Integrating chemical and biological approaches to target NAD production and signaling in cancer

Información del proyecto

INTEGRATA

Identificador del acuerdo de subvención: 813284

DOI

10.3030/813284

Proyecto cerrado

Fecha de la firma de la CE 13 Septiembre 2018

Fecha de inicio 1 Noviembre 2018

Fecha de finalización 30 Abril 2023

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 3 738 573,00

Aportación de la UE

€ 3 738 573,00

Coordinado por

UNIVERSITA DEGLI STUDI DI GENOVA
Italy

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Other (4)

Recruitment of ESRs

Recruitment of the selected ESRs with full employment contracts.

Call publication

Publication of the call for the ESRs on selected websites and through personal contacts

Supervisory Board of the network

Establishemt of a Supervisory Board.

Ranking

Ranking of the applications after the two step evaluation

Documents, reports (10)

Individual CDP

Individual Career Development Plans completed

Secondments

Reports on secondments Multiple dates Months 25 43

Dissemination

Reports on dissemination activities Multiple dates Months 12 24 36 48

Communication/Public engagement report

Reports on outreach activities Multiple dates Months 183042

SCT activities

Organisation of Short Courses of Transferrable training SCT Multiple dates Months 16 28 40

Local training

Reports on local training activities Multiple dates Months 18 30 42

Scientific meetings

Scientific meetings organisationMultiple dates Months 10 22 34

Final Workshop

Final Workshop organisation

PhD thesis

Termination of PhD programmes and thesis discussion

SSC activities

Organisation of Short Scientific Courses Multiple dates Months 10 22 34

Websites, patent fillings, videos etc. (1)

Website

Development of the project website.

Publicaciones

Peer reviewed articles (18)

SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice

Autores: Pamela Becherini, Irene Caffa, Francesco Piacente, Patrizia Damonte, Valerio G. Vellone, Mario Passalacqua, Andrea Benzi, Tommaso Bonfiglio, Daniele Reverberi, Amr Khalifa, Moustafa Ghanem, Ana Guijarro, Luca Tagliafico, Marzia Sucameli, Angelica Persia, Fiammetta Monacelli, Michele Cea, Santina Bruzzone, Silvia Ravera, Alessio Nencioni
Publicado en: Cancer & Metabolism, Edición 9/1, 2021, Página(s) 6, ISSN 2049-3002
Editor: -
DOI: 10.1186/s40170-021-00240-1

Re-Discovery of Pyrimidine Salvage as Target in Cancer Therapy

Autores: Melanie Walter, & Patrick Herr
Publicado en: Cells, Edición 11(4), 2022, Página(s) 739
Editor: -
DOI: 10.3390/cells11040739

Anticancer Activities of Novel Nicotinamide Phosphoribosyltransferase Inhibitors in Hematological Malignancies

Autores: Biniecka P, Matsumoto S, Belotti A, Joussot J, Bai JF, Majjigapu SR, Thoueille P, Spaggiari D, Desfontaine V, Piacente F, Bruzzone S, Cea M, Decosterd LA, Vogel P, Nencioni A, Duchosal MA, Nahimana A.
Publicado en: Molecules, Edición Feb 16;28(4), 2023, Página(s) 1897, ISSN 2078-2489
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules28041897

Identification of NAPRT Inhibitors with Anti-Cancer Properties by In Silico Drug Discovery

Autores: Moustafa S. Ghanem, Irene Caffa, Alberto Del Rio, Jorge Franco, Marco Daniele Parenti, Fiammetta Monacelli, Michele Cea, Amr Khalifa, Aimable Nahimana, Michel A. Duchosal, Silvia Ravera, Nadia Bertola, Santina Bruzzone, Alessio Nencioni and Francesco Piacente.
Publicado en: Pharmaceuticals (Basel), Edición 10;15(7), 2022, Página(s) 848, ISSN 2078-2489
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph15070848

Advances in NAD-Lowering Agents for Cancer Treatment

Autores: Moustafa Ghanem; Fiammetta Monacelli; Alessio Nencioni
Publicado en: Nutrients, Vol 13, Iss 1665, p 1665 (2021), Edición 1, 2021, Página(s) 1665
Editor: -
DOI: 10.3390/nu13051665

Loss of p53 activates thyroid hormone via type 2 deiodinase and enhances DNA damage

Autores: Nappi A, Miro C, Pezone A, Tramontano A, Di Cicco E, Sagliocchi S, Cicatiello AG, Murolo M, Torabinejad S, Abbotto E, Caiazzo G, Raia M, Stornaiuolo M, Antonini D, Fabbrocini G, Salvatore D, Avvedimento VE, Dentice M.
Publicado en: Nat Commun., Edición Mar 4;14(1), 2023, Página(s) 1244, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-36755-y

Synthesis and structure-activity relationship of new nicotinamide phosphoribosyltransferase inhibitors with antitumor activity on solid and haematological cancer.

