Deliverables
Determine the typical viscoelastic fingerprint of cells and tissues.
Viscoelasticity of cells and tissues by nano-indenterCharacterisation of the viscoelastic properties of cells and tissues using a nano-indenter.
WorkshopsOrganisation of Workshops, planned for Months 6,18,30,42.
Organisation of secondmentsOrganisation of secondments of ESRs (from Month 2 to Month 48).
Scientific publicationsWriting of scientific publications and reviews and open access publications (the process will be monitored during the whole project, and the final check will be done at the end).
Accuracy of mechanical testsDetermine the accuracy of mechanical tests, and identify the best measurement conditions.
Project meetingsProject meetings are planned at months 2,6,12,18,24,30,36,42,48.
Online resourcesManagement of online resources: wiki, webpage, social networks.
Contribution of ESRs to workshops, schools, and international conferencesContribution of ESRs to workshops, schools, and international conferences. Planned roughly 6-monthly, starting from Month 6.
Recruitment of ESRs and PhD registrationRecruitment of ESRs and registration into the PhD programme.
Supervisory BoardDefinition of the Supervisory Board of the network.
Identification of mechanical markers of diseasesIdentification of specific mechanical markers of selected diseases.
Identification of links between biomechanics and diseaseIdentification of general links between biomechanics and disease.
Awarding of PhD title to ESRsAwarding of PhD title to ESRs.
SchoolsOrganisation of Schools, planned at Months 12, 24, 36.
Database of mechanical fingerprintsPopulate the database of mechanical fingerprints of disease with data collected for various relevant cases.
Mechanical model of cells and tissuesDevelop mechanical models of cells and tissues, to interpret experimental data.
Definition of secondments planAll secondments plans must be prepared within this date.
Viscoelasticity of cells by microfluidicsDevelopment of characterisation strategies of viscoelasticity of cells by microfluidic tools (beyond AFM).
Optimised correlative approachesDevelopment of optimised correlative approaches for the study of cell and tissue mechanics.
Standardised procedures for sample shippingDevelopment of standardised procedures for cells and tissues transport and shipping.
Consolidating middle-throughput mechanical testingConsolidate a methodology to run mechanical tests on multiple samples at the middle-throughput level.
Final symposiumOrganisation of the final project symposium.
Data processing open source softwareDevelop data processing open source software and applets.
Nano-biomechanics for schoolchildrenNano-biomechanics communicated to schoolchildren (roughly annual).
MOOCOrganisation of a Massive Open Online Course (MOOC).
Determination of mechanical fingerprints of clinical samplesDetermination of the major mechanical fingerprints of clinical samples, in health and disease.
Universal file formatDefinition of a common universal file format for saving and sharing mechanical data in different laboratories.
Social networkingSocial networking: creation and maintenance of Twitter, LinkedIn, ORCID and ResearchID accounts.
Identification of Characteristics of mechanical dynamicsIdentification of the characteristics of the dynamical mechanical properties of cells and tissues.
Wiki accessible to the scientific communityWiki made accessible to the scientific community.
Preparation of the Progress Report.
Standardised procedure for preparation of tissues for mechanical testingDefinition of standardised procedures for the preparation of tissues for testing their mechanical properties.
Standardised cell culture conditions for mechanical testingDefinition of standardised cell culture conditions for mechanical testing.
Standardised procedure for tissue mechanicsDefinition of standardised procedures for the characterisation of tissue mechanics.
Standardised procedure for immobilisation of tissues for mechanical testingDefinition of standardised procedures for the immobilisation of tissues for testing their mechanical properties.
Standardised procedure for cell mechanicsDevelopment of standardised procedures for performing cell mechanics experiments.
Deposition of raw data in open access repository according to ORDP rules
Project website running.
Publications
Author(s):
Narciso M, Ulldemolins A, Júnior C, Otero J, Navajas D, Farré R, Gavara N, Almendros I
Published in:
Frontiers in Bioengineering and Biotechnology, 2022, ISSN 2296-4185
Publisher:
Frontiers Media S.A.
DOI:
10.3389/fbioe.2022.832178
Author(s):
Maria Narciso; Jorge Otero; Daniel Navajas; Ramon Farré; Isaac Almendros; Núria Gavara
Published in:
International Journal of Molecular Sciences, 2021, ISSN 1422-0067
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms22168399
Author(s):
Malgorzata Lekka, Kajangi Gnanachandran, Andrzej Kubiak, Tomasz Zielinski, Joanna Zemla
Published in:
Micron, Issue 150, 2021, Page(s) 103138, ISSN 0968-4328
Publisher:
Pergamon Press Ltd.
