Deliverables Other (4) Recruitment of ESRs Recruitment of the selected ESRs with full employment contracts. Call publication Publication of the call for the ESRs on selected websites and through personal contacts Supervisory Board of the network Establishemt of a Supervisory Board. Ranking Ranking of the applications after the two step evaluation Documents, reports (1) Individual CDP Individual Career Development Plans completed Websites, patent fillings, videos etc. (1) Website Development of the project website. Publications Peer reviewed articles (18) SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice Author(s): Pamela Becherini, Irene Caffa, Francesco Piacente, Patrizia Damonte, Valerio G. Vellone, Mario Passalacqua, Andrea Benzi, Tommaso Bonfiglio, Daniele Reverberi, Amr Khalifa, Moustafa Ghanem, Ana Guijarro, Luca Tagliafico, Marzia Sucameli, Angelica Persia, Fiammetta Monacelli, Michele Cea, Santina Bruzzone, Silvia Ravera, Alessio Nencioni Published in: Cancer & Metabolism, Issue 9/1, 2021, Page(s) 6, ISSN 2049-3002 Publisher: - DOI: 10.1186/s40170-021-00240-1 Re-Discovery of Pyrimidine Salvage as Target in Cancer Therapy Author(s): Melanie Walter, & Patrick Herr Published in: Cells, Issue 11(4), 2022, Page(s) 739 Publisher: - DOI: 10.3390/cells11040739 Anticancer Activities of Novel Nicotinamide Phosphoribosyltransferase Inhibitors in Hematological Malignancies Author(s): Biniecka P, Matsumoto S, Belotti A, Joussot J, Bai JF, Majjigapu SR, Thoueille P, Spaggiari D, Desfontaine V, Piacente F, Bruzzone S, Cea M, Decosterd LA, Vogel P, Nencioni A, Duchosal MA, Nahimana A. Published in: Molecules, Issue Feb 16;28(4), 2023, Page(s) 1897, ISSN 2078-2489 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/molecules28041897 Identification of NAPRT Inhibitors with Anti-Cancer Properties by In Silico Drug Discovery Author(s): Moustafa S. Ghanem, Irene Caffa, Alberto Del Rio, Jorge Franco, Marco Daniele Parenti, Fiammetta Monacelli, Michele Cea, Amr Khalifa, Aimable Nahimana, Michel A. Duchosal, Silvia Ravera, Nadia Bertola, Santina Bruzzone, Alessio Nencioni and Francesco Piacente. Published in: Pharmaceuticals (Basel), Issue 10;15(7), 2022, Page(s) 848, ISSN 2078-2489 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ph15070848 Advances in NAD-Lowering Agents for Cancer Treatment Author(s): Moustafa Ghanem; Fiammetta Monacelli; Alessio Nencioni Published in: Nutrients, Vol 13, Iss 1665, p 1665 (2021), Issue 1, 2021, Page(s) 1665 Publisher: - DOI: 10.3390/nu13051665 Loss of p53 activates thyroid hormone via type 2 deiodinase and enhances DNA damage Author(s): Nappi A, Miro C, Pezone A, Tramontano A, Di Cicco E, Sagliocchi S, Cicatiello AG, Murolo M, Torabinejad S, Abbotto E, Caiazzo G, Raia M, Stornaiuolo M, Antonini D, Fabbrocini G, Salvatore D, Avvedimento VE, Dentice M. Published in: Nat Commun., Issue Mar 4;14(1), 2023, Page(s) 1244, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-023-36755-y Synthesis and structure-activity relationship of new nicotinamide phosphoribosyltransferase inhibitors with antitumor activity on solid and haematological cancer. Author(s): Fratta S, Biniecka P, Moreno-Vargas AJ, Carmona AT, Nahimana A, Duchosal MA, Piacente F, Bruzzone S, Caffa I, Nencioni A, Robina I. Published in: Eur J Med Chem., Issue 15;250, 2023, Page(s) 115170, ISSN 0346-251X Publisher: Pergamon Press Ltd. DOI: 10.1016/j.ejmech.2023.115170 Mitochondrial rewiring drives metabolic adaptation to NAD(H) shortage in triple negative breast cancer cells Author(s): Agata Sofia Assuncao Carreira, Silvia Ravera, Chiara Zucal, Natthakan Thongon, Caffa Irene, Cecilia Astigiano, Nadia Bertola, Arianna Buongiorno, Michela Roccuzzo, Alessandra Bisio, Barbara Pardini, Alessio Nencioni, Santina Bruzzone, Alessandro Provenzani. Published in: Neoplasia, Issue 41, 2023, Page(s) 100903, ISSN 1476-5586 Publisher: Elsevier DOI: 10.1016/j.neo.2023.100903 Iminosugar-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors as Potential Anti-Pancreatic Cancer Agents Author(s): Irene