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Training research pioneers by utilizing and validating the promise of electroporation for minimal invasive oncological treatments.

Descrizione del progetto

Un consorzio di formazione per la ricerca sull’elettroporazione come trattamento antitumorale minimamente invasivo

I tradizionali metodi antitumorali consistono in interventi chirurgici, chemioterapia sistematica e radioterapia. Le procedure minimamente invasive, che includono brachiterapia (una dose locale di radiazioni), ablazione termica (riscaldamento locale) ed elettroporazione (un campo elettrico pulsato ad alta intensità applicato localmente), stanno acquisendo importanza. Attraverso l’elettroporazione, le aree tessutali diventano suscettibili in modo reversibile a una somministrazione migliorata di farmaci antitumorali oppure vengono distrutte tramite l’elettroporazione irreversibile precisa. Finanziato dal programma di azioni Marie Skłodowska-Curie, il progetto ElectroPros sta istituendo una rete di formazione nella ricerca con l’obiettivo di preparare i giovani ricercatori all’evoluzione della tecnologia relativa alle terapie oncologiche minimamente invasive. Durante la loro formazione, i ricercatori in fase iniziale di carriera concentreranno l’attenzione sul trattamento antitumorale basato sull’elettroporazione, affrontando le carenze nelle attrezzature attualmente disponibili e migliorando l’affidabilità della terapia di elettroporazione specifica al paziente.

Obiettivo

The ElectroPros action aims to optimally prepare young researchers for the evolving technology in the healthcare space, especially related to minimal invasive oncology therapies, by offering a unique set of targeted interdisciplinary training and research assignments in the areas of biophysics modelling and simulation, device physics, optimization algorithms, software integration and experimental validation. Four European Industrial Doctorate positions are offered to Early Stage Researchers (ESRs) for a period of three years. In the training program a combination of industrial, academic and clinical research environments are provided by Philips, the University Clinic Aachen and RWTH Aachen, to explore the field of electroporation, as a new and promising technique for minimal invasive oncology treatment.
Based on sound career development plans, and coached by experienced supervisors, the four ESRs involved will develop a competence profile which will springboard their future career in the wide European medical community in the industrial, clinical and academic domain. These researchers have the potential to become pioneers for new minimally-invasive therapies for the oncology domain.
During their training, the ESRs will work on electroporation based treatment of cancer. The ESRs address shortcomings of the currently available equipment to enable for the first time ever a reliable patient-specific electroporation based treatment for cancer. With a focus on liver cancer, the ESRs will collectively establish novel insights on the biophysical effects on various tissues, important to understand the treatment effect, and integrate this knowledge in optimal device (needle) design and multi-physics models for treatment outcome prediction and inverse planning algorithms. Furthermore, the developed assets will be integrated in clinical prototype software to support and optimize the clinical workflow.

Coordinatore

PHILIPS ELECTRONICS NEDERLAND BV
Contribution nette de l'UE
€ 265 619,88
Indirizzo
HIGH TECH CAMPUS 52
5656 AG Eindhoven
Paesi Bassi

Mostra sulla mappa

Regione
Zuid-Nederland Noord-Brabant Zuidoost-Noord-Brabant
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Collegamenti
Costo totale
€ 265 619,88

Partecipanti (1)

Partner (1)