Establishing the molecular fundamentals of arthritic diseases – a step forward to Heal Arthritis | ArthritisHeal | Project | Results | H2020 | CORDIS

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Inhibition of Δ24-dehydrocholesterol reductase activates pro-resolving lipid mediator biosynthesis and inflammation resolution

Auteurs: Körner, Andreas; Zhou, Enchen; Müller, Christoph; Mohammed, Yassene; Herceg, Sandra; Bracher, Franz; Rensen, Patrick C. N.; Wang, Yanan; Mirakaj, Valbona; Giera, Martin
Publié dans: Proceedings of the National Academy of Sciences, 116(41), 20623 - 20634, Numéro 1, 2019, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.1911992116

Biosynthesis of prostaglandin 15dPGJ2 -glutathione and 15dPGJ2-cysteine conjugates in macrophages and mast cells via MGST3

Auteurs: Julia Steinmetz-Späh, Jianyang Liu, Rajkumar Singh, Maria Ekoff, Sanjaykumar Boddul, Xiao Tang, Filip Bergqvist, Helena Idborg, Pascal Heitel, Elin Rönnberg, Daniel Merk, Fredrik Wermeling, Jesper Z. Haeggström, Gunnar Nilsson, Dieter Steinhilber, Karin Larsson, Marina Korotkova, Per-Johan Jakobsson
Publié dans: Journal of lipid research, 2022, ISSN 0022-2275
Éditeur: Lipid Research, Inc.
DOI: 10.1016/j.jlr.2022.100310

Leveraging whole blood based functional flow cytometry assays to open new perspectives for rheumatoid arthritis translational research.

Auteurs: Celia Cartagena García; Nathalie Balandraud; Jean Roudier; Pierre Lafforgue; Nathalie Lambert; Jean-Marc Busnel
Publié dans: Crossref, Numéro 1, 2022, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-022-16622-4

Development of a Flow Cytometry–Based Functional Assay to Study Anti-TNF Mechanisms of Action and Capture Donor Heterogeneity

Auteurs: Celia Cartagena García, Alexandra Lefèvre, Jean-Marc R. Busnel
Publié dans: ImmunoHorizons, Numéro 4/10, 2020, Page(s) 648-658, ISSN 2573-7732
Éditeur: The American Association of Immunologists, Inc
DOI: 10.4049/immunohorizons.2000077

SARS-CoV-2 spike protein induces a differential monocyte activation that may contribute to age bias in COVID-19 severity

Auteurs: Ines Ait-Belkacem; Celia Cartagena García; Ewa Millet-Wallisky; Nicolas Izquierdo; Marie Loosveld; Isabelle Arnoux; Pierre-Emmanuel Morange; Franck Galland; Nathalie Lambert; Fabrice Malergue; Jean-Marc Busnel
Publié dans: Crossref, Numéro 1, 2022, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-022-25259-2

Reproducibility of Targeted Lipidome Analyses (Lipidyzer) in Plasma and Erythrocytes over a 6-Week Period

Auteurs: Marieke Loef, Johannes H. von Hegedus, Mohan Ghorasaini, Féline P. B. Kroon, Martin Giera, Andreea Ioan-Facsinay, Margreet Kloppenburg
Publié dans: Metabolites, Numéro 11/1, 2021, Page(s) 26, ISSN 2218-1989
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/metabo11010026

Sema7A is crucial for resolution of severe inflammation.

Auteurs: Andreas Körner; Alice Bernard; Julia C. Fitzgerald; Juan Carlos Alarcon-Barrera; Sarantos Kostidis; Torsten Kaussen; Martin Giera; Valbona Mirakaj
Publié dans: VOLUME=118;ISSUE=9;TITLE=Proceedings of the National Academy of Sciences, Numéro 1, 2021, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.2017527118

Fa(c)t checking: How fatty acids shape metabolism and function of macrophages and dendritic cells

Auteurs: Luís Almeida, Bart Everts
Publié dans: European Journal of Immunology, 2021, ISSN 0014-2980
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202048944

Dorsal root ganglia CX3CR1 expressing monocytes/macrophages contribute to arthritis pain

Auteurs: Silvia Oggero, Chiara Cecconello, Rita Silva, Lynda Zeboudj, George Sideris-Lampretsas, Mauro Perretti, Marzia Malcangio.
Publié dans: Brain, Behavior, and Immunity, Numéro Volume 106, 2022, Page(s) 289-306, ISSN 0889-1591
Éditeur: Academic Press
DOI: 10.1016/j.bbi.2022.09.008

Cross-Laboratory Standardization of Preclinical Lipidomics Using Differential Mobility Spectrometry and Multiple Reaction Monitoring

Auteurs: Mohan Ghorasaini, Yassene Mohammed, Jerzy Adamski, Lisa Bettcher, John A. Bowden, Matias Cabruja, Kévin Contrepois, Mathew Ellenberger, Bharat Gajera, Mark Haid, Daniel Hornburg, Christie Hunter, Christina M. Jones, Theo Klein, Oleg Mayboroda, Mina Mirzaian, Ruin Moaddel, Luigi Ferrucci, Jacqueline Lovett, Kenneth Nazir, Mackenzie Pearson, Baljit K. Ubhi, Daniel Raftery, Fabien Riols, Rebekah Say
Publié dans: Analytical chemistry, Numéro 2021, 93, 49, 2021, Page(s) 16369–16378, ISSN 0003-2700
Éditeur: American Chemical Society
DOI: 10.1021/acs.analchem.1c02826

Defining the structure of the NF-ĸB pathway in human immune cells using quantitative proteomic data.

Auteurs: Fatma O. Kok; Haoying Wang; Patricia Riedlova; Carl S. Goodyear; Ruaidhrí J. Carmody
Publié dans: Cellular SIgnalling, Numéro 08986568, 2021, Page(s) 110154, ISSN 0898-6568
Éditeur: Elsevier BV
DOI: 10.1016/j.cellsig.2021.110154

Congruence and Complementarity of Differential Mobility Spectrometry and NMR Spectroscopy for Plasma Lipidomics

Auteurs: Mohan Ghorasaini; Konstantina Ismini Tsezou; Aswin Verhoeven; Yassene Mohammed; Panayiotis Vlachoyiannopoulos; Emmanuel Mikros; Martin Giera
Publié dans: VOLUME=12;ISSUE=11;TITLE=Metabolites, Numéro 3, 2022, ISSN 2218-1989
Éditeur: MDPI
DOI: 10.3390/metabo12111030

Novel Resolution Mediators of Severe Systemic Inflammation.

Auteurs: Verena Gudernatsch; Sylwia Anna Stefańczyk; Valbona Mirakaj
Publié dans: ImmunoTargets and Therapy, Numéro 1, 2020, ISSN 2253-1556
Éditeur: Dove press ImmunoTargets and Therapy
DOI: 10.2147/itt.s243238

Chapter 4 - Resolving acute inflammation; what happens when inflammation goes haywire? How can it get back in line?

Auteurs: Chiara Cecconello, Pol Clària Ribas, Lucy V. Norling.
Publié dans: Diet, Inflammation, and Health, 2022, Page(s) 113-162, ISBN 9780128221303
Éditeur: Academic Press
DOI: 10.1016/b978-0-12-822130-3.00018-1

Establishing the molecular fundamentals of arthritic diseases – a step forward to Heal Arthritis

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