Establishing the molecular fundamentals of arthritic diseases – a step forward to Heal Arthritis

Project Information

ArthritisHeal

Grant agreement ID: 812890

DOI 10.3030/812890

Project closed

EC signature date 29 January 2019

Start date 1 March 2019

End date 28 February 2023

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 3 297 271,32

EU contribution € 3 297 271,32

Coordinated by

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (1)

Website and discussion forum

Publications

Peer reviewed articles (17)

Inhibition of Δ24-dehydrocholesterol reductase activates pro-resolving lipid mediator biosynthesis and inflammation resolution

Author(s): Körner, Andreas; Zhou, Enchen; Müller, Christoph; Mohammed, Yassene; Herceg, Sandra; Bracher, Franz; Rensen, Patrick C. N.; Wang, Yanan; Mirakaj, Valbona; Giera, Martin
Published in: Proceedings of the National Academy of Sciences, 116(41), 20623 - 20634, Issue 1, 2019, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1911992116

Biosynthesis of prostaglandin 15dPGJ2 -glutathione and 15dPGJ2-cysteine conjugates in macrophages and mast cells via MGST3

Author(s): Julia Steinmetz-Späh, Jianyang Liu, Rajkumar Singh, Maria Ekoff, Sanjaykumar Boddul, Xiao Tang, Filip Bergqvist, Helena Idborg, Pascal Heitel, Elin Rönnberg, Daniel Merk, Fredrik Wermeling, Jesper Z. Haeggström, Gunnar Nilsson, Dieter Steinhilber, Karin Larsson, Marina Korotkova, Per-Johan Jakobsson
Published in: Journal of lipid research, 2022, ISSN 0022-2275
Publisher: Lipid Research, Inc.
DOI: 10.1016/j.jlr.2022.100310

Leveraging whole blood based functional flow cytometry assays to open new perspectives for rheumatoid arthritis translational research.

Author(s): Celia Cartagena García; Nathalie Balandraud; Jean Roudier; Pierre Lafforgue; Nathalie Lambert; Jean-Marc Busnel
Published in: Crossref, Issue 1, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-16622-4

Development of a Flow Cytometry–Based Functional Assay to Study Anti-TNF Mechanisms of Action and Capture Donor Heterogeneity

Author(s): Celia Cartagena García, Alexandra Lefèvre, Jean-Marc R. Busnel
Published in: ImmunoHorizons, Issue 4/10, 2020, Page(s) 648-658, ISSN 2573-7732
Publisher: The American Association of Immunologists, Inc
DOI: 10.4049/immunohorizons.2000077

SARS-CoV-2 spike protein induces a differential monocyte activation that may contribute to age bias in COVID-19 severity

Author(s): Ines Ait-Belkacem; Celia Cartagena García; Ewa Millet-Wallisky; Nicolas Izquierdo; Marie Loosveld; Isabelle Arnoux; Pierre-Emmanuel Morange; Franck Galland; Nathalie Lambert; Fabrice Malergue; Jean-Marc Busnel
Published in: Crossref, Issue 1, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-25259-2

Reproducibility of Targeted Lipidome Analyses (Lipidyzer) in Plasma and Erythrocytes over a 6-Week Period

Author(s): Marieke Loef, Johannes H. von Hegedus, Mohan Ghorasaini, Féline P. B. Kroon, Martin Giera, Andreea Ioan-Facsinay, Margreet Kloppenburg
Published in: Metabolites, Issue 11/1, 2021, Page(s) 26, ISSN 2218-1989
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/metabo11010026

Sema7A is crucial for resolution of severe inflammation.

Author(s): Andreas Körner; Alice Bernard; Julia C. Fitzgerald; Juan Carlos Alarcon-Barrera; Sarantos Kostidis; Torsten Kaussen; Martin Giera; Valbona Mirakaj
Published in: VOLUME=118;ISSUE=9;TITLE=Proceedings of the National Academy of Sciences, Issue 1, 2021, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2017527118

Fa(c)t checking: How fatty acids shape metabolism and function of macrophages and dendritic cells

Author(s): Luís Almeida, Bart Everts
Published in: European Journal of Immunology, 2021, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202048944

The Annexin-A1 mimetic RTP-026 promotes acute cardioprotection through modulation of immune cell activation

Author(s): Jianmin Chen, Silvia Oggero, Chiara Cecconello, Jesmond Dalli, Hedayatullah Hayat, Ahmad Hjiej Andaloussi, Samra Sanni, Thomas EN Jonassen, Mauro Perretti
Published in: Pharmacological Research, Issue 198, 2023, Page(s) 107005, ISSN 1043-6618
Publisher: Academic Press
DOI: 10.1016/j.phrs.2023.107005