DOI:
10.1016/j.micron.2021.103138
Author(s):
Luca Varinelli, Marcello Guaglio, Silvia Brich, Susanna Zanutto, Antonino Belfiore, Federica Zanardi, Fabio Iannelli, Amanda Oldani, Elisa Costa, Matteo Chighizola, Ewelina Lorenc, Simone P Minardi, Stefano Fortuzzi, Martina Filugelli, Giovanna Garzone, Federica Pisati, Manuela Vecchi, Giancarlo Pruneri, Shigeki Kusamura, Dario Baratti, Laura Cattaneo, Dario Parazzoli, Alessandro Podestà, Massimo
Published in:
Journal of Molecular Cell Biology, 2022, ISSN 1759-4685
Publisher:
Oxford University Press
DOI:
10.1093/jmcb/mjac064
Author(s):
Maria Chatzifrangkeskou, Delf Kah, Janina R. Lange, Wolfgang H. Goldmann, Antoine Muchir
Published in:
Biochemical and Biophysical Research Communications, Issue 529/3, 2020, Page(s) 861-867, ISSN 0006-291X
Publisher:
Academic Press
DOI:
10.1016/j.bbrc.2020.05.102
Author(s):
Sanz-Fraile, H., Amoros, S., Mendizabal, I., Galvez-Monton, C., Prat-Vidal, C., Bayes-Genis, A., Navajas, D., Farre, R., & Otero, J.
Published in:
Tissue Engineering Part A, 2020, ISSN 1937-335X
Publisher:
Mary Ann Liebert Inc.
DOI:
10.1089/ten.tea.2019.0199
Author(s):
Malgorzata Lekka
Published in:
Phil. Trans. R. Soc. A, 2022, ISSN 1471-2962
Publisher:
The Royal Society publishing
DOI:
10.1098/rsta.2021.0346
Author(s):
Matteo Chighizola; Tania Dini; Stefania Marcotti; Mirko D’Urso; Claudio Piazzoni; Francesca Borghi; Anita Previdi; Laura Ceriani; Claudia Folliero; Brian Stramer; Cristina Lenardi; Paolo Milani; Alessandro Podestà; Carsten Schulte
Published in:
Journal of Nanobiotechnology, 2022, Page(s) 418, ISSN 1477-3155
Publisher:
BioMed Central
DOI:
10.1186/s12951-022-01585-5
Author(s):
Arnaud Millet
Published in:
Biology (Basel), Issue 10(1), 2021, Page(s) 64, ISSN 2079-7737
Publisher:
Biology
DOI:
10.3390/biology10010064
Author(s):
Falcones B, Sanz-Fraile H, Marhuenda E, Mendizábal I, Cabrera-Aguilera I, Malandain N, Uriarte JJ, Almendros I, Navajas D, Weiss DJ, Farré R, Otero J.
Published in:
Polymers, 2021, ISSN 2073-4360
Publisher:
MDPI AG
DOI:
10.3390/polym13142350
Author(s):
Shu-wen W. Chen, Jean-Marie Teulon, Harinderbir Kaur, Christian Godon and Jean-Luc Pellequer
Published in:
Nanoscale Horizons, Issue 20556764, 2022, ISSN 2055-6764
Publisher:
Royal Society of Chemistry
DOI:
10.1039/d2nh00390b
Author(s):
Narciso M, Ulldemolins A, Júnior C, Otero J, Navajas D, Farré R, Gavara N, Almendros I
Published in:
Bio-protocol Journal, 2022, ISSN 2331-8325
Publisher:
Sunnyvale CA: Bio-protocol LLC
DOI:
10.21769/bioprotoc.4550
Author(s):
Richard Gerum; Elham Mirzahossein; Mar Eroles; Jennifer Elsterer; Astrid Mainka; Andreas Bauer; Selina Sonntag; Alexander Winterl; Johannes Bartl; Lena Fischer; Shada Abuhattum; Ruchi Goswami; Salvatore Girardo; Jochen Guck; Stefan Schrüfer; Nadine Ströhlein; Mojtaba Nosratlo; Harald Herrmann; Dorothea Schultheis; Felix Rico; Sebastian Müller; Stephan Gekle; Ben Fabry
Published in:
eLife, 2022, ISSN 2050-084X
Publisher:
eLife Sciences Publications
DOI:
10.7554/elife.78823
Author(s):
Kajangi Gnanachandran, Sylwia Kędracka-Krok, Joanna Pabijan, Małgorzata Lekka
Published in:
Journal of Biomechanics, Issue 144, 2022, Page(s) 111346, ISSN 0021-9290
Publisher:
Elsevier BV
DOI:
10.1016/j.jbiomech.2022.111346
Author(s):
Daniel Navajas; José Manuel Garcia-Aznar; Gabriel Beltran
Published in:
Journal of the Mechanical Behavior of Biomedical Materials, 2022, ISSN 1751-6161
Publisher:
Elsevier BV
DOI:
10.1016/j.jmbbm.2021.105043
Author(s):
Massimiliano Berardi, Kajangi Gnanachandran, Jieke Jiang, Kevin Bielawski, Claas W. Visser, Małgorzata Lekka, B. Imran akca
Published in:
Soft Matter, 2022, ISSN 1744-683X
Publisher:
Royal Society of Chemistry
DOI:
10.1039/d2sm01173e
Author(s):
Malier M, Gharzeddine K, Laverriere MH, Marsili S, Thomas F, Court M, Decaens T, Roth G, Millet A.
