Livrables Other (4) Recruitment of ESRs Recruitment of the selected ESRs with full employment contracts. Call publication Publication of the call for the ESRs on selected websites and through personal contacts Supervisory Board of the network Establishemt of a Supervisory Board. Ranking Ranking of the applications after the two step evaluation Documents, reports (10) Individual CDP Individual Career Development Plans completed Secondments Reports on secondments Multiple dates Months 25 43 Dissemination Reports on dissemination activities Multiple dates Months 12 24 36 48 Communication/Public engagement report Reports on outreach activities Multiple dates Months 183042 SCT activities Organisation of Short Courses of Transferrable training SCT Multiple dates Months 16 28 40 Local training Reports on local training activities Multiple dates Months 18 30 42 Scientific meetings Scientific meetings organisationMultiple dates Months 10 22 34 Final Workshop Final Workshop organisation PhD thesis Termination of PhD programmes and thesis discussion SSC activities Organisation of Short Scientific Courses Multiple dates Months 10 22 34 Websites, patent fillings, videos etc. (1) Website Development of the project website. Publications Peer reviewed articles (18) SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice Auteurs: Pamela Becherini, Irene Caffa, Francesco Piacente, Patrizia Damonte, Valerio G. Vellone, Mario Passalacqua, Andrea Benzi, Tommaso Bonfiglio, Daniele Reverberi, Amr Khalifa, Moustafa Ghanem, Ana Guijarro, Luca Tagliafico, Marzia Sucameli, Angelica Persia, Fiammetta Monacelli, Michele Cea, Santina Bruzzone, Silvia Ravera, Alessio Nencioni Publié dans: Cancer & Metabolism, Issue 9/1, 2021, Page(s) 6, ISSN 2049-3002 Éditeur: - DOI: 10.1186/s40170-021-00240-1 Re-Discovery of Pyrimidine Salvage as Target in Cancer Therapy Auteurs: Melanie Walter, & Patrick Herr Publié dans: Cells, Issue 11(4), 2022, Page(s) 739 Éditeur: - DOI: 10.3390/cells11040739 Anticancer Activities of Novel Nicotinamide Phosphoribosyltransferase Inhibitors in Hematological Malignancies Auteurs: Biniecka P, Matsumoto S, Belotti A, Joussot J, Bai JF, Majjigapu SR, Thoueille P, Spaggiari D, Desfontaine V, Piacente F, Bruzzone S, Cea M, Decosterd LA, Vogel P, Nencioni A, Duchosal MA, Nahimana A. Publié dans: Molecules, Issue Feb 16;28(4), 2023, Page(s) 1897, ISSN 2078-2489 Éditeur: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/molecules28041897 Identification of NAPRT Inhibitors with Anti-Cancer Properties by In Silico Drug Discovery Auteurs: Moustafa S. Ghanem, Irene Caffa, Alberto Del Rio, Jorge Franco, Marco Daniele Parenti, Fiammetta Monacelli, Michele Cea, Amr Khalifa, Aimable Nahimana, Michel A. Duchosal, Silvia Ravera, Nadia Bertola, Santina Bruzzone, Alessio Nencioni and Francesco Piacente. Publié dans: Pharmaceuticals (Basel), Issue 10;15(7), 2022, Page(s) 848, ISSN 2078-2489 Éditeur: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ph15070848 Advances in NAD-Lowering Agents for Cancer Treatment Auteurs: Moustafa Ghanem; Fiammetta Monacelli; Alessio Nencioni Publié dans: Nutrients, Vol 13, Iss 1665, p 1665 (2021), Issue 1, 2021, Page(s) 1665 Éditeur: - DOI: 10.3390/nu13051665 Loss of p53 activates thyroid hormone via type 2 deiodinase and enhances DNA damage Auteurs: Nappi A, Miro C, Pezone A, Tramontano A, Di Cicco E, Sagliocchi S, Cicatiello AG, Murolo M, Torabinejad S, Abbotto E, Caiazzo G, Raia M, Stornaiuolo M, Antonini D, Fabbrocini G, Salvatore D, Avvedimento VE, Dentice M. Publié dans: Nat Commun., Issue Mar 4;14(1), 2023, Page(s) 1244, ISSN 2041-1723 Éditeur: Nature Publishing Group DOI: 10.1038/s41467-023-36755-y Synthesis and structure-activity relationship of new nicotinamide phosphoribosyltransferase inhibitors with antitumor activity on solid and haematological cancer. Auteurs: Fratta S, Biniecka P, Moreno-Vargas AJ, Carmona AT, Nahimana A, Duchosal MA, Piacente F, Bruzzone S, Caffa I, Nencioni A, Robina I. Publié dans: Eur J Med Chem., Issue 15;250, 2023, Page(s) 115170, ISSN 0346-251X Éditeur: Pergamon Press Ltd. DOI: 10.1016/j.ejmech.2023.115170 Mitochondrial rewiring drives metabolic adaptation to NAD(H) shortage in triple negative breast cancer cells Auteurs: Agata Sofia Assuncao Carreira, Silvia Ravera, Chiara Zucal, Natthakan Thongon, Caffa Irene, Cecilia Astigiano, Nadia Bertola, Arianna Buongiorno, Michela