Project description
Research training network to study nicotinamide adenine dinucleotide signalling and biosynthesis in cancer
Deregulation of nicotinamide adenine dinucleotide (NAD) signalling and the upregulation of its biosynthetic enzymes nicotinamide phosphoribosyltransferase (NAMPT) and nicotinic acid phosphoribosyltransferase are linked to cancerogenesis, increasing cell proliferation, motility, de-differentiation and immune escape. NAD signalling and biosynthesis deregulation were shown to be present in solid and haematological malignancies. Funded by the Marie Skłodowska-Curie Actions programme, the INTEGRATA project will provide interdisciplinary training in drug discovery to young researchers, focusing specifically on NAD production and signalling as targets for developing new cancer therapeutics. Mainly, INTEGRATA aims to study the therapeutic potential of NAMPT as an anticancer drug target.
Fields of science
Programme(s)
Coordinator
16126 Genova
Italy
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Participants (12)
53127 Bonn
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S10 2TN Sheffield
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1011 Lausanne
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1211 Geneve
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10124 Torino
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41004 Sevilla
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38122 Trento
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20251 Hamburg
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34090 Montpellier
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41126 Modena
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
1228 Plan Les Ouates Geneve
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
68526 Ladenburg
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Partners (2)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
1015 Lausanne
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
53100 Siena
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.