CORDIS - EU research results
CORDIS

Ocular Research By Integrated Training And Learning

Deliverables

Launch of ORBITAL website and social media

ORBITALs website and social media presence will be launched at an early a stage as possible to ensure awareness as well as a platform for engagement with the scientific and lay communities

Publications

Validation of a Rapid and Easy-to-Apply Method to Simultaneously Quantify Co-Loaded Dexamethasone and Melatonin PLGA Microspheres by HPLC-UV: Encapsulation Efficiency and In Vitro Release

Author(s): Marco Brugnera; Marta Vicario-de-la-Torre; Vanessa Andrés-Guerrero; Irene Bravo-Osuna; Irene Teresa Molina-Martínez; Rocío Herrero-Vanrell
Published in: Pharmaceutics; Volume 14; Issue 2; Pages: 288, Issue 5, 2022, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14020288

Phosphorylcholine-Based Contact Lenses for Sustained Release of Resveratrol: Design, Antioxidant and Antimicrobial Performances, and In Vivo Behavior

Author(s): Maria Vivero-Lopez, Ana F. Pereira-da-Mota, Gonzalo Carracedo, Fernando Huete-Toral, Ana Parga, Ana Otero, Angel Concheiro, and Carmen Alvarez-Lorenzo
Published in: ACS Appl. Mater. Interfaces, Issue 14, 2022, Page(s) 55431–55446, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.2c18217

Oxidative Stress in the Anterior Ocular Diseases: Diagnostic and Treatment

Author(s): Azza Dammak; Cristina Pastrana; Alba Martin-Gil; Carlos Carpena-Torres; Assumpta Peral Cerda; Mirjam Simovart; Pilar Alarma; Fernando Huete-Toral; Gonzalo Carracedo
Published in: instname:, Issue 4, 2023, ISSN 2227-9059
Publisher: MDPI
DOI: 10.3390/biomedicines11020292

Ocular application of electrospun materials for drug delivery and cellular therapies

Author(s): Deepakkumar Mishra; Shilpkala Gade; Varun Pathak; Lalitkumar K Vora; Kiran Mcloughlin; Reinhold Medina; Ryan F Donnelly; Thakur Raghu Raj Singh
Published in: Mishra , D , Gade , S , Pathak , V , Vora , L K , Mcloughlin , K , Medina , R , Donnelly , R F & Raghu Raj Singh , T 2023 , ' Ocular application of electrospun materials for drug delivery and cellular therapies ' , Drug Discovery Today , vol. 28 , no. 9 , 103676 . https://doi.org/10.1016/j.drudis.2023.103676, Issue 1, 2023, ISSN 1359-6446
Publisher: Elsevier BV
DOI: 10.1016/j.drudis.2023.103676

Melatonin-Eluting Contact Lenses Effect on Tear Volume: In Vitro and In Vivo Experiments

Author(s): María Serramito, Ana F. Pereira-da-Mota, Carlos Carpena-Torres, Fernando Huete-Toral, Carmen Alvarez-Lorenzo, and Gonzalo Carracedo
Published in: Pharmaceutics, Issue 1019, 2022, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14051019

Epidemiologie okulärer Manifestationen bei Autoimmunkrankheiten

Author(s): Katie Glover; Deepakkumar Mishra; Thakur Raghu Raj Singh
Published in: Kompass Ophthalmologie, Issue Volume 8, Issue 1, 2022, Page(s) 2-17, ISSN 2297-0118
Publisher: KARGER
DOI: 10.1159/000521961

Ocular Disorders and Associated Drug Development Challenges: The Current Scenario

Author(s): Mishra, Deepakkumar; Gade, Shilpkala; Singh, Thakur Raghu Raj
Published in: EC Ophthalmology, Issue 11.6, 2020, Page(s) 92-101, ISSN 2453-188X
Publisher: Queens University Belfast

Diabetic eye: associated diseases, drugs in clinic, and role of self-assembled carriers in topical treatment

Author(s): Axel Kattar, Angel Concheiro, Carmen Alvarez-Lorenzo
Published in: Expert Opinion on Drug Delivery, 2021, Page(s) 1-19, ISSN 1742-5247
Publisher: Ashley Publications Ltd.
DOI: 10.1080/17425247.2021.1953466

How patient/public involvement impacts the research journey – an overview of the visual impairment research field

Author(s): Tess Ames; Evan Matthews; Alison Reynolds; Laurence Fitzhenry; Ann Logan; Martina Gooney; Helena Prior Filipe
Published in: Open Research Europe, Issue 2, 2023, ISSN 2732-5121
Publisher: Open Research Europe
DOI: 10.12688/openreseurope.16057.1

In vitro–in vivo correlation of drug release profiles from medicated contact lenses using an in vitro eye blink model.

