Ocular Research By Integrated Training And Learning

Project Information

ORBITAL

Grant agreement ID: 813440

DOI 10.3030/813440

Project closed

EC signature date 9 April 2019

Start date 1 September 2019

End date 29 February 2024

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 4 066 231,32

EU contribution € 4 066 231,32

Coordinated by

SOUTH EAST TECHNOLOGICAL UNIVERSITY
Ireland

Deliverables

Websites, patent fillings, videos etc. (1)

Launch of ORBITAL website and social media

ORBITALs website and social media presence will be launched at an early a stage as possible to ensure awareness as well as a platform for engagement with the scientific and lay communities

Publications

Peer reviewed articles (34)

Validation of a Rapid and Easy-to-Apply Method to Simultaneously Quantify Co-Loaded Dexamethasone and Melatonin PLGA Microspheres by HPLC-UV: Encapsulation Efficiency and In Vitro Release

Author(s): Marco Brugnera; Marta Vicario-de-la-Torre; Vanessa Andrés-Guerrero; Irene Bravo-Osuna; Irene Teresa Molina-Martínez; Rocío Herrero-Vanrell
Published in: Pharmaceutics; Volume 14; Issue 2; Pages: 288, Issue 5, 2022, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14020288

Phosphorylcholine-Based Contact Lenses for Sustained Release of Resveratrol: Design, Antioxidant and Antimicrobial Performances, and In Vivo Behavior

Author(s): Maria Vivero-Lopez, Ana F. Pereira-da-Mota, Gonzalo Carracedo, Fernando Huete-Toral, Ana Parga, Ana Otero, Angel Concheiro, and Carmen Alvarez-Lorenzo
Published in: ACS Appl. Mater. Interfaces, Issue 14, 2022, Page(s) 55431–55446, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.2c18217

Oxidative Stress in the Anterior Ocular Diseases: Diagnostic and Treatment

Author(s): Azza Dammak; Cristina Pastrana; Alba Martin-Gil; Carlos Carpena-Torres; Assumpta Peral Cerda; Mirjam Simovart; Pilar Alarma; Fernando Huete-Toral; Gonzalo Carracedo
Published in: instname:, Issue 4, 2023, ISSN 2227-9059
Publisher: MDPI
DOI: 10.3390/biomedicines11020292

Ocular application of electrospun materials for drug delivery and cellular therapies

Author(s): Deepakkumar Mishra; Shilpkala Gade; Varun Pathak; Lalitkumar K Vora; Kiran Mcloughlin; Reinhold Medina; Ryan F Donnelly; Thakur Raghu Raj Singh
Published in: Mishra , D , Gade , S , Pathak , V , Vora , L K , Mcloughlin , K , Medina , R , Donnelly , R F & Raghu Raj Singh , T 2023 , ' Ocular application of electrospun materials for drug delivery and cellular therapies ' , Drug Discovery Today , vol. 28 , no. 9 , 103676 . https://doi.org/10.1016/j.drudis.2023.103676, Issue 1, 2023, ISSN 1359-6446
Publisher: Elsevier BV
DOI: 10.1016/j.drudis.2023.103676

Melatonin-Eluting Contact Lenses Effect on Tear Volume: In Vitro and In Vivo Experiments

Author(s): María Serramito, Ana F. Pereira-da-Mota, Carlos Carpena-Torres, Fernando Huete-Toral, Carmen Alvarez-Lorenzo, and Gonzalo Carracedo
Published in: Pharmaceutics, Issue 1019, 2022, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14051019

Epidemiologie okulärer Manifestationen bei Autoimmunkrankheiten

Author(s): Katie Glover; Deepakkumar Mishra; Thakur Raghu Raj Singh
Published in: Kompass Ophthalmologie, Issue Volume 8, Issue 1, 2022, Page(s) 2-17, ISSN 2297-0118
Publisher: KARGER
DOI: 10.1159/000521961

Ocular Disorders and Associated Drug Development Challenges: The Current Scenario

Author(s): Mishra, Deepakkumar; Gade, Shilpkala; Singh, Thakur Raghu Raj
Published in: EC Ophthalmology, Issue 11.6, 2020, Page(s) 92-101, ISSN 2453-188X
Publisher: Queens University Belfast

