Training innovative future leaders in research and development of materials and implants for the spine

Informazioni relative al progetto

NU-SPINE

ID dell’accordo di sovvenzione: 812765

DOI

10.3030/812765

Progetto chiuso

Data della firma CE 13 Settembre 2018

Data di avvio 1 Gennaio 2019

Data di completamento 30 Settembre 2023

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 4 272 380,36

Contributo UE

€ 4 272 380,36

Coordinato da

UPPSALA UNIVERSITET
Sweden

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (12)

Assessment of the facet joint prosthesis incl. tribological testing

Assessment of the facet joint prosthesis incl tribological testing

Yearly publication lists
Testing standard for dynamic characterisation of Si3N4 implants
New testing protocols developed
Report on in vivo trials
Validation of ParFE optimization algorithm
Tribocorrosion and degradation mechanisms of coated implants
Method for wear particle isolation and full characterisation of wear products
Advanced 3D in vitro models for neurotoxicity assessment
Testing protocols deployed and validated
Neurotoxicity of wear products of SixNy
Yearly newsletters

Other (4)

Delivery of ESR courses 5 and 7
Report on network-wide ESR courses 1-4
Online introductory course to IPR 1
Report on network-wide ESR courses 5-7

Websites, patent fillings, videos etc. (2)

Public Engagement Seminar series delivered by ESRs
Website and online repository

Pubblicazioni

Peer reviewed articles (29)

Comprehensive in vitro comparison of cellular and osteogenic response to alternative biomaterials for spinal implants

Autori: Seung-Hun Lee; Stephanie Huber; Stephen J. Ferguson
Pubblicato in: Biomaterials Advances, 127, Numero 17, 2021, ISSN 0928-4931
Editore: Elsevier BV
DOI: 10.1016/j.bas.2021.100006

In Vitro Biomechanics of the Cervical Spine: A Systematic Review.

Autori: Hossein Ansaripour; Stephen J. Ferguson; Markus Flohr
Pubblicato in: Journal of Biomechanical Engineering, 144 (10), Numero 11, 2022, ISSN 0148-0731
Editore: ASME
DOI: 10.1115/1.4054439

An ex-vivo model for the biomechanical assessment of cement discoplasty

Autori: Ghandour S, Pazarlis K, Lewin S, Isaksson P, Försth P, Persson C.
Pubblicato in: Front Bioeng Biotechnol, 2022, ISSN 2296-4185
Editore: PubMed
DOI: 10.3389/fbioe.2022.939717

Non-linear mechanical properties and dynamic response of silicon nitride bioceramic

Autori: Xiaoyu Du, Gurdial Blugan, Tina Künniger, Seunghun S. Lee, Liliya Vladislavova, Stephen J. Ferguson
Pubblicato in: Ceramics International, Numero 47/23, 2021, Pagina/e 33525-33536, ISSN 0272-8842
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.ceramint.2021.08.261

3D-Printed PEEK/Silicon Nitride Scaffolds with a Triply Periodic Minimal Surface Structure for Spinal Fusion Implants

Autori: Xiaoyu Du; Sean Ronayne; Seunghun S. Lee; Jackson Hendry; Douglas Hoxworth; Ryan Bock; Stephen J. Ferguson
Pubblicato in: ACS Applied Bio Materials, 6 (8), Numero 11, 2023, ISSN 2576-6422
Editore: ACS Appl. Bio Mater.
DOI: 10.1021/acsabm.3c00383

Structural Si3N4-SiO2 glass ceramics with bioactive and anti-bacterial properties

Autori: Huasi Zhou, Cecilia Persson, Olivier Donzel-Gargand, Håkan Engqvist, Wei Xia
Pubblicato in: Journal of the European Ceramic Society, Numero 44, 2024, Pagina/e 4260-4271, ISSN 0955-2219
Editore: Elsevier BV
DOI: 10.1016/j.jeurceramsoc.2024.01.016

Bioactive silicon nitride implants through surface modification

Autori: Ioannis Katsaros; Ken Welch; Wei Xia; Cecilia Persson; Håkan Engqvist
Pubblicato in: Brain and Spine, Vol 1, Iss , Pp 100124- (2021), Numero 13, 2021, ISSN 2772-5294
Editore: Elsevier
DOI: 10.1016/j.bas.2021.100124

Conceptual design of compliant bone scaffolds by full-scale topology optimization

Autori: Thijs Smit; Stijn Koppen; Stephen J. Ferguson; Benedikt Helgason
Pubblicato in: urn:issn:1751-6161, Numero 20, 2023, ISSN 1751-6161
Editore: Elsevier BV
DOI: 10.1016/j.jmbbm.2023.105886

