Integrating chemical and biological approaches to target NAD production and signaling in cancer

Informacje na temat projektu

INTEGRATA

Identyfikator umowy o grant: 813284

DOI

10.3030/813284

Projekt został zamknięty

Data podpisania przez KE 13 Września 2018

Data rozpoczęcia 1 Listopada 2018

Data zakończenia 30 Kwietnia 2023

Finansowanie w ramach

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Koszt całkowity

€ 3 738 573,00

Wkład UE

€ 3 738 573,00

Koordynowany przez

UNIVERSITA DEGLI STUDI DI GENOVA
Italy

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Other (4)

Recruitment of ESRs

Recruitment of the selected ESRs with full employment contracts.

Call publication

Publication of the call for the ESRs on selected websites and through personal contacts

Supervisory Board of the network

Establishemt of a Supervisory Board.

Ranking

Ranking of the applications after the two step evaluation

Documents, reports (10)

Individual CDP

Individual Career Development Plans completed

Secondments

Reports on secondments Multiple dates Months 25 43

Dissemination

Reports on dissemination activities Multiple dates Months 12 24 36 48

Communication/Public engagement report

Reports on outreach activities Multiple dates Months 183042

SCT activities

Organisation of Short Courses of Transferrable training SCT Multiple dates Months 16 28 40

Local training

Reports on local training activities Multiple dates Months 18 30 42

Scientific meetings

Scientific meetings organisationMultiple dates Months 10 22 34

Final Workshop

Final Workshop organisation

PhD thesis

Termination of PhD programmes and thesis discussion

SSC activities

Organisation of Short Scientific Courses Multiple dates Months 10 22 34

Websites, patent fillings, videos etc. (1)

Website

Development of the project website.

Publikacje

Peer reviewed articles (18)

SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice

Autorzy: Pamela Becherini, Irene Caffa, Francesco Piacente, Patrizia Damonte, Valerio G. Vellone, Mario Passalacqua, Andrea Benzi, Tommaso Bonfiglio, Daniele Reverberi, Amr Khalifa, Moustafa Ghanem, Ana Guijarro, Luca Tagliafico, Marzia Sucameli, Angelica Persia, Fiammetta Monacelli, Michele Cea, Santina Bruzzone, Silvia Ravera, Alessio Nencioni
Opublikowane w: Cancer & Metabolism, Numer 9/1, 2021, Strona(/y) 6, ISSN 2049-3002
Wydawca: -
DOI: 10.1186/s40170-021-00240-1

Re-Discovery of Pyrimidine Salvage as Target in Cancer Therapy

Autorzy: Melanie Walter, & Patrick Herr
Opublikowane w: Cells, Numer 11(4), 2022, Strona(/y) 739
Wydawca: -
DOI: 10.3390/cells11040739

Anticancer Activities of Novel Nicotinamide Phosphoribosyltransferase Inhibitors in Hematological Malignancies

Autorzy: Biniecka P, Matsumoto S, Belotti A, Joussot J, Bai JF, Majjigapu SR, Thoueille P, Spaggiari D, Desfontaine V, Piacente F, Bruzzone S, Cea M, Decosterd LA, Vogel P, Nencioni A, Duchosal MA, Nahimana A.
Opublikowane w: Molecules, Numer Feb 16;28(4), 2023, Strona(/y) 1897, ISSN 2078-2489
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules28041897

Identification of NAPRT Inhibitors with Anti-Cancer Properties by In Silico Drug Discovery

Autorzy: Moustafa S. Ghanem, Irene Caffa, Alberto Del Rio, Jorge Franco, Marco Daniele Parenti, Fiammetta Monacelli, Michele Cea, Amr Khalifa, Aimable Nahimana, Michel A. Duchosal, Silvia Ravera, Nadia Bertola, Santina Bruzzone, Alessio Nencioni and Francesco Piacente.
Opublikowane w: Pharmaceuticals (Basel), Numer 10;15(7), 2022, Strona(/y) 848, ISSN 2078-2489
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph15070848

Advances in NAD-Lowering Agents for Cancer Treatment

Autorzy: Moustafa Ghanem; Fiammetta Monacelli; Alessio Nencioni
Opublikowane w: Nutrients, Vol 13, Iss 1665, p 1665 (2021), Numer 1, 2021, Strona(/y) 1665
Wydawca: -
DOI: 10.3390/nu13051665

Loss of p53 activates thyroid hormone via type 2 deiodinase and enhances DNA damage

Autorzy: Nappi A, Miro C, Pezone A, Tramontano A, Di Cicco E, Sagliocchi S, Cicatiello AG, Murolo M, Torabinejad S, Abbotto E, Caiazzo G, Raia M, Stornaiuolo M, Antonini D, Fabbrocini G, Salvatore D, Avvedimento VE, Dentice M.
Opublikowane w: Nat Commun., Numer Mar 4;14(1), 2023, Strona(/y) 1244, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-023-36755-y

Synthesis and structure-activity relationship of new nicotinamide phosphoribosyltransferase inhibitors with antitumor activity on solid and haematological cancer.