Author(s): Ana F. Pereira-da-Mota, Maria Vivero-Lopez, Piyush Garg, Chau-Minh Phan, Angel Concheiro, Lyndon Jones & Carmen Alvarez-Lorenzo
Published in: Drug Delivery and Translational Research, Issue 13, 2023, Page(s) 1116–1127, ISSN 2190-3948
Publisher: Springer Nature
DOI: 10.1007/s13346-022-01276-6

Testing drug release from medicated contact lenses: the missing link to predict in vivo performance

Author(s): Ana F. Pereira-da-Mota, Chau-Minh Phan, Angel Concheiro, Lyndon Jones, Carmen Alvarez-Lorenzo
Published in: Journal of Controlled Release, Issue 343, 2022, Page(s) 672-702, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2022.02.014

New Biomarker Combination Related to Oxidative Stress and Inflammation in Primary Open-Angle Glaucoma

Author(s): Azza Dammak; Juan Sanchez Naves; Fernando Huete-Toral; Gonzalo Carracedo
Published in: Life; Volume 13; Issue 7; Pages: 1455, Issue 2, 2023, Page(s) 13/7:1455, ISSN 2075-1729
Publisher: MDPI
DOI: 10.3390/life13071455

Atorvastatin-Eluting Contact Lenses: Effects of Molecular Imprinting and Sterilization on Drug Loading and Release

Author(s): Ana F. Pereira-da-Mota, María Vivero-Lopez, Ana Topete, Ana Paula Serro, Angel Concheiro, Carmen Alvarez-Lorenzo
Published in: Pharmaceutics, Issue 13/5, 2021, Page(s) 606, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13050606

Novel electrospun implants of Sunitinib can depress ex-vivo ocular neovascularization

Author(s): Deepakkumar Mishra; Hákon Hrafn Sigurðsson; Ana Paula Serro; Giedrius Kalesnykas; Ryan F Donnelly; Raghu Raj Singh Thakur
Published in: Mishra , D , Sigurðsson , H H , Serro , A P , Kalesnykas , G , Donnelly , R & Singh , T R R 2022 , ' Novel electrospun implants of Sunitinib can depress ex-vivo ocular neovascularization ' , British Journal of Pharmacy , vol. 7 , no. 2 . https://doi.org/10.5920/bjpharm.1174, Issue 1, 2022, ISSN 2058-8356
Publisher: British Journal of Pharmacy
DOI: 10.5920/bjpharm.1174

Nanostructured Lipid Carriers for Enhanced Transscleral Delivery of Dexamethasone Acetate: Development, Ex Vivo Characterization and Multiphoton Microscopy Studies

Author(s): González-Fernández, Felipe M; Delledonne, Andrea; Nicoli, Sara; Gasco, Paolo; Padula, Cristina; Santi, Patrizia; Sissa, Cristina; Pescina, Silvia
Published in: Pharmaceutics, Volume 15, Issue 2 (February 2023), Issue 3, 2023, Page(s) 407, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15020407

Niosomes-based gene delivery systems for effective transfection of human mesenchymal stem cells

Author(s): Natalia Carballo-Pedrares, Axel Kattar, Angel Concheiro, Carmen Alvarez-Lorenzo, Ana Rey-Rico
Published in: Materials Science and Engineering: C, Issue 128, 2021, Page(s) 112307, ISSN 0928-4931
Publisher: Elsevier BV
DOI: 10.1016/j.msec.2021.112307

Injectable depot forming thermoresponsive hydrogel for sustained intrascleral delivery of sunitinib using hollow microneedles

Author(s): Gade, Shilpkala Shankar; Pentlavalli, Sreekanth; Mishra, Deepakkumar; Vora, Lalitkumar K.; Waite, David; Alvarez-Lorenzo, Carmen Isabel; Herrero Vanrell, Maria Roccio; Laverty, Garry; Larrañeta, Eneko; Donnelly, Ryan F.; Singh Thakur, Raghu Raj
Published in: ournal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, Issue 38(6), 2022, Page(s) 433-448, ISSN 1557-7732
Publisher: Mary Ann Liebert, Inc
DOI: 10.1089/jop.2022.0016

From Oxidative Stress to Inflammation in the Posterior Ocular Diseases: Diagnosis and Treatment.

