Establishing the molecular fundamentals of arthritic diseases – a step forward to Heal Arthritis

Informazioni relative al progetto

ArthritisHeal

ID dell’accordo di sovvenzione: 812890

DOI

10.3030/812890

Progetto chiuso

Data della firma CE 29 Gennaio 2019

Data di avvio 1 Marzo 2019

Data di completamento 28 Febbraio 2023

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 3 297 271,32

Contributo UE

€ 3 297 271,32

Coordinato da

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Websites, patent fillings, videos etc. (1)

Website and discussion forum

Pubblicazioni

Peer reviewed articles (17)

Inhibition of Δ24-dehydrocholesterol reductase activates pro-resolving lipid mediator biosynthesis and inflammation resolution

Autori: Körner, Andreas; Zhou, Enchen; Müller, Christoph; Mohammed, Yassene; Herceg, Sandra; Bracher, Franz; Rensen, Patrick C. N.; Wang, Yanan; Mirakaj, Valbona; Giera, Martin
Pubblicato in: Proceedings of the National Academy of Sciences, 116(41), 20623 - 20634, Numero 1, 2019, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1911992116

Biosynthesis of prostaglandin 15dPGJ2 -glutathione and 15dPGJ2-cysteine conjugates in macrophages and mast cells via MGST3

Autori: Julia Steinmetz-Späh, Jianyang Liu, Rajkumar Singh, Maria Ekoff, Sanjaykumar Boddul, Xiao Tang, Filip Bergqvist, Helena Idborg, Pascal Heitel, Elin Rönnberg, Daniel Merk, Fredrik Wermeling, Jesper Z. Haeggström, Gunnar Nilsson, Dieter Steinhilber, Karin Larsson, Marina Korotkova, Per-Johan Jakobsson
Pubblicato in: Journal of lipid research, 2022, ISSN 0022-2275
Editore: Lipid Research, Inc.
DOI: 10.1016/j.jlr.2022.100310

Leveraging whole blood based functional flow cytometry assays to open new perspectives for rheumatoid arthritis translational research.

Autori: Celia Cartagena García; Nathalie Balandraud; Jean Roudier; Pierre Lafforgue; Nathalie Lambert; Jean-Marc Busnel
Pubblicato in: Crossref, Numero 1, 2022, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-022-16622-4

Development of a Flow Cytometry–Based Functional Assay to Study Anti-TNF Mechanisms of Action and Capture Donor Heterogeneity

Autori: Celia Cartagena García, Alexandra Lefèvre, Jean-Marc R. Busnel
Pubblicato in: ImmunoHorizons, Numero 4/10, 2020, Pagina/e 648-658, ISSN 2573-7732
Editore: The American Association of Immunologists, Inc
DOI: 10.4049/immunohorizons.2000077

SARS-CoV-2 spike protein induces a differential monocyte activation that may contribute to age bias in COVID-19 severity

Autori: Ines Ait-Belkacem; Celia Cartagena García; Ewa Millet-Wallisky; Nicolas Izquierdo; Marie Loosveld; Isabelle Arnoux; Pierre-Emmanuel Morange; Franck Galland; Nathalie Lambert; Fabrice Malergue; Jean-Marc Busnel
Pubblicato in: Crossref, Numero 1, 2022, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-022-25259-2

Reproducibility of Targeted Lipidome Analyses (Lipidyzer) in Plasma and Erythrocytes over a 6-Week Period

Autori: Marieke Loef, Johannes H. von Hegedus, Mohan Ghorasaini, Féline P. B. Kroon, Martin Giera, Andreea Ioan-Facsinay, Margreet Kloppenburg
Pubblicato in: Metabolites, Numero 11/1, 2021, Pagina/e 26, ISSN 2218-1989
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/metabo11010026

Sema7A is crucial for resolution of severe inflammation.

Autori: Andreas Körner; Alice Bernard; Julia C. Fitzgerald; Juan Carlos Alarcon-Barrera; Sarantos Kostidis; Torsten Kaussen; Martin Giera; Valbona Mirakaj
Pubblicato in: VOLUME=118;ISSUE=9;TITLE=Proceedings of the National Academy of Sciences, Numero 1, 2021, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2017527118

Fa(c)t checking: How fatty acids shape metabolism and function of macrophages and dendritic cells

Autori: Luís Almeida, Bart Everts
Pubblicato in: European Journal of Immunology, 2021, ISSN 0014-2980
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202048944

The Annexin-A1 mimetic RTP-026 promotes acute cardioprotection through modulation of immune cell activation

Autori: Jianmin Chen, Silvia Oggero, Chiara Cecconello, Jesmond Dalli, Hedayatullah Hayat, Ahmad Hjiej Andaloussi, Samra Sanni, Thomas EN Jonassen, Mauro Perretti
Pubblicato in: Pharmacological Research, Numero 198, 2023, Pagina/e 107005, ISSN 1043-6618
Editore: Academic Press
DOI: 10.1016/j.phrs.2023.107005

