Ocular Research By Integrated Training And Learning

Deliverables

Websites, patent fillings, videos etc. (1)

Launch of ORBITAL website and social media

ORBITALs website and social media presence will be launched at an early a stage as possible to ensure awareness as well as a platform for engagement with the scientific and lay communities

Publications

Peer reviewed articles (16)

Melatonin-Eluting Contact Lenses Effect on Tear Volume: In Vitro and In Vivo Experiments

Author(s): María Serramito, Ana F. Pereira-da-Mota, Carlos Carpena-Torres, Fernando Huete-Toral, Carmen Alvarez-Lorenzo, and Gonzalo Carracedo
Published in: Pharmaceutics, 1019, 2022, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14051019

Diabetic eye: associated diseases, drugs in clinic, and role of self-assembled carriers in topical treatment

Author(s): Axel Kattar, Angel Concheiro, Carmen Alvarez-Lorenzo
Published in: Expert Opinion on Drug Delivery, 2021, Page(s) 1-19, ISSN 1742-5247
Publisher: Ashley Publications Ltd.
DOI: 10.1080/17425247.2021.1953466

In vitro–in vivo correlation of drug release profiles from medicated contact lenses using an in vitro eye blink model.

Author(s): Ana F. Pereira-da-Mota, Maria Vivero-Lopez, Piyush Garg, Chau-Minh Phan, Angel Concheiro, Lyndon Jones & Carmen Alvarez-Lorenzo
Published in: Drug Delivery and Translational Research, 13, 2023, Page(s) 1116–1127, ISSN 2190-3948
Publisher: Springer Nature
DOI: 10.1007/s13346-022-01276-6

Testing drug release from medicated contact lenses: the missing link to predict in vivo performance

Author(s): Ana F. Pereira-da-Mota, Chau-Minh Phan, Angel Concheiro, Lyndon Jones, Carmen Alvarez-Lorenzo
Published in: Journal of Controlled Release, 343, 2022, Page(s) 672-702, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2022.02.014

Atorvastatin-Eluting Contact Lenses: Effects of Molecular Imprinting and Sterilization on Drug Loading and Release

Author(s): Ana F. Pereira-da-Mota, María Vivero-Lopez, Ana Topete, Ana Paula Serro, Angel Concheiro, Carmen Alvarez-Lorenzo
Published in: Pharmaceutics, 13/5, 2021, Page(s) 606, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13050606

Niosomes-based gene delivery systems for effective transfection of human mesenchymal stem cells

Author(s): Natalia Carballo-Pedrares, Axel Kattar, Angel Concheiro, Carmen Alvarez-Lorenzo, Ana Rey-Rico
Published in: Materials Science and Engineering: C, 128, 2021, Page(s) 112307, ISSN 0928-4931
Publisher: Elsevier BV
DOI: 10.1016/j.msec.2021.112307

From Oxidative Stress to Inflammation in the Posterior Ocular Diseases: Diagnosis and Treatment.

Author(s): Azza Dammak; Fernando Huete-Toral; Carlos Carpena-Torres; Alba Martin-Gil; Cristina Pastrana; Gonzalo Carracedo
Published in: Pharmaceutics, 13, 2021, Page(s) 1376, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13091376

Therapeutic Ophthalmic Lenses: A Review

Author(s): Nadia Toffoletto, Benilde Saramago, Ana Paula Serro
Published in: Pharmaceutics, 13/1, 2021, Page(s) 36, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13010036

Drug-Loaded Hydrogels for Intraocular Lenses with Prophylactic Action against Pseudophakic Cystoid Macular Edema

Author(s): Nadia Toffoletto; Madalena Salema-Oom; Soledad Anguiano Igea; Carmen Alvarez-Lorenzo; Benilde Saramago; Ana Paula Serro
Published in: Volume 13, 13, 2021, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13070976

Lipid-Based Nanocarriers for Ophthalmic Administration: Towards Experimental Design Implementation.

Author(s): Felipe M González-Fernández; Annalisa Bianchera; Paolo Gasco; Sara Nicoli; Silvia Pescina
Published in: Pharmaceutics, 13, 2021, Page(s) 447, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13040447

Penetration Enhancers for Topical Drug Delivery to the Ocular Posterior Segment—A Systematic Review

Author(s): Abhinav Thareja, Helen Hughes, Carmen Alvarez-Lorenzo, Jenni J. Hakkarainen, Zubair Ahmed
Published in: Pharmaceutics, 13/2, 2021, Page(s) 276, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13020276

Contact lenses for pravastatin delivery to eye segments: Design and in vitro-in vivo correlations

Author(s): Ana F.Pereira-da-Mota, Maria Vivero-Lopez, Maria Serramito, Luis Diaz-Gomez, Ana Paula Serro, Gonzalo Carracedo, Fernando Huete-Toral, Angel Concheiro, Carmen Alvarez-Lorenzo
Published in: Journal of Controlled Release, 348, 2022, Page(s) 431-443, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2022.06.001

Asymmetry in Drug Permeability through the Cornea

Author(s): Nadia Toffoletto, Anuj Chauhan, Carmen Alvarez-Lorenzo, Benilde Saramago, Ana Paula Serro
Published in: Pharmaceutics, 13/5, 2021, Page(s) 694, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13050694

Posterior Segment Ophthalmic Drug Delivery: Role of Muco-Adhesion with a Special Focus on Chitosan

Author(s): Ayah Mohammad Burhan; Butsabarat Klahan; Wayne Cummins; Vanessa Andrés-Guerrero; Mark E. Byrne; Niall J. O’Reilly; Anuj Chauhan; Laurence Fitzhenry; Helen Hughes
Published in: Pharmaceutics, 13, 2021, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13101685

Drug-Loaded Hydrogels for Intraocular Lenses with Prophylactic Action against Pseudophakic Cystoid Macular Edema

Author(s): Nadia Toffoletto, Madalena Salema-Oom, Soledad Anguiano Igea, Carmen Alvarez-Lorenzo, Benilde Saramago, Ana Paula Serro
Published in: Pharmaceutics, 13/7, 2021, Page(s) 976, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13070976

Lipid-Based Nanocarriers for Ophthalmic Administration: Towards Experimental Design Implementation

Author(s): Felipe M. González-Fernández, Annalisa Bianchera, Paolo Gasco, Sara Nicoli, Silvia Pescina
Published in: Pharmaceutics, 13/4, 2021, Page(s) 447, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13040447