Project description DEENESFRITPL Molecular mechanisms of arthritic disease resolution The EU-funded ArthritisHeal project aims to discover novel therapeutic targets for rheumatic diseases osteoarthritis and rheumatoid arthritis by training 12 young research specialists. The project is focussing on pro-resolving lipids and the fundamental role they play in stimulating the resolution of inflammation. The mechanism of resolution depends on the active biosynthetic shift from pro-inflammatory to pro-resolution mediators, the pro-resolving lipids, biosynthesised from omega-3 fatty acids. The project will employ clinical samples and animal models to identify clinically relevant lipids: novel pro-resolving lipids discovered in preclinical models will be validated in clinical samples, and the mode of action of known lipids will be determined in preclinical models. Show the project objective Hide the project objective Objective In the ArthritisHeal project 7 universities and 2 companies, together with 8 associated partners, will train 12 young researchers and will discover novel therapeutic targets for two rheumatic diseases: osteoarthritis (OA) and rheumatoid arthritis (RA). The project will focus on the role of pro-resolving lipids, which play an important role in both diseases by stimulating resolution of inflammation. Both OA and RA cause pain and deformation of joints, with inflammation playing large role in the pathogenesis of both diseases. Current therapies, focused on inhibition of inflammation, are insufficient to cure rheumatic diseases. By exploiting pro-resolving mechanisms, novel therapeutic targets will be discovered in this project, ultimately improving RA and OA treatment. During the project both clinical samples and animal models will be used to study mode of action and verify clinically relevant lipids. Novel lipids discovered in pre-clinical models are validated in clinical samples, and the mode-of-action of known lipids will be determined in pre-clinical models.The consortium of academic and industrial beneficiaries with leading expertise in rheumatology, lipidomics, immunology and data analysis will provide scientific and technology training to ESRs. Associated partners will provide secondment opportunities and training, e.g. in regulatory and IP issues and career development. Each ESR will follow a personalised training programme combining clinical, biological and chemical insights to solve challenges in the development of treatments for rheumatic diseases. The ESRs will receive training both in an academic as well as an industrial setting. By studying the role of pro-resolving lipids in two important rheumatic diseases in conjunction, the consortium will: - Train young researchers in the interdisciplinary approach necessary to develop treatments for complex diseases.- Validate therapeutic targets in important pro-resolving lipid pathways. Fields of science natural sciencescomputer and information sciencesdata sciencemedical and health sciencesclinical medicinerheumatologymedical and health sciencesbasic medicineimmunologynatural sciencesbiological sciencesbiochemistrybiomoleculeslipids Keywords Arthritis Resolution of Inflammation Personalised Therapy Arthritis Cure Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.1. - Fostering new skills by means of excellent initial training of researchers Topic(s) MSCA-ITN-2018 - Innovative Training Networks Call for proposal H2020-MSCA-ITN-2018 See other projects for this call Funding Scheme MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN) Coordinator ACADEMISCH ZIEKENHUIS LEIDEN Net EU contribution € 796 859,64 Address Albinusdreef 2 2333 ZA Leiden Netherlands See on map Region West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (8) Sort alphabetically Sort by Net EU contribution Expand all Collapse all KAROLINSKA INSTITUTET Sweden Net EU contribution € 563 965,92 Address Nobels vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 KATHOLIEKE UNIVERSITEIT LEUVEN Belgium Net EU contribution € 256 320,00 Address Oude markt 13 3000 Leuven See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITY OF GLASGOW United Kingdom Net EU contribution € 303 172,56 Address University avenue G12 8QQ Glasgow See on map Region Scotland West Central Scotland Glasgow City Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 EBERHARD KARLS UNIVERSITAET TUEBINGEN Germany Net EU contribution € 252 788,40 Address Geschwister-scholl-platz 72074 Tuebingen See on map Region Baden-Württemberg Tübingen Tübingen, Landkreis Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 QUEEN MARY UNIVERSITY OF LONDON United Kingdom Net EU contribution € 303 172,56 Address 327 mile end road E1 4NS London See on map Region London Inner London — East Tower Hamlets Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 CARDIFF UNIVERSITY United Kingdom Net EU contribution € 303 172,56 Address Newport road 30 36 CF24 0DE Cardiff See on map Region Wales East Wales Cardiff and Vale of Glamorgan Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 PHARMAGNOSE VIOTECHNOLOGIKI ANONYMI ETAIREIA Greece Net EU contribution € 243 017,64 Address Papathanasiou 24 34100 Chalkida See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Κεντρική Ελλάδα Στερεά Ελλάδα Εύβοια Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 IMMUNOTECH SAS France Net EU contribution € 274 802,04 Address Avenue jean de lattre de tassigny 130 13009 Marseille See on map Region Provence-Alpes-Côte d’Azur Provence-Alpes-Côte d’Azur Bouches-du-Rhône Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Partners (8) Sort alphabetically Sort by Net EU contribution Expand all Collapse all Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. PHARMATICS LIMITED United Kingdom Net EU contribution € 0,00 Address 9 little france road edinburgh bioquarter EH16 4UX Edinburgh See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Scotland Eastern Scotland Edinburgh Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. THE SCRIPPS RESEARCH INSTITUTE CORPORATION United States Net EU contribution € 0,00 Address North torrey pines road 10550 92037 1000 La jolla See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. ABBVIE INC United States Net EU contribution € 0,00 Address North waukegan road 1 60064 North chicago il See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. THE REGENTS OF THE UNIVERSITY OF CALIFORNIA United States Net EU contribution € 0,00 Address Franklin street 1111 12 floor 94607 Oakland ca See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. AB Sciex Pte. Ltd Canada Net EU contribution € 0,00 Address 71 four valley dr L4K 4V8 Concord See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. DEHNE MATTHIAS Netherlands Net EU contribution € 0,00 Address See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. Stichting ReumaNederland Netherlands Net EU contribution € 0,00 Address Dr j van breemenstraat 4 1056 AB Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Other Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON Greece Net EU contribution € 0,00 Address 6 christou lada str 10561 Athina See on map Region Αττική Aττική Κεντρικός Τομέας Αθηνών Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
