Integrating chemical and biological approaches to target NAD production and signaling in cancer

Project Information

INTEGRATA

Grant agreement ID: 813284

DOI

10.3030/813284

Project closed

EC signature date 13 September 2018

Start date 1 November 2018

End date 30 April 2023

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 3 738 573,00

EU contribution

€ 3 738 573,00

Coordinated by

UNIVERSITA DEGLI STUDI DI GENOVA
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Other (4)

Recruitment of ESRs

Recruitment of the selected ESRs with full employment contracts.

Call publication

Publication of the call for the ESRs on selected websites and through personal contacts

Supervisory Board of the network

Establishemt of a Supervisory Board.

Ranking

Ranking of the applications after the two step evaluation

Documents, reports (10)

Individual CDP

Individual Career Development Plans completed

Secondments

Reports on secondments Multiple dates Months 25 43

Dissemination

Reports on dissemination activities Multiple dates Months 12 24 36 48

Communication/Public engagement report

Reports on outreach activities Multiple dates Months 183042

SCT activities

Organisation of Short Courses of Transferrable training SCT Multiple dates Months 16 28 40

Local training

Reports on local training activities Multiple dates Months 18 30 42

Scientific meetings

Scientific meetings organisationMultiple dates Months 10 22 34

Final Workshop

Final Workshop organisation

PhD thesis

Termination of PhD programmes and thesis discussion

SSC activities

Organisation of Short Scientific Courses Multiple dates Months 10 22 34

Websites, patent fillings, videos etc. (1)

Website

Development of the project website.

Publications

Peer reviewed articles (18)

SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice

Author(s): Pamela Becherini, Irene Caffa, Francesco Piacente, Patrizia Damonte, Valerio G. Vellone, Mario Passalacqua, Andrea Benzi, Tommaso Bonfiglio, Daniele Reverberi, Amr Khalifa, Moustafa Ghanem, Ana Guijarro, Luca Tagliafico, Marzia Sucameli, Angelica Persia, Fiammetta Monacelli, Michele Cea, Santina Bruzzone, Silvia Ravera, Alessio Nencioni
Published in: Cancer & Metabolism, Issue 9/1, 2021, Page(s) 6, ISSN 2049-3002
Publisher: -
DOI: 10.1186/s40170-021-00240-1

Re-Discovery of Pyrimidine Salvage as Target in Cancer Therapy

Author(s): Melanie Walter, & Patrick Herr
Published in: Cells, Issue 11(4), 2022, Page(s) 739
Publisher: -
DOI: 10.3390/cells11040739

Anticancer Activities of Novel Nicotinamide Phosphoribosyltransferase Inhibitors in Hematological Malignancies

Author(s): Biniecka P, Matsumoto S, Belotti A, Joussot J, Bai JF, Majjigapu SR, Thoueille P, Spaggiari D, Desfontaine V, Piacente F, Bruzzone S, Cea M, Decosterd LA, Vogel P, Nencioni A, Duchosal MA, Nahimana A.
Published in: Molecules, Issue Feb 16;28(4), 2023, Page(s) 1897, ISSN 2078-2489
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules28041897

Identification of NAPRT Inhibitors with Anti-Cancer Properties by In Silico Drug Discovery

Author(s): Moustafa S. Ghanem, Irene Caffa, Alberto Del Rio, Jorge Franco, Marco Daniele Parenti, Fiammetta Monacelli, Michele Cea, Amr Khalifa, Aimable Nahimana, Michel A. Duchosal, Silvia Ravera, Nadia Bertola, Santina Bruzzone, Alessio Nencioni and Francesco Piacente.
Published in: Pharmaceuticals (Basel), Issue 10;15(7), 2022, Page(s) 848, ISSN 2078-2489
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph15070848

Advances in NAD-Lowering Agents for Cancer Treatment

Author(s): Moustafa Ghanem; Fiammetta Monacelli; Alessio Nencioni
Published in: Nutrients, Vol 13, Iss 1665, p 1665 (2021), Issue 1, 2021, Page(s) 1665
Publisher: -
DOI: 10.3390/nu13051665

Loss of p53 activates thyroid hormone via type 2 deiodinase and enhances DNA damage

Author(s): Nappi A, Miro C, Pezone A, Tramontano A, Di Cicco E, Sagliocchi S, Cicatiello AG, Murolo M, Torabinejad S, Abbotto E, Caiazzo G, Raia M, Stornaiuolo M, Antonini D, Fabbrocini G, Salvatore D, Avvedimento VE, Dentice M.
Published in: Nat Commun., Issue Mar 4;14(1), 2023, Page(s) 1244, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-36755-y

Synthesis and structure-activity relationship of new nicotinamide phosphoribosyltransferase inhibitors with antitumor activity on solid and haematological cancer.