Author(s): Azza Dammak; Fernando Huete-Toral; Carlos Carpena-Torres; Alba Martin-Gil; Cristina Pastrana; Gonzalo Carracedo
Published in: Pharmaceutics, Issue 13, 2021, Page(s) 1376, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13091376

Therapeutic Ophthalmic Lenses: A Review

Author(s): Nadia Toffoletto, Benilde Saramago, Ana Paula Serro
Published in: Pharmaceutics, Issue 13/1, 2021, Page(s) 36, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13010036

Drug-Loaded Hydrogels for Intraocular Lenses with Prophylactic Action against Pseudophakic Cystoid Macular Edema

Author(s): Nadia Toffoletto; Madalena Salema-Oom; Soledad Anguiano Igea; Carmen Alvarez-Lorenzo; Benilde Saramago; Ana Paula Serro
Published in: Volume 13, Issue 13, 2021, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13070976

Neuroprotective Nanoparticles Targeting the Retina: A Polymeric Platform for Ocular Drug Delivery Applications

Author(s): Patrizia Colucci; Martina Giannaccini; Matteo Baggiani; Breandán N. Kennedy; Luciana Dente; Vittoria Raffa; Chiara Gabellini
Published in: Pharmaceutics; Volume 15; Issue 4; Pages: 1096, Issue 2, 2023, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15041096

Development and characterization of injectable depot forming thermoresponsive hydrogel for the sustained intrascleral delivery of Sunitinib

Author(s): Shilpkala Gade; Eneko Larrañeta; Ryan F Donnelly; Rocio Herrero Vanrell; Carmen Isabel Alvarez Lorenzo; Raghu Raj Singh Thakur
Published in: British Journal of Pharmacy, Issue Volume 7, Issue 2, 2022, ISSN 2058-8356
Publisher: University of Huddersfield Press
DOI: 10.5920/bjpharm.1175

A physiology-based mathematical model to understand drug delivery from contact lenses to the back of the eye

Author(s): N. Toffoletto, B. Saramago, A.P. Serro, A. Chauhan
Published in: Pharmaceutical Research, 2023, Page(s) 40(8) 1939–1951, ISSN 0724-8741
Publisher: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11095-023-03560-7

Dexamethasone phosphate and penetratin co-eluting contact lenses: a strategy to enhance ocular drug permeability

Author(s): N. Toffoletto, M. Salema-Oom, S. Nicoli, S. Pescina, F.M. González-Fernández C.A. Pinto, J.A. Saraiva, A.P.A. Matos, M. Vivero-Lopez; F. Huete-Toral, G. Carracedo, B. Saramago, A.P. Serro
Published in: International Journal of Pharmaceutics, 2024, Page(s) 650 (2024)123685, ISSN 0378-5173
Publisher: Elsevier BV
DOI: 10.1016/j.ijpharm.2023.123685

Formulation and Characterization of Epalrestat-Loaded Polysorbate 60 Cationic Niosomes for Ocular Delivery

Author(s): Axel Kattar; Ana Quelle-Regaldie; Laura Sánchez; Angel Concheiro; Carmen Alvarez-Lorenzo
Published in: reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela, Issue 1, 2023, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15041247

Lipid-Based Nanocarriers for Ophthalmic Administration: Towards Experimental Design Implementation.