Autores: Fratta S, Biniecka P, Moreno-Vargas AJ, Carmona AT, Nahimana A, Duchosal MA, Piacente F, Bruzzone S, Caffa I, Nencioni A, Robina I.
Publicado en: Eur J Med Chem., Edición 15;250, 2023, Página(s) 115170, ISSN 0346-251X
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.ejmech.2023.115170

Mitochondrial rewiring drives metabolic adaptation to NAD(H) shortage in triple negative breast cancer cells

Autores: Agata Sofia Assuncao Carreira, Silvia Ravera, Chiara Zucal, Natthakan Thongon, Caffa Irene, Cecilia Astigiano, Nadia Bertola, Arianna Buongiorno, Michela Roccuzzo, Alessandra Bisio, Barbara Pardini, Alessio Nencioni, Santina Bruzzone, Alessandro Provenzani.
Publicado en: Neoplasia, Edición 41, 2023, Página(s) 100903, ISSN 1476-5586
Editor: Elsevier
DOI: 10.1016/j.neo.2023.100903

Iminosugar-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors as Potential Anti-Pancreatic Cancer Agents

Autores: Irene Conforti, Andrea Benzi, Irene Caffa, Santina Bruzzone, Alessio Nencioni, Alberto Marra
Publicado en: Pharmaceutics, Edición 15, 2023, Página(s) 1472
Editor: -
DOI: 10.3390/pharmaceutics15051472

Iminosugars as glycosyltransferase inhibitors

Autores: Irene Conforti; Alberto Marra
Publicado en: Org. Biomol. Chem, Edición 1, 2021, Página(s) 5439-5475
Editor: -
DOI: 10.1039/d1ob00382h

Targeting of the A2A adenosine receptor counteracts immunosuppression in vivo in a mouse model of chronic lymphocytic leukemia

Autores: Francesca Arruga, Sara Serra, Nicoletta Vitale, Giulia Guerra, Andrea Papait, Benjamin Baffour Gyau, Francesco Tito, Dimitar Efremov, Tiziana Vaisitti, Silvia Deaglio
Publicado en: Haematologica, 2020, Página(s) haematol.2019.242016, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2019.242016

Sirtuin 6 inhibition protects against glucocorticoid-induced skeletal muscle atrophy by regulating IGF/PI3K/AKT signaling

Autores: Mishra S, Cosentino C, Tamta AK, Khan D, Srinivasan S, Ravi V, Abbotto E, Arathi BP, Kumar S, Jain A, Ramaian AS, Kizkekra SM, Rajagopal R, Rao S, Krishna S, Asirvatham-Jeyaraj N, Haggerty ER, Silberman DM, Kurland IJ, Veeranna RP, Jayavelu T, Bruzzone S, Mostoslavsky R, Sundaresan NR.
Publicado en: Nat Commun., Edición Sep 15;13(1), 2022, Página(s) 5415, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-32905-w

Virtual Screening in the Identification of Sirtuins' Activity Modulators

Autores: Abbotto E, Scarano N, Piacente F, Millo E, Cichero E, Bruzzone S.
Publicado en: Molecules, Edición Sep 1;27(17), 2022, Página(s) 5641, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27175641

Immune Response Dysfunction in Chronic Lymphocytic Leukemia: Dissecting Molecular Mechanisms and Microenvironmental Conditions

Autores: Francesca Arruga, Benjamin Baffour Gyau, Andrea Iannello, Nicoletta Vitale, Tiziana Vaisitti, Silvia Deaglio
Publicado en: International Journal of Molecular Sciences, Edición 21/5, 2020, Página(s) 1825, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21051825

Structure-Based Identification and Biological Characterization of New NAPRT Inhibitors

Autores: Franco, J.; Piacente, F.; Walter, M.; Fratta, S.; Ghanem, M.; Benzi, A.; Caffa, I.; Kurkin, A.V.; Altieri, A.; Herr, P.; Martínez-Bailén, M.; Robina, I.; Bruzzone, S.; Nencioni, A.; Del Rio, A.
Publicado en: Pharmaceuticals, Edición 15, 2022, Página(s) 855, ISSN 1424-8247
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph15070855

Gut microbiota severely hampers the efficacy of NAD-lowering therapy in leukemia.

Autores: ElMokh O, Matsumoto S, Biniecka P, Bellotti A, Schaeuble K, Piacente F, Gallart-Ayala H, Ivanisevic J, Stamenkovic I, Nencioni A, Nahimana A, Duchosal MA
Publicado en: Cell Death Dis, Edición 13(4), 2022, Página(s) 320
Editor: -
DOI: 10.1038/s41419-022-04763-3

NUDT22 promotes cancer growth through pyrimidine salvage

Autores: Melanie Walter; Florian Mayr; Bishoy M. F. Hanna; Victoria Cookson; Oliver Mortusewicz; Thomas Helleday; Patrick Herr
Publicado en: Oncogene, Edición 42, 2023, Página(s) 1282-1293
Editor: Nature Publishing Group
DOI: 10.1038/s41388-023-02643-4

Dendritic cells direct circadian anti-tumour immune responses

Autores: Wang C, Barnoud C, Cenerenti M, Sun M, Caffa I, Kizil B, Bill R, Liu Y, Pick R, Garnier L, Gkountidi OA, Ince LM, Holtkamp S, Fournier N, Michielin O, Speiser DE, Hugues S, Nencioni A, Pittet MJ, Jandus C, Scheiermann C.
Publicado en: Nature, Edición 2023 Feb;614(7946), 2023, Página(s) 136-143, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-022-05605-0

Conference proceedings (1)

Development of Small Molecule NUDT22 Inhibitors for Uses in Cancer

Autores: Walter Melanie, Evert Homan, Tobias Koolmeister, Oliver Mortusewicz, Thomas Helleday and Patrick Herr
Publicado en: Medical Science Forum, Edición 3, 2021, Página(s) 1
Editor: -
DOI: 10.3390/iecc2021-09197