Diabetic eye: associated diseases, drugs in clinic, and role of self-assembled carriers in topical treatment

Author(s): Axel Kattar, Angel Concheiro, Carmen Alvarez-Lorenzo
Published in: Expert Opinion on Drug Delivery, 2021, Page(s) 1-19, ISSN 1742-5247
Publisher: Ashley Publications Ltd.
DOI: 10.1080/17425247.2021.1953466

How patient/public involvement impacts the research journey – an overview of the visual impairment research field

Author(s): Tess Ames; Evan Matthews; Alison Reynolds; Laurence Fitzhenry; Ann Logan; Martina Gooney; Helena Prior Filipe
Published in: Open Research Europe, Issue 2, 2023, ISSN 2732-5121
Publisher: Open Research Europe
DOI: 10.12688/openreseurope.16057.1

In vitro–in vivo correlation of drug release profiles from medicated contact lenses using an in vitro eye blink model.

Author(s): Ana F. Pereira-da-Mota, Maria Vivero-Lopez, Piyush Garg, Chau-Minh Phan, Angel Concheiro, Lyndon Jones & Carmen Alvarez-Lorenzo
Published in: Drug Delivery and Translational Research, Issue 13, 2023, Page(s) 1116–1127, ISSN 2190-3948
Publisher: Springer Nature
DOI: 10.1007/s13346-022-01276-6

Testing drug release from medicated contact lenses: the missing link to predict in vivo performance

Author(s): Ana F. Pereira-da-Mota, Chau-Minh Phan, Angel Concheiro, Lyndon Jones, Carmen Alvarez-Lorenzo
Published in: Journal of Controlled Release, Issue 343, 2022, Page(s) 672-702, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2022.02.014

New Biomarker Combination Related to Oxidative Stress and Inflammation in Primary Open-Angle Glaucoma

Author(s): Azza Dammak; Juan Sanchez Naves; Fernando Huete-Toral; Gonzalo Carracedo
Published in: Life; Volume 13; Issue 7; Pages: 1455, Issue 2, 2023, Page(s) 13/7:1455, ISSN 2075-1729
Publisher: MDPI
DOI: 10.3390/life13071455

Atorvastatin-Eluting Contact Lenses: Effects of Molecular Imprinting and Sterilization on Drug Loading and Release

Author(s): Ana F. Pereira-da-Mota, María Vivero-Lopez, Ana Topete, Ana Paula Serro, Angel Concheiro, Carmen Alvarez-Lorenzo
Published in: Pharmaceutics, Issue 13/5, 2021, Page(s) 606, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13050606

Novel electrospun implants of Sunitinib can depress ex-vivo ocular neovascularization

Author(s): Deepakkumar Mishra; Hákon Hrafn Sigurðsson; Ana Paula Serro; Giedrius Kalesnykas; Ryan F Donnelly; Raghu Raj Singh Thakur
Published in: Mishra , D , Sigurðsson , H H , Serro , A P , Kalesnykas , G , Donnelly , R & Singh , T R R 2022 , ' Novel electrospun implants of Sunitinib can depress ex-vivo ocular neovascularization ' , British Journal of Pharmacy , vol. 7 , no. 2 . https://doi.org/10.5920/bjpharm.1174, Issue 1, 2022, ISSN 2058-8356
Publisher: British Journal of Pharmacy
DOI: 10.5920/bjpharm.1174

Nanostructured Lipid Carriers for Enhanced Transscleral Delivery of Dexamethasone Acetate: Development, Ex Vivo Characterization and Multiphoton Microscopy Studies

Author(s): González-Fernández, Felipe M; Delledonne, Andrea; Nicoli, Sara; Gasco, Paolo; Padula, Cristina; Santi, Patrizia; Sissa, Cristina; Pescina, Silvia
Published in: Pharmaceutics, Volume 15, Issue 2 (February 2023), Issue 3, 2023, Page(s) 407, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15020407

Niosomes-based gene delivery systems for effective transfection of human mesenchymal stem cells