Dorsal root ganglia CX3CR1 expressing monocytes/macrophages contribute to arthritis pain

Autori: Silvia Oggero, Chiara Cecconello, Rita Silva, Lynda Zeboudj, George Sideris-Lampretsas, Mauro Perretti, Marzia Malcangio.
Pubblicato in: Brain, Behavior, and Immunity, Numero Volume 106, 2022, Pagina/e 289-306, ISSN 0889-1591
Editore: Academic Press
DOI: 10.1016/j.bbi.2022.09.008

Cross-Laboratory Standardization of Preclinical Lipidomics Using Differential Mobility Spectrometry and Multiple Reaction Monitoring

Autori: Mohan Ghorasaini, Yassene Mohammed, Jerzy Adamski, Lisa Bettcher, John A. Bowden, Matias Cabruja, Kévin Contrepois, Mathew Ellenberger, Bharat Gajera, Mark Haid, Daniel Hornburg, Christie Hunter, Christina M. Jones, Theo Klein, Oleg Mayboroda, Mina Mirzaian, Ruin Moaddel, Luigi Ferrucci, Jacqueline Lovett, Kenneth Nazir, Mackenzie Pearson, Baljit K. Ubhi, Daniel Raftery, Fabien Riols, Rebekah Say
Pubblicato in: Analytical chemistry, Numero 2021, 93, 49, 2021, Pagina/e 16369–16378, ISSN 0003-2700
Editore: American Chemical Society
DOI: 10.1021/acs.analchem.1c02826

Synthesis and evaluation of antiproliferative and mPGES-1 inhibitory activities of novel carvacrol-triazole conjugates

Autori: İlkay Küçükgüzel, İlker Demirbolat, Necla Kulabaş, Merve Gürboğa, Özlem Bingöl Özakpınar, Gamze Çiftçi, Kemal Yelekçi, Jianyang Liu, Per-Johan Jakobsson, Özkan Danış, Ayşe Ogan
Pubblicato in: Organic Communications, 2022, Pagina/e 356-377, ISSN 1307-6175
Editore: Academy of Chemistry of Globe Publications
DOI: 10.25135/acg.oc.142.2212.2651

Defining the structure of the NF-ĸB pathway in human immune cells using quantitative proteomic data.

Autori: Fatma O. Kok; Haoying Wang; Patricia Riedlova; Carl S. Goodyear; Ruaidhrí J. Carmody
Pubblicato in: Cellular SIgnalling, Numero 08986568, 2021, Pagina/e 110154, ISSN 0898-6568
Editore: Elsevier BV
DOI: 10.1016/j.cellsig.2021.110154

A whole blood-based functional assay to characterize immunoglobulin A effector functions

Autori: Alice Bacon, Celia Cartagena García, Karin A. van Schie, René E. M. Toes, Jean-Marc Busnel
Pubblicato in: Autoimmunity, 2024, ISSN 0891-6934
Editore: Taylor & Francis
DOI: 10.1080/08916934.2024.2341629

The anti-inflammatory and vasoprotective properties of mPGES-1 inhibition offer promising therapeutic potential

Autori: Julia Steinmetz-Späh, Per-Johan Jakobsson
Pubblicato in: Expert Opinion on Therapeutic Targets, Numero 27, 2024, Pagina/e 1115-1123, ISSN 1472-8222
Editore: Ashley Publications Ltd.
DOI: 10.1080/14728222.2023.2285785

Congruence and Complementarity of Differential Mobility Spectrometry and NMR Spectroscopy for Plasma Lipidomics

Autori: Mohan Ghorasaini; Konstantina Ismini Tsezou; Aswin Verhoeven; Yassene Mohammed; Panayiotis Vlachoyiannopoulos; Emmanuel Mikros; Martin Giera
Pubblicato in: VOLUME=12;ISSUE=11;TITLE=Metabolites, Numero 3, 2022, ISSN 2218-1989
Editore: MDPI
DOI: 10.3390/metabo12111030

Novel Resolution Mediators of Severe Systemic Inflammation.

Autori: Verena Gudernatsch; Sylwia Anna Stefańczyk; Valbona Mirakaj
Pubblicato in: ImmunoTargets and Therapy, Numero 1, 2020, ISSN 2253-1556
Editore: Dove press ImmunoTargets and Therapy
DOI: 10.2147/itt.s243238

Book chapters (1)

Chapter 4 - Resolving acute inflammation; what happens when inflammation goes haywire? How can it get back in line?

Autori: Chiara Cecconello, Pol Clària Ribas, Lucy V. Norling.
Pubblicato in: Diet, Inflammation, and Health, 2022, Pagina/e 113-162, ISBN 9780128221303
Editore: Academic Press
DOI: 10.1016/b978-0-12-822130-3.00018-1