Integrating chemical and biological approaches to target NAD production and signaling in cancer

Livrables

Recruitment of ESRs

Recruitment of the selected ESRs with full employment contracts.

Call publication

Publication of the call for the ESRs on selected websites and through personal contacts

Supervisory Board of the network

Establishemt of a Supervisory Board.

Ranking

Ranking of the applications after the two step evaluation

Individual CDP

Individual Career Development Plans completed

Secondments

Reports on secondments Multiple dates Months 25 43

Dissemination

Reports on dissemination activities Multiple dates Months 12 24 36 48

Communication/Public engagement report

Reports on outreach activities Multiple dates Months 183042

SCT activities

Organisation of Short Courses of Transferrable training SCT Multiple dates Months 16 28 40

Local training

Reports on local training activities Multiple dates Months 18 30 42

Scientific meetings

Scientific meetings organisationMultiple dates Months 10 22 34

Final Workshop

Final Workshop organisation

PhD thesis

Termination of PhD programmes and thesis discussion

SSC activities

Organisation of Short Scientific Courses Multiple dates Months 10 22 34

Website

Development of the project website.

Publications

SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice

Auteurs: Pamela Becherini, Irene Caffa, Francesco Piacente, Patrizia Damonte, Valerio G. Vellone, Mario Passalacqua, Andrea Benzi, Tommaso Bonfiglio, Daniele Reverberi, Amr Khalifa, Moustafa Ghanem, Ana Guijarro, Luca Tagliafico, Marzia Sucameli, Angelica Persia, Fiammetta Monacelli, Michele Cea, Santina Bruzzone, Silvia Ravera, Alessio Nencioni
Publié dans: Cancer & Metabolism, Numéro 9/1, 2021, Page(s) 6, ISSN 2049-3002
Éditeur: -
DOI: 10.1186/s40170-021-00240-1

Re-Discovery of Pyrimidine Salvage as Target in Cancer Therapy

Auteurs: Melanie Walter, & Patrick Herr
Publié dans: Cells, Numéro 11(4), 2022, Page(s) 739
Éditeur: -
DOI: 10.3390/cells11040739

Anticancer Activities of Novel Nicotinamide Phosphoribosyltransferase Inhibitors in Hematological Malignancies

Auteurs: Biniecka P, Matsumoto S, Belotti A, Joussot J, Bai JF, Majjigapu SR, Thoueille P, Spaggiari D, Desfontaine V, Piacente F, Bruzzone S, Cea M, Decosterd LA, Vogel P, Nencioni A, Duchosal MA, Nahimana A.
Publié dans: Molecules, Numéro Feb 16;28(4), 2023, Page(s) 1897, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules28041897

Identification of NAPRT Inhibitors with Anti-Cancer Properties by In Silico Drug Discovery

Auteurs: Moustafa S. Ghanem, Irene Caffa, Alberto Del Rio, Jorge Franco, Marco Daniele Parenti, Fiammetta Monacelli, Michele Cea, Amr Khalifa, Aimable Nahimana, Michel A. Duchosal, Silvia Ravera, Nadia Bertola, Santina Bruzzone, Alessio Nencioni and Francesco Piacente.
Publié dans: Pharmaceuticals (Basel), Numéro 10;15(7), 2022, Page(s) 848, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph15070848

Advances in NAD-Lowering Agents for Cancer Treatment

Auteurs: Moustafa Ghanem; Fiammetta Monacelli; Alessio Nencioni
Publié dans: Nutrients, Vol 13, Iss 1665, p 1665 (2021), Numéro 1, 2021, Page(s) 1665
Éditeur: -
DOI: 10.3390/nu13051665

Loss of p53 activates thyroid hormone via type 2 deiodinase and enhances DNA damage

Auteurs: Nappi A, Miro C, Pezone A, Tramontano A, Di Cicco E, Sagliocchi S, Cicatiello AG, Murolo M, Torabinejad S, Abbotto E, Caiazzo G, Raia M, Stornaiuolo M, Antonini D, Fabbrocini G, Salvatore D, Avvedimento VE, Dentice M.
Publié dans: Nat Commun., Numéro Mar 4;14(1), 2023, Page(s) 1244, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-023-36755-y

Synthesis and structure-activity relationship of new nicotinamide phosphoribosyltransferase inhibitors with antitumor activity on solid and haematological cancer.

Auteurs: Fratta S, Biniecka P, Moreno-Vargas AJ, Carmona AT, Nahimana A, Duchosal MA, Piacente F, Bruzzone S, Caffa I, Nencioni A, Robina I.
Publié dans: Eur J Med Chem., Numéro 15;250, 2023, Page(s) 115170, ISSN 0346-251X
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.ejmech.2023.115170

Mitochondrial rewiring drives metabolic adaptation to NAD(H) shortage in triple negative breast cancer cells

Auteurs: Agata Sofia Assuncao Carreira, Silvia Ravera, Chiara Zucal, Natthakan Thongon, Caffa Irene, Cecilia Astigiano, Nadia Bertola, Arianna Buongiorno, Michela Roccuzzo, Alessandra Bisio, Barbara Pardini, Alessio Nencioni, Santina Bruzzone, Alessandro Provenzani.
Publié dans: Neoplasia, Numéro 41, 2023, Page(s) 100903, ISSN 1476-5586
Éditeur: Elsevier
DOI: 10.1016/j.neo.2023.100903