Author(s): Fratta S, Biniecka P, Moreno-Vargas AJ, Carmona AT, Nahimana A, Duchosal MA, Piacente F, Bruzzone S, Caffa I, Nencioni A, Robina I.
Published in: Eur J Med Chem., Issue 15;250, 2023, Page(s) 115170, ISSN 0346-251X
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.ejmech.2023.115170

Mitochondrial rewiring drives metabolic adaptation to NAD(H) shortage in triple negative breast cancer cells

Author(s): Agata Sofia Assuncao Carreira, Silvia Ravera, Chiara Zucal, Natthakan Thongon, Caffa Irene, Cecilia Astigiano, Nadia Bertola, Arianna Buongiorno, Michela Roccuzzo, Alessandra Bisio, Barbara Pardini, Alessio Nencioni, Santina Bruzzone, Alessandro Provenzani.
Published in: Neoplasia, Issue 41, 2023, Page(s) 100903, ISSN 1476-5586
Publisher: Elsevier
DOI: 10.1016/j.neo.2023.100903

Iminosugar-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors as Potential Anti-Pancreatic Cancer Agents

Author(s): Irene Conforti, Andrea Benzi, Irene Caffa, Santina Bruzzone, Alessio Nencioni, Alberto Marra
Published in: Pharmaceutics, Issue 15, 2023, Page(s) 1472
Publisher: -
DOI: 10.3390/pharmaceutics15051472

Iminosugars as glycosyltransferase inhibitors

Author(s): Irene Conforti; Alberto Marra
Published in: Org. Biomol. Chem, Issue 1, 2021, Page(s) 5439-5475
Publisher: -
DOI: 10.1039/d1ob00382h

Targeting of the A2A adenosine receptor counteracts immunosuppression in vivo in a mouse model of chronic lymphocytic leukemia

Author(s): Francesca Arruga, Sara Serra, Nicoletta Vitale, Giulia Guerra, Andrea Papait, Benjamin Baffour Gyau, Francesco Tito, Dimitar Efremov, Tiziana Vaisitti, Silvia Deaglio
Published in: Haematologica, 2020, Page(s) haematol.2019.242016, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2019.242016

Sirtuin 6 inhibition protects against glucocorticoid-induced skeletal muscle atrophy by regulating IGF/PI3K/AKT signaling

Author(s): Mishra S, Cosentino C, Tamta AK, Khan D, Srinivasan S, Ravi V, Abbotto E, Arathi BP, Kumar S, Jain A, Ramaian AS, Kizkekra SM, Rajagopal R, Rao S, Krishna S, Asirvatham-Jeyaraj N, Haggerty ER, Silberman DM, Kurland IJ, Veeranna RP, Jayavelu T, Bruzzone S, Mostoslavsky R, Sundaresan NR.
Published in: Nat Commun., Issue Sep 15;13(1), 2022, Page(s) 5415, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32905-w

Virtual Screening in the Identification of Sirtuins' Activity Modulators

Author(s): Abbotto E, Scarano N, Piacente F, Millo E, Cichero E, Bruzzone S.
Published in: Molecules, Issue Sep 1;27(17), 2022, Page(s) 5641, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27175641

Immune Response Dysfunction in Chronic Lymphocytic Leukemia: Dissecting Molecular Mechanisms and Microenvironmental Conditions

Author(s): Francesca Arruga, Benjamin Baffour Gyau, Andrea Iannello, Nicoletta Vitale, Tiziana Vaisitti, Silvia Deaglio
Published in: International Journal of Molecular Sciences, Issue 21/5, 2020, Page(s) 1825, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21051825

Structure-Based Identification and Biological Characterization of New NAPRT Inhibitors

Author(s): Franco, J.; Piacente, F.; Walter, M.; Fratta, S.; Ghanem, M.; Benzi, A.; Caffa, I.; Kurkin, A.V.; Altieri, A.; Herr, P.; Martínez-Bailén, M.; Robina, I.; Bruzzone, S.; Nencioni, A.; Del Rio, A.
Published in: Pharmaceuticals, Issue 15, 2022, Page(s) 855, ISSN 1424-8247
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph15070855

Gut microbiota severely hampers the efficacy of NAD-lowering therapy in leukemia.

Author(s): ElMokh O, Matsumoto S, Biniecka P, Bellotti A, Schaeuble K, Piacente F, Gallart-Ayala H, Ivanisevic J, Stamenkovic I, Nencioni A, Nahimana A, Duchosal MA
Published in: Cell Death Dis, Issue 13(4), 2022, Page(s) 320
Publisher: -
DOI: 10.1038/s41419-022-04763-3

NUDT22 promotes cancer growth through pyrimidine salvage

Author(s): Melanie Walter; Florian Mayr; Bishoy M. F. Hanna; Victoria Cookson; Oliver Mortusewicz; Thomas Helleday; Patrick Herr
Published in: Oncogene, Issue 42, 2023, Page(s) 1282-1293
Publisher: Nature Publishing Group
DOI: 10.1038/s41388-023-02643-4

Dendritic cells direct circadian anti-tumour immune responses

Author(s): Wang C, Barnoud C, Cenerenti M, Sun M, Caffa I, Kizil B, Bill R, Liu Y, Pick R, Garnier L, Gkountidi OA, Ince LM, Holtkamp S, Fournier N, Michielin O, Speiser DE, Hugues S, Nencioni A, Pittet MJ, Jandus C, Scheiermann C.
Published in: Nature, Issue 2023 Feb;614(7946), 2023, Page(s) 136-143, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-05605-0

Conference proceedings (1)

Development of Small Molecule NUDT22 Inhibitors for Uses in Cancer

Author(s): Walter Melanie, Evert Homan, Tobias Koolmeister, Oliver Mortusewicz, Thomas Helleday and Patrick Herr
Published in: Medical Science Forum, Issue 3, 2021, Page(s) 1
Publisher: -
DOI: 10.3390/iecc2021-09197