Author(s): Felipe M González-Fernández; Annalisa Bianchera; Paolo Gasco; Sara Nicoli; Silvia Pescina
Published in: Pharmaceutics, Issue 13, 2021, Page(s) 447, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13040447

Penetration Enhancers for Topical Drug Delivery to the Ocular Posterior Segment—A Systematic Review

Author(s): Abhinav Thareja, Helen Hughes, Carmen Alvarez-Lorenzo, Jenni J. Hakkarainen, Zubair Ahmed
Published in: Pharmaceutics, Issue 13/2, 2021, Page(s) 276, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13020276

Mucoadhesive gellan gum-based and carboxymethyl cellulose -based hydrogels containing gemcitabine and papain for bladder cancer treatment

Author(s): Caroline S.A. de Lima; M. Isabel Rial-Hermida; Lucas Freitas de Freitas; Ana F. Pereira-da-Mota; Maria Vivero-Lopez; Aryel Heitor Ferreira; Sławomir Kadłubowski; Gustavo H.C. Varca; Ademar B. Lugão; Carmen Alvarez-Lorenzo
Published in: Crossref, Issue 2, 2023, ISSN 0141-8130
Publisher: Elsevier BV
DOI: 10.1016/j.ijbiomac.2023.124957

Contact lenses for pravastatin delivery to eye segments: Design and in vitro-in vivo correlations

Author(s): Ana F.Pereira-da-Mota, Maria Vivero-Lopez, Maria Serramito, Luis Diaz-Gomez, Ana Paula Serro, Gonzalo Carracedo, Fernando Huete-Toral, Angel Concheiro, Carmen Alvarez-Lorenzo
Published in: Journal of Controlled Release, Issue 348, 2022, Page(s) 431-443, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2022.06.001

Asymmetry in Drug Permeability through the Cornea

Author(s): Nadia Toffoletto, Anuj Chauhan, Carmen Alvarez-Lorenzo, Benilde Saramago, Ana Paula Serro
Published in: Pharmaceutics, Issue 13/5, 2021, Page(s) 694, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13050694

Posterior Segment Ophthalmic Drug Delivery: Role of Muco-Adhesion with a Special Focus on Chitosan

Author(s): Ayah Mohammad Burhan; Butsabarat Klahan; Wayne Cummins; Vanessa Andrés-Guerrero; Mark E. Byrne; Niall J. O’Reilly; Anuj Chauhan; Laurence Fitzhenry; Helen Hughes
Published in: Pharmaceutics, Issue 13, 2021, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13101685

Epidemiology of Ocular Manifestations in Autoimmune Disease

Author(s): Katie Glover; Deepakkumar Mishra; Thakur Raghu Raj Singh
Published in: Frontiers in Immunology, Issue 2, 2021, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2021.744396

Penetration enhancers for topical drug delivery to the ocular posterior segment: a systematic Review

Author(s): Thareja, Abhinav; Hughes, Helen; Álvarez Lorenzo, Carmen Isabel; Hakkarainen, Jenni J.; Ahmed, Zubair
Published in: reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela, Issue 1, 2021, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13020276

Drug-Loaded Hydrogels for Intraocular Lenses with Prophylactic Action against Pseudophakic Cystoid Macular Edema

Author(s): Nadia Toffoletto, Madalena Salema-Oom, Soledad Anguiano Igea, Carmen Alvarez-Lorenzo, Benilde Saramago, Ana Paula Serro
Published in: Pharmaceutics, Issue 13/7, 2021, Page(s) 976, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13070976

Langmuir monolayer studies of non-ionic surfactants and DOTMA for the design of ophthalmic niosomes

Author(s): Axel Kattar Emílio V. Lage Matilde Casas Angel Concheiro Carmen Alvarez-Lorenzo
Published in: Heliyon, 2024, ISSN 2405-8440
Publisher: Elsevier
DOI: 10.1016/j.heliyon.2024.e25887

Lipid-Based Nanocarriers for Ophthalmic Administration: Towards Experimental Design Implementation

Author(s): Felipe M. González-Fernández, Annalisa Bianchera, Paolo Gasco, Sara Nicoli, Silvia Pescina
Published in: Pharmaceutics, Issue 13/4, 2021, Page(s) 447, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13040447

Development of 3D-printed devices for the study of transscleral drug delivery on freshly excised whole porcine eyes

Author(s): Felipe M. González-Fernández, Daniele A. Cauzzi, Sara Nicoli, Paolo Gasco, Silvia Pescina
Published in: Volume 100, Issue S275 Special Issue:Abstracts from the 2022 European Association for Vision and Eye Research Festival, 13‐15 October 2022, Valencia, 2022
Publisher: Wiley
DOI: 10.1111/j.1755-3768.2022.15545

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