Iminosugar-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors as Potential Anti-Pancreatic Cancer Agents

Auteurs: Irene Conforti, Andrea Benzi, Irene Caffa, Santina Bruzzone, Alessio Nencioni, Alberto Marra
Publié dans: Pharmaceutics, Numéro 15, 2023, Page(s) 1472
Éditeur: -
DOI: 10.3390/pharmaceutics15051472

Iminosugars as glycosyltransferase inhibitors

Auteurs: Irene Conforti; Alberto Marra
Publié dans: Org. Biomol. Chem, Numéro 1, 2021, Page(s) 5439-5475
Éditeur: -
DOI: 10.1039/d1ob00382h

Targeting of the A2A adenosine receptor counteracts immunosuppression in vivo in a mouse model of chronic lymphocytic leukemia

Auteurs: Francesca Arruga, Sara Serra, Nicoletta Vitale, Giulia Guerra, Andrea Papait, Benjamin Baffour Gyau, Francesco Tito, Dimitar Efremov, Tiziana Vaisitti, Silvia Deaglio
Publié dans: Haematologica, 2020, Page(s) haematol.2019.242016, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
DOI: 10.3324/haematol.2019.242016

Sirtuin 6 inhibition protects against glucocorticoid-induced skeletal muscle atrophy by regulating IGF/PI3K/AKT signaling

Auteurs: Mishra S, Cosentino C, Tamta AK, Khan D, Srinivasan S, Ravi V, Abbotto E, Arathi BP, Kumar S, Jain A, Ramaian AS, Kizkekra SM, Rajagopal R, Rao S, Krishna S, Asirvatham-Jeyaraj N, Haggerty ER, Silberman DM, Kurland IJ, Veeranna RP, Jayavelu T, Bruzzone S, Mostoslavsky R, Sundaresan NR.
Publié dans: Nat Commun., Numéro Sep 15;13(1), 2022, Page(s) 5415, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-022-32905-w

Virtual Screening in the Identification of Sirtuins' Activity Modulators

Auteurs: Abbotto E, Scarano N, Piacente F, Millo E, Cichero E, Bruzzone S.
Publié dans: Molecules, Numéro Sep 1;27(17), 2022, Page(s) 5641, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27175641

Immune Response Dysfunction in Chronic Lymphocytic Leukemia: Dissecting Molecular Mechanisms and Microenvironmental Conditions

Auteurs: Francesca Arruga, Benjamin Baffour Gyau, Andrea Iannello, Nicoletta Vitale, Tiziana Vaisitti, Silvia Deaglio
Publié dans: International Journal of Molecular Sciences, Numéro 21/5, 2020, Page(s) 1825, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21051825

Structure-Based Identification and Biological Characterization of New NAPRT Inhibitors

Auteurs: Franco, J.; Piacente, F.; Walter, M.; Fratta, S.; Ghanem, M.; Benzi, A.; Caffa, I.; Kurkin, A.V.; Altieri, A.; Herr, P.; Martínez-Bailén, M.; Robina, I.; Bruzzone, S.; Nencioni, A.; Del Rio, A.
Publié dans: Pharmaceuticals, Numéro 15, 2022, Page(s) 855, ISSN 1424-8247
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph15070855

Gut microbiota severely hampers the efficacy of NAD-lowering therapy in leukemia.

Auteurs: ElMokh O, Matsumoto S, Biniecka P, Bellotti A, Schaeuble K, Piacente F, Gallart-Ayala H, Ivanisevic J, Stamenkovic I, Nencioni A, Nahimana A, Duchosal MA
Publié dans: Cell Death Dis, Numéro 13(4), 2022, Page(s) 320
Éditeur: -
DOI: 10.1038/s41419-022-04763-3

NUDT22 promotes cancer growth through pyrimidine salvage

Auteurs: Melanie Walter; Florian Mayr; Bishoy M. F. Hanna; Victoria Cookson; Oliver Mortusewicz; Thomas Helleday; Patrick Herr
Publié dans: Oncogene, Numéro 42, 2023, Page(s) 1282-1293
Éditeur: Nature Publishing Group
DOI: 10.1038/s41388-023-02643-4

Dendritic cells direct circadian anti-tumour immune responses

Auteurs: Wang C, Barnoud C, Cenerenti M, Sun M, Caffa I, Kizil B, Bill R, Liu Y, Pick R, Garnier L, Gkountidi OA, Ince LM, Holtkamp S, Fournier N, Michielin O, Speiser DE, Hugues S, Nencioni A, Pittet MJ, Jandus C, Scheiermann C.
Publié dans: Nature, Numéro 2023 Feb;614(7946), 2023, Page(s) 136-143, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/s41586-022-05605-0

Development of Small Molecule NUDT22 Inhibitors for Uses in Cancer

Auteurs: Walter Melanie, Evert Homan, Tobias Koolmeister, Oliver Mortusewicz, Thomas Helleday and Patrick Herr
Publié dans: Medical Science Forum, Numéro 3, 2021, Page(s) 1
Éditeur: -
DOI: 10.3390/iecc2021-09197

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