Scaffolds for bone-tissue engineering

Autori: Seunghun S. Lee; Xiaoyu Du; Inseon Kim; Stephen J. Ferguson
Pubblicato in: Matter, 5 (9), Numero 1, 2022, ISSN 2590-2385
Editore: ScienceDirect
DOI: 10.1016/j.matt.2022.06.003

Current status and future potential of wear-resistant coatings and articulating surfaces for hip and knee implants

Autori: Charlotte Skjöldebrand; Joanne L. Tipper; Peter Hatto; Michael Bryant; Richard M. Hall; Cecilia Persson
Pubblicato in: Crossref, Numero 4, 2022, ISSN 2590-0064
Editore: PubMed
DOI: 10.1016/j.mtbio.2022.100270

Correlation between mechanical properties and porosity in silicon nitride bioceramic

Autori: Xiaoyu Du; Gurdial Blugan; Stephen J. Ferguson
Pubblicato in: Brain and Spine, Vol 1, Iss , Pp 100075- (2021), Numero 23, 2021, ISSN 2772-5294
Editore: ELSEVIER
DOI: 10.1016/j.bas.2021.100075

Silicon Nitride as a Biomedical Material: An Overview

Autori: Du, Xiaoyu; id_orcid0000-0003-2532-731X; Lee, Seunghun S.; Blugan, Gurdial; Ferguson, Stephen J.; id_orcid0000-0003-0650-5889
Pubblicato in: International Journal of Molecular Sciences, 23 (12), Numero 22, 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23126551

Topology optimization using PETSc: a Python wrapper and extended functionality

Autori: Thijs Smit; Niels Aage; Stephen J. Ferguson; Benedikt Helgason
Pubblicato in: Structural and Multidisciplinary Optimization, 64 (4), Numero 14, 2021, ISSN 1615-1488
Editore: SpringerLink
DOI: 10.1007/s00158-021-03018-7

Silicon Nitride, a Bioceramic for Bone Tissue Engineering: A Reinforced Cryogel System With Antibiofilm and Osteogenic Effects

Autori: Seunghun S. Lee; Leanid Laganenka; Xiaoyu Du; Wolf-Dietrich Hardt; Stephen J. Ferguson
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Vol 9 (2021), Numero 3, 2021, ISSN 2296-4185
Editore: Frontiers
DOI: 10.3389/fbioe.2021.794586

Bioactive Silicon Nitride Implant Surfaces with Maintained Antibacterial Properties

Autori: Ioannis Katsaros; Yijun Zhou; Ken Welch; Wei Xia; Cecilia Persson; Håkan Engqvist
Pubblicato in: Journal of Functional Biomaterials; Volume 13; Numero 3; Pages: 129, Numero 10, 2022, ISSN 2079-4983
Editore: National Library of Medicine
DOI: 10.3390/jfb13030129

The porous cantilever beam as a model for spinal implants: Experimental, analytical and finite element analysis of dynamic properties

Autori: Xiaoyu Du; Yijun Zhou; Lingzhen Li; Cecilia Persson; Stephen J. Ferguson
Pubblicato in: Mathematical Biosciences and Engineering, 20 (4), Numero 7, 2023, ISSN 1551-0018
Editore: AIMS Press
DOI: 10.3934/mbe.2023270

Hydroxyapatite particle shape affects screw attachment in cancellous bone when augmented with hydroxyapatite-containing hydrogels

Autori: Yijun Zhou; Lisa Höglund; Ayan Samanta; Philip Procter; Cecilia Persson
Pubblicato in: Journal of the Mechanical Behavior of Biomedical Materials, 2024, ISSN 1751-6161
Editore: Elsevier BV
DOI: 10.1016/j.jmbbm.2023.106241

SiNx Coating Deposition on CoCr by Plasma-Enhanced Chemical Vapor Deposition

Autori: Huasi Zhou, Cecilia Persson, Wei Xia, Håkan Engqvist
Pubblicato in: Biomedical Materials & Devices, Numero 2, 2024, Pagina/e 376-383, ISSN 2731-4812
Editore: Springer Science and Business Media LLC
DOI: 10.1007/s44174-023-00083-y

A Biomimetic Macroporous Hybrid Scaffold with Sustained Drug Delivery for Enhanced Bone Regeneration

Autori: Seung-Hun Lee; Matthias Santschi; Stephen J. Ferguson
Pubblicato in: Biomacromolecules, 22 (6), Numero 5, 2022, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.3929/ethz-b-000493840

Ceramics in total disc replacements: A scoping review

Autori: Lucia Kölle; Dominika Ignasiak; Stephen J. Ferguson; Benedikt Helgason
Pubblicato in: Clinical Biomechanics, 100, Numero 5, 2022, ISSN 0268-0033
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.clinbiomech.2022.105796