Conforti, Andrea Benzi, Irene Caffa, Santina Bruzzone, Alessio Nencioni, Alberto Marra Published in: Pharmaceutics, Issue 15, 2023, Page(s) 1472 Publisher: - DOI: 10.3390/pharmaceutics15051472 Iminosugars as glycosyltransferase inhibitors Author(s): Irene Conforti; Alberto Marra Published in: Org. Biomol. Chem, Issue 1, 2021, Page(s) 5439-5475 Publisher: - DOI: 10.1039/d1ob00382h Targeting of the A2A adenosine receptor counteracts immunosuppression in vivo in a mouse model of chronic lymphocytic leukemia Author(s): Francesca Arruga, Sara Serra, Nicoletta Vitale, Giulia Guerra, Andrea Papait, Benjamin Baffour Gyau, Francesco Tito, Dimitar Efremov, Tiziana Vaisitti, Silvia Deaglio Published in: Haematologica, 2020, Page(s) haematol.2019.242016, ISSN 0390-6078 Publisher: Ferrata Storti Foundation DOI: 10.3324/haematol.2019.242016 Sirtuin 6 inhibition protects against glucocorticoid-induced skeletal muscle atrophy by regulating IGF/PI3K/AKT signaling Author(s): Mishra S, Cosentino C, Tamta AK, Khan D, Srinivasan S, Ravi V, Abbotto E, Arathi BP, Kumar S, Jain A, Ramaian AS, Kizkekra SM, Rajagopal R, Rao S, Krishna S, Asirvatham-Jeyaraj N, Haggerty ER, Silberman DM, Kurland IJ, Veeranna RP, Jayavelu T, Bruzzone S, Mostoslavsky R, Sundaresan NR. Published in: Nat Commun., Issue Sep 15;13(1), 2022, Page(s) 5415, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-022-32905-w Virtual Screening in the Identification of Sirtuins' Activity Modulators Author(s): Abbotto E, Scarano N, Piacente F, Millo E, Cichero E, Bruzzone S. Published in: Molecules, Issue Sep 1;27(17), 2022, Page(s) 5641, ISSN 1420-3049 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/molecules27175641 Immune Response Dysfunction in Chronic Lymphocytic Leukemia: Dissecting Molecular Mechanisms and Microenvironmental Conditions Author(s): Francesca Arruga, Benjamin Baffour Gyau, Andrea Iannello, Nicoletta Vitale, Tiziana Vaisitti, Silvia Deaglio Published in: International Journal of Molecular Sciences, Issue 21/5, 2020, Page(s) 1825, ISSN 1422-0067 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms21051825 Structure-Based Identification and Biological Characterization of New NAPRT Inhibitors Author(s): Franco, J.; Piacente, F.; Walter, M.; Fratta, S.; Ghanem, M.; Benzi, A.; Caffa, I.; Kurkin, A.V.; Altieri, A.; Herr, P.; Martínez-Bailén, M.; Robina, I.; Bruzzone, S.; Nencioni, A.; Del Rio, A. Published in: Pharmaceuticals, Issue 15, 2022, Page(s) 855, ISSN 1424-8247 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ph15070855 Gut microbiota severely hampers the efficacy of NAD-lowering therapy in leukemia. Author(s): ElMokh O, Matsumoto S, Biniecka P, Bellotti A, Schaeuble K, Piacente F, Gallart-Ayala H, Ivanisevic J, Stamenkovic I, Nencioni A, Nahimana A, Duchosal MA Published in: Cell Death Dis, Issue 13(4), 2022, Page(s) 320 Publisher: - DOI: 10.1038/s41419-022-04763-3 NUDT22 promotes cancer growth through pyrimidine salvage Author(s): Melanie Walter; Florian Mayr; Bishoy M. F. Hanna; Victoria Cookson; Oliver Mortusewicz; Thomas Helleday; Patrick Herr Published in: Oncogene, Issue 42, 2023, Page(s) 1282-1293 Publisher: Nature Publishing Group DOI: 10.1038/s41388-023-02643-4 Dendritic cells direct circadian anti-tumour immune responses Author(s): Wang C, Barnoud C, Cenerenti M, Sun M, Caffa I, Kizil B, Bill R, Liu Y, Pick R, Garnier L, Gkountidi OA, Ince LM, Holtkamp S, Fournier N, Michielin O, Speiser DE, Hugues S, Nencioni A, Pittet MJ, Jandus C, Scheiermann C. Published in: Nature, Issue 2023 Feb;614(7946), 2023, Page(s) 136-143, ISSN 0028-0836 Publisher: Nature Publishing Group DOI: 10.1038/s41586-022-05605-0 Conference proceedings (1) Development of Small Molecule NUDT22 Inhibitors for Uses in Cancer Author(s): Walter Melanie, Evert Homan, Tobias Koolmeister, Oliver Mortusewicz, Thomas Helleday and Patrick Herr Published in: Medical Science Forum, Issue 3, 2021, Page(s) 1 Publisher: - DOI: 10.3390/iecc2021-09197 Searching for OpenAIRE data... 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