Establishing the molecular fundamentals of arthritic diseases – a step forward to Heal Arthritis | ArthritisHeal | Project | Results | H2020 | CORDIS

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Inhibition of Δ24-dehydrocholesterol reductase activates pro-resolving lipid mediator biosynthesis and inflammation resolution

Autores: Körner, Andreas; Zhou, Enchen; Müller, Christoph; Mohammed, Yassene; Herceg, Sandra; Bracher, Franz; Rensen, Patrick C. N.; Wang, Yanan; Mirakaj, Valbona; Giera, Martin
Publicado en: Proceedings of the National Academy of Sciences, 116(41), 20623 - 20634, Edición 1, 2019, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1911992116

Biosynthesis of prostaglandin 15dPGJ2 -glutathione and 15dPGJ2-cysteine conjugates in macrophages and mast cells via MGST3

Autores: Julia Steinmetz-Späh, Jianyang Liu, Rajkumar Singh, Maria Ekoff, Sanjaykumar Boddul, Xiao Tang, Filip Bergqvist, Helena Idborg, Pascal Heitel, Elin Rönnberg, Daniel Merk, Fredrik Wermeling, Jesper Z. Haeggström, Gunnar Nilsson, Dieter Steinhilber, Karin Larsson, Marina Korotkova, Per-Johan Jakobsson
Publicado en: Journal of lipid research, 2022, ISSN 0022-2275
Editor: Lipid Research, Inc.
DOI: 10.1016/j.jlr.2022.100310

Leveraging whole blood based functional flow cytometry assays to open new perspectives for rheumatoid arthritis translational research.

Autores: Celia Cartagena García; Nathalie Balandraud; Jean Roudier; Pierre Lafforgue; Nathalie Lambert; Jean-Marc Busnel
Publicado en: Crossref, Edición 1, 2022, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-022-16622-4

Development of a Flow Cytometry–Based Functional Assay to Study Anti-TNF Mechanisms of Action and Capture Donor Heterogeneity

Autores: Celia Cartagena García, Alexandra Lefèvre, Jean-Marc R. Busnel
Publicado en: ImmunoHorizons, Edición 4/10, 2020, Página(s) 648-658, ISSN 2573-7732
Editor: The American Association of Immunologists, Inc
DOI: 10.4049/immunohorizons.2000077

SARS-CoV-2 spike protein induces a differential monocyte activation that may contribute to age bias in COVID-19 severity

Autores: Ines Ait-Belkacem; Celia Cartagena García; Ewa Millet-Wallisky; Nicolas Izquierdo; Marie Loosveld; Isabelle Arnoux; Pierre-Emmanuel Morange; Franck Galland; Nathalie Lambert; Fabrice Malergue; Jean-Marc Busnel
Publicado en: Crossref, Edición 1, 2022, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-022-25259-2

Reproducibility of Targeted Lipidome Analyses (Lipidyzer) in Plasma and Erythrocytes over a 6-Week Period

Autores: Marieke Loef, Johannes H. von Hegedus, Mohan Ghorasaini, Féline P. B. Kroon, Martin Giera, Andreea Ioan-Facsinay, Margreet Kloppenburg
Publicado en: Metabolites, Edición 11/1, 2021, Página(s) 26, ISSN 2218-1989
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/metabo11010026

Sema7A is crucial for resolution of severe inflammation.

Autores: Andreas Körner; Alice Bernard; Julia C. Fitzgerald; Juan Carlos Alarcon-Barrera; Sarantos Kostidis; Torsten Kaussen; Martin Giera; Valbona Mirakaj
Publicado en: VOLUME=118;ISSUE=9;TITLE=Proceedings of the National Academy of Sciences, Edición 1, 2021, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2017527118

Fa(c)t checking: How fatty acids shape metabolism and function of macrophages and dendritic cells

Autores: Luís Almeida, Bart Everts
Publicado en: European Journal of Immunology, 2021, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202048944

Dorsal root ganglia CX3CR1 expressing monocytes/macrophages contribute to arthritis pain

Autores: Silvia Oggero, Chiara Cecconello, Rita Silva, Lynda Zeboudj, George Sideris-Lampretsas, Mauro Perretti, Marzia Malcangio.
Publicado en: Brain, Behavior, and Immunity, Edición Volume 106, 2022, Página(s) 289-306, ISSN 0889-1591
Editor: Academic Press
DOI: 10.1016/j.bbi.2022.09.008

Cross-Laboratory Standardization of Preclinical Lipidomics Using Differential Mobility Spectrometry and Multiple Reaction Monitoring

Autores: Mohan Ghorasaini, Yassene Mohammed, Jerzy Adamski, Lisa Bettcher, John A. Bowden, Matias Cabruja, Kévin Contrepois, Mathew Ellenberger, Bharat Gajera, Mark Haid, Daniel Hornburg, Christie Hunter, Christina M. Jones, Theo Klein, Oleg Mayboroda, Mina Mirzaian, Ruin Moaddel, Luigi Ferrucci, Jacqueline Lovett, Kenneth Nazir, Mackenzie Pearson, Baljit K. Ubhi, Daniel Raftery, Fabien Riols, Rebekah Say
Publicado en: Analytical chemistry, Edición 2021, 93, 49, 2021, Página(s) 16369–16378, ISSN 0003-2700
Editor: American Chemical Society
DOI: 10.1021/acs.analchem.1c02826

Defining the structure of the NF-ĸB pathway in human immune cells using quantitative proteomic data.

Autores: Fatma O. Kok; Haoying Wang; Patricia Riedlova; Carl S. Goodyear; Ruaidhrí J. Carmody
Publicado en: Cellular SIgnalling, Edición 08986568, 2021, Página(s) 110154, ISSN 0898-6568
Editor: Elsevier BV
DOI: 10.1016/j.cellsig.2021.110154

Congruence and Complementarity of Differential Mobility Spectrometry and NMR Spectroscopy for Plasma Lipidomics

Autores: Mohan Ghorasaini; Konstantina Ismini Tsezou; Aswin Verhoeven; Yassene Mohammed; Panayiotis Vlachoyiannopoulos; Emmanuel Mikros; Martin Giera
Publicado en: VOLUME=12;ISSUE=11;TITLE=Metabolites, Edición 3, 2022, ISSN 2218-1989
Editor: MDPI
DOI: 10.3390/metabo12111030

Novel Resolution Mediators of Severe Systemic Inflammation.

Autores: Verena Gudernatsch; Sylwia Anna Stefańczyk; Valbona Mirakaj
Publicado en: ImmunoTargets and Therapy, Edición 1, 2020, ISSN 2253-1556
Editor: Dove press ImmunoTargets and Therapy
DOI: 10.2147/itt.s243238

Chapter 4 - Resolving acute inflammation; what happens when inflammation goes haywire? How can it get back in line?

Autores: Chiara Cecconello, Pol Clària Ribas, Lucy V. Norling.
Publicado en: Diet, Inflammation, and Health, 2022, Página(s) 113-162, ISBN 9780128221303
Editor: Academic Press
DOI: 10.1016/b978-0-12-822130-3.00018-1

Establishing the molecular fundamentals of arthritic diseases – a step forward to Heal Arthritis

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