Comprehensive in vitro comparison of cellular and osteogenic response to alternative biomaterials for spinal implants

Autori: Seunghun S. Lee, Stephanie Huber, Stephen J. Ferguson
Pubblicato in: Materials Science and Engineering: C, Numero 127, 2021, Pagina/e 112251, ISSN 0928-4931
Editore: Elsevier BV
DOI: 10.1016/j.msec.2021.112251

Correction to “A Biomimetic Macroporous Hybrid Scaffold with Sustained Drug Delivery for Enhanced Bone Regeneration”

Autori: Seunghun S. Lee; Matthias Santschi; Stephen J. Ferguson
Pubblicato in: Crossref, Numero 4, 2023, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.2c00203

A Biomimetic Macroporous Hybrid Scaffold with Sustained Drug Delivery for Enhanced Bone Regeneration

Autori: Seunghun S. Lee, Matthias Santschi, Stephen J. Ferguson
Pubblicato in: Biomacromolecules, 2021, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.1c00241

A 3D-Printed Assemblable Bespoke Scaffold as a Versatile Microcryogel Carrier for Site-Specific Regenerative Medicine

Autori: Lee, Seunghun S.; Kleger, Nicole; Kuhn, Gisela A.; Greutert, Helen; Du, Xiaoyu; Smit, Thijs; Studart, André R.; Ferguson, Stephen J.
Pubblicato in: Advanced Materials, Numero 7, 2023, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.3929/ethz-b-000634325

Fe and C additions decrease the dissolution rate of silicon nitride coatings and are compatible with microglial viability in 3D collagen hydrogels

Autori: Estefanía Echeverri; Charlotte Skjöldebrand; Paul O'Callaghan; Anders Palmquist; Johan Kreuger; Gry Hulsart-Billström; Cecilia Persson
Pubblicato in: Crossref, Numero 5, 2023, ISSN 2047-4830
Editore: Royal Society of Chemistry
DOI: 10.1039/d2bm02074b

A self-renewing biomimetic skeletal muscle construct engineered using induced myogenic progenitor cells

Autori: Inseon Kim; Seunghun S. Lee; Adhideb Ghosh; Stephen J. Ferguson; Ori Bar‐Nur
Pubblicato in: Advanced Functional Materials, Numero 11, 2024, ISSN 1616-301X
Editore: John Wiley & Sons Ltd.
DOI: 10.1101/2023.04.10.534929

Tailoring the dissolution rate and in vitro cell response of silicon nitride coatings through combinatorial sputtering with chromium and niobium

Autori: Charlotte Skjöldebrand; Estefanía Echeverri; Gry Hulsart-Billström; Cecilia Persson
Pubblicato in: Crossref, Numero 4, 2022, ISSN 2047-4830
Editore: Royal Society of Chemistry
DOI: 10.1039/d1bm01978c

3D-printed LEGO®-inspired titanium scaffolds for patient-specific regenerative medicine

Autori: Seunghun S. Lee; Xiaoyu Du; Thijs Smit; Elisa G. Bissacco; Daniel Seiler; Michael de Wild; Stephen J. Ferguson
Pubblicato in: Crossref, Numero 4, 2023, ISSN 2772-9508
Editore: ScienceDirect
DOI: 10.1016/j.bioadv.2023.213617

Quasi-static and dynamic mechanical properties of a linoleic acid-modified, low-modulus bone cement for spinal applications

Autori: Salim Ghandour, Iain Christie, Caroline Öhman Mägi, Cecilia Persson
Pubblicato in: Open Research Europe, Numero 3, 2024, Pagina/e 203, ISSN 2732-5121
Editore: F1000 Research Ltd
DOI: 10.12688/openreseurope.16683.2

Thesis and dissertations (1)

Osseointegration of Biomaterials for Orthopaedic Implants

Autori: Lee, Seung Hun
Pubblicato in: 2023
Editore: ETH Zurich
DOI: 10.3929/ethz-b-000600496

Other (2)

Explicit FE simulation results for orthopedic screw-bone interaction, for different screw geometries and bone quality

Autori: Zhou, Yijun Helgason, Benedikt Ferguson, Stephen Persson, Cecilia
Pubblicato in: 2023
Editore: Zenodo
DOI: 10.5281/zenodo.8388808

Quasi-static and dynamic mechanical properties of a low-modulus bone cement for spinal applications

Autori: Salim Ghandour; Iain Christie; Caroline Öhman Mägi; Cecilia Persson
Pubblicato in: 2023
Editore: Open Research Europe
DOI: 10.12688/openreseurope.16683.1