Descrizione del progetto
Uno sguardo più approfondito alle funzioni terapeutiche dei perossisomi
I perossisomi sono piccoli organelli racchiusi nella membrana che contengono enzimi attivi in un’ampia gamma di reazioni metaboliche, inclusi diversi aspetti del metabolismo energetico. Alcuni studi emergenti hanno scoperto che il perossisoma può anche funzionare in qualità di compartimento di segnalazione intracellulare e come piattaforma organizzativa che prende decisioni di sviluppo cruciali dall’interno della cellula. Il progetto PERICO, finanziato dall’UE, condurrà una ricerca multidisciplinare rivoluzionaria incentrata sulle interazioni e sulla comunicazione dei perossisomi. Pertanto, 15 ricercatori e ricercatrici in fase iniziale di carriera riceveranno una formazione in materia di competenze eccellenti e trasferibili che permetteranno loro di promuovere nuove terapie e farmaci concepiti per contrastare le crescenti malattie implicate dal perossisoma.
Obiettivo
PERICO fosters education of ESRs in a project to uncover how a central metabolic organelle, the peroxisome, participates in controlling cellular metabolism. It trains 15 ESRs at world-leading academic institutions, including university hospitals, and companies, thus forming strong interdisciplinary links between industry, life and medical sciences, and end-users.
PERICO aims to train a new generation of highly qualified ESRs with entrepreneurial competencies in modern Life Sciences through state-of-the-art research projects focusing on the communication between peroxisomes and the rest of the cell – required to enable optimal metabolic decisions - and to use this knowledge to develop novel leads for drug discovery and therapies for a growing list of serious human diseases in which peroxisomes have been implicated.
The new field on organelle communication requires highly skilled scientists who have expert knowledge on more than one discipline (e.g. cell biology, biochemistry, systems biology and medical sciences), more than one type of cell organelle or more than one model organism to optimally translate their research data to other disciplines and sectors, including medicine.
PERICO overcomes current barriers by establishing a strong, multidisciplinary and inter-sectoral training network, developing technologies tailored to solve key questions in organelle biology. The PERICO programme will exploit recent developments in high throughput and genome wide screening technologies, combine these with modern molecular cell biology and systems biology and ultimately translate the data into new leads for drug discovery and therapy. This specific cross-disciplinary training program will educate young scientists to a next level, which is needed to advance this research field for the upcoming decennium and to efficiently translate findings into applications. The training programme will be complemented with a complete set of transferable skills.
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Meccanismo di finanziamento
MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinatore
9712CP Groningen
Paesi Bassi