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Integrating chemical and biological approaches to target NAD production and signaling in cancer


Recruitment of ESRs

Recruitment of the selected ESRs with full employment contracts.

Call publication

Publication of the call for the ESRs on selected websites and through personal contacts

Supervisory Board of the network

Establishemt of a Supervisory Board.


Ranking of the applications after the two step evaluation

Individual CDP

Individual Career Development Plans completed


Development of the project website.

Searching for OpenAIRE data...


SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice

Author(s): Pamela Becherini, Irene Caffa, Francesco Piacente, Patrizia Damonte, Valerio G. Vellone, Mario Passalacqua, Andrea Benzi, Tommaso Bonfiglio, Daniele Reverberi, Amr Khalifa, Moustafa Ghanem, Ana Guijarro, Luca Tagliafico, Marzia Sucameli, Angelica Persia, Fiammetta Monacelli, Michele Cea, Santina Bruzzone, Silvia Ravera, Alessio Nencioni
Published in: Cancer & Metabolism, 9/1, 2021, Page(s) 6, ISSN 2049-3002
Publisher: -
DOI: 10.1186/s40170-021-00240-1

Re-Discovery of Pyrimidine Salvage as Target in Cancer Therapy

Author(s): Melanie Walter, & Patrick Herr
Published in: Cells, 11(4), 2022, Page(s) 739
Publisher: -
DOI: 10.3390/cells11040739

Advances in NAD-Lowering Agents for Cancer Treatment

Author(s): Moustafa Ghanem; Fiammetta Monacelli; Alessio Nencioni
Published in: Nutrients, Vol 13, Iss 1665, p 1665 (2021), 1, 2021, Page(s) 1665
Publisher: -
DOI: 10.3390/nu13051665

Iminosugars as glycosyltransferase inhibitors

Author(s): Irene Conforti; Alberto Marra
Published in: Org. Biomol. Chem, 1, 2021, Page(s) 5439-5475
Publisher: -
DOI: 10.1039/d1ob00382h

Targeting of the A2A adenosine receptor counteracts immunosuppression in vivo in a mouse model of chronic lymphocytic leukemia

Author(s): Francesca Arruga, Sara Serra, Nicoletta Vitale, Giulia Guerra, Andrea Papait, Benjamin Baffour Gyau, Francesco Tito, Dimitar Efremov, Tiziana Vaisitti, Silvia Deaglio
Published in: Haematologica, 2020, Page(s) haematol.2019.242016, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2019.242016

Immune Response Dysfunction in Chronic Lymphocytic Leukemia: Dissecting Molecular Mechanisms and Microenvironmental Conditions

Author(s): Francesca Arruga, Benjamin Baffour Gyau, Andrea Iannello, Nicoletta Vitale, Tiziana Vaisitti, Silvia Deaglio
Published in: International Journal of Molecular Sciences, 21/5, 2020, Page(s) 1825, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21051825

Gut microbiota severely hampers the efficacy of NAD-lowering therapy in leukemia.

Author(s): ElMokh O, Matsumoto S, Biniecka P, Bellotti A, Schaeuble K, Piacente F, Gallart-Ayala H, Ivanisevic J, Stamenkovic I, Nencioni A, Nahimana A, Duchosal MA
Published in: Cell Death Dis, 13(4), 2022, Page(s) 320
Publisher: -
DOI: 10.1038/s41419-022-04763-3

Development of Small Molecule NUDT22 Inhibitors for Uses in Cancer

Author(s): Walter Melanie, Evert Homan, Tobias Koolmeister, Oliver Mortusewicz, Thomas Helleday and Patrick Herr
Published in: Medical Science Forum, 3, 2021, Page(s) 1
Publisher: -
DOI: 10.3390/iecc2021-09197