Published in:
Cancer research, 2021, ISSN 0008-5472
Publisher:
American Association for Cancer Research
DOI:
10.1158/0008-5472.can-21-1572
Author(s):
López-Mengual A, Segura-Feliu M, Sunyer R, Sanz-Fraile H, Otero J, Mesquida-Veny F, Gil V, Hervera A, Ferrer I, Soriano J, Trepat X, Farré R, Navajas D, Del Río JA
Published in:
Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Publisher:
Frontiers Media S.A.
DOI:
10.3389/fcell.2022.886110
Author(s):
Martins C. S., Taveneau C., Castro-Linares G., Baibakov M., Buzhinsky N., Eroles M., Milanović V., Omi S., Pedelacq J.-D., Iv F., Bouillard L., Llewellyn A., Gomes M., Belhabib M., Kuzmić M., Verdier-Pinard P., Lee S., Badache A., Kumar S., Chandre C., Brasselet S., Rico F., Rossier O., Koenderink G. H., Wenger J., Cabantous S., Mavrakis M.
Published in:
Journal of Cell Biology, 2023, ISSN 0021-9525
Publisher:
Rockefeller University Press
DOI:
10.1083/jcb.202203016
Author(s):
Júnior C, Narciso M, Marhuenda E, Almendros I, Farré R, Navajas D, Otero J, Gavara N
Published in:
International Journal of Molecular Sciences, 2021, ISSN 1422-0067
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms222312928
Author(s):
M. Chighizola, A. Previdi, T. Dini, C. Piazzoni, C. Lenardi, P. Milani, C. Schulte, A. Podestà
Published in:
Nanoscale, Issue 12/27, 2020, Page(s) 14708-14723, ISSN 2040-3364
Publisher:
Royal Society of Chemistry
DOI:
10.1039/d0nr01991g
Author(s):
Lolo F-N, Walani N, Seemann E, Zalvidea D, Pavón DM, Cojoc G, Zamai M, Viaris de Lesegno C, Martínez de Benito F, Sánchez-Álvarez M, Uriarte JJ, Echarri A, Escolano J-C, Sánchez SA, Caiolfa VR, Navajas D, Trepat X, Guck J, Lamaze C, Roca-Cusachs P, Kessels MM, Qualmann B, Arroyo M, del Pozo MA.