Author(s): Natalia Carballo-Pedrares, Axel Kattar, Angel Concheiro, Carmen Alvarez-Lorenzo, Ana Rey-Rico
Published in: Materials Science and Engineering: C, Issue 128, 2021, Page(s) 112307, ISSN 0928-4931
Publisher: Elsevier BV
DOI: 10.1016/j.msec.2021.112307

Injectable depot forming thermoresponsive hydrogel for sustained intrascleral delivery of sunitinib using hollow microneedles

Author(s): Gade, Shilpkala Shankar; Pentlavalli, Sreekanth; Mishra, Deepakkumar; Vora, Lalitkumar K.; Waite, David; Alvarez-Lorenzo, Carmen Isabel; Herrero Vanrell, Maria Roccio; Laverty, Garry; Larrañeta, Eneko; Donnelly, Ryan F.; Singh Thakur, Raghu Raj
Published in: ournal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, Issue 38(6), 2022, Page(s) 433-448, ISSN 1557-7732
Publisher: Mary Ann Liebert, Inc
DOI: 10.1089/jop.2022.0016

From Oxidative Stress to Inflammation in the Posterior Ocular Diseases: Diagnosis and Treatment.

Author(s): Azza Dammak; Fernando Huete-Toral; Carlos Carpena-Torres; Alba Martin-Gil; Cristina Pastrana; Gonzalo Carracedo
Published in: Pharmaceutics, Issue 13, 2021, Page(s) 1376, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13091376

Therapeutic Ophthalmic Lenses: A Review

Author(s): Nadia Toffoletto, Benilde Saramago, Ana Paula Serro
Published in: Pharmaceutics, Issue 13/1, 2021, Page(s) 36, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13010036

Neuroprotective Nanoparticles Targeting the Retina: A Polymeric Platform for Ocular Drug Delivery Applications

Author(s): Patrizia Colucci; Martina Giannaccini; Matteo Baggiani; Breandán N. Kennedy; Luciana Dente; Vittoria Raffa; Chiara Gabellini
Published in: Pharmaceutics; Volume 15; Issue 4; Pages: 1096, Issue 2, 2023, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15041096

Development and characterization of injectable depot forming thermoresponsive hydrogel for the sustained intrascleral delivery of Sunitinib

Author(s): Shilpkala Gade; Eneko Larrañeta; Ryan F Donnelly; Rocio Herrero Vanrell; Carmen Isabel Alvarez Lorenzo; Raghu Raj Singh Thakur
Published in: British Journal of Pharmacy, Issue Volume 7, Issue 2, 2022, ISSN 2058-8356
Publisher: University of Huddersfield Press
DOI: 10.5920/bjpharm.1175

A physiology-based mathematical model to understand drug delivery from contact lenses to the back of the eye

Author(s): N. Toffoletto, B. Saramago, A.P. Serro, A. Chauhan
Published in: Pharmaceutical Research, 2023, Page(s) 40(8) 1939–1951, ISSN 0724-8741
Publisher: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11095-023-03560-7

Dexamethasone phosphate and penetratin co-eluting contact lenses: a strategy to enhance ocular drug permeability

Author(s): N. Toffoletto, M. Salema-Oom, S. Nicoli, S. Pescina, F.M. González-Fernández C.A. Pinto, J.A. Saraiva, A.P.A. Matos, M. Vivero-Lopez; F. Huete-Toral, G. Carracedo, B. Saramago, A.P. Serro
Published in: International Journal of Pharmaceutics, 2024, Page(s) 650 (2024)123685, ISSN 0378-5173
Publisher: Elsevier BV
DOI: 10.1016/j.ijpharm.2023.123685

Formulation and Characterization of Epalrestat-Loaded Polysorbate 60 Cationic Niosomes for Ocular Delivery

Author(s): Axel Kattar; Ana Quelle-Regaldie; Laura Sánchez; Angel Concheiro; Carmen Alvarez-Lorenzo
Published in: reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela, Issue 1, 2023, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15041247

Penetration Enhancers for Topical Drug Delivery to the Ocular Posterior Segment—A Systematic Review

Author(s): Abhinav Thareja, Helen Hughes, Carmen Alvarez-Lorenzo, Jenni J. Hakkarainen, Zubair Ahmed
Published in: Pharmaceutics, Issue 13/2, 2021, Page(s) 276, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13020276

