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Biomechanics in health and disease: advanced physical tools for innovative early diagnosis

Deliverables

Progress Report

Preparation of the Progress Report.

Standardised procedure for preparation of tissues for mechanical testing

Definition of standardised procedures for the preparation of tissues for testing their mechanical properties.

Standardised cell culture conditions for mechanical testing

Definition of standardised cell culture conditions for mechanical testing.

Standardised procedure for tissue mechanics

Definition of standardised procedures for the characterisation of tissue mechanics.

Standardised procedure for immobilisation of tissues for mechanical testing

Definition of standardised procedures for the immobilisation of tissues for testing their mechanical properties.

Standardised procedure for cell mechanics

Development of standardised procedures for performing cell mechanics experiments.

Workshops

Organisation of Workshops, planned for Months 6,18,30,42.

Organisation of secondments

Organisation of secondments of ESRs (from Month 2 to Month 48).

Accuracy of mechanical tests

Determine the accuracy of mechanical tests, and identify the best measurement conditions.

Project meetings

Project meetings are planned at months 2,6,12,18,24,30,36,42,48.

Online resources

Management of online resources: wiki, webpage, social networks.

Contribution of ESRs to workshops, schools, and international conferences

Contribution of ESRs to workshops, schools, and international conferences. Planned roughly 6-monthly, starting from Month 6.

Recruitment of ESRs and PhD registration

Recruitment of ESRs and registration into the PhD programme.

Supervisory Board

Definition of the Supervisory Board of the network.

Identification of mechanical markers of diseases

Identification of specific mechanical markers of selected diseases.

Identification of links between biomechanics and disease

Identification of general links between biomechanics and disease.

Schools

Organisation of Schools, planned at Months 12, 24, 36.

Definition of secondments plan

All secondments plans must be prepared within this date.

Viscoelasticity of cells by microfluidics

Development of characterisation strategies of viscoelasticity of cells by microfluidic tools (beyond AFM).

Standardised procedures for sample shipping

Development of standardised procedures for cells and tissues transport and shipping.

Nano-biomechanics for schoolchildren

Nano-biomechanics communicated to schoolchildren (roughly annual).

Universal file format

Definition of a common universal file format for saving and sharing mechanical data in different laboratories.

Social networking

Social networking: creation and maintenance of Twitter, LinkedIn, ORCID and ResearchID accounts.

Searching for OpenAIRE data...

Publications

Adhesion force spectroscopy with nanostructured colloidal probes reveals nanotopography-dependent early mechanotransductive interactions at the cell membrane level

Author(s): M. Chighizola, A. Previdi, T. Dini, C. Piazzoni, C. Lenardi, P. Milani, C. Schulte, A. Podestà
Published in: Nanoscale, Issue 12/27, 2020, Page(s) 14708-14723, ISSN 2040-3364
DOI: 10.1039/d0nr01991g

Mechanotransduction in neuronal cell development and functioning

Author(s): Matteo Chighizola, Tania Dini, Cristina Lenardi, Paolo Milani, Alessandro Podestà, Carsten Schulte
Published in: Biophysical Reviews, Issue 11/5, 2019, Page(s) 701-720, ISSN 1867-2450
DOI: 10.1007/s12551-019-00587-2

Atomic force microscopy for cell mechanics and diseases

Author(s): Sandra Pérez-Domínguez, Shruti G. Kulkarni, Carmela Rianna, Manfred Radmacher
Published in: Neuroforum, Issue 0/0, 2020, ISSN 0947-0875
DOI: 10.1515/nf-2020-0001

Large colloidal probes for atomic force microscopy: Fabrication and calibration issues

Author(s): Matteo Chighizola, Luca Puricelli, Ludovic Bellon, Alessandro Podestà
Published in: Journal of Molecular Recognition, Issue 34/1, 2021, ISSN 0952-3499
DOI: 10.1002/jmr.2879

αvβ3 integrin expression increases elasticity in human melanoma cells

Author(s): Leda Lacaria, Janina R. Lange, Wolfgang H. Goldmann, Felix Rico, José Luis Alonso
Published in: Biochemical and Biophysical Research Communications, Issue 525/4, 2020, Page(s) 836-840, ISSN 0006-291X
DOI: 10.1016/j.bbrc.2020.02.156