Dorsal root ganglia CX3CR1 expressing monocytes/macrophages contribute to arthritis pain

Author(s): Silvia Oggero, Chiara Cecconello, Rita Silva, Lynda Zeboudj, George Sideris-Lampretsas, Mauro Perretti, Marzia Malcangio.
Published in: Brain, Behavior, and Immunity, Issue Volume 106, 2022, Page(s) 289-306, ISSN 0889-1591
Publisher: Academic Press
DOI: 10.1016/j.bbi.2022.09.008

Cross-Laboratory Standardization of Preclinical Lipidomics Using Differential Mobility Spectrometry and Multiple Reaction Monitoring

Author(s): Mohan Ghorasaini, Yassene Mohammed, Jerzy Adamski, Lisa Bettcher, John A. Bowden, Matias Cabruja, Kévin Contrepois, Mathew Ellenberger, Bharat Gajera, Mark Haid, Daniel Hornburg, Christie Hunter, Christina M. Jones, Theo Klein, Oleg Mayboroda, Mina Mirzaian, Ruin Moaddel, Luigi Ferrucci, Jacqueline Lovett, Kenneth Nazir, Mackenzie Pearson, Baljit K. Ubhi, Daniel Raftery, Fabien Riols, Rebekah Say
Published in: Analytical chemistry, Issue 2021, 93, 49, 2021, Page(s) 16369–16378, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.1c02826

Synthesis and evaluation of antiproliferative and mPGES-1 inhibitory activities of novel carvacrol-triazole conjugates

Author(s): İlkay Küçükgüzel, İlker Demirbolat, Necla Kulabaş, Merve Gürboğa, Özlem Bingöl Özakpınar, Gamze Çiftçi, Kemal Yelekçi, Jianyang Liu, Per-Johan Jakobsson, Özkan Danış, Ayşe Ogan
Published in: Organic Communications, 2022, Page(s) 356-377, ISSN 1307-6175
Publisher: Academy of Chemistry of Globe Publications
DOI: 10.25135/acg.oc.142.2212.2651

Defining the structure of the NF-ĸB pathway in human immune cells using quantitative proteomic data.

Author(s): Fatma O. Kok; Haoying Wang; Patricia Riedlova; Carl S. Goodyear; Ruaidhrí J. Carmody
Published in: Cellular SIgnalling, Issue 08986568, 2021, Page(s) 110154, ISSN 0898-6568
Publisher: Elsevier BV
DOI: 10.1016/j.cellsig.2021.110154

A whole blood-based functional assay to characterize immunoglobulin A effector functions

Author(s): Alice Bacon, Celia Cartagena García, Karin A. van Schie, René E. M. Toes, Jean-Marc Busnel
Published in: Autoimmunity, 2024, ISSN 0891-6934
Publisher: Taylor & Francis
DOI: 10.1080/08916934.2024.2341629

The anti-inflammatory and vasoprotective properties of mPGES-1 inhibition offer promising therapeutic potential

Author(s): Julia Steinmetz-Späh, Per-Johan Jakobsson
Published in: Expert Opinion on Therapeutic Targets, Issue 27, 2024, Page(s) 1115-1123, ISSN 1472-8222
Publisher: Ashley Publications Ltd.
DOI: 10.1080/14728222.2023.2285785

Congruence and Complementarity of Differential Mobility Spectrometry and NMR Spectroscopy for Plasma Lipidomics

Author(s): Mohan Ghorasaini; Konstantina Ismini Tsezou; Aswin Verhoeven; Yassene Mohammed; Panayiotis Vlachoyiannopoulos; Emmanuel Mikros; Martin Giera
Published in: VOLUME=12;ISSUE=11;TITLE=Metabolites, Issue 3, 2022, ISSN 2218-1989
Publisher: MDPI
DOI: 10.3390/metabo12111030

Novel Resolution Mediators of Severe Systemic Inflammation.

Author(s): Verena Gudernatsch; Sylwia Anna Stefańczyk; Valbona Mirakaj
Published in: ImmunoTargets and Therapy, Issue 1, 2020, ISSN 2253-1556
Publisher: Dove press ImmunoTargets and Therapy
DOI: 10.2147/itt.s243238

Book chapters (1)

Chapter 4 - Resolving acute inflammation; what happens when inflammation goes haywire? How can it get back in line?

Author(s): Chiara Cecconello, Pol Clària Ribas, Lucy V. Norling.
Published in: Diet, Inflammation, and Health, 2022, Page(s) 113-162, ISBN 9780128221303
Publisher: Academic Press
DOI: 10.1016/b978-0-12-822130-3.00018-1