024, Page(s) 203, ISSN 2732-5121
Publisher: F1000 Research Ltd
DOI: 10.12688/openreseurope.16683.2

Thesis and dissertations (1)

Osseointegration of Biomaterials for Orthopaedic Implants

Author(s): Lee, Seung Hun
Published in: 2023
Publisher: ETH Zurich
DOI: 10.3929/ethz-b-000600496

Other (2)

Explicit FE simulation results for orthopedic screw-bone interaction, for different screw geometries and bone quality

Author(s): Zhou, Yijun Helgason, Benedikt Ferguson, Stephen Persson, Cecilia
Published in: 2023
Publisher: Zenodo
DOI: 10.5281/zenodo.8388808

Quasi-static and dynamic mechanical properties of a low-modulus bone cement for spinal applications

Author(s): Salim Ghandour; Iain Christie; Caroline Öhman Mägi; Cecilia Persson
Published in: 2023
Publisher: Open Research Europe
DOI: 10.12688/openreseurope.16683.1