Descripción del proyecto
Un análisis más detallado sobre las funciones terapéuticas de los peroxisomas
Los peroxisomas son diminutos orgánulos que están encapsulados dentro de una membrana. Contienen enzimas activas en una amplia gama de reacciones metabólicas, incluidos varios aspectos del metabolismo energético. En unos nuevos estudios, se ha descubierto que el peroxisoma también puede funcionar como compartimento de señalización intracelular y como plataforma organizadora que, desde el interior de la célula, toma decisiones cruciales relacionadas con el desarrollo. El equipo del proyecto PERICO, financiado con fondos europeos, llevará a cabo una investigación multidisciplinar pionera que se centra en las interacciones y la comunicación de los peroxisomas. De este modo, quince investigadores noveles recibirán una formación en capacidades transferibles y de excelencia que les permitirán desarrollar nuevas terapias y fármacos dirigidos a las crecientes enfermedades en las que el peroxisoma está implicado.
Objetivo
PERICO fosters education of ESRs in a project to uncover how a central metabolic organelle, the peroxisome, participates in controlling cellular metabolism. It trains 15 ESRs at world-leading academic institutions, including university hospitals, and companies, thus forming strong interdisciplinary links between industry, life and medical sciences, and end-users.
PERICO aims to train a new generation of highly qualified ESRs with entrepreneurial competencies in modern Life Sciences through state-of-the-art research projects focusing on the communication between peroxisomes and the rest of the cell – required to enable optimal metabolic decisions - and to use this knowledge to develop novel leads for drug discovery and therapies for a growing list of serious human diseases in which peroxisomes have been implicated.
The new field on organelle communication requires highly skilled scientists who have expert knowledge on more than one discipline (e.g. cell biology, biochemistry, systems biology and medical sciences), more than one type of cell organelle or more than one model organism to optimally translate their research data to other disciplines and sectors, including medicine.
PERICO overcomes current barriers by establishing a strong, multidisciplinary and inter-sectoral training network, developing technologies tailored to solve key questions in organelle biology. The PERICO programme will exploit recent developments in high throughput and genome wide screening technologies, combine these with modern molecular cell biology and systems biology and ultimately translate the data into new leads for drug discovery and therapy. This specific cross-disciplinary training program will educate young scientists to a next level, which is needed to advance this research field for the upcoming decennium and to efficiently translate findings into applications. The training programme will be complemented with a complete set of transferable skills.
Ámbito científico
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Régimen de financiación
MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinador
9712CP Groningen
Países Bajos