Description du projet
Zoom sur les fonctions thérapeutiques des peroxysomes
Les peroxysomes sont de minuscules organites entourés d’une membrane. Ils contiennent des enzymes actives dans un large éventail de réactions métaboliques, notamment plusieurs facettes du métabolisme énergétique. Des études émergentes ont révélé que le peroxysome peut également fonctionner en tant que compartiment de signalisation intracellulaire et comme une plateforme d’organisation capable de prendre des décisions cruciales en matière de développement depuis l’intérieur de la cellule. Le projet PERICO, financé par l’UE, mènera des recherches pluridisciplinaires révolutionnaires axées sur les interactions et la communication entre les peroxysomes. À ce titre, 15 chercheurs en début de carrière recevront une formation à des disciplines remarquables et transférables qui leur permettront de faire progresser de nouvelles thérapies et de nouveaux médicaments ciblant les maladies toujours plus nombreuses impliquant le peroxysome.
Objectif
PERICO fosters education of ESRs in a project to uncover how a central metabolic organelle, the peroxisome, participates in controlling cellular metabolism. It trains 15 ESRs at world-leading academic institutions, including university hospitals, and companies, thus forming strong interdisciplinary links between industry, life and medical sciences, and end-users.
PERICO aims to train a new generation of highly qualified ESRs with entrepreneurial competencies in modern Life Sciences through state-of-the-art research projects focusing on the communication between peroxisomes and the rest of the cell – required to enable optimal metabolic decisions - and to use this knowledge to develop novel leads for drug discovery and therapies for a growing list of serious human diseases in which peroxisomes have been implicated.
The new field on organelle communication requires highly skilled scientists who have expert knowledge on more than one discipline (e.g. cell biology, biochemistry, systems biology and medical sciences), more than one type of cell organelle or more than one model organism to optimally translate their research data to other disciplines and sectors, including medicine.
PERICO overcomes current barriers by establishing a strong, multidisciplinary and inter-sectoral training network, developing technologies tailored to solve key questions in organelle biology. The PERICO programme will exploit recent developments in high throughput and genome wide screening technologies, combine these with modern molecular cell biology and systems biology and ultimately translate the data into new leads for drug discovery and therapy. This specific cross-disciplinary training program will educate young scientists to a next level, which is needed to advance this research field for the upcoming decennium and to efficiently translate findings into applications. The training programme will be complemented with a complete set of transferable skills.
Champ scientifique
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MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinateur
9712CP Groningen
Pays-Bas