Autorzy: Fratta S, Biniecka P, Moreno-Vargas AJ, Carmona AT, Nahimana A, Duchosal MA, Piacente F, Bruzzone S, Caffa I, Nencioni A, Robina I.
Opublikowane w: Eur J Med Chem., Numer 15;250, 2023, Strona(/y) 115170, ISSN 0346-251X
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.ejmech.2023.115170

Mitochondrial rewiring drives metabolic adaptation to NAD(H) shortage in triple negative breast cancer cells

Autorzy: Agata Sofia Assuncao Carreira, Silvia Ravera, Chiara Zucal, Natthakan Thongon, Caffa Irene, Cecilia Astigiano, Nadia Bertola, Arianna Buongiorno, Michela Roccuzzo, Alessandra Bisio, Barbara Pardini, Alessio Nencioni, Santina Bruzzone, Alessandro Provenzani.
Opublikowane w: Neoplasia, Numer 41, 2023, Strona(/y) 100903, ISSN 1476-5586
Wydawca: Elsevier
DOI: 10.1016/j.neo.2023.100903

Iminosugar-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors as Potential Anti-Pancreatic Cancer Agents

Autorzy: Irene Conforti, Andrea Benzi, Irene Caffa, Santina Bruzzone, Alessio Nencioni, Alberto Marra
Opublikowane w: Pharmaceutics, Numer 15, 2023, Strona(/y) 1472
Wydawca: -
DOI: 10.3390/pharmaceutics15051472

Iminosugars as glycosyltransferase inhibitors

Autorzy: Irene Conforti; Alberto Marra
Opublikowane w: Org. Biomol. Chem, Numer 1, 2021, Strona(/y) 5439-5475
Wydawca: -
DOI: 10.1039/d1ob00382h

Targeting of the A2A adenosine receptor counteracts immunosuppression in vivo in a mouse model of chronic lymphocytic leukemia

Autorzy: Francesca Arruga, Sara Serra, Nicoletta Vitale, Giulia Guerra, Andrea Papait, Benjamin Baffour Gyau, Francesco Tito, Dimitar Efremov, Tiziana Vaisitti, Silvia Deaglio
Opublikowane w: Haematologica, 2020, Strona(/y) haematol.2019.242016, ISSN 0390-6078
Wydawca: Ferrata Storti Foundation
DOI: 10.3324/haematol.2019.242016

Sirtuin 6 inhibition protects against glucocorticoid-induced skeletal muscle atrophy by regulating IGF/PI3K/AKT signaling

Autorzy: Mishra S, Cosentino C, Tamta AK, Khan D, Srinivasan S, Ravi V, Abbotto E, Arathi BP, Kumar S, Jain A, Ramaian AS, Kizkekra SM, Rajagopal R, Rao S, Krishna S, Asirvatham-Jeyaraj N, Haggerty ER, Silberman DM, Kurland IJ, Veeranna RP, Jayavelu T, Bruzzone S, Mostoslavsky R, Sundaresan NR.
Opublikowane w: Nat Commun., Numer Sep 15;13(1), 2022, Strona(/y) 5415, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-022-32905-w

Virtual Screening in the Identification of Sirtuins' Activity Modulators

Autorzy: Abbotto E, Scarano N, Piacente F, Millo E, Cichero E, Bruzzone S.
Opublikowane w: Molecules, Numer Sep 1;27(17), 2022, Strona(/y) 5641, ISSN 1420-3049
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27175641

Immune Response Dysfunction in Chronic Lymphocytic Leukemia: Dissecting Molecular Mechanisms and Microenvironmental Conditions

Autorzy: Francesca Arruga, Benjamin Baffour Gyau, Andrea Iannello, Nicoletta Vitale, Tiziana Vaisitti, Silvia Deaglio
Opublikowane w: International Journal of Molecular Sciences, Numer 21/5, 2020, Strona(/y) 1825, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21051825

Structure-Based Identification and Biological Characterization of New NAPRT Inhibitors

Autorzy: Franco, J.; Piacente, F.; Walter, M.; Fratta, S.; Ghanem, M.; Benzi, A.; Caffa, I.; Kurkin, A.V.; Altieri, A.; Herr, P.; Martínez-Bailén, M.; Robina, I.; Bruzzone, S.; Nencioni, A.; Del Rio, A.
Opublikowane w: Pharmaceuticals, Numer 15, 2022, Strona(/y) 855, ISSN 1424-8247
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph15070855

Gut microbiota severely hampers the efficacy of NAD-lowering therapy in leukemia.

Autorzy: ElMokh O, Matsumoto S, Biniecka P, Bellotti A, Schaeuble K, Piacente F, Gallart-Ayala H, Ivanisevic J, Stamenkovic I, Nencioni A, Nahimana A, Duchosal MA
Opublikowane w: Cell Death Dis, Numer 13(4), 2022, Strona(/y) 320
Wydawca: -
DOI: 10.1038/s41419-022-04763-3

NUDT22 promotes cancer growth through pyrimidine salvage

Autorzy: Melanie Walter; Florian Mayr; Bishoy M. F. Hanna; Victoria Cookson; Oliver Mortusewicz; Thomas Helleday; Patrick Herr
Opublikowane w: Oncogene, Numer 42, 2023, Strona(/y) 1282-1293
Wydawca: Nature Publishing Group
DOI: 10.1038/s41388-023-02643-4

Dendritic cells direct circadian anti-tumour immune responses

Autorzy: Wang C, Barnoud C, Cenerenti M, Sun M, Caffa I, Kizil B, Bill R, Liu Y, Pick R, Garnier L, Gkountidi OA, Ince LM, Holtkamp S, Fournier N, Michielin O, Speiser DE, Hugues S, Nencioni A, Pittet MJ, Jandus C, Scheiermann C.
Opublikowane w: Nature, Numer 2023 Feb;614(7946), 2023, Strona(/y) 136-143, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/s41586-022-05605-0

Conference proceedings (1)

Development of Small Molecule NUDT22 Inhibitors for Uses in Cancer

Autorzy: Walter Melanie, Evert Homan, Tobias Koolmeister, Oliver Mortusewicz, Thomas Helleday and Patrick Herr
Opublikowane w: Medical Science Forum, Numer 3, 2021, Strona(/y) 1
Wydawca: -
DOI: 10.3390/iecc2021-09197