Published in:
Nat Cell Biol., Issue 25, 2023, Page(s) 120-133, ISSN 1465-7392
Publisher:
Nature Publishing Group
DOI:
10.1038/s41556-022-01034-3
Author(s):
Júnior C, Ulldemolins A, Narciso M, Almendros I, Farre R, Navajas D, Lopez J, Eroles M, Rico F, Gavara N
Published in:
Int J Mol Sci, Issue 24, 2023, Page(s) 1708, ISSN 1422-0067
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms24021708
Author(s):
Andrzej Kubiak; Matteo Chighizola; Carsten Schulte; Natalia Bryniarska; Julita Wesołowska; Maciej Pudełek; Małgorzata Lasota; Damian Ryszawy; Agnieszka Basta-Kaim; Piotr Laidler; Alessandro Podestà; Małgorzata Lekka
Published in:
Nanoscale, 2021, ISSN 2040-3372
Publisher:
Royal Society of Chemistry
DOI:
10.1039/d0nr06464e
Author(s):
Matteo Chighizola, Tania Dini, Cristina Lenardi, Paolo Milani, Alessandro Podestà, Carsten Schulte
Published in:
Biophysical Reviews, Issue 11/5, 2019, Page(s) 701-720, ISSN 1867-2450
Publisher:
Springer Verlag
DOI:
10.1007/s12551-019-00587-2
Author(s):
Katerina Karkali, Ignasi Jorba, Daniel Navajas, Enrique Martin-Blanco
Published in:
STAR protocols, Issue 3, 2022, Page(s) 101901, ISSN 2666-1667
Publisher:
Cell Press
DOI:
10.1016/j.xpro.2022.101901
Author(s):
Sandra Pérez-Domínguez, Elisabeth Werkmeister, Maria Luisa Marini, Vicent Dupres, Sébastien Janel, Frank Lafont, Manfred Radmacher
Published in:
Frontiers in Physics, Sec. Biophysics, 2022, ISSN 2296-424X
Publisher:
Frontiers Media
DOI:
10.3389/fphy.2022.1052203
Author(s):
Sandra Pérez-Domínguez, Javier López-Alonso, Frank Lafont and Manfred Radmacher
Published in:
International Journal of Molecular Science, 2023, ISSN 1422-0067
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms24032043
Author(s):
L. Martinez-Vidal, M. Chighizola, M. Berardi, E. Alchera, I. Locatelli, F. Pederzoli, C. Venegoni, R. Lucianò, P. Milani, K. Bielawski, A. Salonia, A. Podestà, M. Alfano
Published in:
Communications Biology, 2023, ISSN 2399-3642
Publisher:
Springer Nature
DOI:
10.1038/s42003-023-04572-0
Author(s):
Sandra Pérez-Domínguez, Shruti G. Kulkarni, Carmela Rianna, Manfred Radmacher
Published in:
Neuroforum, Issue 0/0, 2020, ISSN 0947-0875
Publisher:
Spektrum Akademischer Verlag GmbH
DOI:
10.1515/nf-2020-0001
Author(s):
Matteo Chighizola, Luca Puricelli, Ludovic Bellon, Alessandro Podestà
Published in:
Journal of Molecular Recognition, Issue 34/1, 2021, ISSN 0952-3499
Publisher:
John Wiley & Sons Inc.
DOI:
10.1002/jmr.2879
Author(s):
Leda Lacaria, Janina R. Lange, Wolfgang H. Goldmann, Felix Rico, José Luis Alonso
Published in:
Biochemical and Biophysical Research Communications, Issue 525/4, 2020, Page(s) 836-840, ISSN 0006-291X
Publisher:
Academic Press
DOI:
10.1016/j.bbrc.2020.02.156
Author(s):
Hatice Holuigue; Ewelina Lorenc; Matteo Chighizola; Carsten Schulte; Luca Varinelli; Marcello Deraco; Marcello Guaglio; Manuela Gariboldi; Alessandro Podestà
Published in:
Sensors, Issue 22(6), 2022, Page(s) 2197, ISSN 1424-8220
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/s22062197
Author(s):
Massimiliano Berardi, Kevin Bielawski, Niek Rijnveld, Grzegorz Gruca, Hilde Aardema, Leni van Tol, Gijs Wuite, B. Imran Akca
Published in:
Communications Biology, 2021, ISSN 2399-3642
Publisher:
Nature Portfolio
DOI:
10.1038/s42003-021-02121-1
Author(s):
Edited by: M. Lekka, D. Navajas, M. Radmacher, A. Podestà
Published in:
MECHANICS OF CELLS AND TISSUES IN DISEASES, 2023
Publisher:
De Gruyter
Author(s):
H. Holuigue, L. Nacci, P. Di Chiaro, M. Chighizola, I. Locatelli, C. Schulte, M. Alfano, G.R. Diaferia, A. Podestà
Published in:
bioRxiv, 2022
Publisher:
Cold Spring Harbor Laboratory
DOI:
10.1101/2022.12.02.518867
Author(s):
E. Lorenc, L. Varinelli, M. Chighizola, S. Brich, F. Pisati, M. Guaglio, D. Baratti, M. Deraco, M. Gariboldi,A. Podestà
Published in:
bioRxiv, 2022
Publisher:
Cold Spring Harbor Laboratory
DOI:
10.1101/2022.08.17.504271
Author(s):
Mar Eroles, Javier Lopez-Alonso, Alexandre Ortega, Thomas Boudier, Khaldoun Gharzeddine, Frank Lafont, Clemens M. Franz, Arnaud Millet, Claire Valoteau, Felix Rico
Published in:
BioRxiv, 2022
Publisher:
Cold Spring Harbor Laboratory
DOI:
10.1101/2022.11.29.518356
Intellectual Property Rights
Application/Publication number:
20
22054291
Date:
2022-02-21
Applicant(s):
OPTICS11 BV
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