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Integrating chemical and biological approaches to target NAD production and signaling in cancer

Project description

Research training network to study nicotinamide adenine dinucleotide signalling and biosynthesis in cancer

Deregulation of nicotinamide adenine dinucleotide (NAD) signalling and the upregulation of its biosynthetic enzymes nicotinamide phosphoribosyltransferase (NAMPT) and nicotinic acid phosphoribosyltransferase are linked to cancerogenesis, increasing cell proliferation, motility, de-differentiation and immune escape. NAD signalling and biosynthesis deregulation were shown to be present in solid and haematological malignancies. Funded by the Marie Skłodowska-Curie Actions programme, the INTEGRATA project will provide interdisciplinary training in drug discovery to young researchers, focusing specifically on NAD production and signalling as targets for developing new cancer therapeutics. Mainly, INTEGRATA aims to study the therapeutic potential of NAMPT as an anticancer drug target.

Coordinator

UNIVERSITA DEGLI STUDI DI GENOVA
Net EU contribution
€ 522 999,36
Address
Via Balbi 5
16126 Genova
Italy

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Region
Nord-Ovest Liguria Genova
Activity type
Higher or Secondary Education Establishments
Other funding
€ 522 999,36

Participants (12)

UNIVERSITATSKLINIKUM BONN
Germany
Net EU contribution
€ 252 788,40
Address
Venusberg-campus 1
53127 Bonn

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Region
Nordrhein-Westfalen Köln Bonn, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 252 788,40
THE UNIVERSITY OF SHEFFIELD
United Kingdom
Net EU contribution
€ 303 172,56
Address
Firth Court Western Bank
S10 2TN Sheffield

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Region
Yorkshire and the Humber South Yorkshire Sheffield
Activity type
Higher or Secondary Education Establishments
Other funding
€ 303 172,56
CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS
Switzerland
Net EU contribution
€ 281 276,64
Address
Rue Du Bugnon 21
1011 Lausanne

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Region
Schweiz/Suisse/Svizzera Région lémanique Vaud
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 281 276,64
UNIVERSITE DE GENEVE
Switzerland
Net EU contribution
€ 281 276,64
Address
Rue Du General Dufour 24
1211 Geneve

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Region
Schweiz/Suisse/Svizzera Région lémanique Genève
Activity type
Higher or Secondary Education Establishments
Other funding
€ 281 276,64
UNIVERSITA DEGLI STUDI DI TORINO
Italy
Net EU contribution
€ 261 499,68
Address
Via Giuseppe Verdi 8
10124 Torino

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Region
Nord-Ovest Piemonte Torino
Activity type
Higher or Secondary Education Establishments
Other funding
€ 261 499,68
UNIVERSIDAD DE SEVILLA
Spain
Net EU contribution
€ 250 904,88
Address
Calle S. Fernando 4
41004 Sevilla

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Region
Andalucía Sevilla
Activity type
Higher or Secondary Education Establishments
Other funding
€ 250 904,88
UNIVERSITA DEGLI STUDI DI TRENTO
Italy
Net EU contribution
€ 261 499,68
Address
Via Calepina 14
38122 Trento

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Region
Nord-Est Provincia Autonoma di Trento Trento
Activity type
Higher or Secondary Education Establishments
Other funding
€ 261 499,68
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany
Net EU contribution
€ 252 788,40
Address
Martinistrasse 52
20251 Hamburg

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Other funding
€ 252 788,40
UNIVERSITE DE MONTPELLIER
France
Net EU contribution
€ 274 802,04
Address
163 Rue Auguste Broussonnet
34090 Montpellier

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Region
Occitanie Languedoc-Roussillon Hérault
Activity type
Higher or Secondary Education Establishments
Other funding
€ 274 802,04
INNOVAMOL CONSULTING SRL
Italy
Net EU contribution
€ 261 499,68
Address
Strada San Faustino 167
41126 Modena

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Nord-Est Emilia-Romagna Modena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 261 499,68
NOVIMMUNE SA
Switzerland
Net EU contribution
€ 281 276,64
Address
Chemin Des Aulx 14
1228 Plan Les Ouates Geneve

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Schweiz/Suisse/Svizzera Région lémanique Genève
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 281 276,64
HEIDELBERG PHARMA RESEARCH GMBH
Germany
Net EU contribution
€ 252 788,40
Address
Gregor Mendel Strasse 22
68526 Ladenburg

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Region
Baden-Württemberg Karlsruhe Rhein-Neckar-Kreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 252 788,40

Partners (2)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

UNIVERSITE DE LAUSANNE
Switzerland
Net EU contribution
€ 0,00
Address
Quartier Unil-centre Bâtiment Unicentre
1015 Lausanne

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Region
Schweiz/Suisse/Svizzera Région lémanique Vaud
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

INNOVATION ACTA S.R.L.
Italy
Net EU contribution
€ 0,00
Address
Via D.a. Azuni, 9
00196 Roma

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Centro (IT) Lazio Roma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00