Mucoadhesive gellan gum-based and carboxymethyl cellulose -based hydrogels containing gemcitabine and papain for bladder cancer treatment

Author(s): Caroline S.A. de Lima; M. Isabel Rial-Hermida; Lucas Freitas de Freitas; Ana F. Pereira-da-Mota; Maria Vivero-Lopez; Aryel Heitor Ferreira; Sławomir Kadłubowski; Gustavo H.C. Varca; Ademar B. Lugão; Carmen Alvarez-Lorenzo
Published in: Crossref, Issue 2, 2023, ISSN 0141-8130
Publisher: Elsevier BV
DOI: 10.1016/j.ijbiomac.2023.124957

Contact lenses for pravastatin delivery to eye segments: Design and in vitro-in vivo correlations

Author(s): Ana F.Pereira-da-Mota, Maria Vivero-Lopez, Maria Serramito, Luis Diaz-Gomez, Ana Paula Serro, Gonzalo Carracedo, Fernando Huete-Toral, Angel Concheiro, Carmen Alvarez-Lorenzo
Published in: Journal of Controlled Release, Issue 348, 2022, Page(s) 431-443, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2022.06.001

Asymmetry in Drug Permeability through the Cornea

Author(s): Nadia Toffoletto, Anuj Chauhan, Carmen Alvarez-Lorenzo, Benilde Saramago, Ana Paula Serro
Published in: Pharmaceutics, Issue 13/5, 2021, Page(s) 694, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13050694

Posterior Segment Ophthalmic Drug Delivery: Role of Muco-Adhesion with a Special Focus on Chitosan

Author(s): Ayah Mohammad Burhan; Butsabarat Klahan; Wayne Cummins; Vanessa Andrés-Guerrero; Mark E. Byrne; Niall J. O’Reilly; Anuj Chauhan; Laurence Fitzhenry; Helen Hughes
Published in: Pharmaceutics, Issue 13, 2021, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13101685

Epidemiology of Ocular Manifestations in Autoimmune Disease

Author(s): Katie Glover; Deepakkumar Mishra; Thakur Raghu Raj Singh
Published in: Frontiers in Immunology, Issue 2, 2021, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2021.744396

Penetration enhancers for topical drug delivery to the ocular posterior segment: a systematic Review

Author(s): Thareja, Abhinav; Hughes, Helen; Álvarez Lorenzo, Carmen Isabel; Hakkarainen, Jenni J.; Ahmed, Zubair
Published in: reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela, Issue 1, 2021, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13020276

Drug-Loaded Hydrogels for Intraocular Lenses with Prophylactic Action against Pseudophakic Cystoid Macular Edema

Author(s): Nadia Toffoletto, Madalena Salema-Oom, Soledad Anguiano Igea, Carmen Alvarez-Lorenzo, Benilde Saramago, Ana Paula Serro
Published in: Pharmaceutics, Issue 13/7, 2021, Page(s) 976, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13070976

Langmuir monolayer studies of non-ionic surfactants and DOTMA for the design of ophthalmic niosomes

Author(s): Axel Kattar Emílio V. Lage Matilde Casas Angel Concheiro Carmen Alvarez-Lorenzo
Published in: Heliyon, 2024, ISSN 2405-8440
Publisher: Elsevier
DOI: 10.1016/j.heliyon.2024.e25887

Lipid-Based Nanocarriers for Ophthalmic Administration: Towards Experimental Design Implementation

Author(s): Felipe M. González-Fernández, Annalisa Bianchera, Paolo Gasco, Sara Nicoli, Silvia Pescina
Published in: Pharmaceutics, Issue 13/4, 2021, Page(s) 447, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13040447

Conference proceedings (1)

Development of 3D-printed devices for the study of transscleral drug delivery on freshly excised whole porcine eyes

Author(s): Felipe M. González-Fernández, Daniele A. Cauzzi, Sara Nicoli, Paolo Gasco, Silvia Pescina
Published in: Volume 100, Issue S275 Special Issue:Abstracts from the 2022 European Association for Vision and Eye Research Festival, 13‐15 October 2022, Valencia, 2022
Publisher: Wiley
DOI: 10.1111/j.1755-3768.2022.15545