Roccuzzo, Alessandra Bisio, Barbara Pardini, Alessio Nencioni, Santina Bruzzone, Alessandro Provenzani. Publié dans: Neoplasia, Issue 41, 2023, Page(s) 100903, ISSN 1476-5586 Éditeur: Elsevier DOI: 10.1016/j.neo.2023.100903 Iminosugar-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors as Potential Anti-Pancreatic Cancer Agents Auteurs: Irene Conforti, Andrea Benzi, Irene Caffa, Santina Bruzzone, Alessio Nencioni, Alberto Marra Publié dans: Pharmaceutics, Issue 15, 2023, Page(s) 1472 Éditeur: - DOI: 10.3390/pharmaceutics15051472 Iminosugars as glycosyltransferase inhibitors Auteurs: Irene Conforti; Alberto Marra Publié dans: Org. Biomol. Chem, Issue 1, 2021, Page(s) 5439-5475 Éditeur: - DOI: 10.1039/d1ob00382h Targeting of the A2A adenosine receptor counteracts immunosuppression in vivo in a mouse model of chronic lymphocytic leukemia Auteurs: Francesca Arruga, Sara Serra, Nicoletta Vitale, Giulia Guerra, Andrea Papait, Benjamin Baffour Gyau, Francesco Tito, Dimitar Efremov, Tiziana Vaisitti, Silvia Deaglio Publié dans: Haematologica, 2020, Page(s) haematol.2019.242016, ISSN 0390-6078 Éditeur: Ferrata Storti Foundation DOI: 10.3324/haematol.2019.242016 Sirtuin 6 inhibition protects against glucocorticoid-induced skeletal muscle atrophy by regulating IGF/PI3K/AKT signaling Auteurs: Mishra S, Cosentino C, Tamta AK, Khan D, Srinivasan S, Ravi V, Abbotto E, Arathi BP, Kumar S, Jain A, Ramaian AS, Kizkekra SM, Rajagopal R, Rao S, Krishna S, Asirvatham-Jeyaraj N, Haggerty ER, Silberman DM, Kurland IJ, Veeranna RP, Jayavelu T, Bruzzone S, Mostoslavsky R, Sundaresan NR. Publié dans: Nat Commun., Issue Sep 15;13(1), 2022, Page(s) 5415, ISSN 2041-1723 Éditeur: Nature Publishing Group DOI: 10.1038/s41467-022-32905-w Virtual Screening in the Identification of Sirtuins' Activity Modulators Auteurs: Abbotto E, Scarano N, Piacente F, Millo E, Cichero E, Bruzzone S. Publié dans: Molecules, Issue Sep 1;27(17), 2022, Page(s) 5641, ISSN 1420-3049 Éditeur: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/molecules27175641 Immune Response Dysfunction in Chronic Lymphocytic Leukemia: Dissecting Molecular Mechanisms and Microenvironmental Conditions Auteurs: Francesca Arruga, Benjamin Baffour Gyau, Andrea Iannello, Nicoletta Vitale, Tiziana Vaisitti, Silvia Deaglio Publié dans: International Journal of Molecular Sciences, Issue 21/5, 2020, Page(s) 1825, ISSN 1422-0067 Éditeur: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms21051825 Structure-Based Identification and Biological Characterization of New NAPRT Inhibitors Auteurs: Franco, J.; Piacente, F.; Walter, M.; Fratta, S.; Ghanem, M.; Benzi, A.; Caffa, I.; Kurkin, A.V.; Altieri, A.; Herr, P.; Martínez-Bailén, M.; Robina, I.; Bruzzone, S.; Nencioni, A.; Del Rio, A. Publié dans: Pharmaceuticals, Issue 15, 2022, Page(s) 855, ISSN 1424-8247 Éditeur: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ph15070855 Gut microbiota severely hampers the efficacy of NAD-lowering therapy in leukemia. Auteurs: ElMokh O, Matsumoto S, Biniecka P, Bellotti A, Schaeuble K, Piacente F, Gallart-Ayala H, Ivanisevic J, Stamenkovic I, Nencioni A, Nahimana A, Duchosal MA Publié dans: Cell Death Dis, Issue 13(4), 2022, Page(s) 320 Éditeur: - DOI: 10.1038/s41419-022-04763-3 NUDT22 promotes cancer growth through pyrimidine salvage Auteurs: Melanie Walter; Florian Mayr; Bishoy M. F. Hanna; Victoria Cookson; Oliver Mortusewicz; Thomas Helleday; Patrick Herr Publié dans: Oncogene, Issue 42, 2023, Page(s) 1282-1293 Éditeur: Nature Publishing Group DOI: 10.1038/s41388-023-02643-4 Dendritic cells direct circadian anti-tumour immune responses Auteurs: Wang C, Barnoud C, Cenerenti M, Sun M, Caffa I, Kizil B, Bill R, Liu Y, Pick R, Garnier L, Gkountidi OA, Ince LM, Holtkamp S, Fournier N, Michielin O, Speiser DE, Hugues S, Nencioni A, Pittet MJ, Jandus C, Scheiermann C. Publié dans: Nature, Issue 2023 Feb;614(7946), 2023, Page(s) 136-143, ISSN 0028-0836 Éditeur: Nature Publishing Group DOI: 10.1038/s41586-022-05605-0 Conference proceedings (1) Development of Small Molecule NUDT22 Inhibitors for Uses in Cancer Auteurs: Walter Melanie, Evert Homan, Tobias Koolmeister, Oliver Mortusewicz, Thomas Helleday and Patrick Herr Publié dans: Medical Science Forum, Issue 3, 2021, Page(s) 1 Éditeur: - DOI: 10.3390/iecc2021-09197 Recherche de données OpenAIRE... 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